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Conserved domains on  [gi|1907184040|ref|XP_036009321|]
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zinc finger protein 715 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-87 2.04e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 2.04e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907184040  48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAV 87
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-817 3.37e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 378 TPFICDICGKAFLRKSELTSHKQCHNGEKPYKCND--CEKSFKFPSQLKVHHQIHTGEKPYECR-ECGKSFSKTAKLKVH 454
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 455 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 527
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 528 SFNFPCELKVHYQNHTGEKPYKcrecwklfskmsqLKAHYRVHTGERPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 607
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 608 ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETglqeatliphqqlhigeKPYKCPDCGKLFNYPSQLKSHYQ--IHTGE- 684
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESDSSSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 685 -KPCKCP--DCGKSFSKTSQLKAHSRIHTGERPYVC--SVCGKAFKQLSTLSRHEKIHM-----VEKPYKC--SFCGKSF 752
Cdd:COG5048   319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907184040 753 CSPSELKVHLLIHTGERP--YKCSSCWKAFCTKVQLQEHERIHTgERPYVCTHCGKAFRSRSVFSKH 817
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-87 2.04e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 2.04e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907184040  48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAV 87
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
48-88 2.77e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 2.77e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907184040   48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVE 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 48-84 2.95e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.95e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907184040  48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHL 84
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-817 3.37e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 378 TPFICDICGKAFLRKSELTSHKQCHNGEKPYKCND--CEKSFKFPSQLKVHHQIHTGEKPYECR-ECGKSFSKTAKLKVH 454
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 455 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 527
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 528 SFNFPCELKVHYQNHTGEKPYKcrecwklfskmsqLKAHYRVHTGERPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 607
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 608 ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETglqeatliphqqlhigeKPYKCPDCGKLFNYPSQLKSHYQ--IHTGE- 684
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESDSSSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 685 -KPCKCP--DCGKSFSKTSQLKAHSRIHTGERPYVC--SVCGKAFKQLSTLSRHEKIHM-----VEKPYKC--SFCGKSF 752
Cdd:COG5048   319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907184040 753 CSPSELKVHLLIHTGERP--YKCSSCWKAFCTKVQLQEHERIHTgERPYVCTHCGKAFRSRSVFSKH 817
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-475 2.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|....*
gi 1907184040 451 LKVHQRIHTGEKPYVCSQCGKAFNQ 475
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-87 2.04e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 2.04e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907184040  48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAV 87
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
48-88 2.77e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 2.77e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907184040   48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVE 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 48-84 2.95e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.95e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907184040  48 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHL 84
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-817 3.37e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 378 TPFICDICGKAFLRKSELTSHKQCHNGEKPYKCND--CEKSFKFPSQLKVHHQIHTGEKPYECR-ECGKSFSKTAKLKVH 454
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 455 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 527
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 528 SFNFPCELKVHYQNHTGEKPYKcrecwklfskmsqLKAHYRVHTGERPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 607
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 608 ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETglqeatliphqqlhigeKPYKCPDCGKLFNYPSQLKSHYQ--IHTGE- 684
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESDSSSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 685 -KPCKCP--DCGKSFSKTSQLKAHSRIHTGERPYVC--SVCGKAFKQLSTLSRHEKIHM-----VEKPYKC--SFCGKSF 752
Cdd:COG5048   319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907184040 753 CSPSELKVHLLIHTGERP--YKCSSCWKAFCTKVQLQEHERIHTgERPYVCTHCGKAFRSRSVFSKH 817
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-734 2.93e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 322 DPYKCSSCEKSFCNAAALQQHEQIHTEEKLYVCTL--CGKAFSDGSAFYEHELIHKNHTPFICDICG---KAFLRKSELT 396
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 397 SHkqCHNGEKPYKCNDCEKSFKFPSQLKVHHQIHTGEKPYECRECGKSFSKTaklKVHQRIHtGEKPYVCSQCGKAFNQK 476
Cdd:COG5048   112 SS--SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNT---PQSNSLH-PPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 477 SILdrHEKLHPGEKPYKCNDCGKSFNYPSQLKVHCHSHTGEKPYKCHECgkSFNFPCELKVHYQNHTGEKPYKCRECWKL 556
Cdd:COG5048   186 LLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 557 FS----KMSQLKAHYRVHTGER-----PYKCSHCGKAFSTKEQVQEHER--IHTGE--KPFVCTE--CGKAFSSRSSFRK 621
Cdd:COG5048   262 RSslptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 622 HQLIHTKEKPF---------VSQKCETGLQEATLIPHQQLHIgEKPYKCPDCGKLFNYPSQ--LKSHYQIHTGEKP--CK 688
Cdd:COG5048   342 HILLHTSISPAkekllnsssKFSPLLNNEPPQSLQQYKDLKN-DKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCK 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1907184040 689 CPDCGKSFSKTSQLKAHSRIHTGERPYVCSVCGKAFKQLSTLSRHE 734
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 654-735 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 654 IGEKPYKCP--DCGKLFNYPSQLKSH-YQIHTGEKPCKCPDCGKsfsktsqlkaHSRIHTGERPYVCSVCGKAFKQLSTL 730
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*
gi 1907184040 731 SRHEK 735
Cdd:COG5189   415 KYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-475 2.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|....*
gi 1907184040 451 LKVHQRIHTGEKPYVCSQCGKAFNQ 475
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
730-752 4.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.80e-04
                          10        20
                  ....*....|....*....|...
