|
Name |
Accession |
Description |
Interval |
E-value |
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1134-1343 |
3.14e-118 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
:
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 367.37 E-value: 3.14e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1291
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1720354714 1292 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
566-756 |
3.22e-20 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 96.61 E-value: 3.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 566 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 640
Cdd:COG3401 201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 641 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 712
Cdd:COG3401 279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1720354714 713 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 756
Cdd:COG3401 355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
203-231 |
7.71e-16 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
:
Pssm-ID: 376143 Cd Length: 29 Bit Score: 72.33 E-value: 7.71e-16
10 20
....*....|....*....|....*....
gi 1720354714 203 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 231
Cdd:pfam18720 1 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
865-944 |
1.57e-14 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 940
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1720354714 941 ESER 944
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
416-496 |
2.65e-12 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 416 STPQGLQFKTITETTVEVQWE-PFSFS--FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTpPPDGNgpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1720354714 492 RSPPT 496
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
328-398 |
5.96e-12 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 5.96e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 328 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAV 398
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1042-1127 |
1.29e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 62.13 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 1117 RS-SLTSTVFTT 1127
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
776-855 |
3.29e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 776 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 851
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1720354714 852 TSEP 855
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
507-586 |
5.68e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.12 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 507 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 583
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
...
gi 1720354714 584 EAS 586
Cdd:pfam00041 83 PPS 85
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
235-261 |
1.62e-08 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 51.53 E-value: 1.62e-08
10 20
....*....|....*....|....*..
gi 1720354714 235 CPTDCSSRGLCVDGECVCEEPYTGEDC 261
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
207-317 |
6.94e-08 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.84 E-value: 6.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 207 GCSSRG-VCVDGQCICdseysGDDCSELR--------CPTDCSSRGLCVDGECVCEEPYT--GEDCRELRC-PGDCSGKG 274
Cdd:NF041328 13 GCPEPGaVCPEGLSVC-----GGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACVDTASdPAHCGACG 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 275 Q-------CANGTCL--CQEGYAgeDCSqRRCLNACSGRGHCqeGLC--ICEEG 317
Cdd:NF041328 88 AacapgqvCEGGACReaCSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG 136
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
954-1026 |
9.48e-08 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 9.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 1025
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
|
.
gi 1720354714 1026 G 1026
Cdd:pfam00041 78 G 78
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1134-1343 |
3.14e-118 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 367.37 E-value: 3.14e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1291
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1720354714 1292 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1134-1342 |
6.17e-118 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 366.57 E-value: 6.17e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:cd00087 2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1292
Cdd:cd00087 81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 1293 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1342
Cdd:cd00087 161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1135-1343 |
1.00e-97 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 311.76 E-value: 1.00e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1135 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1213
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1285
Cdd:pfam00147 81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720354714 1286 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:pfam00147 161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
566-756 |
3.22e-20 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 96.61 E-value: 3.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 566 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 640
Cdd:COG3401 201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 641 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 712
Cdd:COG3401 279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1720354714 713 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 756
Cdd:COG3401 355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
203-231 |
7.71e-16 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 72.33 E-value: 7.71e-16
10 20
....*....|....*....|....*....
gi 1720354714 203 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 231
Cdd:pfam18720 1 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
687-766 |
2.94e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 72.06 E-value: 2.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 687 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1720354714 762 QSLES 766
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
865-944 |
1.57e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 940
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1720354714 941 ESER 944
Cdd:pfam00041 81 EGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
687-772 |
1.05e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.91 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 687 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 1720354714 762 QSLESTVDAFT 772
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
687-763 |
2.74e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 66.48 E-value: 2.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 687 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1720354714 762 QS 763
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
865-943 |
6.03e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 6.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFAITRLYPATEYEISLNSVRGRE 940
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
...
