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Conserved domains on  [gi|1720390816|ref|XP_030105809|]
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uncharacterized protein LOC631624 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 5.84e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 5.84e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720390816  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-650 8.41e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 8.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 209 KPYKCNECEKCFSYKSSLRTHQRIHTGENPYKCS--ECDKCFSHKGSLSIHQMYHTGKKPYKCSeceKCFIQVGDLRRHE 286
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 287 RIHtgEKPYKCNECEKCFSSKTNLRTHQRIHtgekpykcsecdkGFTLKCSLIIHQVYHTGKKPYKCSECEKCFIQvgdl 366
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQL-------------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 367 rKHQRIHTGEKPYKCSecdksftqkgSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKTYKCSECDkCFSH 446
Cdd:COG5048   170 -PLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 447 KGSLKV-HLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHTGE-------KPYKCSECDKSFTLKGNLRDHQR--IHTGE 516
Cdd:COG5048   238 KSLLSQsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 517 --KPYKCSE--CDKYYTRKSHLIVHQKIHAGEKPYKC--SECDKYYTRKS----HLIVHQRIHIGEKPYKC---SECNKC 583
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720390816 584 FTNKYHLRTH--QRIHSANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLNVHQ 650
Cdd:COG5048   398 FKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
645-669 6.38e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.38e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390816 645 SLNVHQRVHTGEKPYKCSECDKCFS 669
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 5.84e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 5.84e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720390816  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-61 6.86e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.19  E-value: 6.86e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720390816   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFVENQYMCPEF 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDL 49
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.44e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 3.44e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390816  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-650 8.41e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 8.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 209 KPYKCNECEKCFSYKSSLRTHQRIHTGENPYKCS--ECDKCFSHKGSLSIHQMYHTGKKPYKCSeceKCFIQVGDLRRHE 286
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 287 RIHtgEKPYKCNECEKCFSSKTNLRTHQRIHtgekpykcsecdkGFTLKCSLIIHQVYHTGKKPYKCSECEKCFIQvgdl 366
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQL-------------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 367 rKHQRIHTGEKPYKCSecdksftqkgSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKTYKCSECDkCFSH 446
Cdd:COG5048   170 -PLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 447 KGSLKV-HLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHTGE-------KPYKCSECDKSFTLKGNLRDHQR--IHTGE 516
Cdd:COG5048   238 KSLLSQsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 517 --KPYKCSE--CDKYYTRKSHLIVHQKIHAGEKPYKC--SECDKYYTRKS----HLIVHQRIHIGEKPYKC---SECNKC 583
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720390816 584 FTNKYHLRTH--QRIHSANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLNVHQ 650
Cdd:COG5048   398 FKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 2.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390816 365 DLRKHQRIHTGEKPYKCSECDKSFTQ 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 601-653 3.46e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720390816 601 KPYkCSECDKCF-TEKYrLIIHQRIHTgekpYKCSECDKYFTRKSSLNVH-QRVH 653
Cdd:cd20908     1 KPW-CYYCDREFdDEKI-LIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
645-669 6.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.38e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390816 645 SLNVHQRVHTGEKPYKCSECDKCFS 669
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 5.84e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 5.84e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720390816  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-61 6.86e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.19  E-value: 6.86e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720390816   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFVENQYMCPEF 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDL 49
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.44e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 3.44e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390816  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-650 8.41e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 8.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 209 KPYKCNECEKCFSYKSSLRTHQRIHTGENPYKCS--ECDKCFSHKGSLSIHQMYHTGKKPYKCSeceKCFIQVGDLRRHE 286
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 287 RIHtgEKPYKCNECEKCFSSKTNLRTHQRIHtgekpykcsecdkGFTLKCSLIIHQVYHTGKKPYKCSECEKCFIQvgdl 366
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQL-------------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 367 rKHQRIHTGEKPYKCSecdksftqkgSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKTYKCSECDkCFSH 446
Cdd:COG5048   170 -PLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 447 KGSLKV-HLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHTGE-------KPYKCSECDKSFTLKGNLRDHQR--IHTGE 516
Cdd:COG5048   238 KSLLSQsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 517 --KPYKCSE--CDKYYTRKSHLIVHQKIHAGEKPYKC--SECDKYYTRKS----HLIVHQRIHIGEKPYKC---SECNKC 583
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720390816 584 FTNKYHLRTH--QRIHSANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLNVHQ 650
Cdd:COG5048   398 FKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-688 7.53e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 293 KPYKCNECEKCFSSKTNLRTHQRIHTGEKPYKCS--ECDKGFTLKCSLIIHQVYHTGKKPYKCSecEKCFIQVGDLRKHQ 370
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 371 RIHTGE---KPYKCSECDKSFTQKGSLSI--HQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTgektykcSECDKCFS 445
Cdd:COG5048   110 LSSSSSnsnDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-------SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 446 HKGSLKVHLRIHTGENLYKCSECDKcFTKKWRLTSHQTIHTGEKPYKCSECdkSFTLKGNLRDHQRIHTGEKPYKCSECD 525
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 526 KYYTRKSHLIVHQKIH---------AGEKPYKCSECDKYYTRKSHLIVHQR--IHIGE--KPYKCSE--CNKCFTNKYHL 590
Cdd:COG5048   260 SPRSSLPTASSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 591 RTHQRIHSANKPYKCSEC------DKCFTEKYRLIIHQRIHTGEKPYKC---SECDKYFTRKSSLNVHQRVHTGEKP--Y 659
Cdd:COG5048   340 KRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynC 419

