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Conserved domains on  [gi|1724784168|ref|XP_030274324|]
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ankyrin repeat domain-containing protein 34A [Sparus aurata]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-152 1.50e-30

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  11 GNALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALMHAc 90
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE------IVKLLLEAGADVNARDNDGETPLHLA- 193

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724784168  91 AELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDACKAKGKEVIIITTD 152
Cdd:COG0666   194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-152 1.50e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  11 GNALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALMHAc 90
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE------IVKLLLEAGADVNARDNDGETPLHLA- 193

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724784168  91 AELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDACKAKGKEVIIITTD 152
Cdd:COG0666   194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
Ank_2 pfam12796
Ankyrin repeats (3 copies);
14-113 4.23e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 4.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  14 LLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKgADPNIPDKsGRTALMHACaeL 93
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE------IVKLLLEH-ADVNLKDN-GRTALHYAA--R 70

                          90       100
                  ....*....|....*....|.
gi 1724784168  94 AG-KEVVSLLLENGADPSLKD 113
Cdd:pfam12796  71 SGhLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-122 1.54e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 1.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  19 FQGKLRLTRLLLEGGAYINEGNERGETPISAaCIASyddPQTRQRMVRYLLEKGADPNIPDKSGRTALmHACAELAGK-- 96
Cdd:PHA03095   93 NATTLDVIKLLIKAGADVNAKDKVGRTPLHV-YLSG---FNINPKVIRLLLRKGADVNALDLYGMTPL-AVLLKSRNAnv 167

                          90       100
                  ....*....|....*....|....*.
gi 1724784168  97 EVVSLLLENGADPSLKDYSGSSALVH 122
Cdd:PHA03095  168 ELLRLLIDAGADVYAVDDRFRSLLHH 193
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-152 1.50e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  11 GNALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALMHAc 90
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE------IVKLLLEAGADVNARDNDGETPLHLA- 193

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724784168  91 AELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDACKAKGKEVIIITTD 152
Cdd:COG0666   194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-138 2.34e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 2.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  12 NALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAAciASYDDPQtrqrMVRYLLEKGADPNIPDKSGRTALMHACA 91
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA--ARNGDLE----IVKLLLEAGADVNARDKDGETPLHLAAY 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1724784168  92 ElaG-KEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDA 138
Cdd:COG0666   130 N--GnLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-152 1.77e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.72  E-value: 1.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  13 ALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALMHAcAE 92
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE------IVKLLLEAGADVNAKDNDGKTALDLA-AE 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  93 LAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDACKAKGKEVIIITTD 152
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
14-113 4.23e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 4.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  14 LLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKgADPNIPDKsGRTALMHACaeL 93
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE------IVKLLLEH-ADVNLKDN-GRTALHYAA--R 70

                          90       100
                  ....*....|....*....|.
gi 1724784168  94 AG-KEVVSLLLENGADPSLKD 113
Cdd:pfam12796  71 SGhLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-138 6.42e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.21  E-value: 6.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  12 NALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALMHAcA 91
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLL------VALLLLAAGADINAKDDGGNTLLHAA-A 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1724784168  92 ELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDA 138
Cdd:COG0666    96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-137 7.58e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 7.58e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724784168  64 MVRYLLEKGADPNIPDKSGRTALMHACaeLAG-KEVVSLLLENgADPSLKDYsGSSALVHAINKGDRDTLQVLLD 137
Cdd:pfam12796  12 LVKLLLENGADANLQDKNGRTALHLAA--KNGhLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLE 82
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-122 1.54e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 1.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  19 FQGKLRLTRLLLEGGAYINEGNERGETPISAaCIASyddPQTRQRMVRYLLEKGADPNIPDKSGRTALmHACAELAGK-- 96
Cdd:PHA03095   93 NATTLDVIKLLIKAGADVNAKDKVGRTPLHV-YLSG---FNINPKVIRLLLRKGADVNALDLYGMTPL-AVLLKSRNAnv 167

                          90       100
                  ....*....|....*....|....*.
gi 1724784168  97 EVVSLLLENGADPSLKDYSGSSALVH 122
Cdd:PHA03095  168 ELLRLLIDAGADVYAVDDRFRSLLHH 193
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 65-139 1.21e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.07  E-value: 1.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724784168  65 VRYLLEKGADPNIPDKSGRTALMHACAeLAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDAC 139
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACA-NGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 14-138 1.66e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.00  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  14 LLKAVFQGKLRLTRLLLEGGAYINEG-NERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDkSGRTALMHACAE 92
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLD------IMKLLIARGADPDIPN-TDKFSPLHLAVM 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1724784168  93 LAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDA 138
Cdd:PHA02875  145 MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 28-108 2.16e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  28 LLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALmHACAELAGKEVVSLLLENGA 107
Cdd:PHA03100  177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPE------FVKYLLDLGANPNLVNKYGDTPL-HIAILNNNKEIFKLLLNNGP 249