gi 1720354714 941 ESE 943
Cdd:cd00063 82 ESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
416-496 |
2.65e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 416 STPQGLQFKTITETTVEVQWE-PFSFS--FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTpPPDGNgpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1720354714 492 RSPPT 496
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
328-398 |
5.96e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 5.96e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 328 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAV 398
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1042-1127 |
1.29e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 62.13 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 1117 RS-SLTSTVFTT 1127
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
328-413 |
2.38e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.36 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 328 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNIL 403
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|
gi 1720354714 404 SLPITAKVAT 413
Cdd:cd00063 83 SPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
776-855 |
3.29e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 776 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 851
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1720354714 852 TSEP 855
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
507-586 |
5.68e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.12 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 507 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 583
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
...
gi 1720354714 584 EAS 586
Cdd:pfam00041 83 PPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1042-1111 |
6.52e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 59.94 E-value: 6.52e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 1111
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
865-942 |
1.42e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 58.78 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFAITRLYPATEYEISLNSVRGR 939
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 1720354714 940 EES 942
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
416-503 |
1.21e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.35 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 416 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 492 RSPPTSASVSTV 503
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1042-1111 |
2.90e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 55.11 E-value: 2.90e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 1111
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
505-592 |
7.78e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.04 E-value: 7.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 505 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 581
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 582 ESEAS-STQFTT 592
Cdd:cd00063 82 ESPPSeSVTVTT 93
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1138-1177 |
9.45e-09 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 52.56 E-value: 9.45e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720354714 1138 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1177
Cdd:NF040941 2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
776-847 |
1.11e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.39 E-value: 1.11e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 776 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDKEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 847
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
235-261 |
1.62e-08 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 51.53 E-value: 1.62e-08
10 20
....*....|....*....|....*..
gi 1720354714 235 CPTDCSSRGLCVDGECVCEEPYTGEDC 261
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
776-862 |
1.87e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 776 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 852
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|.
gi 1720354714 853 SEPI-VGSITT 862
Cdd:cd00063 83 SPPSeSVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
328-398 |
3.91e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 3.91e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 328 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTIMELEPGLTYNISVYAV 398
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
207-317 |
6.94e-08 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.84 E-value: 6.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 207 GCSSRG-VCVDGQCICdseysGDDCSELR--------CPTDCSSRGLCVDGECVCEEPYT--GEDCRELRC-PGDCSGKG 274
Cdd:NF041328 13 GCPEPGaVCPEGLSVC-----GGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACVDTASdPAHCGACG 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 275 Q-------CANGTCL--CQEGYAgeDCSqRRCLNACSGRGHCqeGLC--ICEEG 317
Cdd:NF041328 88 AacapgqvCEGGACReaCSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG 136
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
954-1026 |
9.48e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 9.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 1025
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
|
.
gi 1720354714 1026 G 1026
Cdd:pfam00041 78 G 78
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
416-486 |
6.34e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 48.38 E-value: 6.34e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 416 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 486
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
505-583 |
3.41e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.45 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 505 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 581
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1720354714 582 ES 583
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
954-1026 |
4.71e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.07 E-value: 4.71e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 1026
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
954-1035 |
1.47e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.79 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 1023
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81
|
90
....*....|..
gi 1720354714 1024 TSGPLMSGTIAT 1035
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
300-323 |
3.18e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 41.95 E-value: 3.18e-05
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
845-1127 |
7.91e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.92 E-value: 7.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 845 VAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVG------RLDSSVVPNTVTEF 918
Cdd:COG3401 115 DEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTsataavATTSLTVTSTTLVD 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 919 AITRLYPATEYEISL---NSVRGREESERIC-TLVHTAMDSPMDLIATNITPTEALLQWKAPMGE-VENYvIVLTHFAIA 993
Cdd:COG3401 195 GGGDIEPGTTYYYRVaatDTGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGY-RVYRSNSGD 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 994 GETILVDGVSE-EFQLVDLLPSTHYTVTMYA------TSGPlmSGTI-ATNFSTLLDPPDNLTASEVTRQSALISWQPPR 1065
Cdd:COG3401 274 GPFTKVATVTTtSYTDTGLTNGTTYYYRVTAvdaagnESAP--SNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASS 351
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 1066 AA-IENYVLTYKSTDGSRKELIVD-AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTT 1127
Cdd:COG3401 352 DAdVTGYNVYRSTSGGGTYTKIAEtVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1134-1343 |
3.14e-118 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 367.37 E-value: 3.14e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1291
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1720354714 1292 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1134-1342 |
6.17e-118 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 366.57 E-value: 6.17e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:cd00087 2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1292
Cdd:cd00087 81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 1293 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1342
Cdd:cd00087 161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1135-1343 |
1.00e-97 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 311.76 E-value: 1.00e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1135 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1213
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1214 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1285
Cdd:pfam00147 81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720354714 1286 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:pfam00147 161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
566-756 |
3.22e-20 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 96.61 E-value: 3.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 566 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 640
Cdd:COG3401 201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 641 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 712
Cdd:COG3401 279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1720354714 713 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 756
Cdd:COG3401 355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
203-231 |
7.71e-16 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 72.33 E-value: 7.71e-16
10 20
....*....|....*....|....*....
