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Conserved domains on  [gi|1720388778|ref|XP_030105297|]
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putative ATP-dependent RNA helicase DHX57 isoform X6 [Mus musculus]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
18-645 1.15e-120

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 385.20  E-value: 1.15e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLnGPPERvanIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGW-GAGGR---IGMLEPRRLAARAAAERMAEELGEPVGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIvmQRAT---LQVILMS 174
Cdd:COG1643    86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALrpdLKLLVMS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 175 ATLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnrtaqeeveedLRLS 254
Cdd:COG1643   164 ATLDAERFARLLGDAPVIESSGRTYPVE----------VRY-----------------------------------RPLP 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 255 LHLQDEEESVKDTIpdqqldfkqllirykgvsksviktmsvmdfekvnlelIEALLEwivdgkhayPPGAVLVFLPGLAE 334
Cdd:COG1643   199 ADERDLEDAVADAV-------------------------------------REALAE---------EPGDILVFLPGERE 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 335 IKMLYEQLQsnslfnNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRY 414
Cdd:COG1643   233 IRRTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRY 306

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 415 DAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNhQLLKQQLPEIQRVPLEQLclrikILEMFS--THNL 492
Cdd:COG1643   307 DPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASL-----ILELAAwgLGDP 380

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 493 QSVfsRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPF 572
Cdd:COG1643   381 EDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR 458

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720388778 573 VSPwdkkeeanqkklefafANSDYLALLcayKGWQlstkesaraSYNYCRQNFLSGRTLQEMASLKRQFTELL 645
Cdd:COG1643   459 RGA----------------AGSDLLARL---NLWR---------RLREQQREFLSYLRLREWRDLARQLRRLL 503
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 688-785 3.24e-22

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 91.16  E-value: 3.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 688 ISAVLCAALYPNVVqvktpegkfqktssgvvRLQPKSAELKFVtKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRV 767
Cdd:pfam07717   1 LRAALAAGLYPNVA-----------------RRDPKGKGYTTL-SDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62

                          90
                  ....*....|....*...
gi 1720388778 768 FIRDCSMVSVYPLVLFGG 785
Cdd:pfam07717  63 YIRTVTAISPEWLLLFAP 80
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
18-645 1.15e-120

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 385.20  E-value: 1.15e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLnGPPERvanIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGW-GAGGR---IGMLEPRRLAARAAAERMAEELGEPVGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIvmQRAT---LQVILMS 174
Cdd:COG1643    86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALrpdLKLLVMS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 175 ATLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnrtaqeeveedLRLS 254
Cdd:COG1643   164 ATLDAERFARLLGDAPVIESSGRTYPVE----------VRY-----------------------------------RPLP 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 255 LHLQDEEESVKDTIpdqqldfkqllirykgvsksviktmsvmdfekvnlelIEALLEwivdgkhayPPGAVLVFLPGLAE 334
Cdd:COG1643   199 ADERDLEDAVADAV-------------------------------------REALAE---------EPGDILVFLPGERE 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 335 IKMLYEQLQsnslfnNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRY 414
Cdd:COG1643   233 IRRTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRY 306

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 415 DAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNhQLLKQQLPEIQRVPLEQLclrikILEMFS--THNL 492
Cdd:COG1643   307 DPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASL-----ILELAAwgLGDP 380

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 493 QSVfsRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPF 572
Cdd:COG1643   381 EDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR 458

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720388778 573 VSPwdkkeeanqkklefafANSDYLALLcayKGWQlstkesaraSYNYCRQNFLSGRTLQEMASLKRQFTELL 645
Cdd:COG1643   459 RGA----------------AGSDLLARL---NLWR---------RLREQQREFLSYLRLREWRDLARQLRRLL 503
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 18-194 1.37e-111

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 338.74  E-value: 1.37e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17985    81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160

                         170
                  ....*....|....*..
gi 1720388778 178 DAGLFSKYFSYCPVITI 194
Cdd:cd17985   161 NAELFSDYFNSCPVIHI 177
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 16-650 2.16e-78

