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Conserved domains on  [gi|1720401435|ref|XP_030108138|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X4 [Mus musculus]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 189-1530 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 912.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  189 LQKDAFLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 267
Cdd:PLN03076   344 LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  268 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAA 346
Cdd:PLN03076   422 MIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSS 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  347 NIFERLVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGK 424
Cdd:PLN03076   502 NIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEP 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  425 G-LDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQ 503
Cdd:PLN03076   578 GsLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKD 657

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  504 EERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFA 583
Cdd:PLN03076   658 ASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFS 735

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  584 SADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQ 663
Cdd:PLN03076   736 SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQ 811

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  664 SVASEKQ-----------RRLLYNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGL 728
Cdd:PLN03076   812 SANSNRIlgldsilniviRKRGEDSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPL 891

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  729 QNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSW 808
Cdd:PLN03076   892 DQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAW 968

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  809 HEILKCISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGG 866
Cdd:PLN03076   969 EHILTCVSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGV 1048

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  867 VDKRQMAS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISY 940
Cdd:PLN03076  1049 VTSEQMNNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAH 1121

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  941 YNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRD 1020
Cdd:PLN03076  1122 YNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRE 1201

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1021 MVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNA 1100
Cdd:PLN03076  1202 LIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSR 1281

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1101 AFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKL 1164
Cdd:PLN03076  1282 FNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRP 1361

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1165 DVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALY 1226
Cdd:PLN03076  1362 EIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQ 1441

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1227 AICDVFTQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLL 1306
Cdd:PLN03076  1442 LVVDLFVKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSY 1520

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1307 TWRPAGMEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTId 1383
Cdd:PLN03076  1521 VVSGEYMPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV- 1579

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1384 nivfypatskkedaehmvaaqqdtldaeihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGF 1462
Cdd:PLN03076  1580 --------------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGS 1627

                         1370      1380      1390      1400      1410      1420
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720401435 1463 KGKSK-PNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1530
Cdd:PLN03076  1628 MTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 189-1530 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 912.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  189 LQKDAFLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 267
Cdd:PLN03076   344 LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  268 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAA 346
Cdd:PLN03076   422 MIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSS 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  347 NIFERLVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGK 424
Cdd:PLN03076   502 NIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEP 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  425 G-LDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQ 503
Cdd:PLN03076   578 GsLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKD 657

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  504 EERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFA 583
Cdd:PLN03076   658 ASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFS 735

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  584 SADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQ 663
Cdd:PLN03076   736 SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQ 811

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  664 SVASEKQ-----------RRLLYNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGL 728
Cdd:PLN03076   812 SANSNRIlgldsilniviRKRGEDSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPL 891

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  729 QNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSW 808
Cdd:PLN03076   892 DQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAW 968

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  809 HEILKCISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGG 866
Cdd:PLN03076   969 EHILTCVSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGV 1048

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  867 VDKRQMAS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISY 940
Cdd:PLN03076  1049 VTSEQMNNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAH 1121

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  941 YNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRD 1020
Cdd:PLN03076  1122 YNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRE 1201

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1021 MVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNA 1100
Cdd:PLN03076  1202 LIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSR 1281

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1101 AFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKL 1164
Cdd:PLN03076  1282 FNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRP 1361

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1165 DVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALY 1226
Cdd:PLN03076  1362 EIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQ 1441

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1227 AICDVFTQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLL 1306
Cdd:PLN03076  1442 LVVDLFVKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSY 1520

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1307 TWRPAGMEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTId 1383
Cdd:PLN03076  1521 VVSGEYMPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV- 1579

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1384 nivfypatskkedaehmvaaqqdtldaeihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGF 1462
Cdd:PLN03076  1580 --------------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGS 1627

                         1370      1380      1390      1400      1410      1420
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720401435 1463 KGKSK-PNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1530
Cdd:PLN03076  1628 MTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 462-646 1.68e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 308.23  E-value: 1.68e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  462 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 541
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  542 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 621
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 1720401435  622 GINDSKDLPEEYLSSIYDEIEGKKI 646
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 462-646 6.84e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 275.26  E-value: 6.84e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  462 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 540
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  541 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 620
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                          170       180
                   ....*....|....*....|....*.
gi 1720401435  621 RGINDSKDLPEEYLSSIYDEIEGKKI 646
Cdd:cd00171    160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 460-646 2.55e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 259.53  E-value: 2.55e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435   460 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 538
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435   539 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 618
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 1720401435   619 MNRGINDSKDLPEEYLSSIYDEIEGKKI 646
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 189-1530 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 912.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  189 LQKDAFLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 267
Cdd:PLN03076   344 LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  268 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAA 346
Cdd:PLN03076   422 MIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSS 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  347 NIFERLVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGK 424
Cdd:PLN03076   502 NIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEP 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  425 G-LDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQ 503
Cdd:PLN03076   578 GsLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKD 657

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  504 EERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFA 583
Cdd:PLN03076   658 ASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFS 735

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  584 SADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQ 663
Cdd:PLN03076   736 SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQ 811

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  664 SVASEKQ-----------RRLLYNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGL 728
Cdd:PLN03076   812 SANSNRIlgldsilniviRKRGEDSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPL 891

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  729 QNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSW 808
Cdd:PLN03076   892 DQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAW 968

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  809 HEILKCISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGG 866
Cdd:PLN03076   969 EHILTCVSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGV 1048

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  867 VDKRQMAS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISY 940
Cdd:PLN03076  1049 VTSEQMNNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAH 1121

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  941 YNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRD 1020
Cdd:PLN03076  1122 YNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRE 1201

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1021 MVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNA 1100
Cdd:PLN03076  1202 LIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSR 1281

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1101 AFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKL 1164
Cdd:PLN03076  1282 FNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRP 1361

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1165 DVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALY 1226
Cdd:PLN03076  1362 EIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQ 1441

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1227 AICDVFTQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLL 1306
Cdd:PLN03076  1442 LVVDLFVKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSY 1520

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1307 TWRPAGMEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTId 1383
Cdd:PLN03076  1521 VVSGEYMPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV- 1579

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1384 nivfypatskkedaehmvaaqqdtldaeihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGF 1462
Cdd:PLN03076  1580 --------------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGS 1627

                         1370      1380      1390      1400      1410      1420
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720401435 1463 KGKSK-PNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1530
Cdd:PLN03076  1628 MTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 462-646 1.68e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 308.23  E-value: 1.68e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  462 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 541
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  542 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 621
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 1720401435  622 GINDSKDLPEEYLSSIYDEIEGKKI 646
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 462-646 6.84e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 275.26  E-value: 6.84e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  462 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 540
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  541 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 620
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                          170       180
                   ....*....|....*....|....*.
gi 1720401435  621 RGINDSKDLPEEYLSSIYDEIEGKKI 646
Cdd:cd00171    160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 460-646 2.55e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 259.53  E-value: 2.55e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435   460 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 538
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435   539 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 618
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 1720401435   619 MNRGINDSKDLPEEYLSSIYDEIEGKKI 646
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1373-1579 1.41e-58

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 199.77  E-value: 1.41e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1373 VVQLELIQTIDNIVfypatskkedaehmvaaqqdtldaeihietenQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYE 1452
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435 1453 QRTVLWRAGFkGKSKPNLLKQETSSLACCLRILFRMYVDENRR-DSWDEIQQRLLRVCSEALAYFITVN-SESHRE--AW 1528
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRtSQREEVEERLIPLCEDILEYYLSLDeEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720401435 1529 TSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFL 1579
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 189-344 1.47e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 181.54  E-value: 1.47e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  189 LQKDAFLVFRSLCKLS-MKPLGEgpPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 267
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720401435  268 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILEtSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLN 344
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 986-1067 1.92e-37

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 135.70  E-value: 1.92e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720401435  986 KFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQ 1065
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 1720401435 1066 TT 1067
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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