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Conserved domains on  [gi|1907076870|ref|XP_036011838|]
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required for meiotic nuclear division protein 1 homolog isoform X1 [Mus musculus]

Protein Classification

RMD1 family protein( domain architecture ID 10495421)

RMD1 family protein contains a DUF155 domain; similar to Saccharomyces cerevisiae sporulation protein RMD1, which is required for sporulation where it is believed to have a role in meiotic nuclear division, and human required for meiotic nuclear division protein 1 homolog (RMND1), which is required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
227-404 1.07e-61

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


:

Pssm-ID: 460604  Cd Length: 173  Bit Score: 197.83  E-value: 1.07e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 227 IFLFREGAAVFWNVKEKTMKHVMQVLERHETQPYEV-ALVHWENEELNYIkTEGQSKLHRGEIKLNSeldldDAILEKFA 305
Cdd:pfam02582   1 VFVFRYGVVVFWNLSEEEEKRFLKDLLRFAEEPSIPpLLEEEETEEFDYV-YPSESRIQNDIIVLGS-----DDLLAKLA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 306 FSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEE 385
Cdd:pfam02582  75 ISHALAQSVKLSVFEELLDKLLESTESIPEELAKTGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEP 154
                         170
                  ....*....|....*....
gi 1907076870 386 LYDKTCQFLSITRRVKVMN 404
Cdd:pfam02582 155 LYEALREYLEIKERIEVLN 173
 
Name Accession Description Interval E-value
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
227-404 1.07e-61

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


Pssm-ID: 460604  Cd Length: 173  Bit Score: 197.83  E-value: 1.07e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 227 IFLFREGAAVFWNVKEKTMKHVMQVLERHETQPYEV-ALVHWENEELNYIkTEGQSKLHRGEIKLNSeldldDAILEKFA 305
Cdd:pfam02582   1 VFVFRYGVVVFWNLSEEEEKRFLKDLLRFAEEPSIPpLLEEEETEEFDYV-YPSESRIQNDIIVLGS-----DDLLAKLA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 306 FSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEE 385
Cdd:pfam02582  75 ISHALAQSVKLSVFEELLDKLLESTESIPEELAKTGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEP 154
                         170
                  ....*....|....*....
gi 1907076870 386 LYDKTCQFLSITRRVKVMN 404
Cdd:pfam02582 155 LYEALREYLEIKERIEVLN 173
Rmd1 COG1723
Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure ...
172-450 9.85e-55

Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441329  Cd Length: 261  Bit Score: 183.10  E-value: 9.85e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 172 MQCTAFATADEYHLGSLSQELVScgyvEVTSLPRDAANIlvmgvessaKEGDPGTIFLFREGAAVFWNVKEKTMKHVMQV 251
Cdd:COG1723     4 LRCRAYCLGERIDLKRLEEALKL----STKYRWRDPLIL---------RVGEGGFVVLFRYGVVVFFGVSEDEEADFLDE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 252 LERHETQPYEVAlvhwENEELNY-IKTEGQSKLHRGEIKLNselDLDDAILEkfAFSNALCLSVKLAIWEATLDKFIESI 330
Cdd:COG1723    71 LKPFVEEPLEEP----ESEEFEIeIGPDEEDRVEEDHIILP---DLDPERLL--LVSDVLAQSVALARYEERVAALFDEI 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 331 QSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHC 410
Cdd:COG1723   142 EPLAQELAKKGKLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEALNRKLEII 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907076870 411 MELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF 450
Cdd:COG1723   222 HETLETLLDLLQHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
 
Name Accession Description Interval E-value
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
227-404 1.07e-61

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


Pssm-ID: 460604  Cd Length: 173  Bit Score: 197.83  E-value: 1.07e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 227 IFLFREGAAVFWNVKEKTMKHVMQVLERHETQPYEV-ALVHWENEELNYIkTEGQSKLHRGEIKLNSeldldDAILEKFA 305
Cdd:pfam02582   1 VFVFRYGVVVFWNLSEEEEKRFLKDLLRFAEEPSIPpLLEEEETEEFDYV-YPSESRIQNDIIVLGS-----DDLLAKLA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 306 FSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEE 385
Cdd:pfam02582  75 ISHALAQSVKLSVFEELLDKLLESTESIPEELAKTGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEP 154
                         170
                  ....*....|....*....
gi 1907076870 386 LYDKTCQFLSITRRVKVMN 404
Cdd:pfam02582 155 LYEALREYLEIKERIEVLN 173
Rmd1 COG1723
Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure ...
172-450 9.85e-55

Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441329  Cd Length: 261  Bit Score: 183.10  E-value: 9.85e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 172 MQCTAFATADEYHLGSLSQELVScgyvEVTSLPRDAANIlvmgvessaKEGDPGTIFLFREGAAVFWNVKEKTMKHVMQV 251
Cdd:COG1723     4 LRCRAYCLGERIDLKRLEEALKL----STKYRWRDPLIL---------RVGEGGFVVLFRYGVVVFFGVSEDEEADFLDE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 252 LERHETQPYEVAlvhwENEELNY-IKTEGQSKLHRGEIKLNselDLDDAILEkfAFSNALCLSVKLAIWEATLDKFIESI 330
Cdd:COG1723    71 LKPFVEEPLEEP----ESEEFEIeIGPDEEDRVEEDHIILP---DLDPERLL--LVSDVLAQSVALARYEERVAALFDEI 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076870 331 QSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHC 410
Cdd:COG1723   142 EPLAQELAKKGKLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEALNRKLEII 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907076870 411 MELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF 450
Cdd:COG1723   222 HETLETLLDLLQHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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