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 277.33  E-value: 2.16e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   16 QLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERAERV 95
Cdd:PRK11131    71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRG----VKGLIGHTQPRRLAARTVANRIAEELETEL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   96 GLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSA 175
Cdd:PRK11131   147 GGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSA 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  176 TLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnRTAQEEVEEDLRlsl 255
Cdd:PRK11131   227 TIDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-------------------------RPIVEEADDTER--- 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  256 hlqdeeesvkdtipDQqldfkqllirykgvsksviktmsvmdfekvnlelIEALLEwIVDGKHAYPPGAVLVFLPGLAEI 335
Cdd:PRK11131   269 --------------DQ----------------------------------LQAIFD-AVDELGREGPGDILIFMSGEREI 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  336 KMLYEQLQSNSLFNNRrshrcvIHPLHSSLSSEEQQAVFvkPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYD 415
Cdd:PRK11131   300 RDTADALNKLNLRHTE------ILPLYARLSNSEQNRVF--QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYS 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  416 AGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHqllKQQL--PEIQRVPLEQLclrikILEMFSThNLQ 493
Cdd:PRK11131   372 YRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS---RPEFtdPEILRTNLASV-----ILQMTAL-GLG 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  494 --SVFSrLIEPP---HI-DSLRAskvrLRDLGALTPDE-----KLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTI 562
Cdd:PRK11131   443 diAAFP-FVEAPdkrNIqDGVRL----LEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMII 517

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  563 AASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLcayKGWQ-LSTKESARASYNY---CRQNFLSGRTLQEMASLK 638
Cdd:PRK11131   518 TSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFV---NLWNyLQEQQKALSSNQFrrlCRTDYLNYLRVREWQDIY 594

                          650
                   ....*....|..
gi 1720388778  639 RQFTELLSDIGF 650
Cdd:PRK11131   595 TQLRQVVKELGI 606
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 17-566 2.23e-75

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 262.78  E-value: 2.23e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  17 LLPAweeretILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGppervANIICTQPRRISAISVAERVAKERAERVG 96
Cdd:TIGR01970   6 VLPA------LRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIG-----GKIIMLEPRRLAARSAAQRLASQLGEAVG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  97 LTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQ-RATLQVILMSA 175
Cdd:TIGR01970  75 QTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 176 TLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnRTAQeeveedlrlsl 255
Cdd:TIGR01970 155 TLDGERLSSLLPDAPVVESEGRSFPVE----------IRY-------------------------LPLR----------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 256 hlqdeeesvkdtiPDQQLDfkqllirykgvsksviktmsvmdfEKVNLELIEALlewivdgkhAYPPGAVLVFLPGLAEI 335
Cdd:TIGR01970 189 -------------GDQRLE------------------------DAVSRAVEHAL---------ASETGSILVFLPGQAEI 222

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 336 KMLYEQLQSnslfnnRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYD 415
Cdd:TIGR01970 223 RRVQEQLAE------RLDSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFD 296

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 416 AGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFtSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLqsv 495
Cdd:TIGR01970 297 PKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLW-SEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDL--- 372

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720388778 496 fsRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASL 566
Cdd:TIGR01970 373 --RWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALL 441
DEXDc smart00487
DEAD-like helicases superfamily;
24-204 5.49e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 100.64  E-value: 5.49e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   24 RETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVaniICTQPRRISAISVAERVAKE----RAERVGLTV 99
Cdd:smart00487  14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRV---LVLVPTRELAEQWAEELKKLgpslGLKVVGLYG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  100 GYQIR--LESVKSSATRLLYCTTGVLLRRLE-GDATLQGVTHIIVDEVHERTEES--DFLLLVLKDIvmqRATLQVILMS 174
Cdd:smart00487  91 GDSKReqLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAHRLLDGGfgDQLEKLLKLL---PKNVQLLLLS 167

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1720388778  175 ATLDAGL--FSKYFSYCPVITIPGRA--FPVDQF 204
Cdd:smart00487 168 ATPPEEIenLLELFLNDPVFIDVGFTplEPIEQF 201
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 515-594 5.51e-23

