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Conserved domains on  [gi|1720383669|ref|XP_030104272|]
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ATP-dependent 6-phosphofructokinase, muscle type isoform X2 [Mus musculus]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10092100)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
13-774 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


:

Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1429.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  93 REREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 173 DMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTP 332
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 333 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRP-PVSKGGLHTVAVMNVGAP 411
Cdd:cd00764   321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 412 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQ 491
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 492 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIE 571
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 572 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 651
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 652 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTd 731
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1720383669 732 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKR 774
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
13-774 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1429.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  93 REREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 173 DMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTP 332
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 333 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRP-PVSKGGLHTVAVMNVGAP 411
Cdd:cd00764   321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 412 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQ 491
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 492 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIE 571
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 572 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 651
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 652 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTd 731
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1720383669 732 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKR 774
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
16-755 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1200.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACV 335
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 336 VSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLA---HVRPPV-SKGGLHTVAVMNVGAP 411
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVpSEASRLRIAIIHVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 412 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQ 491
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 492 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIE 571
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 572 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 651
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 652 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPV-TELKDQT 730
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVkQLLANET 719
                         730       740
                  ....*....|....*....|....*
gi 1720383669 731 DFEHRIPKEQWWLKLRPILKILAKY 755
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
PFK pfam00365
Phosphofructokinase;
18-321 4.05e-141

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 416.36  E-value: 4.05e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGehIREATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  98 RLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllndlqkdgkitaeeatkssyLNIVGLVGSIDNDFCGTDMTIG 177
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 178 TDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 257
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720383669 258 NIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAV 321
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
16-363 1.65e-125

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 379.03  E-value: 1.65e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:COG0205     2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADtfrsewsdllndlqkdgKITAEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:COG0205    80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:COG0205   138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKNGKPI---------------TSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEA 320
Cdd:COG0205   215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1720383669 321 VMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDVTKAMD 363
Cdd:COG0205   295 VELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPVDPDSP 334
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
16-373 4.17e-123

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 371.72  E-value: 4.17e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PRK03202    2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllNDLQKDGkitaeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:PRK03202   80 EGRAKAIENLKKLGIDALVVIGGDGSYMGA-----------KRLTEHG------------IPVIGLPGTIDNDIAGTDYT 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:PRK03202  137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKngkpitsEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacV 335
Cdd:PRK03202  214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1720383669 336 VSLSGNQAVRLPLMECVQVTKdvtKAMDEKRFDEAIKL 373
Cdd:PRK03202  284 VGIQNNKIVHVPIEEAVENMK---HPFDKDLYELAKKL 318
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
13-774 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1429.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  93 REREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 173 DMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTP 332
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 333 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRP-PVSKGGLHTVAVMNVGAP 411
Cdd:cd00764   321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 412 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQ 491
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 492 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIE 571
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 572 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 651
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 652 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTd 731
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1720383669 732 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKR 774
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
16-755 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1200.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACV 335
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 336 VSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLA---HVRPPV-SKGGLHTVAVMNVGAP 411
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVpSEASRLRIAIIHVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 412 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQ 491
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 492 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIE 571
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 572 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 651
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 652 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPV-TELKDQT 730
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVkQLLANET 719
                         730       740
                  ....*....|....*....|....*
gi 1720383669 731 DFEHRIPKEQWWLKLRPILKILAKY 755
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
16-383 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 540.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:cd00363     1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDllndlqkdgkitaeeatKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:cd00363    79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:cd00363   142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACV 335
Cdd:cd00363   222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1720383669 336 VSLSGNQAVRLPLMECVQVTKDVtkamdekrfdeAIKLRGRSFMNNWE 383
Cdd:cd00363   302 QNLNENQVVRHPLTEAVNMTKRV-----------GVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
18-321 4.05e-141

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 416.36  E-value: 4.05e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGehIREATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  98 RLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllndlqkdgkitaeeatkssyLNIVGLVGSIDNDFCGTDMTIG 177
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 178 TDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 257
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720383669 258 NIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAV 321
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
16-363 1.65e-125

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 379.03  E-value: 1.65e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:COG0205     2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADtfrsewsdllndlqkdgKITAEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:COG0205    80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:COG0205   138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKNGKPI---------------TSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEA 320
Cdd:COG0205   215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1720383669 321 VMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDVTKAMD 363
Cdd:COG0205   295 VELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPVDPDSP 334
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
16-373 4.17e-123

