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Conserved domains on  [gi|1720398400|ref|XP_030105674|]
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probable ATP-dependent RNA helicase DDX31 isoform X1 [Mus musculus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13371497)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SrmB super family cl33924
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
2-340 4.41e-66

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0513:

Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 218.48  E-value: 4.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:COG0513   107 GGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEADRMLDMGFIEDIERILKLLPKE---RQTLLF 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkevasiqlnsfAIPESLDQHVVLVPSKLRLVCLAAFIlqkcKFEKN 161
Cdd:COG0513   183 SATMPPEIRKLAKRYLKNPVRIEVAPEN-----------------ATAETIEQRYYLVDKRDKLELLRRLL----RDEDP 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 162 QKMIVFFSSCELVEfhyslFLHTLLCHSGtptsehLPSASwplkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASR 241
Cdd:COG0513   242 ERAIVFCNTKRGAD-----RLAEKLQKRG------ISAAA-------LHGDLSQGQRERALDAFRNGKIRVLVATDVAAR 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 242 GLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNS---LASHKINVGEIK-MEDILAVLAKD- 316
Cdd:COG0513   304 GIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAiekLIGQKIEEEELPgFEPVEEKRLERl 383
                         330       340
                  ....*....|....*....|....*
gi 1720398400 317 -DCFKRRQRGAQKSRASGPQEIRER 340
Cdd:COG0513   384 kPKIKEKLKGKKAGRGGRPGPKGER 408
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
345-405 6.25e-18

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


:

Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 77.44  E-value: 6.25e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398400 345 QTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPkeLKSIFHVRALHLGHVAKSFGLRDAPR 405
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
 
Name Accession Description Interval E-value
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
2-340 4.41e-66

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 218.48  E-value: 4.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:COG0513   107 GGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEADRMLDMGFIEDIERILKLLPKE---RQTLLF 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkevasiqlnsfAIPESLDQHVVLVPSKLRLVCLAAFIlqkcKFEKN 161
Cdd:COG0513   183 SATMPPEIRKLAKRYLKNPVRIEVAPEN-----------------ATAETIEQRYYLVDKRDKLELLRRLL----RDEDP 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 162 QKMIVFFSSCELVEfhyslFLHTLLCHSGtptsehLPSASwplkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASR 241
Cdd:COG0513   242 ERAIVFCNTKRGAD-----RLAEKLQKRG------ISAAA-------LHGDLSQGQRERALDAFRNGKIRVLVATDVAAR 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 242 GLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNS---LASHKINVGEIK-MEDILAVLAKD- 316
Cdd:COG0513   304 GIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAiekLIGQKIEEEELPgFEPVEEKRLERl 383
                         330       340
                  ....*....|....*....|....*
gi 1720398400 317 -DCFKRRQRGAQKSRASGPQEIRER 340
Cdd:COG0513   384 kPKIKEKLKGKKAGRGGRPGPKGER 408
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
1-104 4.23e-55

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 183.17  E-value: 4.23e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEC------- 73
Cdd:cd17949   101 IGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILELLDDKRskaggek 180
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720398400  74 ---QKRQNVLLSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17949   181 skpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
PTZ00110 PTZ00110
helicase; Provisional
2-285 6.67e-38

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 145.30  E-value: 6.67e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKST-KNLhfNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVL 80
Cdd:PTZ00110  239 GGVPKRGQIYALRRGVEILIACPGRLIDFLESNvTNL--RRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPD---RQTLM 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  81 LSATLTEGVTRLV-DISLHNPVSISV--LD-KNCNqpnpkevaSIQLNSFAIPESLDQhvvlvpSKLRLvclaafILQKC 156
Cdd:PTZ00110  314 WSATWPKEVQSLArDLCKEEPVHVNVgsLDlTACH--------NIKQEVFVVEEHEKR------GKLKM------LLQRI 373
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 157 kFEKNQKMIVFfssCELVEfhyslflhtllcHSGTPTSEhLPSASWPLkfLRLHGNMEQEERTSVFHEFSHSETGVLLCT 236
Cdd:PTZ00110  374 -MRDGDKILIF---VETKK------------GADFLTKE-LRLDGWPA--LCIHGDKKQEERTWVLNEFKTGKSPIMIAT 434
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1720398400 237 DVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAP 285
Cdd:PTZ00110  435 DVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
150-274 3.52e-29

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 110.38  E-value: 3.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 150 AFILQKCKFEKNQKMIVFFSSCELVEFHYSLFLHtllchsgtptsehlpsaswPLKFLRLHGNMEQEERTSVFHEFSHSE 229
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKKTLEAELLLEKE-------------------GIKVARLHGDLSQEEREEILEDFRKGK 64
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720398400 230 TGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:pfam00271  65 IDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
204-274 5.54e-26

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 100.75  E-value: 5.54e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398400  204 LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:smart00490  12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
345-405 6.25e-18

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 77.44  E-value: 6.25e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398400 345 QTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPkeLKSIFHVRALHLGHVAKSFGLRDAPR 405
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
 