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 94.23  E-value: 5.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 515 LRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSP----WDKKEEANQKKLEFA 590
Cdd:pfam04408   5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldPRSAAKAARRRRRAA 84


                  ....
gi 1720388778 591 FANS 594
Cdd:pfam04408  85 DEKA 88
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 688-785 3.24e-22

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 91.16  E-value: 3.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 688 ISAVLCAALYPNVVqvktpegkfqktssgvvRLQPKSAELKFVtKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRV 767
Cdd:pfam07717   1 LRAALAAGLYPNVA-----------------RRDPKGKGYTTL-SDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62

                          90
                  ....*....|....*...
gi 1720388778 768 FIRDCSMVSVYPLVLFGG 785
Cdd:pfam07717  63 YIRTVTAISPEWLLLFAP 80
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
18-645 1.15e-120

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 385.20  E-value: 1.15e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLnGPPERvanIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGW-GAGGR---IGMLEPRRLAARAAAERMAEELGEPVGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIvmQRAT---LQVILMS 174
Cdd:COG1643    86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALrpdLKLLVMS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 175 ATLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnrtaqeeveedLRLS 254
Cdd:COG1643   164 ATLDAERFARLLGDAPVIESSGRTYPVE----------VRY-----------------------------------RPLP 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 255 LHLQDEEESVKDTIpdqqldfkqllirykgvsksviktmsvmdfekvnlelIEALLEwivdgkhayPPGAVLVFLPGLAE 334
Cdd:COG1643   199 ADERDLEDAVADAV-------------------------------------REALAE---------EPGDILVFLPGERE 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 335 IKMLYEQLQsnslfnNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRY 414
Cdd:COG1643   233 IRRTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRY 306

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 415 DAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNhQLLKQQLPEIQRVPLEQLclrikILEMFS--THNL 492
Cdd:COG1643   307 DPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASL-----ILELAAwgLGDP 380

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 493 QSVfsRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPF 572
Cdd:COG1643   381 EDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR 458

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720388778 573 VSPwdkkeeanqkklefafANSDYLALLcayKGWQlstkesaraSYNYCRQNFLSGRTLQEMASLKRQFTELL 645
Cdd:COG1643   459 RGA----------------AGSDLLARL---NLWR---------RLREQQREFLSYLRLREWRDLARQLRRLL 503
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 18-194 1.37e-111

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 338.74  E-value: 1.37e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17985    81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160

                         170
                  ....*....|....*..
gi 1720388778 178 DAGLFSKYFSYCPVITI 194
Cdd:cd17985   161 NAELFSDYFNSCPVIHI 177
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 34-194 7.68e-87

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 272.80  E-value: 7.68e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  34 HQVVVISGMTGCGKTTQIPQFILDNSLNGPPErvANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSAT 113
Cdd:cd17917     1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGK--GRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 114 RLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFSKYFSYCPVIT 193
Cdd:cd17917    79 RIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIH 158


                  .
gi 1720388778 194 I 194
Cdd:cd17917   159 I 159
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 16-650 2.16e-78

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 277.33  E-value: 2.16e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   16 QLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERAERV 95
Cdd:PRK11131    71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRG----VKGLIGHTQPRRLAARTVANRIAEELETEL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   96 GLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSA 175
Cdd:PRK11131   147 GGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSA 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  176 TLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnRTAQEEVEEDLRlsl 255
Cdd:PRK11131   227 TIDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-------------------------RPIVEEADDTER--- 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  256 hlqdeeesvkdtipDQqldfkqllirykgvsksviktmsvmdfekvnlelIEALLEwIVDGKHAYPPGAVLVFLPGLAEI 335
Cdd:PRK11131   269 --------------DQ----------------------------------LQAIFD-AVDELGREGPGDILIFMSGEREI 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  336 KMLYEQLQSNSLFNNRrshrcvIHPLHSSLSSEEQQAVFvkPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYD 415
Cdd:PRK11131   300 RDTADALNKLNLRHTE------ILPLYARLSNSEQNRVF--QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYS 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  416 AGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHqllKQQL--PEIQRVPLEQLclrikILEMFSThNLQ 493
Cdd:PRK11131   372 YRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS---RPEFtdPEILRTNLASV-----ILQMTAL-GLG 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  494 --SVFSrLIEPP---HI-DSLRAskvrLRDLGALTPDE-----KLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTI 562
Cdd:PRK11131   443 diAAFP-FVEAPdkrNIqDGVRL----LEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMII 517