gi 1720354714 203 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 231
Cdd:pfam18720 1 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
687-766 |
2.94e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 72.06 E-value: 2.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 687 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1720354714 762 QSLES 766
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
865-944 |
1.57e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 940
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1720354714 941 ESER 944
Cdd:pfam00041 81 EGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
687-772 |
1.05e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.91 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 687 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 1720354714 762 QSLESTVDAFT 772
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
687-763 |
2.74e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 66.48 E-value: 2.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 687 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1720354714 762 QS 763
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
865-943 |
6.03e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 6.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFAITRLYPATEYEISLNSVRGRE 940
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
...
gi 1720354714 941 ESE 943
Cdd:cd00063 82 ESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
416-496 |
2.65e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 416 STPQGLQFKTITETTVEVQWE-PFSFS--FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTpPPDGNgpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1720354714 492 RSPPT 496
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
328-398 |
5.96e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 5.96e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 328 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAV 398
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1042-1127 |
1.29e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 62.13 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 1117 RS-SLTSTVFTT 1127
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
328-413 |
2.38e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.36 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 328 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNIL 403
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|
gi 1720354714 404 SLPITAKVAT 413
Cdd:cd00063 83 SPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
776-855 |
3.29e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 776 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 851
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1720354714 852 TSEP 855
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
507-586 |
5.68e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.12 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 507 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 583
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
...
gi 1720354714 584 EAS 586
Cdd:pfam00041 83 PPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1042-1111 |
6.52e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 59.94 E-value: 6.52e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 1111
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
327-672 |
7.95e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 66.56 E-value: 7.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 327 APPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGdwSGVTIMELEPGLTYNISVYAVISN--- 401
Cdd:COG3401 234 SAPTGLTATADTPGSVTLSWDPVteSDATGYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAgne 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 402 -ILSLPITAKVATHL-STPQGLQFKTITETTVEVQWEPfsfSFDGWEISFI--PKNNEGG---VIAQLPSDvTSFNQTGL 474
Cdd:COG3401 312 sAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNvyRSTSGGGtytKIAETVTT-TSYTDTGL 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 475 KPGEEYIVNVVA---------LKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEG 545
Cdd:COG3401 388 TPGTTYYYKVTAvdaagnesaPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 546 GKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESEASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYK 625
Cdd:COG3401 468 VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLI 547
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1720354714 626 VV-----YSTLAGEQYHEVLVPKGIGPTT-KTTLTDLVPGTEYGVGISAVMNS 672
Cdd:COG3401 548 TDlvsltTSASSSVSGAGLGSGNLYLITTlGGSLLTTTSTNTNDVAGVHGGTL 600
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
865-942 |
1.42e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 58.78 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 865 DPPKNITISNVTKDSLTVSWSSP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFAITRLYPATEYEISLNSVRGR 939
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 1720354714 940 EES 942
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
595-679 |
5.64e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 5.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 595 DAPKNLRVGSRTATSLDLEWD---NSEAEAQEYKVVYSTLAGEQYHEVlvPKGIGPTTKTTLTDLVPGTEYGVGISAVMN 671
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79
|
....*...