Name Accession Description Interval E-value
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
2-340 4.41e-66

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 218.48  E-value: 4.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:COG0513   107 GGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEADRMLDMGFIEDIERILKLLPKE---RQTLLF 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkevasiqlnsfAIPESLDQHVVLVPSKLRLVCLAAFIlqkcKFEKN 161
Cdd:COG0513   183 SATMPPEIRKLAKRYLKNPVRIEVAPEN-----------------ATAETIEQRYYLVDKRDKLELLRRLL----RDEDP 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 162 QKMIVFFSSCELVEfhyslFLHTLLCHSGtptsehLPSASwplkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASR 241
Cdd:COG0513   242 ERAIVFCNTKRGAD-----RLAEKLQKRG------ISAAA-------LHGDLSQGQRERALDAFRNGKIRVLVATDVAAR 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 242 GLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNS---LASHKINVGEIK-MEDILAVLAKD- 316
Cdd:COG0513   304 GIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAiekLIGQKIEEEELPgFEPVEEKRLERl 383
                         330       340
                  ....*....|....*....|....*
gi 1720398400 317 -DCFKRRQRGAQKSRASGPQEIRER 340
Cdd:COG0513   384 kPKIKEKLKGKKAGRGGRPGPKGER 408
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
1-104 4.23e-55

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 183.17  E-value: 4.23e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEC------- 73
Cdd:cd17949   101 IGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILELLDDKRskaggek 180
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720398400  74 ---QKRQNVLLSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17949   181 skpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
132-283 3.41e-41

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 143.42  E-value: 3.41e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 132 LDQHVVLVPSKLRLVCLAAFILQKckfEKNQKMIVFFSSCELVEFhyslfLHTLLCHSGtptsehlpsaswpLKFLRLHG 211
Cdd:cd18787     1 IKQLYVVVEEEEKKLLLLLLLLEK---LKPGKAIIFVNTKKRVDR-----LAELLEELG-------------IKVAALHG 59
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720398400 212 NMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL 283
Cdd:cd18787    60 DLSQEERERALKKFRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
PTZ00110 PTZ00110
helicase; Provisional
2-285 6.67e-38

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 145.30  E-value: 6.67e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKST-KNLhfNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVL 80
Cdd:PTZ00110  239 GGVPKRGQIYALRRGVEILIACPGRLIDFLESNvTNL--RRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPD---RQTLM 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  81 LSATLTEGVTRLV-DISLHNPVSISV--LD-KNCNqpnpkevaSIQLNSFAIPESLDQhvvlvpSKLRLvclaafILQKC 156
Cdd:PTZ00110  314 WSATWPKEVQSLArDLCKEEPVHVNVgsLDlTACH--------NIKQEVFVVEEHEKR------GKLKM------LLQRI 373
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 157 kFEKNQKMIVFfssCELVEfhyslflhtllcHSGTPTSEhLPSASWPLkfLRLHGNMEQEERTSVFHEFSHSETGVLLCT 236
Cdd:PTZ00110  374 -MRDGDKILIF---VETKK------------GADFLTKE-LRLDGWPA--LCIHGDKKQEERTWVLNEFKTGKSPIMIAT 434
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1720398400 237 DVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAP 285
Cdd:PTZ00110  435 DVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
13-278 5.81e-37

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 140.85  E-value: 5.81e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  13 LRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVIlnavNAECQKR-QNVLLSATLT-EGVT 90
Cdd:PRK11192  120 FSENQDIVVATPGRLLQYIKE-ENFDCRAVETLILDEADRMLDMGFAQDIETI----AAETRWRkQTLLFSATLEgDAVQ 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  91 RLVDISLHNPVSISVldkncnQPNPKEVASIQlnsfaipesldQHVVL---VPSKLRLVClaaFILQKckfEKNQKMIVF 167
Cdd:PRK11192  195 DFAERLLNDPVEVEA------EPSRRERKKIH-----------QWYYRaddLEHKTALLC---HLLKQ---PEVTRSIVF 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 168 FSSCELVefhyslflHTLlchsgtptSEHLPSASWPLKFLRlhGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQ 247
Cdd:PRK11192  252 VRTRERV--------HEL--------AGWLRKAGINCCYLE--GEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDD 313
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720398400 248 VTWIVQYSAPSSPAEYIHRIGRTARIGCHGS 278
Cdd:PRK11192  314 VSHVINFDMPRSADTYLHRIGRTGRAGRKGT 344
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
2-104 4.02e-35

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 129.48  E-value: 4.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAecqKRQNVLL 81
Cdd:cd00268    98 GGAPIKKQIEALKKGPDIVVGTPGRLLDLIER-GKLDLSNVKYLVLDEADRMLDMGFEEDVEKILSALPK---DRQTLLF 173
                          90       100
                  ....*....|....*....|...
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd00268   174 SATLPEEVKELAKKFLKNPVRIE 196
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
12-280 7.33e-34

