NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720393121|ref|XP_030106331|]
View 

histone deacetylase complex subunit SAP130 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
654-1024 0e+00

Histone deacetylase complex subunit SAP130 C-terminus;


:

Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 571.49  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  654 AQGSSPRPSILRKKPATDGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIA 733
Cdd:pfam16014    1 ALGSSPRPSILRKKPATEGAKPKPDIHVAVAPPVTVAVEALPGQNSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  734 LSTIPGAVPVTPP----ITTIAATPTLSApVGGTPSTVLGPPVPEIKVKEEAEPVDITRpvsTVPPLATNTVSPSLALLA 809
Cdd:pfam16014   81 LSTLPAAMAVTPPipasMANVVAPPTQPA-ASSTAACAVSSVLPEIKIKQEAEPMDTSQ---SVPPLTPTSISPALTSLA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  810 SNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPP 889
Cdd:pfam16014  157 NNLSVPAGDLLPGASPRKKPRKQQHVISTEEGEMMETNSTDEEKSAPKPLTSRAEKRKSPPKEYIDEEGVRYVPVRPRPP 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  890 ITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGI 969
Cdd:pfam16014  237 ITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKGTLQDMANQKGVTCRAQGWKIHLCAAQLLQLTNLEHDVYSRLTTLQEGL 316
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720393121  970 IPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLN 1024
Cdd:pfam16014  317 IPKKKAGTDDDLHRINELIQGNMQRCKLVMDQITEARDSMMKVLDHKDRVLKLLN 371
PHA03247 super family cl33720
large tegument protein UL36; Provisional
8-359 1.44e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121    8 RLRIPQASGLNVEMSSQQFPRLGTPSPGLSQPPSQIASSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQ 87
Cdd:PHA03247  2597 RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121   88 EPVVVRPYPQVQMLPAHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSlPPKVPGQVT 167
Cdd:PHA03247  2677 SSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-GPATPGGPA 2755
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  168 VTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRgaaaaavmsSSKVTTVLRPTS 247
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP---------AAALPPAASPAG 2826
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  248 QLPNAATAQPAVQHLIHQPIQsrPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSA--AIS 325
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPP--PSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1720393121  326 IQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQ 359
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
PHA02732 super family cl28620
hypothetical protein; Provisional
257-486 4.93e-03

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA02732:

Pssm-ID: 165099 [Multi-domain]  Cd Length: 1467  Bit Score: 40.89  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  257 PAVQHLIHQPIQSRPPVTTSST--IPPAVVA----TVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSAAISIQrPA 330
Cdd:PHA02732  1182 PAPQLLSSYIPTGSVLYQDPIFtyIPPGIIGmsgtNTFTFKAAQLQLSAASSPPAATTPTPPPSSSSSSSAQSISTS-PG 1260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  331 QSR-----DVTTRITLPSHPALGTPKqqlhtmaqktifsTGTPVAAATVapilatntlpSTTTAGSVSHTQAPTSTIVTM 405
Cdd:PHA02732  1261 QIQivlngSTTIHINFLFFPALSTPK-------------IGQILAMPIV----------NSSGAFISLYVNSAISANFNV 1317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  406 TMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPPErSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPT 485
Cdd:PHA02732  1318 TIEYVFSNGTVIKRFTDEPGQIFPLPLINGDEEVIISVENE-STTFNISANNLGSAQLALQLRNAISASLPGPFAFFGPI 1396

                   .
gi 1720393121  486 Y 486
Cdd:PHA02732  1397 L 1397
 
Name Accession Description Interval E-value
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
654-1024 0e+00