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 371.72  E-value: 4.17e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PRK03202    2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllNDLQKDGkitaeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:PRK03202   80 EGRAKAIENLKKLGIDALVVIGGDGSYMGA-----------KRLTEHG------------IPVIGLPGTIDNDIAGTDYT 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:PRK03202  137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKngkpitsEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacV 335
Cdd:PRK03202  214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1720383669 336 VSLSGNQAVRLPLMECVQVTKdvtKAMDEKRFDEAIKL 373
Cdd:PRK03202  284 VGIQNNKIVHVPIEEAVENMK---HPFDKDLYELAKKL 318
PFK pfam00365
Phosphofructokinase;
403-685 2.72e-104

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 321.21  E-value: 2.72e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 403 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKN---LE 479
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTeegRE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 480 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQS 559
Cdd:pfam00365  82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 560 AAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLvQKMKTTVkrgLVLRNEKCNenyTTDF 639
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFS---IIVVAEGAS---DGEF 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1720383669 640 IFNLYsEEGKGIfDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 685
Cdd:pfam00365 228 LAKLI-EEGTGI-ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
18-350 2.34e-103

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 320.06  E-value: 2.34e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  98 RLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllNDLQKDGKItaeeatkssylNIVGLVGSIDNDFCGTDMTIG 177
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGA-----------QKLYEEGGI-----------PVIGLPGTIDNDIPGTDYTIG 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 178 TDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDweeHLCRRLSETRTRGSRL 257
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 258 NIIIVAEGAIDKNGKpitseDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacVVS 337
Cdd:TIGR02482 215 SIIIVAEGNIVGSAK-----EVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MIG 286
                         330
                  ....*....|...
gi 1720383669 338 LSGNQAVRLPLME 350
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
16-362 9.27e-98

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 305.87  E-value: 9.27e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgeHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:cd00763     1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllndlqkdgKITAEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:cd00763    79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGA------------------MRLTEHG-----FPCVGLPGTIDNDIPGTDYT 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:cd00763   136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGtpdTPACV 335
Cdd:cd00763   213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLA 282
                         330       340
                  ....*....|....*....|....*..
gi 1720383669 336 VSLSGNQAVRLPLMECVQVTKDVTKAM 362
Cdd:cd00763   283 VGIQNEQLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
18-352 3.01e-80

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 260.31  E-value: 3.01e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  18 IAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGGEhIREATWESVSMMLQLGGTVIGSARCKDFR-ER 95
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 EGRLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllNDLQKDGkitaeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIA-----------RRLADKG------------LPVVGVPKTIDNDLEATDYT 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPddDWEEhLCRRLSETRTRGS 255
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 256 RLNIIIVAEGAIDKNGKPITSEDIKN----------------LVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVE 319
Cdd:TIGR02483 215 RFAIVVVAEGAKPKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1720383669 320 AVMALLEGTPDTpacVVSLSGNQAVRLPLMECV 352
Cdd:TIGR02483 295 AVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
12-358 3.50e-61

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 210.31  E-value: 3.50e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  12 LGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCK 90
Cdd:PRK14071    1 MGEKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  91 D---FREREGRLR--------AAHNLvkrGITNLCVIGGDGSLTgadtfrsewsdLLNDLQKDGKItaeeatkssylNIV 159
Cdd:PRK14071   81 DpfaFPMPDGSLRdrsqeiidGYHSL---GLDALIGIGGDGSLA-----------ILRRLAQQGGI-----------NLV 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 160 GLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddw 239
Cdd:PRK14071  136 GIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT--- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 240 EEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSED-------------IKNLVVKRLGYDTRVTVLGHVQRGGTPS 306
Cdd:PRK14071  213 LENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPS 292
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720383669 307 AFDRILGSRMGVEAVMALLEGTPDTpacVVSLSGNQAVRLPLMECVQVTKDV 358
Cdd:PRK14071  293 PRDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAV 341
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
402-751 5.30e-53