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 132.62  E-value: 7.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  12 RLRKGINILISTPGRLVDhIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAecqKRQNVLLSATLTEGVTR 91
Cdd:PRK10590  121 KLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLAKLPA---KRQNLLFSATFSDDIKA 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  92 LVDISLHNPVSISVLDKNcnqpnpkeVASiqlnsfaipESLDQHVVLVPSKLRLVCLAAFIlqkckFEKNQKMIVFFSSC 171
Cdd:PRK10590  197 LAEKLLHNPLEIEVARRN--------TAS---------EQVTQHVHFVDKKRKRELLSQMI-----GKGNWQQVLVFTRT 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 172 ElvefHYSLFLHTLLCHSGTPTSEhlpsaswplkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWI 251
Cdd:PRK10590  255 K----HGANHLAEQLNKDGIRSAA-------------IHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHV 317
                         250       260
                  ....*....|....*....|....*....
gi 1720398400 252 VQYSAPSSPAEYIHRIGRTARIGCHGSSL 280
Cdd:PRK10590  318 VNYELPNVPEDYVHRIGRTGRAAATGEAL 346
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
13-294 7.78e-33

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 129.54  E-value: 7.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  13 LRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRL 92
Cdd:PRK11776  120 LEHGAHIIVGTPGRILDHLRK-GTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAPAR---RQTLLFSATYPEGIAAI 195
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  93 VDISLHNPVSIsvldkncnqpnpkEVASIQLNSfaipeSLDQHVVLVPSKLRLVCLAAFILQkckfEKNQKMIVFfssC- 171
Cdd:PRK11776  196 SQRFQRDPVEV-------------KVESTHDLP-----AIEQRFYEVSPDERLPALQRLLLH----HQPESCVVF---Cn 250
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 172 ------ELVEfhyslflhtLLCHSGTptsehlpSAswplkfLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDL 245
Cdd:PRK11776  251 tkkecqEVAD---------ALNAQGF-------SA------LALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDI 308
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1720398400 246 PQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSL 294
Cdd:PRK11776  309 KALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAI 357
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
2-340 2.65e-32

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 127.78  E-value: 2.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVnAECQKRQNVLL 81
Cdd:PRK04837  119 GGDGYDKQLKVLESGVDILIGTTGRLIDYAKQ-NHINLGAIQVVVLDEADRMFDLGFIKDIRWLFRRM-PPANQRLNMLF 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSIsvldkncnqpnpkEVASIQLNSFAIPESLdqhvvLVPS---KLRLvcLAAFILQkckf 158
Cdd:PRK04837  197 SATLSYRVRELAFEHMNNPEYV-------------EVEPEQKTGHRIKEEL-----FYPSneeKMRL--LQTLIEE---- 252
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 159 EKNQKMIVFFS---SCELVEFHYSLFLHtllchsgtptsehlpsaswplkflR---LHGNMEQEERTSVFHEFSHSETGV 232
Cdd:PRK04837  253 EWPDRAIIFANtkhRCEEIWGHLAADGH------------------------RvglLTGDVAQKKRLRILEEFTRGDLDI 308
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 233 LLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSlLILA--------PSEAEYVNslasHKINVGEI 304
Cdd:PRK04837  309 LVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHS-ISLAceeyalnlPAIETYIG----HSIPVSKY 383
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1720398400 305 KMEDILAVLAKDDCFKRRQRGAQKSRASGPQEIRER 340
Cdd:PRK04837  384 DSDALLTDLPKPLRLTRPRTGNGPRRSGAPRNRRRR 419
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
1-100 2.53e-29

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 113.99  E-value: 2.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQKRQNVL 80
Cdd:cd17942    97 IGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQIIKLLP---KRRQTML 173
                          90       100
                  ....*....|....*....|
gi 1720398400  81 LSATLTEGVTRLVDISLHNP 100
Cdd:cd17942   174 FSATQTRKVEDLARISLKKK 193
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
150-274 3.52e-29

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 110.38  E-value: 3.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 150 AFILQKCKFEKNQKMIVFFSSCELVEFHYSLFLHtllchsgtptsehlpsaswPLKFLRLHGNMEQEERTSVFHEFSHSE 229
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKKTLEAELLLEKE-------------------GIKVARLHGDLSQEEREEILEDFRKGK 64
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720398400 230 TGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:pfam00271  65 IDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
2-104 1.90e-27

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 108.50  E-value: 1.90e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVnaeCQKRQNVLL 81
Cdd:cd17947    97 GGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELKEILRLC---PRTRQTMLF 173
                          90       100
                  ....*....|....*....|...
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17947   174 SATMTDEVKDLAKLSLNKPVRVF 196
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
2-280 5.29e-27