gi 1720354714 672 SKQSIPAT 679
Cdd:cd00063 80 GGESPPSE 87
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
416-503 |
1.21e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.35 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 416 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 492 RSPPTSASVSTV 503
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1042-1111 |
2.90e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 55.11 E-value: 2.90e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 1042 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 1111
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
505-592 |
7.78e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.04 E-value: 7.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 505 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 581
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1720354714 582 ESEAS-STQFTT 592
Cdd:cd00063 82 ESPPSeSVTVTT 93
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1138-1177 |
9.45e-09 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 52.56 E-value: 9.45e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720354714 1138 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1177
Cdd:NF040941 2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
776-847 |
1.11e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.39 E-value: 1.11e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 776 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDKEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 847
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
235-261 |
1.62e-08 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 51.53 E-value: 1.62e-08
10 20
....*....|....*....|....*..
gi 1720354714 235 CPTDCSSRGLCVDGECVCEEPYTGEDC 261
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
776-862 |
1.87e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 776 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 852
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|.
gi 1720354714 853 SEPI-VGSITT 862
Cdd:cd00063 83 SPPSeSVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
595-669 |
2.22e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.62 E-value: 2.22e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354714 595 DAPKNLRVGSRTATSLDLEWDNSEAEAQE-YKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAV 669
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
328-398 |
3.91e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 3.91e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 328 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTIMELEPGLTYNISVYAV 398
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
595-669 |
4.38e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 51.65 E-value: 4.38e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720354714 595 DAPKNLRVGSRTATSLDLEW---DNSEAEAQEYKVVYSTLAGEQY-HEVLVPkgiGPTTKTTLTDLVPGTEYGVGISAV 669
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPwNEITVP---GTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
207-317 |
6.94e-08 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.84 E-value: 6.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 207 GCSSRG-VCVDGQCICdseysGDDCSELR--------CPTDCSSRGLCVDGECVCEEPYT--GEDCRELRC-PGDCSGKG 274
Cdd:NF041328 13 GCPEPGaVCPEGLSVC-----GGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACVDTASdPAHCGACG 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 275 Q-------CANGTCL--CQEGYAgeDCSqRRCLNACSGRGHCqeGLC--ICEEG 317
Cdd:NF041328 88 AacapgqvCEGGACReaCSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG 136
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
954-1026 |
9.48e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 9.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 1025
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
|
.
gi 1720354714 1026 G 1026
Cdd:pfam00041 78 G 78
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
370-755 |
1.13e-07 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 56.16 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 370 QQRVPGDWSGVTIMELEPGLTYNISVYAVISN---ILSLPITAKVA-THLSTPQGLQFKTITETTVEVQWEP-FSFSFDG 444
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGgesAPSNEVSVTTPtTPPSAPTGLTATADTPGSVTLSWDPvTESDATG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 445 WEISFipKNNEGGVIAQLPS-DVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDG-----PTQILVRDVSDT 518
Cdd:COG3401 264 YRVYR--SNSGDGPFTKVATvTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaPSGLTATAVGSS 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 519 VAFVEWTPP-----------RAKVDFilLKYGLVGGEGGKTTFR---LQPPLS-QYSVQALRPGSRYEVSISAVRGTNES 583
Cdd:COG3401 342 SITLSWTASsdadvtgynvyRSTSGG--GTYTKIAETVTTTSYTdtgLTPGTTyYYKVTAVDAAGNESAPSEEVSATTAS 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 584 EASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTT----KTTLTDLVPG 659
Cdd:COG3401 420 AASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTtanlSVTTGSLVGG 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 660 TEYGVGISAVMN-SKQSIPATMNARTELDSPrdlmVTASSETSISLIWTKASGPIDHYR---ITFTPSSGISSEVTVPRD 735
Cdd:COG3401 500 SGASSVTNSVSViGASAAAAVGGAPDGTPNV----TGASPVTVGASTGDVLITDLVSLTtsaSSSVSGAGLGSGNLYLIT 575
|
410 420
....*....|....*....|
gi 1720354714 736 RTSYTLTDLEPGAEYIISIT 755
Cdd:COG3401 576 TLGGSLLTTTSTNTNDVAGV 595
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
416-486 |
6.34e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 48.38 E-value: 6.34e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720354714 416 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 486
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
505-583 |
3.41e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.45 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 505 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 581
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1720354714 582 ES 583
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
954-1026 |
4.71e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.07 E-value: 4.71e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 1026
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
954-1035 |
1.47e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.79 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 954 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 1023
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81
|
90
....*....|..