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  563 AASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLcayKGWQ-LSTKESARASYNY---CRQNFLSGRTLQEMASLK 638
Cdd:PRK11131   518 TSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFV---NLWNyLQEQQKALSSNQFrrlCRTDYLNYLRVREWQDIY 594

                          650
                   ....*....|..
gi 1720388778  639 RQFTELLSDIGF 650
Cdd:PRK11131   595 TQLRQVVKELGI 606
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 17-566 2.23e-75

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 262.78  E-value: 2.23e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  17 LLPAweeretILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGppervANIICTQPRRISAISVAERVAKERAERVG 96
Cdd:TIGR01970   6 VLPA------LRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIG-----GKIIMLEPRRLAARSAAQRLASQLGEAVG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  97 LTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQ-RATLQVILMSA 175
Cdd:TIGR01970  75 QTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 176 TLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnRTAQeeveedlrlsl 255
Cdd:TIGR01970 155 TLDGERLSSLLPDAPVVESEGRSFPVE----------IRY-------------------------LPLR----------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 256 hlqdeeesvkdtiPDQQLDfkqllirykgvsksviktmsvmdfEKVNLELIEALlewivdgkhAYPPGAVLVFLPGLAEI 335
Cdd:TIGR01970 189 -------------GDQRLE------------------------DAVSRAVEHAL---------ASETGSILVFLPGQAEI 222

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 336 KMLYEQLQSnslfnnRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYD 415
Cdd:TIGR01970 223 RRVQEQLAE------RLDSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFD 296

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 416 AGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFtSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLqsv 495
Cdd:TIGR01970 297 PKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLW-SEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDL--- 372

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720388778 496 fsRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASL 566
Cdd:TIGR01970 373 --RWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALL 441
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 293-452 2.48e-73

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 237.43  E-value: 2.48e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 293 MSVMDFEKVNLELIEALLEWIVdgkHAYPPGAVLVFLPGLAEIKMLYEQLQSNSLFNNrrSHRCVIHPLHSSLSSEEQQA 372
Cdd:cd18791    17 ISSEKEDPDYVDAAVRLILQIH---RTEEPGDILVFLPGQEEIERLCELLREELLSPD--LGKLLVLPLHSSLPPEEQQR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 373 VFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLF 452
Cdd:cd18791    92 VFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 18-194 1.86e-69

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 227.41  E-value: 1.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSL-NGPPERvanIICTQPRRISAISVAERVAKERAERVG 96
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYaNGIPCR---IFCTQPRRLAAIAVAERVAAERGEKIG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  97 LTVGYQIRLESVKSSATRLLYCTTGVLLRRL-EGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSA 175
Cdd:cd17987    78 QTVGYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157

                         170
                  ....*....|....*....
gi 1720388778 176 TLDAGLFSKYFSYCPVITI 194
Cdd:cd17987   158 ALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 2-194 2.06e-68

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 226.64  E-value: 2.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   2 KQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAI 81
Cdd:cd17972    43 REQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  82 SVAERVAKERAERVGLTVGYQIRLESV-KSSATRLLYCTTGVLLRRLEgdATLQGVTHIIVDEVHERTEESDFLLLVLKD 160
Cdd:cd17972   123 SVAERVAFERGEEVGKSCGYSVRFESVlPRPHASILFCTVGVLLRKLE--AGIRGISHVIVDEIHERDINTDFLLVVLRD 200

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1720388778 161 IVMQRATLQVILMSATLDAGLFSKYFSYCPVITI 194
Cdd:cd17972   201 VVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 18-194 3.46e-67

