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Conserved domains on  [gi|1720376059|ref|XP_030103323|]
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zinc finger protein 782 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 1.17e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.17e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720376059   9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-476 1.99e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 183 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 259
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 260 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 317
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 318 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 397
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 398 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 462
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1720376059 463 NHVRIHTGQKPFKC 476
Cdd:COG5048   341 RHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-176 4.97e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.97e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376059 152 HLKRHERYHTGEQPFTCNECDKVFS 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 1.17e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.17e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720376059   9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-45 4.09e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 4.09e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720376059   9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
9-50 1.21e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.78  E-value: 1.21e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720376059    9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIGF 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-476 1.99e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 183 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 259
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 260 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 317
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 318 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 397
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 398 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 462
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1720376059 463 NHVRIHTGQKPFKC 476
Cdd:COG5048   341 RHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-401 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376059 376 SLQRHIRIHTGEKPYKCNQCDKAFSQ 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-176 4.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.97e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376059 152 HLKRHERYHTGEQPFTCNECDKVFS 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 1.17e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.17e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720376059   9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-45 4.09e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 4.09e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720376059   9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
9-50 1.21e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.78  E-value: 1.21e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720376059    9 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIGF 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-476 1.99e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 183 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 259
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 260 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 317
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 318 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 397
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 398 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 462
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1720376059 463 NHVRIHTGQKPFKC 476
Cdd:COG5048   341 RHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-478 3.15e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 128 HKRTQTGQKPYEC--KQCGKGFAKPSHLKRHERYHTGEQPFTCN-ECDKVFSFKHHLQTHISIRTGEKPFKCNLCDKSFS 204
Cdd:COG5048    52 HIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 205 KHNHLQSHRRTHTGEKPYKCDQC----------------------DKAFSEKCNLQTHIRIHSGEKPYKCDQCDKTFSEK 262
Cdd:COG5048   132 SRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSI 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 263 CHLQKHIRIHTGEKPYKCNQCDKAF-------SQYNTLKTHRRTHTGEKPYKCNQcDKAFSQYGHLQTHRRTHTG-EKPY 334
Cdd:COG5048   212 PSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPI 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 335 KCNQCDKAFSQYNTLKTHRRT--HTGE--KPYKC--NQCDKAFSEKCSLQRHIRIHTGEKPYKC--NQCDKAFSQYST-- 404
Cdd:COG5048   291 KSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNne 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 405 ---LQTHRRTHTGEKPYKC--NQCDKAFSQYSNLQTHRRTHTGEKPY--KCNQCDKAFSMKCNLQNHVRIHTGQKPFKCN 477
Cdd:COG5048   371 ppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450


                  .
gi 1720376059 478 Q 478
Cdd:COG5048   451 I 451
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-457 4.10e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 197 NLCDKSFSKHNHLQSHRRTHTGEKPYKCDQCDKAFSEKCNLQTHIRIHSGEKPYKCDQCdkTFSEKCHLQKHIRIHTGEK 276
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSS 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 277 PYKCNQCDKAFSQYNTLKTHRRTHTG---------EKPYKCNQCDKAFSQYGHLQTHRRT--HTGE--KPYKC--NQCDK 341
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 342 AFSQYNTLKTHRRTHTGEKPYKC--NQCDKAFS-----EKCSLQRHIRIHTGEKPYKC--NQCDKAFSQYSTLQTHRRTH 412
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1720376059 413 TGEKPY--KCNQCDKAFSQYSNLQTHRRTHTGEKPYKCNQCDKAFSM 457
Cdd:COG5048   412 LSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 274-357 2.73e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 274 GEKPYKCN--QCDKAFSQYNTLKTHRrthtgekpyKCNQCDKAFSQYGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKT 351
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720376059 352 HRRTHT 357
Cdd:COG5189   417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 218-301 1.15e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 218 GEKPYKCD--QCDKAFSEKCNLQTHiRIHSgekpykcdQCDKTFSEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKT 295
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720376059 296 HRRTHT 301
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-401 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376059 376 SLQRHIRIHTGEKPYKCNQCDKAFSQ 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-289 2.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376059 264 HLQKHIRIHTGEKPYKCNQCDKAFSQ 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-232 4.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.85e-04
                          10        20
                  ....*....|....*....|....*
gi 1720376059 208 HLQSHRRTHTGEKPYKCDQCDKAFS 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-345 5.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376059 320 HLQTHRRTHTGEKPYKCNQCDKAFSQ 345
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-456 7.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.84e-04
                          10        20
                  ....*....|....*....|....*
gi 1720376059 432 NLQTHRRTHTGEKPYKCNQCDKAFS 456
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-260 8.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.82e-04
                          10        20
                  ....*....|....*....|....*
gi 1720376059 236 NLQTHIRIHSGEKPYKCDQCDKTFS 260
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-317 9.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.63e-04
                          10        20
                  ....*....|....*....|....*
gi 1720376059 293 LKTHRRTHTGEKPYKCNQCDKAFSQ 317
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-429 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376059 405 LQTHRRTHTGEKPYKCNQCDKAFSQ 429
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-372 1.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|....
gi 1720376059 349 LKTHRRTHTGEKPYKCNQCDKAFS 372
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-176 4.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.97e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376059 152 HLKRHERYHTGEQPFTCNECDKVFS 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
362-386 8.63e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 33.68  E-value: 8.63e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376059 362 YKCNQCDKAFSEKCSLQRHIRIHTG 386
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 358-441 9.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376059 358 GEKPYKCN--QCDKAFSEKCSLQRHiRIHtgekpykcNQCDKAFSQYSTLQTHRRTHTGEKPYKCNQCDKAFSQYSNLQT 435
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720376059 436 HRRTHT 441
Cdd:COG5189   417 HRKHSH 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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