                  .
gi 1724784168 108 D 108
Cdd:PHA03100  250 S 250
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 22-167 8.91e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.75  E-value: 8.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  22 KLRLTRLLLEGGAYINEGNErgetpisaaciasyddpqtrqrmVRYLLEKGADPNIPDKSGRTALMHACaELAGKEVVSL 101
Cdd:PHA03100  155 DLKILKLLIDKGVDINAKNR-----------------------VNYLLSYGVPINIKDVYGFTPLHYAV-YNNNPEFVKY 210

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784168 102 LLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDaCKA---KGKEVIIITTDTSPSGTKKTKQYLNS 167
Cdd:PHA03100  211 LLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN-NGPsikTIIETLLYFKDKDLNTITKIKMLKKS 278
PHA03095 PHA03095
ankyrin-like protein; Provisional
 27-138 9.56e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 9.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  27 RLLLEGGAYINEGNERGETPISAaCIASYDDPqtRQRMVRYLLEKGADPNIPDKSGRTALmHACAELAGKE-VVSLLLEN 105
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHL-YLHYSSEK--VKDIVRLLLEAGADVNAPERCGFTPL-HLYLYNATTLdVIKLLIKA 106

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1724784168 106 GADPSLKDYSGSSAL-VHAINKG-DRDTLQVLLDA 138
Cdd:PHA03095  107 GADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRK 141
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-137 2.85e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  24 RLTRLLLEGGAYINEGNERGETPISAACIASYDDPQtrqrmVRYLLEKGADPNIPDKSGRTALMHACAELAGKEVVSLLL 103
Cdd:PHA02876  288 RLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEN-----IRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLL 362

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1724784168 104 ENGADPSLKDYSGSSALVHAINKGDRDTLQVLLD 137
Cdd:PHA02876  363 ELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD 396
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 24-165 6.29e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  24 RLTRLLLEGGAYINEGNERGETPISAAcIASYDDPqtrqrMVRYLLEKGADPNIPDKSGRTALMHACAELAGKEVVSLLL 103
Cdd:PHA02878  182 RLTELLLSYGANVNIPDKTNNSPLHHA-VKHYNKP-----IVHILLENGASTDARDKCGNTPLHISVGYCKDYDILKLLL 255

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724784168 104 ENGADPSLKDY-SGSSALVHAINkgDRDTLQVLLDAckakGKEVIIITTDTSPSGTKKTKQYL 165
Cdd:PHA02878  256 EHGVDVNAKSYiLGLTALHSSIK--SERKLKLLLEY----GADINSLNSYKLTPLSSAVKQYL 312
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-136 7.64e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.50  E-value: 7.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  25 LTRLLLEGGAYINEGNERGETPISAAciASYDDPQTrqrmVRYLLEKGADPNIPDKSGRTALMHACaeLAGKEVVSLLLE 104
Cdd:PHA02874  172 IIKLLLEKGAYANVKDNNGESPLHNA--AEYGDYAC----IKLLIDHGNHIMNKCKNGFTPLHNAI--IHNRSAIELLIN 243

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1724784168 105 NgADPSLKDYSGSSALVHAIN-KGDRDTLQVLL 136
Cdd:PHA02874  244 N-ASINDQDIDGSTPLHHAINpPCDIDIIDILL 275
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 28-137 1.31e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.82  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  28 LLLEGGAYINEGNERGETPISAACIASY---DDPQTrqrmVRYLLEKGADPNIPDKSGRTALMHA-CAELAGKEVVSLLL 103
Cdd:PHA03100   53 ILLDNGADINSSTKNNSTPLHYLSNIKYnltDVKEI----VKLLLEYGANVNAPDNNGITPLLYAiSKKSNSYSIVEYLL 128

