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Conserved domains on  [gi|1720393644|ref|XP_030106470|]
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cullin-2 isoform X1 [Mus musculus]

Protein Classification

cullin family protein( domain architecture ID 12011692)

cullin family protein, similar to cullins that are core components of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
14-644 0e+00

Cullin family;


:

Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 620.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  14 WNKLLTTIKAVvMLEYVERATWNDRFSDIYALCVaypEPLGERLYAETKIFLESHVRHLYKRVLE---SEEQVLVMYHRY 90
Cdd:pfam00888   1 WAKLEDAIDEI-LNKNVSSLSYEELYRAVYNLCL---HKQGEKLYDKLKEYLEEHLKKLVKPLIKeasSGEEFLKAYVKE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  91 WEEYSKGADYMDCLYRYLNTQYIKKnklteadiqygyggvdmnepLMEIGELALDMWRKLMVE-PLQNILIRMLLREIKN 169
Cdd:pfam00888  77 WEDHTISMKMIRDIFMYLDRVYVKR--------------------LPSIYDLGLELFRDHVFRiPLKDKLIDALLDLIEK 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 170 DRGGEDPNQKVIHGVINSFVHVEQYKKKfpLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIR 249
Cdd:pfam00888 137 ERNGEVIDRSLIKSVIDMLVSLGEDEKK--DNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEER 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 250 CRKYLHPSSYTKVIHECQQRMVADHLQFLHS-ECHSIIQQERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLRATS 328
Cdd:pfam00888 215 VRHYLHSSTKKKLLDVLEEVLISDHLEELLEeELQNLLDDNKTEDLKRLYRLLSRVPDGLEPLRKAFEEYIKKEGKAIVK 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 329 NL-TQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYRepKSVCKAPELLAKYCDNLLKKSAKGMT 407
Cdd:pfam00888 295 DAkEQTTDAKKYVEDLLELKDKFDKIVKDAFSNDELFVKALDEAFEEFINKN--TSNSKSPELLAKYIDDLLKKGLKGKS 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 408 ENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLN 487
Cdd:pfam00888 373 EEELEEKLDKVITLFRYIQDKDVFEAFYKKHLAKRLLLGKSASDDAERSMISKLKEECGSEFTSKLEGMFKDMELSKDLM 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 488 NKFNNFIRNQDTvIDLGISFQIYVLQAGAWPLTqaPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMN 567
Cdd:pfam00888 453 KEFKEHLSENKS-SKKGIDLSVNVLTSGAWPTY--LTSDFILPPELEKAIERFEKFYLSKHSGRKLTWLHSLGTAELKAT 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 568 YL-GKPYVAMVTTYQMAVLLAFNNS-ETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMS 643
Cdd:pfam00888 530 FPkGKKHELNVSTYQMAILLLFNDDgDSLSYEEIQEATGLPDEELKRTLQSLAcaKAKVLLKEPMSKDINPTDTFSFNED 609

                  .
gi 1720393644 644 F 644
Cdd:pfam00888 610 F 610
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
675-735 6.96e-30

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


:

Pssm-ID: 463146  Cd Length: 63  Bit Score: 112.16  E-value: 6.96e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720393644 675 DRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQ 735
Cdd:pfam10557   1 DRKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDE 61
 
Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
14-644 0e+00

Cullin family;


Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 620.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  14 WNKLLTTIKAVvMLEYVERATWNDRFSDIYALCVaypEPLGERLYAETKIFLESHVRHLYKRVLE---SEEQVLVMYHRY 90
Cdd:pfam00888   1 WAKLEDAIDEI-LNKNVSSLSYEELYRAVYNLCL---HKQGEKLYDKLKEYLEEHLKKLVKPLIKeasSGEEFLKAYVKE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  91 WEEYSKGADYMDCLYRYLNTQYIKKnklteadiqygyggvdmnepLMEIGELALDMWRKLMVE-PLQNILIRMLLREIKN 169
Cdd:pfam00888  77 WEDHTISMKMIRDIFMYLDRVYVKR--------------------LPSIYDLGLELFRDHVFRiPLKDKLIDALLDLIEK 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 170 DRGGEDPNQKVIHGVINSFVHVEQYKKKfpLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIR 249
Cdd:pfam00888 137 ERNGEVIDRSLIKSVIDMLVSLGEDEKK--DNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEER 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 250 CRKYLHPSSYTKVIHECQQRMVADHLQFLHS-ECHSIIQQERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLRATS 328
Cdd:pfam00888 215 VRHYLHSSTKKKLLDVLEEVLISDHLEELLEeELQNLLDDNKTEDLKRLYRLLSRVPDGLEPLRKAFEEYIKKEGKAIVK 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 329 NL-TQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYRepKSVCKAPELLAKYCDNLLKKSAKGMT 407
Cdd:pfam00888 295 DAkEQTTDAKKYVEDLLELKDKFDKIVKDAFSNDELFVKALDEAFEEFINKN--TSNSKSPELLAKYIDDLLKKGLKGKS 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 408 ENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLN 487
Cdd:pfam00888 373 EEELEEKLDKVITLFRYIQDKDVFEAFYKKHLAKRLLLGKSASDDAERSMISKLKEECGSEFTSKLEGMFKDMELSKDLM 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 488 NKFNNFIRNQDTvIDLGISFQIYVLQAGAWPLTqaPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMN 567
Cdd:pfam00888 453 KEFKEHLSENKS-SKKGIDLSVNVLTSGAWPTY--LTSDFILPPELEKAIERFEKFYLSKHSGRKLTWLHSLGTAELKAT 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 568 YL-GKPYVAMVTTYQMAVLLAFNNS-ETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMS 643
Cdd:pfam00888 530 FPkGKKHELNVSTYQMAILLLFNDDgDSLSYEEIQEATGLPDEELKRTLQSLAcaKAKVLLKEPMSKDINPTDTFSFNED 609

                  .
gi 1720393644 644 F 644
Cdd:pfam00888 610 F 610
COG5647 COG5647
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, ...
8-745 6.09e-136

Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227934 [Multi-domain]  Cd Length: 773  Bit Score: 419.59  E-value: 6.09e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644   8 VDFDETWNKLLTTIKAVVMLEYVERA--TWNDRFSDIYALCVAYPEPL-------------GERLYAETKIFLESHVRHL 72
Cdd:COG5647    18 EDFESTWEFIERAIGQIFERLYDSMAilSLMEVYTKIYNYCTNKTRSLesdlrwkidfiylGSRLIQKLVDYAKNYIEEY 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  73 YK-RVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEAdiqygyggvdmnePLMEIGELALDMWRKLM 151
Cdd:COG5647    98 NRgRSQENMEEFLDELVKFWNRFTKGATMINHLFLYMDRVYLKKARYDKT-------------LVFEVYSLCLVKEKIES 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 152 VEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYK--KKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQE 229
Cdd:COG5647   165 FRLIVDSLINPLLYYVERYRALQSIDRKYIEDAKDMLESLERPSdyKKENLSYYKSVFEPIFLEETWEFYEMESSEVIEL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 230 SNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLH---SECHSIIQQERKNDMANMYVLLRAVSS 306
Cdd:COG5647   245 LSVTEYLEKAHKILEREEELVEIYLKVSTKKPLLEVLEDVLITRHLDDLEeqgSGFREALDASNLEKLQVLYRLLSETKY 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 307 GLPHMIEELQKHIHDEGLRA---TSNLTQ-----------EHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKAL 372
Cdd:COG5647   325 GVQPLQEVFERYVKDEGVLInieTNYIFHckvdvgflgsrECLPKLYVQKLLSCHDLFPSLVNESFEGDGSIVKALGNAF 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 373 TSVVNYREpKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMD 452
Cdd:COG5647   405 KTFINGNE-SADSGPSEYLAKYIDGLLKKDGKQSFIGKIKDLLQDIITLFRYVEEKDVFEKYYKKLLAKRLLNGRSASAQ 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 453 SEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDlgisFQIYVLQAGAWPLtQAPSSTFAIPQE 532
Cdd:COG5647   484 AELKMISMLKKVCGQEFTSKLEGMFRDISLSSEFTEAFQHSPQSYNKYLD----LFVWVLTQAYWPL-SPEEVSIRLPKE 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 533 LEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNY-LGK--PYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKE 609
Cdd:COG5647   559 LVPILEGFKKFYSSKHNGRKLKWYWHLGSGEVKARFnEGQkyLEISTFSVYQLLVFLLFNDHEELTFEEILELTKLSTDD 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 610 LTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMK 689
Cdd:COG5647   639 LKRVLQSLSCAKLVVLLKDDKLVSPNTKFYVNENFSSKLERIKINYIAESECMQDNLDTHETVEEDRQAELQACIVRIMK 718
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720393644 690 ARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERsQASADEYSYVA 745
Cdd:COG5647   719 ARKKLKHGDLVKEVIAQHKSRFEPKVSMVKRAIETLIEKEYLER-QADDEIYVYLA 773
CULLIN smart00182
Cullin;
424-568 2.16e-61