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 571.49  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  654 AQGSSPRPSILRKKPATDGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIA 733
Cdd:pfam16014    1 ALGSSPRPSILRKKPATEGAKPKPDIHVAVAPPVTVAVEALPGQNSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  734 LSTIPGAVPVTPP----ITTIAATPTLSApVGGTPSTVLGPPVPEIKVKEEAEPVDITRpvsTVPPLATNTVSPSLALLA 809
Cdd:pfam16014   81 LSTLPAAMAVTPPipasMANVVAPPTQPA-ASSTAACAVSSVLPEIKIKQEAEPMDTSQ---SVPPLTPTSISPALTSLA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  810 SNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPP 889
Cdd:pfam16014  157 NNLSVPAGDLLPGASPRKKPRKQQHVISTEEGEMMETNSTDEEKSAPKPLTSRAEKRKSPPKEYIDEEGVRYVPVRPRPP 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  890 ITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGI 969
Cdd:pfam16014  237 ITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKGTLQDMANQKGVTCRAQGWKIHLCAAQLLQLTNLEHDVYSRLTTLQEGL 316
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720393121  970 IPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLN 1024
Cdd:pfam16014  317 IPKKKAGTDDDLHRINELIQGNMQRCKLVMDQITEARDSMMKVLDHKDRVLKLLN 371
PHA03247 PHA03247
large tegument protein UL36; Provisional
578-829 8.80e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 8.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  578 APIGTPGiHSAAPINTQGLQPAAMANQQPQPEGKTSVVLADGATIVANPISNPFSAAPAATTVvqthsqSASTNTPAQGS 657
Cdd:PHA03247  2600 APVDDRG-DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV------SRPRRARRLGR 2672
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  658 SPRPSILRKKPATDGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTI 737
Cdd:PHA03247  2673 AAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG 2752
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  738 PGAVPVTPPITTIAATPTLSA-PVGGTPSTVLGPPVPEIKVKEEAEPVDITRPVSTVPPLATNTVSPSLALLASNLSMPP 816
Cdd:PHA03247  2753 GPARPARPPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT 2832
                          250
                   ....*....|...
gi 1720393121  817 SDLPPGASPRKKP 829
Cdd:PHA03247  2833 SAQPTAPPPPPGP 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
8-359 1.44e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121    8 RLRIPQASGLNVEMSSQQFPRLGTPSPGLSQPPSQIASSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQ 87
Cdd:PHA03247  2597 RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121   88 EPVVVRPYPQVQMLPAHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSlPPKVPGQVT 167
Cdd:PHA03247  2677 SSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-GPATPGGPA 2755
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  168 VTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRgaaaaavmsSSKVTTVLRPTS 247
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP---------AAALPPAASPAG 2826
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  248 QLPNAATAQPAVQHLIHQPIQsrPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSA--AIS 325
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPP--PSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1720393121  326 IQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQ 359
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
PHA02732 PHA02732
hypothetical protein; Provisional
257-486 4.93e-03

hypothetical protein; Provisional


Pssm-ID: 165099 [Multi-domain]  Cd Length: 1467  Bit Score: 40.89  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  257 PAVQHLIHQPIQSRPPVTTSST--IPPAVVA----TVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSAAISIQrPA 330
Cdd:PHA02732  1182 PAPQLLSSYIPTGSVLYQDPIFtyIPPGIIGmsgtNTFTFKAAQLQLSAASSPPAATTPTPPPSSSSSSSAQSISTS-PG 1260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  331 QSR-----DVTTRITLPSHPALGTPKqqlhtmaqktifsTGTPVAAATVapilatntlpSTTTAGSVSHTQAPTSTIVTM 405
Cdd:PHA02732  1261 QIQivlngSTTIHINFLFFPALSTPK-------------IGQILAMPIV----------NSSGAFISLYVNSAISANFNV 1317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  406 TMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPPErSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPT 485
Cdd:PHA02732  1318 TIEYVFSNGTVIKRFTDEPGQIFPLPLINGDEEVIISVENE-STTFNISANNLGSAQLALQLRNAISASLPGPFAFFGPI 1396

                   .
gi 1720393121  486 Y 486
Cdd:PHA02732  1397 L 1397
 
Name Accession Description Interval E-value
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
654-1024 0e+00