                         410       420
                  ....*....|....*....|....*....
gi 1720390816 660 KCSECDKCFSLKGDLRKHQRIHTGERTLQ 688
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-606 3.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 162 DKVFDSKETLILKQTKSVKKPYKCSECEKCFIQVGDLRKHQRIHKGEKPYKCN--ECEKCFSYKSSLRTHQRIHTGENPY 239
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 240 KCS-ECDKCFSHKGSLSIHQMYHTGKKPYKCSECEKCFIQVGDLRRHERIHTGekpYKCNECEKCFSSKTNLRTHQRIHt 318
Cdd:COG5048    93 LNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISN---LRNNPLPGNNSSSVNTPQSNSLH- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 319 GEKPYKCSeCDKGFTLKCSLIIHQVYHTGKKPYKCSECEKcFIQVGDLRKHQRIHTGEKPYKCSECDKSFTQKGSLSIHQ 398
Cdd:COG5048   169 PPLPANSL-SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 399 RIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKT-------YKCSECDKCFSHKGSLKVHLR--IHTGENLYKCSE-- 467
Cdd:COG5048   247 SLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpy 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 468 --CDKCFTKKWRLTSHQTIHTGEKPYKC--SECDKSFTLKGNLRDHQRIHtgekpykcsecdkyytrKSHLIVHQKIHAG 543
Cdd:COG5048   327 slCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSET 389

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720390816 544 EKPYKCSECDKYYTRKSHLIVH--QRIHigekPYKCSECNKCFTNKYHLRTHQRIHSANKPYKCS 606
Cdd:COG5048   390 LSNSCIRNFKRDSNLSLHIITHlsFRPY----NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 570-654 1.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 570 IGEKPYKCS--ECNKCFTNKYHLRTHqRIHSankpykcsECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLN 647
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1720390816 648 VHqRVHT 654
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 2.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390816 365 DLRKHQRIHTGEKPYKCSECDKSFTQ 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 515-593 3.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 515 GEKPYKCS--ECDKYYTRKSHLIVHqKIHAgekpykcsECDKYYTRKSHLIVHQRIHIGEKPYKCSECNKCFTN----KY 588
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNlnglKY 416


                  ....*
gi 1720390816 589 HlRTH 593
Cdd:COG5189   417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 3.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390816 281 DLRRHERIHTGEKPYKCNECEKCFSS 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 375-453 7.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 375 GEKPYKCS--ECDKSFTQKGSLSIHqRIHAgekpyrcsECDKGFTLKCSLIIHQIIHTGEKTYKCSECDKCFSHKGSLKV 452
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390816 453 H 453
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 7.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1720390816 309 NLRTHQRIHTGEKPYKCSECDKGFT 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 487-565 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390816 487 GEKPYKCS--ECDKSFTLKGNLRDHqRIHtgekpykcSECDKYYTRKSHLIVHQKIHAGEKPYKCSECDKYYTRKSHLIV 564
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390816 565 H 565
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 1.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390816 505 NLRDHQRIHTGEKPYKCSECDKYYTR 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
598-662 1.93e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720390816 598 SANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCS--ECDKYFTRKSSLNVHQRVHTGEKPYKCS 662
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 2.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390816 225 SLRTHQRIHTGENPYKCSECDKCFSH 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
197-222 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390816 197 DLRKHQRIHKGEKPYKCNECEKCFSY 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 601-653 3.46e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720390816 601 KPYkCSECDKCF-TEKYrLIIHQRIHTgekpYKCSECDKYFTRKSSLNVH-QRVH 653
Cdd:cd20908     1 KPW-CYYCDREFdDEKI-LIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
645-669 6.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.38e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390816 645 SLNVHQRVHTGEKPYKCSECDKCFS 669
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-642 8.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.74e-03
                          10        20
                  ....*....|....*....|..
gi 1720390816 621 HQRIHTGEKPYKCSECDKYFTR 642
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-501 9.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.18e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390816 477 RLTSHQTIHTGEKPYKCSECDKSFT 501
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 575-597 9.31e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.31e-03
                          10        20
                  ....*....|....*....|...
gi 1720390816 575 YKCSECNKCFTNKYHLRTHQRIH 597
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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