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 113.89  E-value: 5.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQkRQNVLL 81
Cdd:PRK04537  120 GGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERGT-RQTLLF 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  82 SATLTEGVTRLVdislhnpvsisvlDKNCNQPNpKEVASIQlnsfAIPESLDQHVVLVPSKLRLVCLAAFILQKckfEKN 161
Cdd:PRK04537  199 SATLSHRVLELA-------------YEHMNEPE-KLVVETE----TITAARVRQRIYFPADEEKQTLLLGLLSR---SEG 257
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 162 QKMIVFFSSCELVEfhyslflhtllchsgtPTSEHLPSASWPLKFLRlhGNMEQEERTSVFHEFSHSETGVLLCTDVASR 241
Cdd:PRK04537  258 ARTMVFVNTKAFVE----------------RVARTLERHGYRVGVLS--GDVPQKKRESLLNRFQKGQLEILVATDVAAR 319
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720398400 242 GLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSL 280
Cdd:PRK04537  320 GLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAI 358
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
1-105 5.55e-27

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 107.38  E-value: 5.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLrKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQKRQNVL 80
Cdd:cd17941    97 IGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAIVENLP---KSRQTLL 172
                          90       100
                  ....*....|....*....|....*
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSISV 105
Cdd:cd17941   173 FSATQTKSVKDLARLSLKNPEYISV 197
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
7-291 7.78e-27

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 112.70  E-value: 7.78e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   7 KSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQkRQNVLLSATLT 86
Cdd:PRK01297  204 KQLKQLEARFCDILVATPGRLLDFNQR-GEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKEE-RQTLLFSATFT 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  87 EGVTRLVDISLHNPVSISVldkncnqpNPKEVASiqlnsfaipESLDQHVVLVPSKLRLVCLAAFILQkckfEKNQKMIV 166
Cdd:PRK01297  282 DDVMNLAKQWTTDPAIVEI--------EPENVAS---------DTVEQHVYAVAGSDKYKLLYNLVTQ----NPWERVMV 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 167 FFSSCELVEFHYslflhtllchsgtptsEHLPSASwpLKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLP 246
Cdd:PRK01297  341 FANRKDEVRRIE----------------ERLVKDG--INAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHID 402
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720398400 247 QVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYV 291
Cdd:PRK01297  403 GISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQL 447
HELICc smart00490
helicase superfamily c-terminal domain;
204-274 5.54e-26

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 100.75  E-value: 5.54e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398400  204 LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:smart00490  12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
PTZ00424 PTZ00424
helicase 45; Provisional
1-307 1.13e-23

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 102.60  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQKrqnVL 80
Cdd:PTZ00424  131 VGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDK-RHLRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQV---AL 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSISVldkncnqpnPKEVASIqlnsfaipESLDQHVVLVPS---KLRLVC---LAAFILQ 154
Cdd:PTZ00424  207 FSATMPNEILELTTKFMRDPKRILV---------KKDELTL--------EGIRQFYVAVEKeewKFDTLCdlyETLTITQ 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 155 KCKFEKNQKMIVFFSScelvEFHYSLFlhTLLChsgtptsehlpsaswplkflrLHGNMEQEERTSVFHEFSHSETGVLL 234
Cdd:PTZ00424  270 AIIYCNTRRKVDYLTK----KMHERDF--TVSC---------------------MHGDMDQKDRDLIMREFRSGSTRVLI 322
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720398400 235 CTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASH-KINVGEIKME 307
Cdd:PTZ00424  323 TTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHyNTQIEEMPME 396
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
2-104 3.37e-23

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 97.00  E-value: 3.37e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:cd17954   104 GGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLNMDFEPEIDKILKVIPRE---RTTYLF 180
                          90       100
                  ....*....|....*....|...
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17954   181 SATMTTKVAKLQRASLKNPVKIE 203
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
2-281 7.23e-23

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 101.85  E-value: 7.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:PRK11634  111 GGQRYDVQLRALRQGPQIVVGTPGRLLDHLKR-GTLDLSKLSGLVLDEADEMLRMGFIEDVETIMAQIPEG---HQTALF 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISVLDKNCNQPNPKE----VASIQLNS----FAIPESLDQHVVLVPSklrlvclaafil 153
Cdd:PRK11634  187 SATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQsywtVWGMRKNEalvrFLEAEDFDAAIIFVRT------------ 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 154 qkckfeKNQKMIVffssCELVEFH-YSlflhtllchsgtptsehlpSASwplkflrLHGNMEQEERTSVFHEFSHSETGV 232
Cdd:PRK11634  255 ------KNATLEV----AEALERNgYN-------------------SAA-------LNGDMNQALREQTLERLKDGRLDI 298
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1720398400 233 LLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLL 281
Cdd:PRK11634  299 LIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALL 347
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
2-92 3.28e-21

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 90.38  E-value: 3.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLrKGINILISTPGRLVDHIKSTKNLhfNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQKRQNVLL 81
Cdd:pfam00270  81 GGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLLDMGFGPDLEEILRRLP---KKRQILLL 154
                          90
                  ....*....|.
gi 1720398400  82 SATLTEGVTRL 92
Cdd:pfam00270 155 SATLPRNLEDL 165
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
1-283 1.46e-20

