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Conserved domains on  [gi|1720402865|ref|XP_030108199|]
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uncharacterized protein C4orf54 homolog isoform X1 [Mus musculus]

Protein Classification

DUF4585 domain-containing protein( domain architecture ID 10633617)

DUF4585 domain-containing protein similar to Homo sapiens protein C4orf54 (also called familial obliterative portal venopathy or FOPV)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4585 pfam15232
Domain of unknown function (DUF4585); The function of this protein domain family is yet to be ...
1604-1667 8.74e-25

Domain of unknown function (DUF4585); The function of this protein domain family is yet to be characterized. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells.


:

Pssm-ID: 464574 [Multi-domain]  Cd Length: 73  Bit Score: 99.37  E-value: 8.74e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720402865 1604 RKMLLDVTTGQYYLVDTPVQPMTRRLFDPETGQYVDVPM---TSQQQPVAPMSLPVPPLALSPGAYG 1667
Cdd:pfam15232    7 RKVLLDPESGQYYVVDAPLQPQLKTLFDPETGQYVEVSIpssESNVSPPTPPELLYSPLALYPGAYP 73
MSCRAMM_ClfB super family cl41468
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
142-469 5.28e-03

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033845:

Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 41.86  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  142 LRMEGGTSDMNSQTS-LTPAEDPVSRPQDSPEPRQQLRPLPEPSASTLPEAKyvetcasaglrrespqtlklPPEQQASR 220
Cdd:NF033845   528 VRYGGGSADGDSAVNpKDPTPGPPVDPEPSPEPEPEPTPDPEPSPDPDPEPS--------------------PDPDPDSD 587
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  221 SPKTKAQDEPSGHAPEAPAPGESPASSqclpsqacendfssssssssslvDSAEDNGLSKMDDPTKLLGVLATSSSSLGF 300
Cdd:NF033845   588 SDSDSGSDSDSGSDSDSDSDSDSDSDS-----------------------DSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 644
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  301 ESDPETSCRQHREEAGDRAGAGEDKRGGVDDGIASCKDIIAKSHSKRGPLRNEDAHYITTHEIQLTEVEQGMDFDVGLAS 380
Cdd:NF033845   645 DSDSDSDSDSDSDSDSDSDSDDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSSDSDSDSDSDSDSDSDSDSDSDS 724
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  381 RWDFEDNNVIYSFVDYASFGGSDETPGDITTEEDDDNScyvsttpstnTTRTPSPISSDLARPGAGSSGRDTSSTEVGSG 460
Cdd:NF033845   725 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS----------DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 794

                   ....*....
gi 1720402865  461 PSDSDTVPP 469
Cdd:NF033845   795 DSDSRVTPP 803
 
Name Accession Description Interval E-value
DUF4585 pfam15232
Domain of unknown function (DUF4585); The function of this protein domain family is yet to be ...
1604-1667 8.74e-25

Domain of unknown function (DUF4585); The function of this protein domain family is yet to be characterized. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells.


Pssm-ID: 464574 [Multi-domain]  Cd Length: 73  Bit Score: 99.37  E-value: 8.74e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720402865 1604 RKMLLDVTTGQYYLVDTPVQPMTRRLFDPETGQYVDVPM---TSQQQPVAPMSLPVPPLALSPGAYG 1667
Cdd:pfam15232    7 RKVLLDPESGQYYVVDAPLQPQLKTLFDPETGQYVEVSIpssESNVSPPTPPELLYSPLALYPGAYP 73
MSCRAMM_ClfB NF033845
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
142-469 5.28e-03

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 41.86  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  142 LRMEGGTSDMNSQTS-LTPAEDPVSRPQDSPEPRQQLRPLPEPSASTLPEAKyvetcasaglrrespqtlklPPEQQASR 220
Cdd:NF033845   528 VRYGGGSADGDSAVNpKDPTPGPPVDPEPSPEPEPEPTPDPEPSPDPDPEPS--------------------PDPDPDSD 587
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  221 SPKTKAQDEPSGHAPEAPAPGESPASSqclpsqacendfssssssssslvDSAEDNGLSKMDDPTKLLGVLATSSSSLGF 300
Cdd:NF033845   588 SDSDSGSDSDSGSDSDSDSDSDSDSDS-----------------------DSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 644
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  301 ESDPETSCRQHREEAGDRAGAGEDKRGGVDDGIASCKDIIAKSHSKRGPLRNEDAHYITTHEIQLTEVEQGMDFDVGLAS 380
Cdd:NF033845   645 DSDSDSDSDSDSDSDSDSDSDDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSSDSDSDSDSDSDSDSDSDSDSDS 724
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  381 RWDFEDNNVIYSFVDYASFGGSDETPGDITTEEDDDNScyvsttpstnTTRTPSPISSDLARPGAGSSGRDTSSTEVGSG 460
Cdd:NF033845   725 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS----------DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 794

                   ....*....
gi 1720402865  461 PSDSDTVPP 469
Cdd:NF033845   795 DSDSRVTPP 803
 
Name Accession Description Interval E-value
DUF4585 pfam15232
Domain of unknown function (DUF4585); The function of this protein domain family is yet to be ...
1604-1667 8.74e-25

Domain of unknown function (DUF4585); The function of this protein domain family is yet to be characterized. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells.


Pssm-ID: 464574 [Multi-domain]  Cd Length: 73  Bit Score: 99.37  E-value: 8.74e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720402865 1604 RKMLLDVTTGQYYLVDTPVQPMTRRLFDPETGQYVDVPM---TSQQQPVAPMSLPVPPLALSPGAYG 1667
Cdd:pfam15232    7 RKVLLDPESGQYYVVDAPLQPQLKTLFDPETGQYVEVSIpssESNVSPPTPPELLYSPLALYPGAYP 73
MSCRAMM_ClfB NF033845
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
142-469 5.28e-03

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 41.86  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  142 LRMEGGTSDMNSQTS-LTPAEDPVSRPQDSPEPRQQLRPLPEPSASTLPEAKyvetcasaglrrespqtlklPPEQQASR 220
Cdd:NF033845   528 VRYGGGSADGDSAVNpKDPTPGPPVDPEPSPEPEPEPTPDPEPSPDPDPEPS--------------------PDPDPDSD 587
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  221 SPKTKAQDEPSGHAPEAPAPGESPASSqclpsqacendfssssssssslvDSAEDNGLSKMDDPTKLLGVLATSSSSLGF 300
Cdd:NF033845   588 SDSDSGSDSDSGSDSDSDSDSDSDSDS-----------------------DSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 644
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  301 ESDPETSCRQHREEAGDRAGAGEDKRGGVDDGIASCKDIIAKSHSKRGPLRNEDAHYITTHEIQLTEVEQGMDFDVGLAS 380
Cdd:NF033845   645 DSDSDSDSDSDSDSDSDSDSDDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSSDSDSDSDSDSDSDSDSDSDSDS 724
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720402865  381 RWDFEDNNVIYSFVDYASFGGSDETPGDITTEEDDDNScyvsttpstnTTRTPSPISSDLARPGAGSSGRDTSSTEVGSG 460
Cdd:NF033845   725 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS----------DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 794

                   ....*....
gi 1720402865  461 PSDSDTVPP 469
Cdd:NF033845   795 DSDSRVTPP 803
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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