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 571.49  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  654 AQGSSPRPSILRKKPATDGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIA 733
Cdd:pfam16014    1 ALGSSPRPSILRKKPATEGAKPKPDIHVAVAPPVTVAVEALPGQNSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  734 LSTIPGAVPVTPP----ITTIAATPTLSApVGGTPSTVLGPPVPEIKVKEEAEPVDITRpvsTVPPLATNTVSPSLALLA 809
Cdd:pfam16014   81 LSTLPAAMAVTPPipasMANVVAPPTQPA-ASSTAACAVSSVLPEIKIKQEAEPMDTSQ---SVPPLTPTSISPALTSLA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  810 SNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPP 889
Cdd:pfam16014  157 NNLSVPAGDLLPGASPRKKPRKQQHVISTEEGEMMETNSTDEEKSAPKPLTSRAEKRKSPPKEYIDEEGVRYVPVRPRPP 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  890 ITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGI 969
Cdd:pfam16014  237 ITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKGTLQDMANQKGVTCRAQGWKIHLCAAQLLQLTNLEHDVYSRLTTLQEGL 316
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720393121  970 IPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLN 1024
Cdd:pfam16014  317 IPKKKAGTDDDLHRINELIQGNMQRCKLVMDQITEARDSMMKVLDHKDRVLKLLN 371
PHA03247 PHA03247
large tegument protein UL36; Provisional
578-829 8.80e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 8.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  578 APIGTPGiHSAAPINTQGLQPAAMANQQPQPEGKTSVVLADGATIVANPISNPFSAAPAATTVvqthsqSASTNTPAQGS 657
Cdd:PHA03247  2600 APVDDRG-DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV------SRPRRARRLGR 2672
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  658 SPRPSILRKKPATDGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTI 737
Cdd:PHA03247  2673 AAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG 2752
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  738 PGAVPVTPPITTIAATPTLSA-PVGGTPSTVLGPPVPEIKVKEEAEPVDITRPVSTVPPLATNTVSPSLALLASNLSMPP 816
Cdd:PHA03247  2753 GPARPARPPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT 2832
                          250
                   ....*....|...
gi 1720393121  817 SDLPPGASPRKKP 829
Cdd:PHA03247  2833 SAQPTAPPPPPGP 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
437-870 9.82e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 9.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  437 PRIQPDYPPERSSLIPiSGHRASPNPVAMETRNDNRPSVPVQfqyflPTYPPSAYPlaahTYTPITSSVSTIRQYPVSAQ 516
Cdd:PHA03247  2641 HPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQ-----RPRRRAARP----TVGSLTSLADPPPPPPTPEP 2710
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  517 APNSTITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTSGIQP--APIGTPGIHSAAPINTQ 594
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPpaAPAAGPPRRLTRPAVAS 2790
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  595 GLQPAAMANQQPQPEGKTSVVLADGATIvaNPISNPFSAAPAATTVVQTHSQSAS----TNTPAQGSSPRPSILRKKPAT 670
Cdd:PHA03247  2791 LSESRESLPSPWDPADPPAAVLAPAAAL--PPAASPAGPLPPPTSAQPTAPPPPPgpppPSLPLGGSVAPGGDVRRRPPS 2868
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  671 DG--AKPKSEVHVSIATPVTVSLETiSNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVTPPIT 748
Cdd:PHA03247  2869 RSpaAKPAAPARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  749 TIAATPtlsAPVGGTPSTVLGP------PVPEIKVKEEAEPVDItrPVSTVPPLaTNTVSPSLALLASNLSMPPSDLPPG 822
Cdd:PHA03247  2948 DPAGAG---EPSGAVPQPWLGAlvpgrvAVPRFRVPQPAPSREA--PASSTPPL-TGHSLSRVSSWASSLALHEETDPPP 3021
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720393121  823 ASprkkpRKQQHVIS--TEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPP 870
Cdd:PHA03247  3022 VS-----LKQTLWPPddTEDSDADSLFDSDSERSDLEALDPLPPEPHDPF 3066
PHA03247 PHA03247
large tegument protein UL36; Provisional
8-359 1.44e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121    8 RLRIPQASGLNVEMSSQQFPRLGTPSPGLSQPPSQIASSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQ 87
Cdd:PHA03247  2597 RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121   88 EPVVVRPYPQVQMLPAHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSlPPKVPGQVT 167
Cdd:PHA03247  2677 SSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-GPATPGGPA 2755
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  168 VTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRgaaaaavmsSSKVTTVLRPTS 247
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP---------AAALPPAASPAG 2826
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  248 QLPNAATAQPAVQHLIHQPIQsrPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSA--AIS 325
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPP--PSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1720393121  326 IQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQ 359
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
PHA03247 PHA03247
large tegument protein UL36; Provisional
118-512 5.49e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 5.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  118 PPAHLTPA---------VPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSLPPKVPGQVTVTMESS-IPQASAIPVATISG 187
Cdd:PHA03247  2551 PPPPLPPAappaapdrsVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSpLPPDTHAPDPPPPS 2630
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  188 QQGHPSNLHHIMTTNVQMSIIRSNAPGPP------------LHIGASHLPRGAAAAAVMSS-SKVTTVLRPTSQLPNAAT 254
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlgRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEP 2710
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  255 AQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPV-ITTTAAHAADSTLSRPTLSIQHPPSAAISIQRPAQSR 333
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  334 DVTTRITLPS------HPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTLPSTTTAGSVSHTQAPtstiVTMTM 407
Cdd:PHA03247  2791 LSESRESLPSpwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD----VRRRP 2866
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  408 PSHSSHATAVTTSNIPVAKVvpqqithtsPRIQPDYPPERSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPTYP 487
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRL---------ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          410       420
                   ....*....|....*....|....*
gi 1720393121  488 PSAYPLAAHTYTPITSSVSTIRQYP 512
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQP 2962
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
725-845 3.61e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 3.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  725 SPPSQPAIALSTIPGAVPVTPPITTIAATPTLSAPVGGTPSTVLGPPVPEIKVKEEAEPV--DITRPVSTVPPLATNTVS 802
Cdd:PRK14950   344 TSYGQLPLELAVIEALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVreTATPPPVPPRPVAPPVPH 423
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1720393121  803 PSLALLASNLSMPPSDLPPGASPrKKPRKQQHVISTEEGDMME 845
Cdd:PRK14950   424 TPESAPKLTRAAIPVDEKPKYTP-PAPPKEEEKALIADGDVLE 465
PHA02732 PHA02732
hypothetical protein; Provisional
257-486 4.93e-03