gi 1907184040 730 LSRHEKIHMVEKPYKCSFCGKSF 752
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
786-810 4.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.94e-04
                          10        20
                  ....*....|....*....|....*
gi 1907184040 786 LQEHERIHTGERPYVCTHCGKAFRS 810
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
702-726 6.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.83e-04
                          10        20
                  ....*....|....*....|....*
gi 1907184040 702 LKAHSRIHTGERPYVCSVCGKAFKQ 726
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
592-615 6.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.90e-04
                          10        20
                  ....*....|....*....|....
gi 1907184040 592 QEHERIHTGEKPFVCTECGKAFSS 615
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
479-503 7.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.39e-04
                          10        20
                  ....*....|....*....|....*
gi 1907184040 479 LDRHEKLHPGEKPYKCNDCGKSFNY 503
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-530 9.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.08e-04
                          10        20
                  ....*....|....*....|....
gi 1907184040 507 LKVHCHSHTGEKPYKCHECGKSFN 530
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
574-854 9.33e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 9.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 574 RPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT--ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETGLQEATL--IPH 649
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASssSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 650 QQLHIGEKPYKCPDCGKLFNYPSQLKSHYQIHTGEKPCKCPDCGKSFSKTSQ----------------------LKAHSR 707
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 708 IHTGERPYVCSVCGKAFKQLSTLSRHEKIHMVEKPYKCSFCGKSF------CSPSELKVHLLIHTGERPYKCSSCWKAFC 781
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 782 TKVQLQEHERIHTGER-PYVCTHCGKAFRSRSVFSKHK--LIHRKE--TPFIC--ERCGKVFLQKSELTSHLQTHIEDKP 854
Cdd:COG5048   272 SSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-587 1.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1907184040 563 LKAHYRVHTGERPYKCSHCGKAFST 587
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
423-447 1.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*
gi 1907184040 423 LKVHHQIHTGEKPYECRECGKSFSK 447
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 600-677 2.75e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 600 GEKPFVC--TECGKAFSSRSSFRKHQLiHTKEKPFVSQKCETglqeatlIPHQQLHIGEKPYKCPDCGKLFNYPSQLKSH 677
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP-------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 684-761 4.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 684 EKPCKCPDCGKSFSKTSQLKAH---SRIHT-GERPYVCSV--CGKAFKQLSTLSRHEK-------------------IHM 738
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSA 394

                          90       100
                  ....*....|....*....|...
gi 1907184040 739 VEKPYKCSFCGKSFCSPSELKVH 761
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 361-514 4.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184040 361 FSDGSAFYEHELIHKNHTpfICDICGkAFLRKSELTSHKQCHNGEK--PYKCNDCEKSFKFPSQLkvhhQIHTGEKPYEC 438
Cdd:COG5189   280 FEESSLGFDYEFIHKSVG--NKEIRG-GISTGEMIDVRKLPCTNSSsnGKLAHGGERNIDTPSRM----LKVKDGKPYKC 352

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907184040 439 R--ECGKSFSKTAKLKVHqRIHtgekpyvcSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKSFNYPSQLKVH-CHSH 514
Cdd:COG5189   353 PveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHrKHSH 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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