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 221.33  E-value: 3.46e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSL-NGPPERVANIICTQPRRISAISVAERVAKERAERVG 96
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  97 -----LTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVI 171
Cdd:cd17975    81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160

                         170       180
                  ....*....|....*....|...
gi 1720388778 172 LMSATLDAGLFSKYFSYCPVITI 194
Cdd:cd17975   161 LMSATVDCEKFSSYFTHCPILRI 183
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 18-194 3.07e-65

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 215.86  E-value: 3.07e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 --TVGYQIRLESVKS-SATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMS 174
Cdd:cd17981    81 gnSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                         170       180
                  ....*....|....*....|
gi 1720388778 175 ATLDAGLFSKYFSYCPVITI 194
Cdd:cd17981   161 ATLNAEKFSDYFNNCPMIHI 180
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 17-567 2.40e-63

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 228.66  E-value: 2.40e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  17 LLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIP-QFILDNSLNGppervaNIICTQPRRISAISVAERVAKERAERV 95
Cdd:PRK11664    3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGING------KIIMLEPRRLAARNVAQRLAEQLGEKP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  96 GLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDiVMQ--RATLQVILM 173
Cdd:PRK11664   77 GETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLD-VQQglRDDLKLLIM 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 174 SATLDAGLFSKYFSYCPVITIPGRAFPVDqffledalavTRYvlqdgspymrsmkqiakeklkarhnrtaqeeveEDLRL 253
Cdd:PRK11664  156 SATLDNDRLQQLLPDAPVIVSEGRSFPVE----------RRY---------------------------------QPLPA 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 254 SLHLqdeEESVKDTIpdqqldfKQLLIRykgvsksviktmsvmdfekvnlelieallewivdgkhayPPGAVLVFLPGLA 333
Cdd:PRK11664  193 HQRF---DEAVARAT-------AELLRQ---------------------------------------ESGSLLLFLPGVG 223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 334 EIKMLYEQLQsnslfnNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKR 413
Cdd:PRK11664  224 EIQRVQEQLA------SRVASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVAR 297

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 414 YDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLkQQLPEIQRVPLEQLCLRikiLEMFSTHNLQ 493
Cdd:PRK11664  298 FDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAA-QSEPEILHSDLSGLLLE---LLQWGCHDPA 373

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720388778 494 SVfsRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRclDPALTIAASLA 567
Cdd:PRK11664  374 QL--SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKLA 443
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 18-194 2.88e-61

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 205.03  E-value: 2.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLES-VKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSAT 176
Cdd:cd17976    81 NVGYQVRLESrPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                         170
                  ....*....|....*...
gi 1720388778 177 LDAGLFSKYFSYCPVITI 194
Cdd:cd17976   161 GDNQRLSRYFGGCPVVRV 178
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 7-194 1.14e-59

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 201.10  E-value: 1.14e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   7 QFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVanIICTQPRRISAISVAER 86
Cdd:cd17973     2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  87 VAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRA 166
Cdd:cd17973    80 VAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRP 159

                         170       180
                  ....*....|....*....|....*...
gi 1720388778 167 TLQVILMSATLDAGLFSKYFSYCPVITI 194
Cdd:cd17973   160 DLKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 18-194 1.80e-55

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 188.81  E-value: 1.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppervaNIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17979    74 KVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATI 153

                         170
                  ....*....|....*..
gi 1720388778 178 DAGLFSKYFSYCPVITI 194
Cdd:cd17979   154 NIELFSGYFEGAPVVQV 170
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 18-187 7.69e-54

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 184.63  E-value: 7.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgpPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRAT-LQVILMSAT 176
Cdd:cd17988    79 LVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSAT 158

                         170
                  ....*....|.
gi 1720388778 177 LDAGLFSKYFS 187
Cdd:cd17988   159 ISCKEFADYFT 169
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 18-194 1.69e-53

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 183.71  E-value: 1.69e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFA----RGGMIGITQPRRVAAVSVAKRVAEEMGVELGQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQR-----ATLQVIL 172
Cdd:cd17978    77 LVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVII 156

