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Conserved domains on  [gi|1720398211|ref|XP_030105250|]
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arrestin domain-containing protein 1 isoform X4 [Mus musculus]

Protein Classification

arrestin family protein( domain architecture ID 10432288)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen); similar to Homo sapiens thioredoxin-interacting protein and arrestin domain-containing protein

CATH:  2.60.40.840
PubMed:  7720881|7833798
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 2.09e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


:

Pssm-ID: 460676  Cd Length: 135  Bit Score: 86.23  E-value: 2.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211 125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAK----RWIYDVRTIAEVEGTGVKAWRRAQ 200
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKtplgESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720398211 201 WQEQILVPaLPQSALP---GCSLIHIDYYLQVSMKAP----EATVTLPLFVGNI 247
Cdd:pfam02752  81 WEKELQLQ-IPTDLPPsstKCKIIKVEYKLKVTVDLSgsasELRLELPITIGTS 133
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 14-102 9.97e-13

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 65.39  E-value: 9.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  14 GRVVYGPGEplagtvHLRLGAPLPFRGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTP-RFSKdhKCSLV 92
Cdd:pfam00339  67 GTEVYLPTE------TSLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPwKFNK--SFRRV 138

                          90
                  ....*....|
gi 1720398211  93 FYILSPLNLN 102
Cdd:pfam00339 139 FTVIPKLDLN 148
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 252-386 1.99e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  252 TPLSPCPGRESSPGTLslVVPSAPPQEEAEAVASGPHfSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHS 331
Cdd:PHA03247  2721 LPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720398211  332 L--------HPPLCISIGATVPYFAEGSAGPVPTTSALILPPEysswgYPYEAPPSYEQSCGA 386
Cdd:PHA03247  2798 LpspwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP-----PPPGPPPPSLPLGGS 2855
 
Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 2.09e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 86.23  E-value: 2.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211 125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAK----RWIYDVRTIAEVEGTGVKAWRRAQ 200
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKtplgESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720398211 201 WQEQILVPaLPQSALP---GCSLIHIDYYLQVSMKAP----EATVTLPLFVGNI 247
Cdd:pfam02752  81 WEKELQLQ-IPTDLPPsstKCKIIKVEYKLKVTVDLSgsasELRLELPITIGTS 133
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 2.54e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 86.24  E-value: 2.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSY-------------KAKRWIYDVRTIAEV-EG 190
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYvssdgpvkrslaeKSKEKKADRKTLVKElDG 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398211  191 TGVKAWRRAQWQEQILVPALPQSaLPGCSLIHIDYYLQVSM----KAPEATVTLPLFVGNI 247
Cdd:smart01017  81 GPVLPGNKDKFEGQLKVPPLPPT-SRTCRLIKVEYKLKVKLrlsgKHSELRLELPITIGTV 140
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 14-102 9.97e-13

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 65.39  E-value: 9.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  14 GRVVYGPGEplagtvHLRLGAPLPFRGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTP-RFSKdhKCSLV 92
Cdd:pfam00339  67 GTEVYLPTE------TSLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPwKFNK--SFRRV 138

                          90
                  ....*....|
gi 1720398211  93 FYILSPLNLN 102
Cdd:pfam00339 139 FTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 42-98 3.76e-04

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 40.40  E-value: 3.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720398211   42 LPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSP 98
Cdd:smart01017  84 LPGNKDKFEGQLKVPPLPPTSRTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTV 140
PHA03247 PHA03247
large tegument protein UL36; Provisional
 252-386 1.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  252 TPLSPCPGRESSPGTLslVVPSAPPQEEAEAVASGPHfSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHS 331
Cdd:PHA03247  2721 LPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720398211  332 L--------HPPLCISIGATVPYFAEGSAGPVPTTSALILPPEysswgYPYEAPPSYEQSCGA 386
Cdd:PHA03247  2798 LpspwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP-----PPPGPPPPSLPLGGS 2855
 
Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 2.09e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 86.23  E-value: 2.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211 125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAK----RWIYDVRTIAEVEGTGVKAWRRAQ 200
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKtplgESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720398211 201 WQEQILVPaLPQSALP---GCSLIHIDYYLQVSMKAP----EATVTLPLFVGNI 247
Cdd:pfam02752  81 WEKELQLQ-IPTDLPPsstKCKIIKVEYKLKVTVDLSgsasELRLELPITIGTS 133
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 2.54e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 86.24  E-value: 2.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSY-------------KAKRWIYDVRTIAEV-EG 190
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYvssdgpvkrslaeKSKEKKADRKTLVKElDG 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720398211  191 TGVKAWRRAQWQEQILVPALPQSaLPGCSLIHIDYYLQVSM----KAPEATVTLPLFVGNI 247
Cdd:smart01017  81 GPVLPGNKDKFEGQLKVPPLPPT-SRTCRLIKVEYKLKVKLrlsgKHSELRLELPITIGTV 140
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 14-102 9.97e-13

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 65.39  E-value: 9.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  14 GRVVYGPGEplagtvHLRLGAPLPFRGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTP-RFSKdhKCSLV 92
Cdd:pfam00339  67 GTEVYLPTE------TSLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPwKFNK--SFRRV 138

                          90
                  ....*....|
gi 1720398211  93 FYILSPLNLN 102
Cdd:pfam00339 139 FTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 42-98 3.76e-04

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 40.40  E-value: 3.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720398211   42 LPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSP 98
Cdd:smart01017  84 LPGNKDKFEGQLKVPPLPPTSRTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTV 140
PHA03247 PHA03247
large tegument protein UL36; Provisional
 252-386 1.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398211  252 TPLSPCPGRESSPGTLslVVPSAPPQEEAEAVASGPHfSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHS 331
Cdd:PHA03247  2721 LPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720398211  332 L--------HPPLCISIGATVPYFAEGSAGPVPTTSALILPPEysswgYPYEAPPSYEQSCGA 386
Cdd:PHA03247  2798 LpspwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP-----PPPGPPPPSLPLGGS 2855
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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