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 187.20  E-value: 5.30e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 402 TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKN---L 478
Cdd:COG0205     3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTeegR 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 479 EQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQ 558
Cdd:COG0205    83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 559 SAAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLqvnVEHLVQKMKTTVKRGLV-----LRNEKCNE 633
Cdd:COG0205   157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIvvaegAGDEDGEA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 634 NYTTD-FIFNLYSEEGKGI-----------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNW-MSGKikesyrngri 700
Cdd:COG0205   233 VLEADtDAFGHVRLGGIGEylakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELlLEGK---------- 302
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720383669 701 fantpdSGCVLGMRKRALVFQPVTELKDQtdfEHRIPKEQWWLKLRPILKI 751
Cdd:COG0205   303 ------TGVMVGIRRGEIVLVPLEEVANK---EKPVDPDSPLIQLARELGI 344
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
403-683 1.82e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 185.58  E-value: 1.82e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 403 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQIS 482
Cdd:cd00363     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 483 A---NITKFNIQGLVIIGGFEAYTGGLELmegRKQFDELCIPFVVI--PATVSNNVPGSDFSIGADTALNTICTTCDRIK 557
Cdd:cd00363    83 KaaeNLKKHGIDALVVIGGDGSYTGADLL---TEEWPSKYQGFNVIglPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 558 QSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDlqvnVEHLVQKMKTTVKRG----LVLRNEKcne 633
Cdd:cd00363   160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383669 634 nyTTDFIFNLYSEEG-------KGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 683
Cdd:cd00363   232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEA 286
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
403-683 3.10e-51

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 181.82  E-value: 3.10e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 403 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLE--- 479
Cdd:PRK03202    4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgra 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 480 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRkqfdelcIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQS 559
Cdd:PRK03202   84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 560 AAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKttvKRGLVLRNEK-CNENYTTD 638
Cdd:PRK03202  157 AS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAK 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720383669 639 FIfnlyseEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 683
Cdd:PRK03202  233 EI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
403-683 5.97e-49

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 175.29  E-value: 5.97e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 403 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRtLPKKNLEQIS 482
Cdd:cd00763     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 483 A----NITKFNIQGLVIIGGFEAYTGGLELMEgrkqfdeLCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQ 558
Cdd:cd00763    82 AkaieQLKKHGIDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 559 SAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKttvKRGLVLRNEKCnenYTTD 638
Cdd:cd00763   155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720383669 639 FIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 683
Cdd:cd00763   228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
18-278 9.06e-23

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 102.43  E-value: 9.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGA--RVFFVHEGYQGLVDggEHIREATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PTZ00286   90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYK--EDWIKLDPKDVKTIHRLGGTILGSSRGGFDPKV 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 egrlrAAHNLVKRGITNLCVIGGDGSLTGADtfrsewsdllndlqkdgKITAEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:PTZ00286  168 -----MVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 176 IGTDSALHRIVEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPEcppdDDWEEHLCRRLSETRTR 253
Cdd:PTZ00286  226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPE----FDIPLEGVLEYIEQRLQ 301
                         250       260
                  ....*....|....*....|....*..
gi 1720383669 254 GSRLNIIIVAEGAID--KNGKPITSED 278
Cdd:PTZ00286  302 KKGHCVIVVAEGAGQslKDADLDLGTD 328
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
19-348 1.62e-22

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 101.10  E-value: 1.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  19 AVLTSGGDAQGMNAAVRAVVRV-----GIftgARVFFVHEGYQGLVDGGEH-IREATWESVSMMLQLGGTVIGSARckdf 92
Cdd:PRK06830   84 AIVTCGGLCPGLNDVIRAIVLElhhhyGV---RRILGIRYGYQGLIPRYGHdPVELTPEVVADIHEFGGTILGSSR---- 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  93 rereGRLRAAH---NLVKRGITNLCVIGGDGSLTGAdtfrsewsdllndlqkdGKITAEEATKSSYLNIVGLVGSIDNDF 169
Cdd:PRK06830  157 ----GPQDPEEivdTLERMNINILFVIGGDGTLRGA-----------------SAIAEEIERRGLKISVIGIPKTIDNDI 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 170 CGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWE----EHL 243
Cdd:PRK06830  216 NFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPngllAAL 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 244 CRRLSEtrtRGSRlnIIIVAEGA----IDKNGKpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTP-------------- 305
Cdd:PRK06830  296 EKRLAE---RGHA--VIVVAEGAgqelFDDTGE---TDASGNPKLGDIGLFLKDRIKEYFKARGIPinlkyidpsyiirs 367
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1720383669 306 ---SAFDRILGSRMGVEAVMALLEGTPDtpaCVVSLSGNQAVRLPL 348
Cdd:PRK06830  368 vpaNANDSVYCGFLGQNAVHAAMAGKTG---MVVGRWNNRFVHLPI 410
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
403-685 3.76e-17