                         170       180
                  ....*....|....*....|..
gi 1720388778 173 MSATLDAGLFSKYFSYCPVITI 194
Cdd:cd17978   157 MSATLDADLFSEYFNGAPVLYI 178
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 13-195 2.10e-48

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 169.59  E-value: 2.10e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  13 QERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERA 92
Cdd:cd17971     1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYT----SRGKIGCTQPRRVAAMSVAKRVAEEFG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  93 ERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVIL 172
Cdd:cd17971    77 CCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIV 156

                         170       180
                  ....*....|....*....|...
gi 1720388778 173 MSATLDAGLFSKYFSYCPVITIP 195
Cdd:cd17971   157 TSATLDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 18-194 4.11e-47

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 165.75  E-value: 4.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNslnGPPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEA---GYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17974    78 EVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATM 157

                         170
                  ....*....|....*..
gi 1720388778 178 DAGLFSKYFSYCPVITI 194
Cdd:cd17974   158 DAEKFSAFFDDAPIFRI 174
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 18-188 5.47e-47

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 165.72  E-value: 5.47e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNslnGPPERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEA---GWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSAT 176
Cdd:cd17980    78 EVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASAT 157

                         170
                  ....*....|..
gi 1720388778 177 LDAGLFSKYFSY 188
Cdd:cd17980   158 LDAEKFRDFFNQ 169
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 18-194 1.01e-43

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 156.08  E-value: 1.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYT----DYGMIGCTQPRRVAAMSVAKRVSEEMGVELGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17983    77 EVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATM 156

                         170
                  ....*....|....*..
gi 1720388778 178 DAGLFSKYFSYCPVITI 194
Cdd:cd17983   157 DADKFADFFGNVPIFTI 173
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 18-194 4.49e-41

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 148.37  E-value: 4.49e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRG----IRGLIGHTQPRRLAARSVAERIAEELKTELGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17989    77 AVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATI 156

                         170
                  ....*....|....*..
gi 1720388778 178 DAGLFSKYFSYCPVITI 194
Cdd:cd17989   157 DAERFSRHFNNAPIIEV 173
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 18-192 1.40e-40

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 147.09  E-value: 1.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPpervANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAG----GKIIVLEPRRVAARAAARRLATLLGEAPGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIV-MQRATLQVILMSAT 176
Cdd:cd17990    77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQqLLRDDLRLLAMSAT 156

                         170
                  ....*....|....*.
gi 1720388778 177 LDAGLFSKYFSYCPVI 192
Cdd:cd17990   157 LDGDGLAALLPEAPVV 172
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 18-177 6.55e-39

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 142.88  E-value: 6.55e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGP-PERVANIICTQPRRISAISVAERVAKERAErVG 96
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPeSDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  97 LTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRAT--------- 167
Cdd:cd17982    80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159

                         170
                  ....*....|.
gi 1720388778 168 -LQVILMSATL 177
Cdd:cd17982   160 pLKLVIMSATL 170
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 18-194 7.62e-37

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 136.52  E-value: 7.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNgppeRVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS----QHGMIGVTQPRRVAAISVAQRVAEEMKCTLGS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRAT-----LQVIL 172
Cdd:cd17984    77 KVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkehLKVVV 156

                         170       180
                  ....*....|....*....|..
gi 1720388778 173 MSATLDAGLFSKYFSYCPVITI 194
Cdd:cd17984   157 MSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 18-192 2.15e-32

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 123.78  E-value: 2.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPpERVANIICTQPRRISAISVAERVAKERAERVGL 97
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAH-YQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  98 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATL 177
Cdd:cd17977    80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPH 159

                         170
                  ....*....|....*
gi 1720388778 178 DAGLFSKYFSYCPVI 192
Cdd:cd17977   160 LSSKLLSYYGNVPLI 174
DEXDc smart00487
DEAD-like helicases superfamily;
24-204 5.49e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 100.64  E-value: 5.49e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778   24 RETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVaniICTQPRRISAISVAERVAKE----RAERVGLTV 99
Cdd:smart00487  14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRV---LVLVPTRELAEQWAEELKKLgpslGLKVVGLYG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  100 GYQIR--LESVKSSATRLLYCTTGVLLRRLE-GDATLQGVTHIIVDEVHERTEES--DFLLLVLKDIvmqRATLQVILMS 174
Cdd:smart00487  91 GDSKReqLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAHRLLDGGfgDQLEKLLKLL---PKNVQLLLLS 167

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1720388778  175 ATLDAGL--FSKYFSYCPVITIPGRA--FPVDQF 204
Cdd:smart00487 168 ATPPEEIenLLELFLNDPVFIDVGFTplEPIEQF 201
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 18-194 8.82e-24

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 99.20  E-value: 8.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  18 LPAWEERETIL-KLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERvANIICTQPRRISAISVAERVAKERAERVG 96
Cdd:cd17986     1 LPIWAAKFTFLeQLESPSGIVLVSGEPGSGKSTQVPQWCAEFALSRGFQK-GQVTVTQPHPLAARSLALRVADEMDLNLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  97 LTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSat 176
Cdd:cd17986    80 HEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVT-- 157

                         170       180
                  ....*....|....*....|.
gi 1720388778 177 lDAGLFSKYFSYC---PVITI 194
Cdd:cd17986   158 -SPALEPKLRAFWgnpPVVHV 177
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 515-594 5.51e-23

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 94.23  E-value: 5.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 515 LRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSP----WDKKEEANQKKLEFA 590
Cdd:pfam04408   5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldPRSAAKAARRRRRAA 84


                  ....
gi 1720388778 591 FANS 594
Cdd:pfam04408  85 DEKA 88
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 518-600 1.20e-22

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 92.33  E-value: 1.20e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  518 LGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFvsPWDKKEEANQKKLEFAFANSDYL 597
Cdd:smart00847   2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHL 79


                   ...
gi 1720388778  598 ALL 600
Cdd:smart00847  80 TLL 82
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 688-785 3.24e-22

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 91.16  E-value: 3.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 688 ISAVLCAALYPNVVqvktpegkfqktssgvvRLQPKSAELKFVtKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRV 767
Cdd:pfam07717   1 LRAALAAGLYPNVA-----------------RRDPKGKGYTTL-SDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62

                          90
                  ....*....|....*...
gi 1720388778 768 FIRDCSMVSVYPLVLFGG 785
Cdd:pfam07717  63 YIRTVTAISPEWLLLFAP 80
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 304-443 2.03e-13

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 67.24  E-value: 2.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 304 ELIEALLEWIvdgkHAYPPGAVLVFLPGlaeIKMLYEQLqsnslFNNRRSHRCVihPLHSSLSSEEQQAVFVKPPMGVTK 383
Cdd:pfam00271   1 EKLEALLELL----KKERGGKVLIFSQT---KKTLEAEL-----LLEKEGIKVA--RLHGDLSQEEREEILEDFRKGKID 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 384 IIISTNIAETSITIDDVVYVIDsgkmkekrYDAGKGMESLedtfvsqanaLQRKGRAGRV 443
Cdd:pfam00271  67 VLVATDVAERGLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGRA 108
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 27-446 4.15e-13

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 73.09  E-value: 4.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  27 ILKLLSKHQVVVISGMTGCGKTTQIPQFIL-DNSLNG---------PPERVANIICTQPR----RISAISVAERVAKERA 92
Cdd:PHA02653  172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLwFNYLFGgfdnldkidPNFIERPIVLSLPRvalvRLHSITLLKSLGFDEI 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  93 ERVGLTVGY---QIRLESVKSSATRLLYCTTGVLLRRLEGDATlqgvthIIVDEVHERTEESDFLLLVL-KDIVMQRAtl 168
Cdd:PHA02653  252 DGSPISLKYgsiPDELINTNPKPYGLVFSTHKLTLNKLFDYGT------VIIDEVHEHDQIGDIIIAVArKHIDKIRS-- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 169 qVILMSATL--DAGLFSKYFSYCPVITIPGRA-FPVDQFfledalavtrYVLQDGSPYMRSMKqiakeklkarhnrtaqe 245
Cdd:PHA02653  324 -LFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISEV----------YVKNKYNPKNKRAY----------------- 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 246 eVEEDLRLSLHlqdeeeSVKDTIPDQQldfkqllirykgvsKSVI---KTMSVMDFEKVNLE-LIEALLEWIVDGKhayp 321
Cdd:PHA02653  376 -IEEEKKNIVT------ALKKYTPPKG--------------SSGIvfvASVSQCEEYKKYLEkRLPIYDFYIIHGK---- 430