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 94.47  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDhIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNaecqKRQNVL 80
Cdd:PLN00206  231 VGGDAMPQQLYRIQQGVELIVGTPGRLID-LLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALS----QPQVLL 305
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSISVldKNCNQPNpkevasiqlnsfaipESLDQHVVLVPSKLRLVCLAAFILQKCKFEK 160
Cdd:PLN00206  306 FSATVSPEVEKFASSLAKDIILISI--GNPNRPN---------------KAVKQLAIWVETKQKKQKLFDILKSKQHFKP 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 161 nqKMIVFFSSCELVEfhyslflhtLLCHSGTPTSEhlpsaswpLKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVAS 240
Cdd:PLN00206  369 --PAVVFVSSRLGAD---------LLANAITVVTG--------LKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLG 429
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720398400 241 RGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL 283
Cdd:PLN00206  430 RGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
1-97 2.49e-20

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 89.18  E-value: 2.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRK-GINILISTPGRLVDHIKSTKNL-HFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQ-KRQ 77
Cdd:cd17964   104 VGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVAkAFTDLDYLVLDEADRLLDMGFRPDLEQILRHLPEKNAdPRQ 183
                          90       100
                  ....*....|....*....|
gi 1720398400  78 NVLLSATLTEGVTRLVDISL 97
Cdd:cd17964   184 TLLFSATVPDEVQQIARLTL 203
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
2-101 8.60e-20

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 87.28  E-value: 8.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKS----TKNLHfnRIRWLIVDEADRILDLGFEKDITVILNAVNAecqKRQ 77
Cdd:cd17955   103 GGMDMVKQALELSKRPHIVVATPGRLADHLRSsddtTKVLS--RVKFLVLDEADRLLTGSFEDDLATILSALPP---KRQ 177
                          90       100
                  ....*....|....*....|....
gi 1720398400  78 NVLLSATLTEGVTRLVDISLHNPV 101
Cdd:cd17955   178 TLLFSATLTDALKALKELFGNKPF 201
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
1-104 1.71e-19

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 86.48  E-value: 1.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSE-KARLRKGINILISTPGRLVD------HIKSTKNLHFnrirwLIVDEADRILDLGFEKDITVILNAVNaec 73
Cdd:cd17960   100 IGGTNVEEDvKKFKRNGPNILVGTPGRLEEllsrkaDKVKVKSLEV-----LVLDEADRLLDLGFEADLNRILSKLP--- 171
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720398400  74 QKRQNVLLSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17960   172 KQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
9-100 1.90e-19

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 86.92  E-value: 1.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   9 EKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAE---------------- 72
Cdd:cd17956   119 TSGRYLSRVDILVATPGRLVDHLNSTPGFTLKHLRFLVIDEADRLLNQSFQDWLETVMKALGRPtapdlgsfgdanller 198
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720398400  73 ----CQKrqnVLLSATLTEGVTRLVDISLHNP 100
Cdd:cd17956   199 svrpLQK---LLFSATLTRDPEKLSSLKLHRP 227
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
2-104 3.78e-19

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 85.16  E-value: 3.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKArLRKGINILISTPGRLVDHIKsTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:cd17952   100 GGSKWEQAKA-LQEGAEIVVATPGRLIDMVK-KKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGHVRPD---RQTLLF 174
                          90       100
                  ....*....|....*....|...
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17952   175 SATFKKKIEQLARDILSDPIRVV 197
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
2-105 4.06e-19

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 86.00  E-value: 4.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAVN-AECQKRQNVL 80
Cdd:cd17967   114 GGADVVHQQLQLLRGCDILVATPGRLVDFIERGR-ISLSSIKFLVLDEADRMLDMGFEPQIRKIVEHPDmPPKGERQTLM 192
                          90       100
                  ....*....|....*....|....*
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSISV 105
Cdd:cd17967   193 FSATFPREIQRLAADFLKNYIFLTV 217
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
2-104 1.21e-18

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 84.29  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQK------ 75
Cdd:cd17945   102 GGHSIEEQAFSLRNGCEILIATPGRLLDCLER-RLLVLNQCTYVVLDEADRMIDMGFEPQVTKILDAMPVSNKKpdteea 180
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720398400  76 -----------RQNVLLSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17945   181 eklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
DEXDc smart00487
DEAD-like helicases superfamily;
1-110 2.47e-18

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 83.31  E-value: 2.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400    1 MGGEKRKSEKARLRKG-INILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQKRQNV 79
Cdd:smart00487  89 YGGDSKREQLRKLESGkTDILVTTPGRLLDLLEN-DKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLP---KNVQLL 164
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1720398400   80 LLSATLTEGVTRLVDISLHNPVSISVLDKNC 110
Cdd:smart00487 165 LLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
2-105 5.19e-18

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 82.25  E-value: 5.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQKRqnVLL 81
Cdd:cd17957    97 SLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGP-IDLSSVEYLVLDEADKLFEPGFREQTDEILAACTNPNLQR--SLF 173
                          90       100
                  ....*....|....*....|....
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISV 105
Cdd:cd17957   174 SATIPSEVEELARSVMKDPIRIIV 197
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
345-405 6.25e-18

