run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X5 [Mus musculus]
run domain Beclin-1-interacting and cysteine-rich domain-containing protein( domain architecture ID 17730331)
run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) is part of a Beclin-1-Vps34-containing autophagy complex; it negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
zf-RING_9 | pfam13901 | Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members ... |
689-889 | 2.18e-103 | |||||
Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169 : Pssm-ID: 464030 Cd Length: 205 Bit Score: 319.56 E-value: 2.18e-103
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RUN_RUBCN | cd17686 | RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ... |
18-174 | 5.46e-69 | |||||
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN. : Pssm-ID: 439048 Cd Length: 151 Bit Score: 226.00 E-value: 5.46e-69
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Herpes_BLLF1 super family | cl37540 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
181-391 | 1.38e-03 | |||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. The actual alignment was detected with superfamily member pfam05109: Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.60 E-value: 1.38e-03
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Name | Accession | Description | Interval | E-value | |||||
zf-RING_9 | pfam13901 | Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members ... |
689-889 | 2.18e-103 | |||||
Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169 Pssm-ID: 464030 Cd Length: 205 Bit Score: 319.56 E-value: 2.18e-103
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RUN_RUBCN | cd17686 | RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ... |
18-174 | 5.46e-69 | |||||
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN. Pssm-ID: 439048 Cd Length: 151 Bit Score: 226.00 E-value: 5.46e-69
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RUN | smart00593 | domain involved in Ras-like GTPase signaling; |
106-166 | 9.82e-12 | |||||
domain involved in Ras-like GTPase signaling; Pssm-ID: 214736 [Multi-domain] Cd Length: 64 Bit Score: 61.09 E-value: 9.82e-12
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Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
181-391 | 1.38e-03 | |||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.60 E-value: 1.38e-03
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RUN | pfam02759 | RUN domain; This domain is present in several proteins that are linked to the functions of ... |
40-157 | 3.23e-03 | |||||
RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. Pssm-ID: 460679 Cd Length: 134 Bit Score: 38.80 E-value: 3.23e-03
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Name | Accession | Description | Interval | E-value | |||||
zf-RING_9 | pfam13901 | Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members ... |
689-889 | 2.18e-103 | |||||
Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169 Pssm-ID: 464030 Cd Length: 205 Bit Score: 319.56 E-value: 2.18e-103
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RUN_RUBCN | cd17686 | RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ... |
18-174 | 5.46e-69 | |||||
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN. Pssm-ID: 439048 Cd Length: 151 Bit Score: 226.00 E-value: 5.46e-69
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RUN | cd17671 | RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ... |
21-161 | 4.14e-20 | |||||
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways. Pssm-ID: 439038 Cd Length: 154 Bit Score: 87.87 E-value: 4.14e-20
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RUN | smart00593 | domain involved in Ras-like GTPase signaling; |
106-166 | 9.82e-12 | |||||
domain involved in Ras-like GTPase signaling; Pssm-ID: 214736 [Multi-domain] Cd Length: 64 Bit Score: 61.09 E-value: 9.82e-12
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RUN_PLEKHM2 | cd17680 | RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and ... |
38-160 | 3.04e-07 | |||||
RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and similar proteins; PLEKHM2, also called PH domain-containing family M member 2, or Salmonella-induced filaments A (SifA) and Kinesin-Interacting Protein (SKIP), is the lysosome, melanosome and lytic granule cargo adaptor that controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. In addition to kinesin-1, it also interacts with several Rabs to affect endosomal trafficking. This model represents the RUN domain of PLEKHM2. Pssm-ID: 439042 Cd Length: 145 Bit Score: 50.70 E-value: 3.04e-07
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RUN_RUFY4_like | cd17682 | RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ... |
15-159 | 2.57e-04 | |||||
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain. Pssm-ID: 439044 Cd Length: 150 Bit Score: 42.21 E-value: 2.57e-04
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RUN_SNX29 | cd17689 | RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ... |
64-153 | 3.02e-04 | |||||
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29. Pssm-ID: 439051 Cd Length: 166 Bit Score: 42.22 E-value: 3.02e-04
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Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
181-391 | 1.38e-03 | |||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.60 E-value: 1.38e-03
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RUN | pfam02759 | RUN domain; This domain is present in several proteins that are linked to the functions of ... |
40-157 | 3.23e-03 | |||||
RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. Pssm-ID: 460679 Cd Length: 134 Bit Score: 38.80 E-value: 3.23e-03
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Blast search parameters | ||||
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