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1724784168 104 ENGADPSLKDYSGSSALvHAI---NKGDRDTLQVLLD 137
Cdd:PHA03100  129 DNGANVNIKNSDGENLL-HLYlesNKIDLKILKLLID 164
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-103 1.39e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 1.39e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  45 TPISAACIASyddpqtRQRMVRYLLEKGADPNIPDKSGRTALMHACaeLAG-KEVVSLLL 103
Cdd:pfam13637   3 TALHAAAASG------HLELLRLLLEKGADINAVDGNGETALHFAA--SNGnVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 14-137 2.00e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  14 LLKAVFQGKLRLTRLLLEGGAYINEGNERGETPI-SAACIASYDD----------------PQTRQRMVRYLLEKGADPN 76
Cdd:PHA02874   39 LIDAIRSGDAKIVELFIKHGADINHINTKIPHPLlTAIKIGAHDIikllidngvdtsilpiPCIEKDMIKTILDCGIDVN 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724784168  77 IPDKSGRTALMHACAElAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLD 137
Cdd:PHA02874  119 IKDAELKTFLHYAIKK-GDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-136 2.22e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 2.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1724784168  83 RTALMHACAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLL 136
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
12-79 2.35e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 2.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724784168  12 NALLKAVFQGKLRLTRLLLEgGAYINEGNErGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPD 79
Cdd:pfam12796  32 TALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLE------IVKLLLEKGADINVKD 91
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 82-113 3.79e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.43  E-value: 3.79e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1724784168  82 GRTALMHACAELAGKEVVSLLLENGADPSLKD 113
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 27-103 4.60e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  27 RLLLEGGAYINEGNERGETPISAACIASyddpqtRQRMVRYLLEKGADPNIPDKSGRTALmhacaELAGK----EVVSLL 102
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANG------HVQVVRVLLEFGADPTLLDKDGKTPL-----ELAEEngfrEVVQLL 167


                  .
gi 1724784168 103 L 103
Cdd:PTZ00322  168 S 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 65-137 5.27e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.81  E-value: 5.27e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724784168  65 VRYLLEKGADPNIPDKSGRTALmHACAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLD 137
Cdd:PHA02874  140 IKMLFEYGADVNIEDDNGCYPI-HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLID 211
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 51-136 1.02e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  51 CIASYDDpQTRQRMVRYLLEKGADPNIPDKSGRTALMHACAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRD 130
Cdd:PHA02878  137 DKKSKDD-IIEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKP 215


                  ....*.
gi 1724784168 131 TLQVLL 136
Cdd:PHA02878  216 IVHILL 221
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 6-126 1.31e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.57  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168   6 PLQTEGNALLKAVFQGKLRLTRLLLEGGAYINEGNERGETP--ISAACIASYDdpqtrqrMVRYLLEKGADPNIpdKS-- 81
Cdd:PHA02878  197 PDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPlhISVGYCKDYD-------ILKLLLEHGVDVNA--KSyi 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1724784168  82 -GRTALMHAcaeLAGKEVVSLLLENGADPSLKDYSGSSALVHAINK 126
Cdd:PHA02878  268 lGLTALHSS---IKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-137 1.31e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 1.31e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784168  59 QTRQRMVRYLLEKGADPNIPDKSGRTALmHACAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLD 137
Cdd:PHA02876  155 QDELLIAEMLLEGGADVNAKDIYCITPI-HYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-145 1.56e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 1.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784168  87 MHACAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDACKAKGKE 145
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD 59
Ank_5 pfam13857
Ankyrin repeats (many copies);
28-89 1.66e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 1.66e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724784168  28 LLLEGGAYINEGNERGETPISAACIASYDDpqtrqrMVRYLLEKGADPNIPDKSGRTALMHA 89
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALE------IVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-123 2.66e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 2.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1724784168  68 LLEKG-ADPNIPDKSGRTALMHACaeLAGK-EVVSLLLENGADPSLKDYSGSSALVHA 123
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAA--KYGAlEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 29-89 1.44e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 1.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724784168  29 LLEGGAYINEGNERGETPISAAciASYDDPqtrqRMVRYLLEKGADPNIPDKSGRTALMHA 89
Cdd:PHA03095  243 LLIAGISINARNRYGQTPLHYA--AVFNNP----RACRRLIALGADINAVSSDGNTPLSLM 297
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 68-135 1.68e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 1.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724784168  68 LLEKGADPNIPDKSGRTALmHACAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINKGDRDTLQVL 135
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPL-HIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 64-126 1.93e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.89  E-value: 1.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1724784168  64 MVRYLLEKGADPNIPDKSGRTALMHACAELA----GKEVVSLLLENGADPSLKDYSGSSALVHAINK 126
Cdd:PHA03100   50 VVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdVKEIVKLLLEYGANVNAPDNNGITPLLYAISK 116
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-138 2.04e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  20 QGKLRLTRLLLEGGAYINEGNERGETPISAAciASYDDpqtrQRMVRYLLEKGADPNIPDKSGRTALMHAcAELAGKEVV 99
Cdd:PHA02876  155 QDELLIAEMLLEGGADVNAKDIYCITPIHYA--AERGN----AKMVNLLLSYGADVNIIALDDLSVLECA-VDSKNIDTI 227