gi 1720354714 1024 TSGPLMSGTIAT 1035
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
300-323 |
3.18e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 41.95 E-value: 3.18e-05
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
845-1127 |
7.91e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.92 E-value: 7.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 845 VAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVG------RLDSSVVPNTVTEF 918
Cdd:COG3401 115 DEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTsataavATTSLTVTSTTLVD 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 919 AITRLYPATEYEISL---NSVRGREESERIC-TLVHTAMDSPMDLIATNITPTEALLQWKAPMGE-VENYvIVLTHFAIA 993
Cdd:COG3401 195 GGGDIEPGTTYYYRVaatDTGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGY-RVYRSNSGD 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 994 GETILVDGVSE-EFQLVDLLPSTHYTVTMYA------TSGPlmSGTI-ATNFSTLLDPPDNLTASEVTRQSALISWQPPR 1065
Cdd:COG3401 274 GPFTKVATVTTtSYTDTGLTNGTTYYYRVTAvdaagnESAP--SNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASS 351
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354714 1066 AA-IENYVLTYKSTDGSRKELIVD-AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTT 1127
Cdd:COG3401 352 DAdVTGYNVYRSTSGGGTYTKIAEtVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
208-230 |
5.21e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 5.21e-04
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
494-692 |
6.14e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 44.55 E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 494 PPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDF-ILLKYGlvggeGGKTTFRLQPPLSQYSVQALRPGsRYEV 572
Cdd:COG4733 528 PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAYeVEWRRD-----DGNWVSVPRTSGTSFEVPGIYAG-DYEV 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 573 SisaVRGTNESEASS-TQFTTEID---------APKNLRVGSRTaTSLDLEWDNS-EAEAQEYKVVYSTLAGEQyhEVLV 641
Cdd:COG4733 602 R---VRAINALGVSSaWAASSETTvtgktapppAPTGLTATGGL-GGITLSWSFPvDADTLRTEIRYSTTGDWA--SATV 675
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720354714 642 PKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDL 692
Cdd:COG4733 676 AQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGIL 726
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
297-324 |
9.85e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.66 E-value: 9.85e-04
10 20
....*....|....*....|....*...
gi 1720354714 297 CLNACSGRGHCQEGLCICEEGYQGPDCS 324
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
269-292 |
4.99e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 35.79 E-value: 4.99e-03
|
| COG3979 |
COG3979 |
Chitodextrinase [Carbohydrate transport and metabolism]; |
689-916 |
7.68e-03 |
|
Chitodextrinase [Carbohydrate transport and metabolism];
Pssm-ID: 443178 [Multi-domain] Cd Length: 369 Bit Score: 40.14 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 689 PRDLMVTASSETSISLIWTKASG--PIDHYRITftpSSGisSEVTVPRDRTSYTLTDLEPGAEYIISITAergrqQSLES 766
Cdd:COG3979 6 PTGLTASNVTSSSVSLSWDASTDnvGVTGYDVY---RGG--DQVATVTGLTAWTVTGLTPGTEYTFTVGA-----CDAAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354714 767 TVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVA 846
Cdd:COG3979 76 NVSAASGTSTAMFGGSSTTLGSAEGVADTSGNLAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGGTTTII 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720354714 847 VHGTVTSEP--IVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVGRLDSSVVPNTVT 916
Cdd:COG3979 156 TTGVEGGGGskTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSG 227
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