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 77.44  E-value: 6.25e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398400 345 QTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPkeLKSIFHVRALHLGHVAKSFGLRDAPR 405
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
2-104 1.84e-17

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 80.49  E-value: 1.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTK-NLHfnRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVL 80
Cdd:cd17966    99 GGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKtNLR--RVTYLVLDEADRMLDMGFEPQIRKIVDQIRPD---RQTLM 173
                          90       100
                  ....*....|....*....|....
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17966   174 WSATWPKEVRRLAEDFLKDYIQVN 197
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
2-103 4.55e-17

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 80.11  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHI--KSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNV 79
Cdd:cd17953   121 GGSGISEQIAELKRGAEIVVCTPGRMIDILtaNNGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPD---RQTV 197
                          90       100
                  ....*....|....*....|....
gi 1720398400  80 LLSATLTEGVTRLVDISLHNPVSI 103
Cdd:cd17953   198 LFSATFPRKVEALARKVLHKPIEI 221
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
12-92 3.36e-16

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 78.47  E-value: 3.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  12 RLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAVN-AECQKRQNVLLSATLTEGVT 90
Cdd:cd18052   166 QIEKGCHILVATPGRLLDFIGRGK-ISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGmPSKEDRQTLMFSATFPEEIQ 244

                  ..
gi 1720398400  91 RL 92
Cdd:cd18052   245 RL 246
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
2-103 6.69e-16

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 75.96  E-value: 6.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDhIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:cd17958    99 GGGNRNEQIEDLSKGVDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKILLDIRPD---RQTIMT 174
                          90       100
                  ....*....|....*....|..
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSI 103
Cdd:cd17958   175 SATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
1-103 3.43e-15

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 74.30  E-value: 3.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKsTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVL 80
Cdd:cd17951   107 IGGMSVKEQLEVIRKGVHIVVATPGRLMDMLN-KKKINLDICRYLCLDEADRMIDMGFEEDIRTIFSYFKGQ---RQTLL 182
                          90       100
                  ....*....|....*....|...
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSI 103
Cdd:cd17951   183 FSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
2-105 1.13e-14

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 73.50  E-value: 1.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNlHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:cd18049   133 GGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPD---RQTLMW 208
                          90       100
                  ....*....|....*....|....
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISV 105
Cdd:cd18049   209 SATWPKEVRQLAEDFLKDYIHINI 232
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
1-104 2.97e-14

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 71.04  E-value: 2.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIK-STKNLHfnRIRWLIVDEADRILDLGFEKDITVILNAVNAECqkrQNV 79
Cdd:cd17962    94 VGGLPLPPQLYRLQQGVKVIIATPGRLLDILKqSSVELD--NIKIVVVDEADTMLKMGFQQQVLDILENISHDH---QTI 168
                          90       100
                  ....*....|....*....|....*
gi 1720398400  80 LLSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17962   169 LVSATIPRGIEQLAGQLLQNPVRIT 193
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
2-103 3.10e-14

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 71.20  E-value: 3.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQKrqnVLL 81
Cdd:cd17939   101 GGTSVREDRRKLQYGPHIVVGTPGRVFDMLQR-RSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQV---VLF 176
                          90       100
                  ....*....|....*....|..
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSI 103
Cdd:cd17939   177 SATMPHEVLEVTKKFMRDPVRI 198
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
2-105 6.72e-14

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 71.58  E-value: 6.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNlHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLL 81
Cdd:cd18050   171 GGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPD---RQTLMW 246
                          90       100
                  ....*....|....*....|....
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSISV 105
Cdd:cd18050   247 SATWPKEVRQLAEDFLRDYVQINI 270
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
2-101 1.05e-13

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 69.66  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILN---AVNAECQKRQN 78
Cdd:cd17938    99 GGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGK-LDLSSVRFFVLDEADRLLSQGNLETINRIYNripKITSDGKRLQV 177
                          90       100
                  ....*....|....*....|....
gi 1720398400  79 VLLSATL-TEGVTRLVDISLHNPV 101
Cdd:cd17938   178 IVCSATLhSFEVKKLADKIMHFPT 201
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
7-103 1.63e-13

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 69.15  E-value: 1.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   7 KSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECqkrQNVLLSATLT 86
Cdd:cd17961   111 SVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSYGYEEDLKSLLSYLPKNY---QTFLMSATLS 187
                          90
                  ....*....|....*..
gi 1720398400  87 EGVTRLVDISLHNPVSI 103
Cdd:cd17961   188 EDVEALKKLVLHNPAIL 204
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
2-103 2.70e-13