hypothetical protein; Provisional


Pssm-ID: 165099 [Multi-domain]  Cd Length: 1467  Bit Score: 40.89  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  257 PAVQHLIHQPIQSRPPVTTSST--IPPAVVA----TVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSAAISIQrPA 330
Cdd:PHA02732  1182 PAPQLLSSYIPTGSVLYQDPIFtyIPPGIIGmsgtNTFTFKAAQLQLSAASSPPAATTPTPPPSSSSSSSAQSISTS-PG 1260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  331 QSR-----DVTTRITLPSHPALGTPKqqlhtmaqktifsTGTPVAAATVapilatntlpSTTTAGSVSHTQAPTSTIVTM 405
Cdd:PHA02732  1261 QIQivlngSTTIHINFLFFPALSTPK-------------IGQILAMPIV----------NSSGAFISLYVNSAISANFNV 1317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  406 TMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPPErSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPT 485
Cdd:PHA02732  1318 TIEYVFSNGTVIKRFTDEPGQIFPLPLINGDEEVIISVENE-STTFNISANNLGSAQLALQLRNAISASLPGPFAFFGPI 1396

                   .
gi 1720393121  486 Y 486
Cdd:PHA02732  1397 L 1397
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
473-813 5.51e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 5.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  473 PSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQ-YPVSAQAPNSTI-TAQTGVGVASTVHLNPMQLMTVDASHAR 550
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQgSPATSQPPNQTQsTAAPHTLIQQTPTLHPQRLPSPHPPLQP 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  551 HIQGIQPAPISTQGIQPAPIGTSGI-QPAPIGTPGIHSAAPINTQGLQPAAMANQQPQPEGKTSVVLADGATIVANPISN 629
Cdd:pfam03154  252 MTQPPPPSQVSPQPLPQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQ 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  630 PFSAA--------------------PAATTVVQTHSQSASTNTPAQGSSPRP----SILRKKPATDGAKPKSEVHVSIAT 685
Cdd:pfam03154  332 SQLQSqqppreqplppaplsmphikPPPTTPIPQLPNPQSHKHPPHLSGPSPfqmnSNLPPPPALKPLSSLSTHHPPSAH 411
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393121  686 PVTVSLETISNQ----NAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIAL-STIPGAVPV-----TPPITTIAATPT 755
Cdd:pfam03154  412 PPPLQLMPQSQQlpppPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQhPFVPGGPPPitppsGPPTSTSSAMPG 491
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720393121  756 LSAPVGGTPST------VLGPPVPEIKVKEEAePVDITRPVSTVPPLATNTVSPSLALLASNLS 813
Cdd:pfam03154  492 IQPPSSASVSSsgpvpaAVSCPLPPVQIKEEA-LDEAEEPESPPPPPRSPSPEPTVVNTPSHAS 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH