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Conserved domains on  [gi|1907178910|ref|XP_036008747|]
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zinc finger protein 143 isoform X3 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-221 7.51e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  48 AHHLKVHERSHTGdRPYQCEHSGCGKAFATGYGLKSHFRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 123
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910 124 FKCPIEGCGRSFTTSNIRK-----VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 198
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 1907178910 199 SSLYKHHVVHTHSKPYNCNHCGK 221
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 4-89 8.61e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910   4 ENEQEKKMQIVLQGHATRVTPKSQQ--SGEKAFRCKYDGCGKLYTTAHHLKVH---------------ERSHTG----DR 62
Cdd:COG5189   318 CTNSSSNGKLAHGGERNIDTPSRMLkvKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDK 397

                          90       100
                  ....*....|....*....|....*..
gi 1907178910  63 PYQCEHsgCGKAFATGYGLKSHfRTHT 89
Cdd:COG5189   398 PYRCEV--CDKRYKNLNGLKYH-RKHS 421
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-221 7.51e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  48 AHHLKVHERSHTGdRPYQCEHSGCGKAFATGYGLKSHFRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 123
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910 124 FKCPIEGCGRSFTTSNIRK-----VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 198
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 1907178910 199 SSLYKHHVVHTHSKPYNCNHCGK 221
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 4-89 8.61e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910   4 ENEQEKKMQIVLQGHATRVTPKSQQ--SGEKAFRCKYDGCGKLYTTAHHLKVH---------------ERSHTG----DR 62
Cdd:COG5189   318 CTNSSSNGKLAHGGERNIDTPSRMLkvKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDK 397

                          90       100
                  ....*....|....*....|....*..
gi 1907178910  63 PYQCEHsgCGKAFATGYGLKSHfRTHT 89
Cdd:COG5189   398 PYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
81-107 1.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.55e-04
                          10        20
                  ....*....|....*....|....*..
gi 1907178910  81 LKSHFRTHTGEKPYRCSEdnCTKSFKT 107
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-221 7.51e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  48 AHHLKVHERSHTGdRPYQCEHSGCGKAFATGYGLKSHFRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 123
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910 124 FKCPIEGCGRSFTTSNIRK-----VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 198
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 1907178910 199 SSLYKHHVVHTHSKPYNCNHCGK 221
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-227 4.46e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.46e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907178910 152 RPYYCtePGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS 227
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 180-237 5.86e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 5.86e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907178910 180 GEKPYVCTVPGCDKRFTEYSSLyKHHVVHTH--------------------SKPYNCNHCGKTYKQISTLAMHKRTAH 237
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHqnqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 46-210 7.71e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.34  E-value: 7.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  46 TTAHHLKVHERSHTGDrpYQCEHSGCGKA-----FATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIrthtG 120
Cdd:COG5189   273 SQGSAELFEESSLGFD--YEFIHKSVGNKeirggISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVK----D 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910 121 ERPFKCPIEGCGRSFTTSNIRKVH-IRTHTGERPYYCTEPGCGRAFASAtnyknhvrihtgEKPYVCTVpgCDKRFTEYS 199
Cdd:COG5189   347 GKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNLN 412

                         170
                  ....*....|.
gi 1907178910 200 SLyKHHVVHTH 210
Cdd:COG5189   413 GL-KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
61-139 3.32e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.32e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907178910  61 DRPYQCEhsGCGKAFATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPIEGCGRSFTTSN 139
Cdd:COG5048    31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
29-205 4.92e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 4.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  29 SGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKafatgyglkshfrTHTGEKPYrcsednctksfKTS 108
Cdd:COG5048   317 ESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-------------KFSPLLNN-----------EPP 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910 109 GDLQKHIRTHTgERPFKCPIEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCtv 188
Cdd:COG5048   373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                         170
                  ....*....|....*..
gi 1907178910 189 pgCDKRFTEYSSLYKHH 205
Cdd:COG5048   450 --SILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 4-89 8.61e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910   4 ENEQEKKMQIVLQGHATRVTPKSQQ--SGEKAFRCKYDGCGKLYTTAHHLKVH---------------ERSHTG----DR 62
Cdd:COG5189   318 CTNSSSNGKLAHGGERNIDTPSRMLkvKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDK 397

                          90       100
                  ....*....|....*....|....*..
gi 1907178910  63 PYQCEHsgCGKAFATGYGLKSHfRTHT 89
Cdd:COG5189   398 PYRCEV--CDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-228 1.02e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907178910 156 CTEPGCGRAFASATNYKNHVR--IHTGE--KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNC--NHCGKTYKQIST 228
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368
zf-H2C2_2 pfam13465
Zinc-finger double domain;
81-107 1.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.55e-04
                          10        20
                  ....*....|....*....|....*..
gi 1907178910  81 LKSHFRTHTGEKPYRCSEdnCTKSFKT 107
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
110-137 1.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|....*...
gi 1907178910 110 DLQKHIRTHTGERPFKCPIegCGRSFTT 137
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
25-145 4.44e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  25 KSQQSGEKAFRCKYDGCGKLY----TTAHHLKVHERSH-TGDRPYQCEHSGCGKAFATGYGLKSHFRTHTGEKPYRCSED 99
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFspllNNEPPQSLQQYKDlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNP 422

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907178910 100 NCTKSFKTSGDLQKHIRTHTGERPFKCpiEGCGRSFTTSNIRKVHI 145
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNHGK 466
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 66-153 4.45e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 39.32  E-value: 4.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  66 CEHSGCGKAFATGYGLKSHFRTHTGE------KPYRCSEDNCTKSFKTSGDLQKHIRTH-TGERPFKCpiEGCGRSFTT- 137
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 1907178910 138 -SNIRKVHIRTHTGERP 153
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-111 6.30e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  18 HATRVTPKS-QQSGEKAFRC-KYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKAFATGYGLKSHFRTHTGEKPYR 95
Cdd:COG5048    14 SVLSSTPKStLKSLSNAPRPdSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90
                  ....*....|....*.
gi 1907178910  96 CSEDNCTKSFKTSGDL 111
Cdd:COG5048    94 NSKSLPLSNSKASSSS 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
50-77 6.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.55e-04
                          10        20
                  ....*....|....*....|....*...
gi 1907178910  50 HLKVHERSHTGDRPYQCEHsgCGKAFAT 77
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-196 8.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.79e-04
                          10        20
                  ....*....|....*....|....*..
gi 1907178910 170 NYKNHVRIHTGEKPYVCTVpgCDKRFT 196
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 94-118 7.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.37e-03
                          10        20
                  ....*....|....*....|....*
gi 1907178910  94 YRCSEdnCTKSFKTSGDLQKHIRTH 118
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 96-212 7.44e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 35.86  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907178910  96 CSEDNCTKSFKTSGDLQKHIRTHTgerPFKCPIEGcgrsfttsnirkvhirthtgeRPYYCTEPGCGRAFASATNYKNHV 175
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC---PPTQSLEG---------------------KLFRCSALSCTETFPSMQELVAHS 57

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907178910 176 RIHTGEKPYVcTVPGCDKRFTEYSSLYKH-HVVHTHSK 212
Cdd:pfam15909  58 KLHYKPNRYF-KCENCLLRFRTHRSLFKHlHVCAEHAQ 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
142-167 8.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907178910 142 KVHIRTHTGERPYYCTEpgCGRAFAS 167
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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