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 68.49  E-value: 2.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVdHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQKRQNVLL 81
Cdd:cd17959   107 GGDSLEEQFEALASNPDIIIATPGRLL-HLLVEMNLKLSSVEYVVFDEADRLFEMGFAEQLHEILSRLP---ENRQTLLF 182
                          90       100
                  ....*....|....*....|..
gi 1720398400  82 SATLTEGVTRLVDISLHNPVSI 103
Cdd:cd17959   183 SATLPKLLVEFAKAGLNEPVLI 204
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
13-87 8.61e-12

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 64.95  E-value: 8.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400  13 LRKGINILISTPGRLVDHIKStKNLHFNR---IRWLIVDEADRILDLGFEKDITVILNAVN----AECQKRQNVLLSATL 85
Cdd:cd17946   115 LKKRPEIVVATPGRLWELIQE-GNEHLANlksLRFLVLDEADRMLEKGHFAELEKILELLNkdraGKKRKRQTFVFSATL 193

                  ..
gi 1720398400  86 TE 87
Cdd:cd17946   194 TL 195
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
1-103 1.20e-11

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 63.64  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAecqKRQNVL 80
Cdd:cd18045   102 IGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRR-RSLRTRHIKMLVLDEADEMLNKGFKEQIYDVYRYLPP---ATQVVL 177
                          90       100
                  ....*....|....*....|...
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSI 103
Cdd:cd18045   178 VSATLPQDILEMTNKFMTDPIRI 200
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
2-103 1.45e-11

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 63.47  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKstKNL-HFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVL 80
Cdd:cd17940   103 GGTSLRDDIMRLYQTVHVLVGTPGRILDLAK--KGVaDLSHCKTLVLDEADKLLSQDFQPIIEKILNFLPKE---RQILL 177
                          90       100
                  ....*....|....*....|...
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSI 103
Cdd:cd17940   178 FSATFPLTVKNFMDRHMHNPYEI 200
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
13-84 2.28e-11

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 63.91  E-value: 2.28e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720398400  13 LRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAVN-AECQKRQNVLLSAT 84
Cdd:cd18051   152 LERGCHLLVATPGRLVDMLERGK-IGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTmPPTGERQTLMFSAT 223
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
2-84 4.71e-11

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 62.17  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAV---NAEcQKRQN 78
Cdd:cd17944    98 GGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGR-LDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVSykkDSE-DNPQT 175

                  ....*.
gi 1720398400  79 VLLSAT 84
Cdd:cd17944   176 LLFSAT 181
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
213-272 6.95e-10

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 57.37  E-value: 6.95e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 213 MEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTAR 272
Cdd:cd18801    74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
1-103 1.36e-09

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 57.84  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQKRQNVL 80
Cdd:cd18046   102 IGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINR-RYLRTDYIKMFVLDEADEMLSRGFKDQIYDIFQKLP---PDTQVVL 177
                          90       100
                  ....*....|....*....|...
gi 1720398400  81 LSATLTEGVTRLVDISLHNPVSI 103
Cdd:cd18046   178 LSATMPNDVLEVTTKFMRDPIRI 200
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
209-434 1.42e-09

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 60.04  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 209 LHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL----- 283
Cdd:COG1061   335 VTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYdfvgn 414
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 284 -APSEAEYVNSLASHKINVGEIKMEDILAVLAKDDCFKRRQRGAQKSRASGPQEIRERATVLQTVFEDYVHSSQRMVSWA 362
Cdd:COG1061   415 dVPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALE 494
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720398400 363 KKALQSFIRAYATYPKELKSIFHVRALHLGHVAKSFGLRDAPRNLSVSAVKKASLKRPHPRRKTQRKQHLVP 434
Cdd:COG1061   495 LLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLELLAALLRLEELAALLLKELLRAALAA 566
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
1-104 2.66e-09

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 56.50  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLrKGINILISTPGRlvdhIKSTKNLHF---NRIRWLIVDEADRILDLGFEKDITVILNAVNAecqKRQ 77
Cdd:cd17943    94 IGGTPVKEDKKKL-KGCHIAVGTPGR----IKQLIELGAlnvSHVRLFVLDEADKLMEGSFQKDVNWIFSSLPK---NKQ 165
                          90       100
                  ....*....|....*....|....*..
gi 1720398400  78 NVLLSATLTEGVTRLVDISLHNPVSIS 104
Cdd:cd17943   166 VIAFSATYPKNLDNLLARYMRKPVLVR 192
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
2-87 1.62e-08

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 54.66  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRIL-DLGFEKDITVILNAVNaecQKRQNVL 80
Cdd:cd17950   108 GVPIKKDIEVLKNKCPHIVVGTPGRILALVRE-KKLKLSHVKHFVLDECDKMLeQLDMRRDVQEIFRATP---HDKQVMM 183

                  ....*..
gi 1720398400  81 LSATLTE 87
Cdd:cd17950   184 FSATLSK 190
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
228-274 1.49e-07

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 48.47  E-value: 1.49e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720398400 228 SETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:cd18785    21 SSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
133-274 2.46e-07

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 49.78  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 133 DQHVVLVPSKLRLVCLaafILQKCKfEKNQKMIVFfsScelvefHYSLFLHTLlchsgtptSEHLPSASWplKFLRLHGN 212
Cdd:cd18793     3 PKIEEVVSGKLEALLE---LLEELR-EPGEKVLIF--S------QFTDTLDIL--------EEALRERGI--KYLRLDGS 60
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720398400 213 MEQEERTSVFHEFSHSETG--VLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:cd18793    61 TSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIG 124
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
12-85 1.04e-06

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 50.07  E-value: 1.04e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720398400  12 RLRKGINILISTPGRLVDHIKSTKNLhFNRIRWLIVDEADRILDLGFEKDIT-VILNAVNAECQkrqnVLLSATL 85
Cdd:cd17965   157 AFKGRIDILVTTPGKLASLAKSRPKI-LSRVTHLVVDEADTLFDRSFLQDTTsIIKRAPKLKHL----ILCSATI 226
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
213-274 1.44e-06

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 50.88  E-value: 1.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720398400 213 MEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 274
Cdd:COG1111   395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKR 456
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
1-84 3.27e-06

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 46.63  E-value: 3.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   1 MGGEKRKSEKARLRKG-INILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDIT--VILNAVNAECQKrq 77
Cdd:cd00046    63 LVGGSSAEEREKNKLGdADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILdlAVRKAGLKNAQV-- 140

                  ....*..
gi 1720398400  78 nVLLSAT 84
Cdd:cd00046   141 -ILLSAT 146
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
2-92 1.20e-05

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 46.59  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400   2 GGEKRKSEKARLRKGINILISTPGRLVdhiKSTKN--LHFNRIRWLIVDEADRILDLGFEKDITVIL----------NAV 69
Cdd:cd17948   101 GGRTKRQIRNPHFEEVDILVATPGALS---KLLTSriYSLEQLRHLVLDEADTLLDDSFNEKLSHFLrrfplasrrsENT 177
                          90       100
                  ....*....|....*....|...
gi 1720398400  70 NAECQKRQNVLLSATLTEGVTRL 92
Cdd:cd17948   178 DGLDPGTQLVLVSATMPSGVGEV 200
SF2_C_RecG_TRCF cd18792
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ...
194-256 2.89e-05

C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350179 [Multi-domain]  Cd Length: 160  Bit Score: 44.18  E-value: 2.89e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720398400 194 SEHLPSASWPLkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSA 256
Cdd:cd18792    55 KELVPEARVAL----LHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDA 113
SF2_C_RecG cd18811
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ...
193-287 3.76e-05

C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350198 [Multi-domain]  Cd Length: 159  Bit Score: 43.87  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 193 TSEHLPSASWP-LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRI-GRT 270
Cdd:cd18811    50 MYEYLKERFRPeLNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHQLrGRV 129
                          90
                  ....*....|....*..
gi 1720398400 271 ARiGCHGSSLLILAPSE 287
Cdd:cd18811   130 GR-GDHQSYCLLVYKDP 145
SF2_C_XPB cd18789
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ...
140-272 6.66e-05

C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350176 [Multi-domain]  Cd Length: 153  Bit Score: 43.01  E-value: 6.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 140 PSKLRLVclaAFILQKckFEKNQKMIVFFSSCELVEfHYSLFLHTLLCHSGTPTSEhlpsaswplkflrlhgnmeqeeRT 219
Cdd:cd18789    33 PNKLRAL---EELLKR--HEQGDKIIVFTDNVEALY-RYAKRLLKPFITGETPQSE----------------------RE 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720398400 220 SVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSA-PSSPAEYIHRIGRTAR 272
Cdd:cd18789    85 EILQNFREGEYNTLVVSKVGDEGIDLPEANVAIQISGhGGSRRQEAQRLGRILR 138
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
157-285 6.85e-05

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 43.02  E-value: 6.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 157 KFEKNQKMIVFFSSCELVEfhysLFLHTLLchsgtptsEHLPSASWPLKFLRLHGNMEQEERTSVFHEFSHSETGVLLCT 236
Cdd:cd18796    34 LLERHKSTLVFTNTRSQAE----RLAQRLR--------ELCPDRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVAT 101
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720398400 237 DVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGcHGSSLLILAP 285
Cdd:cd18796   102 SSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRP-GAASKGRLVP 149
SF2_C_TRCF cd18810
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ...
209-252 1.76e-04

C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350197 [Multi-domain]  Cd Length: 151  Bit Score: 41.95  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720398400 209 LHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIV 252
Cdd:cd18810    57 AHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTII 100
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
204-276 1.91e-04

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 41.43  E-value: 1.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720398400 204 LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG----CH 276
Cdd:cd18794    55 ISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGlpseCI 131
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
210-281 2.44e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 40.65  E-value: 2.44e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720398400  210 HGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLL 281
Cdd:PLN03137   711 HGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVL 782
PRK13766 PRK13766
Hef nuclease; Provisional
213-272 3.95e-03

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 39.86  E-value: 3.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398400 213 MEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTAR 272
Cdd:PRK13766  407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR 466
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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