Cullin;


Pssm-ID: 214545 [Multi-domain]  Cd Length: 143  Bit Score: 202.55  E-value: 2.16e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  424 YIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQdTVIDL 503
Cdd:smart00182   1 YIQDKDVFEKYYKKHLAKRLILNRSASDDAEENMITKLKQECGYEFTSKLERMFRDISLSKDLNQSFKDMLENN-PSAKP 79
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720393644  504 GISFQIYVLQAGAWPLTQAPsSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNY 568
Cdd:smart00182  80 IIDLNVRVLTSGYWPTSSTE-VEINLPQELEDALEEFEEFYLAKHSGRKLTWLHSLGRGEVKANF 143
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
675-735 6.96e-30

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 463146  Cd Length: 63  Bit Score: 112.16  E-value: 6.96e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720393644 675 DRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQ 735
Cdd:pfam10557   1 DRKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDE 61
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
672-739 6.60e-28

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 106.86  E-value: 6.60e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720393644  672 VDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASAD 739
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
 
Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
14-644 0e+00

Cullin family;


Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 620.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  14 WNKLLTTIKAVvMLEYVERATWNDRFSDIYALCVaypEPLGERLYAETKIFLESHVRHLYKRVLE---SEEQVLVMYHRY 90
Cdd:pfam00888   1 WAKLEDAIDEI-LNKNVSSLSYEELYRAVYNLCL---HKQGEKLYDKLKEYLEEHLKKLVKPLIKeasSGEEFLKAYVKE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  91 WEEYSKGADYMDCLYRYLNTQYIKKnklteadiqygyggvdmnepLMEIGELALDMWRKLMVE-PLQNILIRMLLREIKN 169
Cdd:pfam00888  77 WEDHTISMKMIRDIFMYLDRVYVKR--------------------LPSIYDLGLELFRDHVFRiPLKDKLIDALLDLIEK 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 170 DRGGEDPNQKVIHGVINSFVHVEQYKKKfpLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIR 249
Cdd:pfam00888 137 ERNGEVIDRSLIKSVIDMLVSLGEDEKK--DNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEER 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 250 CRKYLHPSSYTKVIHECQQRMVADHLQFLHS-ECHSIIQQERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLRATS 328
Cdd:pfam00888 215 VRHYLHSSTKKKLLDVLEEVLISDHLEELLEeELQNLLDDNKTEDLKRLYRLLSRVPDGLEPLRKAFEEYIKKEGKAIVK 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 329 NL-TQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYRepKSVCKAPELLAKYCDNLLKKSAKGMT 407
Cdd:pfam00888 295 DAkEQTTDAKKYVEDLLELKDKFDKIVKDAFSNDELFVKALDEAFEEFINKN--TSNSKSPELLAKYIDDLLKKGLKGKS 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 408 ENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLN 487
Cdd:pfam00888 373 EEELEEKLDKVITLFRYIQDKDVFEAFYKKHLAKRLLLGKSASDDAERSMISKLKEECGSEFTSKLEGMFKDMELSKDLM 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 488 NKFNNFIRNQDTvIDLGISFQIYVLQAGAWPLTqaPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMN 567
Cdd:pfam00888 453 KEFKEHLSENKS-SKKGIDLSVNVLTSGAWPTY--LTSDFILPPELEKAIERFEKFYLSKHSGRKLTWLHSLGTAELKAT 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 568 YL-GKPYVAMVTTYQMAVLLAFNNS-ETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMS 643
Cdd:pfam00888 530 FPkGKKHELNVSTYQMAILLLFNDDgDSLSYEEIQEATGLPDEELKRTLQSLAcaKAKVLLKEPMSKDINPTDTFSFNED 609