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 322 pgavlvfLPGLAEIkmlyeqlqSNSLFNNRRSHrcvihplhsslsseeqqavfvkppmgvtkIIISTNIAETSITIDDVV 401
Cdd:PHA02653  431 -------VPNIDEI--------LEKVYSSKNPS-----------------------------IIISTPYLESSVTIRNAT 466

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1720388778 402 YVIDSGKMKEKRYDAGKgmesleDTFVSQANALQRKGRAGRVASG 446
Cdd:PHA02653  467 HVYDTGRVYVPEPFGGK------EMFISKSMRTQRKGRVGRVSPG 505
HELICc smart00490
helicase superfamily c-terminal domain;
352-442 1.03e-12

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.16  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  352 RSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSgkmkekrydagkgmesleDTFVSQA 431
Cdd:smart00490   8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIY------------------DLPWSPA 69

                           90
                   ....*....|.
gi 1720388778  432 NALQRKGRAGR 442
Cdd:smart00490  70 SYIQRIGRAGR 80
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 37-176 8.23e-12

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 63.58  E-value: 8.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  37 VVISGMTGCGKTTQIPQFILDNSLNGPPERVanIICtqPRRISAISVAERVAKERaeRVGLTVGYQIRLESVKSSATR-- 114
Cdd:cd00046     4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL--VLV--PTKALALQTAERLRELF--GPGIRVAVLVGGSSAEEREKNkl 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720388778 115 ----LLYCTTGVLLRRLEGDA--TLQGVTHIIVDEVHERTEESDFLLLV-LKDIVMQRATLQVILMSAT 176
Cdd:cd00046    78 gdadIIIATPDMLLNLLLREDrlFLKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 24-178 7.22e-11

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 61.49  E-value: 7.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  24 RETILKLLSKHQVVVISGmTGCGKTT--QIPqfILDNSLNGPPERVANIICtqPRRISAISVAERvAKERAERVGLTV-- 99
Cdd:pfam00270   5 AEAIPAILEGRDVLVQAP-TGSGKTLafLLP--ALEALDKLDNGPQALVLA--PTRELAEQIYEE-LKKLGKGLGLKVas 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 100 ---GYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHeRTEESDF---LLLVLKDIvmqRATLQVILM 173
Cdd:pfam00270  79 llgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFgpdLEEILRRL---PKKRQILLL 154


                  ....*
gi 1720388778 174 SATLD 178
Cdd:pfam00270 155 SATLP 159
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 24-195 4.19e-04

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 42.25  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778  24 RETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPervaNIICTQPRRisAIsVAERVA--KERAERVGLTVGY 101
Cdd:cd17921     7 REALRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGG----KAVYIAPTR--AL-VNQKEAdlRERFGPLGKNVGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388778 102 QIRLESV---KSSATRLLYCTT---GVLLRRLeGDATLQGVTHIIVDEVH--ERTEESDFLLLVLKDIVMQRATLQVILM 173
Cdd:cd17921    80 LTGDPSVnklLLAEADILVATPeklDLLLRNG-GERLIQDVRLVVVDEAHliGDGERGVVLELLLSRLLRINKNARFVGL 158

                         170       180
                  ....*....|....*....|...
gi 1720388778 174 SATLD-AGLFSKYFSYCPVITIP 195
Cdd:cd17921   159 SATLPnAEDLAEWLGVEDLIRFD 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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