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 83.97  E-value: 3.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 403 VAVMNVGAPAAGMNAAVRSTVRIGLIQ-GNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKRT------- 472
Cdd:PRK14071    7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNKgdpfafp 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 473 LPKKNLEQISANIT----KFNIQGLVIIGGfeayTGGLELMegRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNT 548
Cdd:PRK14071   87 MPDGSLRDRSQEIIdgyhSLGLDALIGIGG----DGSLAIL--RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVNI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 549 ICTTCDRIKQSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIrdlqvnvEHLVQKMKTTVKRG----L 624
Cdd:PRK14071  161 ATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfcL 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720383669 625 VLRNEKC----NENYTTDFIF--NLYSEEGKGIFD---------SRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 685
Cdd:PRK14071  233 VVVSEAVrteeGEQVTKTQALgeDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAAVD 308
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
16-327 1.56e-15

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 79.52  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVravvrVGIFTGAR-------VFFVHEGYQGLVDggEHIREATWESVSMMLQLGGT---VIG 85
Cdd:PRK14072    4 GNALYAQSGGPTAVINASA-----AGVIEEARkhkkigkVYGARNGIIGILD--EDLIDLSKESDEALAALAHTpsgALG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  86 SAR--CKDFREREGRL-RAAHNLVKRGITNLCVIGGDGSltgADTFRsewsdllndlqkdgKItAEEATKSSY-LNIVGL 161
Cdd:PRK14072   77 SCRykLKSLEEDRAEYeRLLEVFKAHDIGYFFYNGGNDS---MDTAL--------------KV-SQLAKKMGYpIRCIGI 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 162 VGSIDNDFCGTDMTIGTDSALHRI----VEI---VDAITTTaqshQRTFVLEVMGRHCGYLALVTSLSC-----GADWVF 229
Cdd:PRK14072  139 PKTIDNDLPGTDHCPGFGSAAKYIatsvLEAaldVAAMANT----SKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIY 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 230 IPECPPDDDweehlcRRLSETRTRGSRLN--IIIVAEGAIDKNGKPI----TSED-------------IKNLVVKRLGYD 290
Cdd:PRK14072  215 LPERPFDEE------KFLADVRAIVKRYGycVVVVSEGIRDADGKFIaeagLAEDafghaqlggvapvLANLIKEKLGKK 288
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1720383669 291 TRVTVLGHVQR--GGTPSAFDRILGSRMGVEAVMALLEG 327
Cdd:PRK14072  289 VHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALAG 327
PLN02884 PLN02884
6-phosphofructokinase
19-358 1.47e-14

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 76.39  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  19 AVLTSGGDAQGMNAAVRAVV-RVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARckdfrereG 97
Cdd:PLN02884   57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------G 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  98 RLRAAH---NLVKRGITNLCVIGGDGSLTGADTfrsewsdllndlqkdgkITAEEATKSSYLNIVGLVGSIDNDFCGTDM 174
Cdd:PLN02884  129 GAKTSDivdSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDK 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 175 TIGTDSALHRIVEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWEEHLCRRLSE-TR 251
Cdd:PLN02884  192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHlIE 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 252 TRGSRlnIIIVAEGAIDKNGKPITSEDIK-NLVVKRLGYDTRVTVLGHVQRGGTPS-----------------AFDRILG 313
Cdd:PLN02884  272 TKGSA--VVCVAEGAGQDLLQKTNATDASgNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILC 349
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1720383669 314 SRMGVEAVMALLEGtpdTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Cdd:PLN02884  350 TVLGQNAVHGAFAG---FSGITVGICNTHYVYLPIPEVIAYPRRV 391
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
16-266 1.21e-13

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 73.50  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  16 KAIAVLTSGGDAQGMNAAVRAVVR--VGIFTGARVFFVHEGYQGLVDGGE-HIREATWESVSMMLQLGGTVIGSARCK-- 90
Cdd:PRK06555    4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLGDSiEITPAVRANAGLLHRYGGSPIGNSRVKlt 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  91 ---D------FREREGRLR-AAHNLVKRGITNLCVIGGDGSLTGAdtfrsewSDLLNDLQKDGkitaeeatkssY-LNIV 159
Cdd:PRK06555   84 nvaDcvkrglVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG-----------YdLTVV 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 160 GLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTS-----------------L 221
Cdd:PRK06555  146 GLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayrewldrqeyvpgfgL 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1720383669 222 SCGA---DWVFIPECPPDDDWEehlCRRLSETRTRGSRLNiIIVAEGA 266
Cdd:PRK06555  226 SAERwdiHAVYLPEMAFDLEAE---AERLKAVMDEVGNVN-IFLSEGA 269
PLN02564 PLN02564
6-phosphofructokinase
19-266 7.36e-12

