NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907184964|ref|XP_036009448|]
View 

DENN domain-containing protein 2B isoform X4 [Mus musculus]

Protein Classification

uDENN domain-containing protein( domain architecture ID 10655158)

uDENN domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 694-781 5.65e-24

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 96.63  E-value: 5.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184964  694 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 770
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 1907184964  771 SRRFGYCRRLL 781
Cdd:smart00800  79 SRRYGFCLRFY 89
 
Name Accession Description Interval E-value
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 694-781 5.65e-24

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 96.63  E-value: 5.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184964  694 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 770
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 1907184964  771 SRRFGYCRRLL 781
Cdd:smart00800  79 SRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 713-779 2.16e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 68.02  E-value: 2.16e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907184964 713 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 779
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPL------PDGIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGACLT 59
 
Name Accession Description Interval E-value
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 694-781 5.65e-24

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 96.63  E-value: 5.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184964  694 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 770
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 1907184964  771 SRRFGYCRRLL 781
Cdd:smart00800  79 SRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 713-779 2.16e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 68.02  E-value: 2.16e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907184964 713 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 779
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPL------PDGIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGACLT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH