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Conserved domains on  [gi|1720390027|ref|XP_030105630|]
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zinc finger protein 760 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-55 8.40e-21

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 8.40e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720390027   13 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSVEKH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-586 1.60e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 211 KPWKCKECGKSFKWLSHLKAHCRIHTGEKPFKCN--ECDKGFSRLSRLKSHYRTHTGEKPYKCEECG------KCFSRLS 282
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 283 RLKNHYRIHTGEKPYKCKECGKSFTHCTGLST--HQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREK--------- 351
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 352 ---PYKCKECGKFFHWLSGLKSHYRIHT---GETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTALK 425
Cdd:COG5048   192 vstSIPSSSENSPLSSSYSIPSSSSDQNlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 426 RHQKIHTDE-------KPYKCEECSKCFYVLSHLKSHCRT--HTGE--KPYKCEE--CGKCLSQLSKLKSHYRIHTGEKP 492
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 493 YKCK--ECDKSFTHC-----TALSTHQKIHTGEKPYSC--KDCGKSFYLLSRLKEHYRVHTGEKPYNCK--ECGKFFHWL 561
Cdd:COG5048   352 AKEKllNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*
gi 1720390027 562 SNLKRHSRIHTGEKPYKCEECDKSF 586
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 573-623 1.45e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720390027 573 GEKPYKCE--ECDKSFTHCSSLKAH-------QKIH------------AGVKPYKCEECSKSFYWLSNLKTH 623
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
619-644 1.97e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 619 NLKTHSRIHTGEKPYKCGKCDKSFTQ 644
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-55 8.40e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 8.40e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720390027   13 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSVEKH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.65e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.65e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720390027  12 LLTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.95e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 3.95e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390027  13 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVS 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-586 1.60e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 211 KPWKCKECGKSFKWLSHLKAHCRIHTGEKPFKCN--ECDKGFSRLSRLKSHYRTHTGEKPYKCEECG------KCFSRLS 282
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 283 RLKNHYRIHTGEKPYKCKECGKSFTHCTGLST--HQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREK--------- 351
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 352 ---PYKCKECGKFFHWLSGLKSHYRIHT---GETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTALK 425
Cdd:COG5048   192 vstSIPSSSENSPLSSSYSIPSSSSDQNlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 426 RHQKIHTDE-------KPYKCEECSKCFYVLSHLKSHCRT--HTGE--KPYKCEE--CGKCLSQLSKLKSHYRIHTGEKP 492
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 493 YKCK--ECDKSFTHC-----TALSTHQKIHTGEKPYSC--KDCGKSFYLLSRLKEHYRVHTGEKPYNCK--ECGKFFHWL 561
Cdd:COG5048   352 AKEKllNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*
gi 1720390027 562 SNLKRHSRIHTGEKPYKCEECDKSF 586
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-588 1.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 563 NLKRHSRIHTGEKPYKCEECDKSFTH 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 573-623 1.45e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720390027 573 GEKPYKCE--ECDKSFTHCSSLKAH-------QKIH------------AGVKPYKCEECSKSFYWLSNLKTH 623
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
619-644 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 619 NLKTHSRIHTGEKPYKCGKCDKSFTQ 644
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-55 8.40e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 8.40e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720390027   13 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSVEKH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.65e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.65e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720390027  12 LLTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.95e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 3.95e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390027  13 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVS 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-586 1.60e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 211 KPWKCKECGKSFKWLSHLKAHCRIHTGEKPFKCN--ECDKGFSRLSRLKSHYRTHTGEKPYKCEECG------KCFSRLS 282
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 283 RLKNHYRIHTGEKPYKCKECGKSFTHCTGLST--HQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREK--------- 351
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 352 ---PYKCKECGKFFHWLSGLKSHYRIHT---GETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTALK 425
Cdd:COG5048   192 vstSIPSSSENSPLSSSYSIPSSSSDQNlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 426 RHQKIHTDE-------KPYKCEECSKCFYVLSHLKSHCRT--HTGE--KPYKCEE--CGKCLSQLSKLKSHYRIHTGEKP 492
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 493 YKCK--ECDKSFTHC-----TALSTHQKIHTGEKPYSC--KDCGKSFYLLSRLKEHYRVHTGEKPYNCK--ECGKFFHWL 561
Cdd:COG5048   352 AKEKllNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*
gi 1720390027 562 SNLKRHSRIHTGEKPYKCEECDKSF 586
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-656 2.04e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 2.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 267 KPYKCEECGKCFSRLSRLKNHYRIHTGEKPYKC--KECGKSFTHCTGLSTHQKIHTGEKPHKC-KNCGKSFHLLSTLKEH 343
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 344 FRVHTREKPYKCKECGkffhwLSGLKSHYRIHTGETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTA 423
Cdd:COG5048   112 SSSSNSNDNNLLSSHS-----LPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 424 LKRHQKIHTDEKPYKCEECSKcFYVLSHLKSHCRTHTGEKPYKCEECGKCLSQLSKLKSHYRIHTGEKPYKCKECDKSFT 503
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 504 HCTALSTHQKIHTGE-------KPYSCKDCGKSFYLLSRLKEHYR--VHTGE--KPYNCKE--CGKFFHWLSNLKRHSRI 570
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 571 HTGEKPYKC--EECDKSFTHCSSLKAHQKIHA--GVKPYKCEECSKSFYWL-----SNLKTHSRIHTGEKP--YKCGKCD 639
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykDLKNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCS 425

                         410
                  ....*....|....*..
gi 1720390027 640 KSFTQRSLLTKHNRIHT 656
Cdd:COG5048   426 KSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-651 1.82e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 239 KPFKCNECDKGFSRLSRLKSHYRTHTGEKPYKC--EECGKCFSRLSRLKNHYRIHTGEKPYKC-KECGKSFTHCTGLSTH 315
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 316 QKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREKPYKCKECGKFFHWLSG-LKSHYRIHTGETpykckeCDKSFSQLS 394
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 395 RLKSHYRTHTGEKSCKCLECDKYftqcTALKRHQKIHTDEKPYKCEECSKCFYVLSHLKSHCRTHTGEKPYKCEECGKCL 474
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSS----YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 475 S-----QLSKLKSHYRIHTGE-----KPYKCKECDKSFTHCTALSTHQ--KIHTGE--KPYSC--KDCGKSFYLLSRLKE 538
Cdd:COG5048   262 RsslptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 539 HYRVHTGEKPYNCK--ECGKFFHWLSNLKRHSRI--HTGEKPYKCEECDKSFT-------HCSSLKAHQKIHAGVKPYKC 607
Cdd:COG5048   342 HILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720390027 608 EECSKSFYWLSNLKTHSRIHTGEKPYKCgkCDKSFTQRSLLTKH 651
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-588 1.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 563 NLKRHSRIHTGEKPYKCEECDKSFTH 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 573-623 1.45e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720390027 573 GEKPYKCE--ECDKSFTHCSSLKAH-------QKIH------------AGVKPYKCEECSKSFYWLSNLKTH 623
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 377-460 2.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 377 GETPYKCK--ECDKSFSQLSRLKSHyRTHTgeksckclECDKYFTQCTALKRHQKIHTDEKPYKCEECSKCFYVLSHLKS 454
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720390027 455 HcRTHT 460
Cdd:COG5189   417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 293-371 4.71e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 293 GEKPYKCK--ECGKSFTHCTGLSTHqKIHtgekphkcKNCGKSFHLLSTLKEHFRVHTREKPYKCKECGKFFHWLSGLKS 370
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390027 371 H 371
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-504 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390027 480 LKSHYRIHTGEKPYKCKECDKSFTH 504
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 1.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 283 RLKNHYRIHTGEKPYKCKECGKSFTH 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
619-644 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 619 NLKTHSRIHTGEKPYKCGKCDKSFTQ 644
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-280 2.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 255 RLKSHYRTHTGEKPYKCEECGKCFSR 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-252 3.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390027 227 HLKAHCRIHTGEKPFKCNECDKGFSR 252
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-392 4.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.00e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390027 368 LKSHYRIHTGETPYKCKECDKSFSQ 392
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 461-544 7.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390027 461 GEKPYKCE--ECGKCLSQLSKLKSHyRIHtgekpykcKECDKSFTHCTALSTHQKIHTGEKPYSCKDCGKSFYLLSRLKE 538
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720390027 539 HyRVHT 544
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-472 9.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.03e-03
                          10        20
                  ....*....|....*....|..
gi 1720390027 451 HLKSHCRTHTGEKPYKCEECGK 472
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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