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Conserved domains on  [gi|1720419114|ref|XP_030111526|]
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kelch domain-containing protein 10 isoform X2 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
54-227 4.83e-29

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 4.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  54 HAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPnnlscdLPEERYRHEIA--HDGqRIYILGGGTSWTAYS-- 129
Cdd:COG3055    16 AAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP------LPGPPRHHAAAvaQDG-KLYVFGGFTGANPSStp 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 130 LNKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVY 209
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-LPTPRD 160

                         170
                  ....*....|....*...
gi 1720419114 210 FHCAAVTPAGCMYIHGGV 227
Cdd:COG3055   161 HLAAAVLPDGKILVIGGR 178
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
54-227 4.83e-29

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 4.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  54 HAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPnnlscdLPEERYRHEIA--HDGqRIYILGGGTSWTAYS-- 129
Cdd:COG3055    16 AAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP------LPGPPRHHAAAvaQDG-KLYVFGGFTGANPSStp 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 130 LNKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVY 209
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-LPTPRD 160

                         170
                  ....*....|....*...
gi 1720419114 210 FHCAAVTPAGCMYIHGGV 227
Cdd:COG3055   161 HLAAAVLPDGKILVIGGR 178
PLN02153 PLN02153
epithiospecifier protein
 40-201 7.98e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.76  E-value: 7.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  40 WVQM----ATCPGNwhQC-HAMALINGSLYVFGG--TTGYIYSTDLHKLDLNTMVWTQLKPNNlscDLPE-ERYRHEIAH 111
Cdd:PLN02153    9 WIKVeqkgGKGPGP--RCsHGIAVVGDKLYSFGGelKPNEHIDKDLYVFDFNTHTWSIAPANG---DVPRiSCLGVRMVA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 112 DGQRIYILGGGTSWTAYslNKIHAYNLETNAWEeIATKPHEKiGFPAARRCHSCVQIKNDVFICGGYNGEVILG------ 185
Cdd:PLN02153   84 VGTKLYIFGGRDEKREF--SDFYSYDTVKNEWT-FLTKLDEE-GGPEARTFHSMASDENHVYVFGGVSKGGLMKtperfr 159

                         170
                  ....*....|....*.
gi 1720419114 186 DIWKLNLQTFQWVKLP 201
Cdd:PLN02153  160 TIEAYNIADGKWVQLP 175
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 159-205 2.29e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 2.29e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720419114 159 ARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPaTMP 205
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP-SMP 46
Kelch smart00612
Kelch domain;
172-216 5.38e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 5.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1720419114  172 VFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYFHCAAVT 216
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
54-227 4.83e-29

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 4.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  54 HAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPnnlscdLPEERYRHEIA--HDGqRIYILGGGTSWTAYS-- 129
Cdd:COG3055    16 AAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP------LPGPPRHHAAAvaQDG-KLYVFGGFTGANPSStp 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 130 LNKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVY 209
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-LPTPRD 160

                         170
                  ....*....|....*...
gi 1720419114 210 FHCAAVTPAGCMYIHGGV 227
Cdd:COG3055   161 HLAAAVLPDGKILVIGGR 178
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
39-245 3.50e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 93.30  E-value: 3.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  39 RWVQMATCPGN--WHqcHAMALINGSLYVFGGTTG----YIYSTDLHKLDLNTMVWTQLKPnnlscdLPEERYRHEIAHD 112
Cdd:COG3055    49 TWSELAPLPGPprHH--AAAVAQDGKLYVFGGFTGanpsSTPLNDVYVYDPATNTWTKLAP------MPTPRGGATALLL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 113 GQRIYILGGGTSWTAysLNKIHAYNLETNAWEEIATKPHEKIGF-------------------------------PAARR 161
Cdd:COG3055   121 DGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRDHLaaavlpdgkilviggrngsgfsntwttlaplPTARA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 162 CHSCVQIKNDVFICGGYNGevILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGvvnihENKRTGSLFK 241
Cdd:COG3055   199 GHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALG-ELPTPRHGH-AAVLTDGKVYVIGG-----ETKPGVRTPL 269


                  ....
gi 1720419114 242 IWLV 245
Cdd:COG3055   270 VTSA 273
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
88-234 9.49e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.19  E-value: 9.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  88 WTQLKpnnlscDLPEERYRHEIAHDGQRIYILGGGTSWTAysLNKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQ 167
Cdd:COG3055     3 WSSLP------DLPTPRSEAAAALLDGKVYVAGGLSGGSA--SNSFEVYDPATNTWSELAP-------LPGPPRHHAAAV 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419114 168 -IKNDVFICGGYNG----EVILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGVVNIHENK 234
Cdd:COG3055    68 aQDGKLYVFGGFTGanpsSTPLNDVYVYDPATNTWTKLA-PMPTPRGGA-TALLLDGKIYVVGGWDDGGNVA 137
PLN02153 PLN02153
epithiospecifier protein
 40-201 7.98e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.76  E-value: 7.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  40 WVQM----ATCPGNwhQC-HAMALINGSLYVFGG--TTGYIYSTDLHKLDLNTMVWTQLKPNNlscDLPE-ERYRHEIAH 111
Cdd:PLN02153    9 WIKVeqkgGKGPGP--RCsHGIAVVGDKLYSFGGelKPNEHIDKDLYVFDFNTHTWSIAPANG---DVPRiSCLGVRMVA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 112 DGQRIYILGGGTSWTAYslNKIHAYNLETNAWEeIATKPHEKiGFPAARRCHSCVQIKNDVFICGGYNGEVILG------ 185
Cdd:PLN02153   84 VGTKLYIFGGRDEKREF--SDFYSYDTVKNEWT-FLTKLDEE-GGPEARTFHSMASDENHVYVFGGVSKGGLMKtperfr 159

                         170
                  ....*....|....*.
gi 1720419114 186 DIWKLNLQTFQWVKLP 201
Cdd:PLN02153  160 TIEAYNIADGKWVQLP 175
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 159-205 2.29e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 2.29e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720419114 159 ARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPaTMP 205
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP-SMP 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
159-206 5.01e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 48.38  E-value: 5.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720419114 159 ARRCHSCVQIKND-VFICGGYNGE-VILGDIWKLNLQTFQWVKLPaTMPE 206
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLG-SLPS 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
113-168 1.24e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 1.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720419114 113 GQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKphekigfPAARRCHSCVQI 168
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDL-------PPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 15-226 6.04e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.34  E-value: 6.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  15 GRITKTTLSSGSFGGIILQQACGTRWV---QMATCPGnwHQC-HAMALINGSLYVFGG--TTGYIYSTDLHKLDLNTMVW 88
Cdd:PLN02193  128 GRSTDVLHSLGAYISLPSTPKLLGKWIkveQKGEGPG--LRCsHGIAQVGNKIYSFGGefTPNQPIDKHLYVFDLETRTW 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  89 TqLKPN-----NLSCdlpeerYRHEIAHDGQRIYILGGGTSWTAYslNKIHAYNLETNAWEEIAtkPHEKigFPAARRCH 163
Cdd:PLN02193  206 S-ISPAtgdvpHLSC------LGVRMVSIGSTLYVFGGRDASRQY--NGFYSFDTTTNEWKLLT--PVEE--GPTPRSFH 272

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720419114 164 SCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWvklpatmpepvyFHCAavTPAGCMYIHGG 226
Cdd:PLN02193  273 SMAADEENVYVFGGVSATARLKTLDSYNIVDKKW------------FHCS--TPGDSFSIRGG 321
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 104-150 1.58e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 1.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720419114 104 RYRHEIAHDGQRIYILGGGTSWTaySLNKIHAYNLETNAWEEIATKP 150
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
110-227 5.91e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.93  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 110 AHDGQRIYI-LG-GGTSWTAYSLNKIHAynletnAWEEIATkphekigFPAARRCHS-CVQIKNDVFICGGY-----NGE 181
Cdd:PRK14131   35 AIDNNTVYVgLGsAGTSWYKLDLNAPSK------GWTKIAA-------FPGGPREQAvAAFIDGKLYVFGGIgktnsEGS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720419114 182 VIL-GDIWKLNLQTFQWVKLPATMPEPVYFHcAAVTPAGCM-YIHGGV 227
Cdd:PRK14131  102 PQVfDDVYKYDPKTNSWQKLDTRSPVGLAGH-VAVSLHNGKaYITGGV 148
Kelch_6 pfam13964
Kelch motif;
104-151 9.08e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.32  E-value: 9.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720419114 104 RYRHEIAHDGQRIYILGGGTSWTAYSlNKIHAYNLETNAWEEIATKPH 151
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPAL-NKLEVYNPLTKSWEELPPLPT 48
PLN02193 PLN02193
nitrile-specifier protein
 56-180 1.07e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.49  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  56 MALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNlscDLPEERYRHEIAHDGQRIYILgGGTSWTAySLNKIHA 135
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVE---EGPTPRSFHSMAADEENVYVF-GGVSATA-RLKTLDS 298

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720419114 136 YNLETNAWEEIATkPHEKIgfpAARRCHSCVQIKNDVFICGGYNG 180
Cdd:PLN02193  299 YNIVDKKWFHCST-PGDSF---SIRGGAGLEVVQGKVWVVYGFNG 339
Kelch_6 pfam13964
Kelch motif;
50-91 1.92e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 1.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1720419114  50 WHQCHAMALINGSLYVFGGTTGY-IYSTDLHKLDLNTMVWTQL 91
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEEL 43
Kelch smart00612
Kelch domain;
172-216 5.38e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 5.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1720419114  172 VFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYFHCAAVT 216
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 101-141 5.56e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 39.86  E-value: 5.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720419114 101 PEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETN 141
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPTF 41
Kelch_6 pfam13964
Kelch motif;
159-207 1.90e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.47  E-value: 1.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720419114 159 ARRCHSCVQIKNDVFICGGY-NGEVILGDIWKLNLQTFQWVKLPaTMPEP 207
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELP-PLPTP 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
109-151 2.33e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 2.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1720419114 109 IAHDGQRIYILGGgTSWTAYSLNKIHAYNLETNAWEEIATKPH 151
Cdd:pfam13418   8 TSIPDDTIYLFGG-EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
PHA03098 PHA03098
kelch-like protein; Provisional
 116-236 4.39e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 41.68  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 116 IYILGGGTSwTAYSLNKIHAYNLETNAWEEIAtkpheKIGFPaaRRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTF 195
Cdd:PHA03098  297 IYFIGGMNK-NNLSVNSVVSYDTKTKSWNKVP-----ELIYP--RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGES 368