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 68.62  E-value: 7.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  19 AVLTSGGDAQGMNAAVRAVVrVGIFTG---ARVFFVHEGYQGLVdgGEHIREATWESVSMMLQLGGTVIGSARckdfrer 95
Cdd:PLN02564   91 CIVTCGGLCPGLNTVIREIV-CGLSYMygvTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSR------- 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  96 egrlrAAHNLVK-------RGITNLCVIGGDGSLTGADTFRSEwsdllndLQKDGKITAeeatkssylnIVGLVGSIDND 168
Cdd:PLN02564  161 -----GGHDTSKivdsiqdRGINQVYIIGGDGTQKGASVIYEE-------IRRRGLKVA----------VAGIPKTIDND 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 169 FCGTDMTIGTDSALHRIVEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSL-SCGADWVFIPECPPDDDWE----EH 242
Cdd:PLN02564  219 IPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFYLEGKgglfEF 298
                         250       260
                  ....*....|....*....|....
gi 1720383669 243 LCRRLSEtrtrgSRLNIIIVAEGA 266
Cdd:PLN02564  299 IEKRLKE-----NGHMVIVVAEGA 317
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
402-581 1.13e-08

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 58.13  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 402 TVAVMNVGAPAAGMNAAVRSTVRIGLI--QGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTlpKKNLE 479
Cdd:PTZ00286   89 KAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPK 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669 480 QISANITKFNIQGLVIIGGFEAYTGGLELM-EGRKQfdELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQ 558
Cdd:PTZ00286  167 VMVDTLIRHGINILFTLGGDGTHRGALAIYkELRRR--KLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244
                         170       180
                  ....*....|....*....|...
gi 1720383669 559 SAAGTKRRVFIIETMGGYCGYLA 581
Cdd:PTZ00286  245 EAKSAKNGVGIVKLMGRDSGFIA 267
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
3-268 2.83e-05

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 47.73  E-value: 2.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669    3 HEEHHAAKTLGIGkaiaVLTSGGDAQGMNAAVRavvrvGIFTGARVFFVHEGYQGLVDGGEHIREATWESV--SMM---L 77
Cdd:PTZ00287   169 HESFKGGNVLKIG----IILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTItdSLMnrfR 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669   78 QLGG-TVIGSARCKdFREREGrLRAAHNLV-KRGITNLCVIGGDGSLTGAdTFRSEWSdllndlqkdgkitaeeATKSSY 155
Cdd:PTZ00287   240 NLGGfNMLWSGRGK-VRNKDD-LIAIENIVaKLKLNGLVIIGGDGSNSNA-ALISEYF----------------AERQIP 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  156 LNIVGLVGSIDNDFC--GTDMTIGTDSALHRIVEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPE 232
Cdd:PTZ00287   301 ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGE 380
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1720383669  233 CPPDD-----DWEEHLCRRLSETRTRGSRLNIIIVAEGAID 268
Cdd:PTZ00287   381 EVEKEnlslkDIVSNIVNTILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
16-268 5.58e-05

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 46.89  E-value: 5.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669   16 KAIAVLTSGGDAQGMNAAVRAVVR-VGIFTGARVFFvheGYQGLVDG--GEHIREATWESVSMMLQLGG-TVIGSARCKd 91
Cdd:PTZ00468   103 RRIGVVLSGGQASGGHNVIAGLMSyIKLCNQSSQLF---GFLGGPEGvySERYRELTEDDINGILNQGGfNIICSGRHK- 178
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669   92 fREREGRLRAAHNLV-KRGITNLCVIGGDGSLTGAdtfrsewsdllndlqkdgKITAEEATK-SSYLNIVGLVGSIDNDF 169
Cdd:PTZ00468   179 -IETEEQMRASLEICeKLKLHGLVVIGGDDSNTNA------------------AVLAEYFKRnSSSTVVVGCPKTIDGDL 239
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383669  170 CG--TDMTIGTDSALHRIVEIVDAITTTAQSHQ-RTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD---------D 237
Cdd:PTZ00468   240 KNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEenrslmsivD 319
                          250       260       270
                   ....*....|....*....|....*....|.
gi 1720383669  238 DWEEHLCRRLSetrtRGSRLNIIIVAEGAID 268
Cdd:PTZ00468   320 EIVEMILKRDS----LGKKHGIVLLPEGLIE 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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