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1724784168 100 SLLLENGADPSLKDYSgssaLVHAINKGDRDTLQVLLDA 138
Cdd:PHA02876  228 KAIIDNRSNINKNDLS----LLKAIRNEDLETSLLLYDA 262
PHA03095 PHA03095
ankyrin-like protein; Provisional
 65-120 2.53e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.47  E-value: 2.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1724784168  65 VRYLLEKGADPNIPDKSGRTALmHACAELAG---KEVVSLLLENGADPSLKDYSGSSAL 120
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKTPL-HLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPL 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
 27-120 2.71e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.47  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  27 RLLLEGGAYINEGNERGETPIsAACIASYD-DPqtrqRMVRYLLEKGADPNIPDKSGRTALMHACAEL-AGKEVVSLLLE 104
Cdd:PHA03095  136 RLLLRKGADVNALDLYGMTPL-AVLLKSRNaNV----ELLRLLIDAGADVYAVDDRFRSLLHHHLQSFkPRARIVRELIR 210

                          90
                  ....*....|....*.
gi 1724784168 105 NGADPSLKDYSGSSAL 120
Cdd:PHA03095  211 AGCDPAATDMLGNTPL 226
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 17-108 4.92e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 4.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  17 AVFQGKLRLTRLLLEGGAYINEGNERGETPISAAciASYDDPQtrqrMVRYLLEKGADPNIPDKSGRTALMHACAELAGK 96
Cdd:PHA02875  142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIA--MAKGDIA----ICKMLLDSGANIDYFGKNGCVAALCYAIENNKI 215

                          90
                  ....*....|..
gi 1724784168  97 EVVSLLLENGAD 108
Cdd:PHA02875  216 DIVRLFIKRGAD 227
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-80 1.12e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1724784168  42 RGETPISAACiASYDDPQtrqrMVRYLLEKGADPNIPDK 80
Cdd:pfam00023   1 DGNTPLHLAA-GRRGNLE----IVKLLLSKGADVNARDK 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 24-139 2.74e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  24 RLTRLLLEGGAYINEGNERGETPISAACIASyddpQTRQRMVRYLLEKGADPNIPDKSGRTALMHAcAELAGKEVVSLLL 103
Cdd:PHA03095  203 RIVRELIRAGCDPAATDMLGNTPLHSMATGS----SCKRSLVLPLLIAGISINARNRYGQTPLHYA-AVFNNPRACRRLI 277

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1724784168 104 ENGADPSLKDYSGSSALVHAINKGDRDTLQVLLDAC 139
Cdd:PHA03095  278 ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKN 313
PHA02798 PHA02798
ankyrin-like protein; Provisional
 19-108 3.21e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  19 FQGKLRLTRLLLEGGAYINEGNERGETPISAACIASYDDpqtRQRMVRYLLEKGADPNIPDKSGRTALM--HACAELAGK 96
Cdd:PHA02798   85 YKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYIN---NLEILLFMIENGADTTLLDKDGFTMLQvyLQSNHHIDI 161

                          90
                  ....*....|..
gi 1724784168  97 EVVSLLLENGAD 108
Cdd:PHA02798  162 EIIKLLLEKGVD 173
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 13-137 6.15e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.28  E-value: 6.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  13 ALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASyddpqTRQRMVRYLLEKGADPNIPDKSGRTALMHACAE 92
Cdd:PHA02876  243 SLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAP-----SLSRLVPKLLERGADVNAKNIKGETPLYLMAKN 317

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1724784168  93 LAGKEVVSLLLENGADPSLKDYSGSSALvHAINKGDR--DTLQVLLD 137
Cdd:PHA02876  318 GYDTENIRTLIMLGADVNAADRLYITPL-HQASTLDRnkDIVITLLE 363
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 14-77 6.64e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.82  E-value: 6.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724784168  14 LLKAVFQGKLRLTRLLLEGGAYINEGNERGEtpISAACIASYDDpqtRQRMVRYLLEKGADPNI 77
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGANIDYFGKNGC--VAALCYAIENN---KIDIVRLFIKRGADCNI 230
PHA02917 PHA02917
ankyrin-like protein; Provisional
 31-126 7.84e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 38.83  E-value: 7.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  31 EGGAYINEGNErGETPISAACIASYDdpqtRQRMVRYLLEKG---------------------ADPNIPDKSGRTaLMHA 89
Cdd:PHA02917  385 EGGDAVNHLDD-GEIPIGHLCKSNYG----CYNFYTYTYKKGlcdmsyacpilstiniclpylKDINMIDKRGET-LLHK 458

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1724784168  90 CAELAGKEVVSLLLENGADPSLKDYSGSSALVHAINK 126
Cdd:PHA02917  459 AVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAINE 495
Ank_4 pfam13637
Ankyrin repeats (many copies);
10-69 8.36e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 8.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724784168  10 EGNALLKAVFQGKLRLTRLLLEGGAYINEGNERGETPISAACIASyddpqtRQRMVRYLL 69
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG------NVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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