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1720419114 196 QWVKLPaTMPEPVYFHCAAVTpAGCMYIHGGVVNIHENKRT 236
Cdd:PHA03098  369 KWREEP-PLIFPRYNPCVVNV-NNLIYVIGGISKNDELLKT 407
PRK14131 PRK14131
N-acetylneuraminate epimerase;
57-179 4.67e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.15  E-value: 4.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  57 ALINGSLYVFGGTTGyiysTDLHKLDLNTMV--WTQLKpnnlscDLP-EERYRHEIAHDGQRIYILGG-GTSWTAYSL-- 130
Cdd:PRK14131   35 AIDNNTVYVGLGSAG----TSWYKLDLNAPSkgWTKIA------AFPgGPREQAVAAFIDGKLYVFGGiGKTNSEGSPqv 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720419114 131 -NKIHAYNLETNAWEEIATKPhekigfPAARRCHSCVQIKND-VFICGGYN 179
Cdd:PRK14131  105 fDDVYKYDPKTNSWQKLDTRS------PVGLAGHVAVSLHNGkAYITGGVN 149
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 53-95 5.77e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 5.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1720419114  53 CHAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNN 95
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
34-228 5.90e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.77  E-value: 5.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  34 QACGTRWVQMATCPGNWHQCHAMALINGSLYVFGG-------TTGYIYStDLHKLDLNTMVWTQLK---PNNLSCDLpee 103
Cdd:PRK14131   58 NAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGigktnseGSPQVFD-DVYKYDPKTNSWQKLDtrsPVGLAGHV--- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 104 ryrhEIAHDGQRIYILGG-------------------------------GTSWTAYSLNK-IHAYNLETNAWEEIATkph 151
Cdd:PRK14131  134 ----AVSLHNGKAYITGGvnknifdgyfedlaaagkdktpkdkindayfDKKPEDYFFNKeVLSYDPSTNQWKNAGE--- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114 152 ekigFPAARRCHSCVQIKNDVFICggYNGEVILG----DIWKLNLQ--TFQWVKLPATMPEPVYFHCAAVtpAGCM--YI 223
Cdd:PRK14131  207 ----SPFLGTAGSAVVIKGNKLWL--INGEIKPGlrtdAVKQGKFTgnNLKWQKLPDLPPAPGGSSQEGV--AGAFagYS 278


                  ....*
gi 1720419114 224 HGGVV 228
Cdd:PRK14131  279 NGVLL 283
PHA03098 PHA03098
kelch-like protein; Provisional
 53-201 7.97e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 7.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419114  53 CHAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPnnlscdLPEERYRHEIAHDGQRIYILgGGTSWTAYSLNK 132
Cdd:PHA03098  335 NPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP------LIFPRYNPCVVNVNNLIYVI-GGISKNDELLKT 407

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419114 133 IHAYNLETNAWEEIATKPHEKIGfpaarrcHSCVQIKNDVFICGGY---NGEVILGDIWKLNLQTFQWVKLP 201
Cdd:PHA03098  408 VECFSLNTNKWSKGSPLPISHYG-------GCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELS 472
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 50-93 8.27e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 8.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720419114  50 WHQCHAMALINGSLYVFGGTTGY--IYSTDLHKLDLNTMVWTQLKP 93
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPR 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
60-107 1.89e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 1.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720419114  60 NGSLYVFGG--TTGYIYSTDLHKLDLNTMVWTQLKpnnlscDLPEERYRH 107
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGH 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
52-93 2.27e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720419114  52 QCHAMALI-NGSLYVFGGTT--GYIYStDLHKLDLNTMVWTQLKP 93
Cdd:pfam13418   3 AYHTSTSIpDDTIYLFGGEGedGTLLS-DLWVFDLSTNEWTRLGS 46
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 157-195 4.32e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.46  E-value: 4.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720419114 157 PAARRCHSCVQIKNDVFICGGYNGE--VILGDIWKLNLQTF 195
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGegQPSDDVYVLSLPTF 41
Kelch_3 pfam13415
Galactose oxidase, central domain;
169-215 6.23e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.19  E-value: 6.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720419114 169 KNDVFICGGYN--GEVILGDIWKLNLQTFQWVKLpATMPEPVYFHCAAV 215
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQI-GDLPPPRSGHSATY 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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