                  .
gi 1720393644 644 F 644
Cdd:pfam00888 610 F 610
COG5647 COG5647
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, ...
8-745 6.09e-136

Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227934 [Multi-domain]  Cd Length: 773  Bit Score: 419.59  E-value: 6.09e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644   8 VDFDETWNKLLTTIKAVVMLEYVERA--TWNDRFSDIYALCVAYPEPL-------------GERLYAETKIFLESHVRHL 72
Cdd:COG5647    18 EDFESTWEFIERAIGQIFERLYDSMAilSLMEVYTKIYNYCTNKTRSLesdlrwkidfiylGSRLIQKLVDYAKNYIEEY 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  73 YK-RVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEAdiqygyggvdmnePLMEIGELALDMWRKLM 151
Cdd:COG5647    98 NRgRSQENMEEFLDELVKFWNRFTKGATMINHLFLYMDRVYLKKARYDKT-------------LVFEVYSLCLVKEKIES 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 152 VEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYK--KKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQE 229
Cdd:COG5647   165 FRLIVDSLINPLLYYVERYRALQSIDRKYIEDAKDMLESLERPSdyKKENLSYYKSVFEPIFLEETWEFYEMESSEVIEL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 230 SNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLH---SECHSIIQQERKNDMANMYVLLRAVSS 306
Cdd:COG5647   245 LSVTEYLEKAHKILEREEELVEIYLKVSTKKPLLEVLEDVLITRHLDDLEeqgSGFREALDASNLEKLQVLYRLLSETKY 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 307 GLPHMIEELQKHIHDEGLRA---TSNLTQ-----------EHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKAL 372
Cdd:COG5647   325 GVQPLQEVFERYVKDEGVLInieTNYIFHckvdvgflgsrECLPKLYVQKLLSCHDLFPSLVNESFEGDGSIVKALGNAF 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 373 TSVVNYREpKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMD 452
Cdd:COG5647   405 KTFINGNE-SADSGPSEYLAKYIDGLLKKDGKQSFIGKIKDLLQDIITLFRYVEEKDVFEKYYKKLLAKRLLNGRSASAQ 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 453 SEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDlgisFQIYVLQAGAWPLtQAPSSTFAIPQE 532
Cdd:COG5647   484 AELKMISMLKKVCGQEFTSKLEGMFRDISLSSEFTEAFQHSPQSYNKYLD----LFVWVLTQAYWPL-SPEEVSIRLPKE 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 533 LEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNY-LGK--PYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKE 609
Cdd:COG5647   559 LVPILEGFKKFYSSKHNGRKLKWYWHLGSGEVKARFnEGQkyLEISTFSVYQLLVFLLFNDHEELTFEEILELTKLSTDD 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644 610 LTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMK 689
Cdd:COG5647   639 LKRVLQSLSCAKLVVLLKDDKLVSPNTKFYVNENFSSKLERIKINYIAESECMQDNLDTHETVEEDRQAELQACIVRIMK 718
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720393644 690 ARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERsQASADEYSYVA 745
Cdd:COG5647   719 ARKKLKHGDLVKEVIAQHKSRFEPKVSMVKRAIETLIEKEYLER-QADDEIYVYLA 773
CULLIN smart00182
Cullin;
424-568 2.16e-61

Cullin;


Pssm-ID: 214545 [Multi-domain]  Cd Length: 143  Bit Score: 202.55  E-value: 2.16e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393644  424 YIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQdTVIDL 503
Cdd:smart00182   1 YIQDKDVFEKYYKKHLAKRLILNRSASDDAEENMITKLKQECGYEFTSKLERMFRDISLSKDLNQSFKDMLENN-PSAKP 79
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720393644  504 GISFQIYVLQAGAWPLTQAPsSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNY 568
Cdd:smart00182  80 IIDLNVRVLTSGYWPTSSTE-VEINLPQELEDALEEFEEFYLAKHSGRKLTWLHSLGRGEVKANF 143
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
675-735 6.96e-30

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 463146  Cd Length: 63  Bit Score: 112.16  E-value: 6.96e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720393644 675 DRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQ 735
Cdd:pfam10557   1 DRKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDE 61
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
672-739 6.60e-28

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 106.86  E-value: 6.60e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720393644  672 VDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASAD 739
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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