NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720375891|ref|XP_030103293|]
View 

solute carrier family 22 member 23 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 134-485 2.90e-173

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17444:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 364  Bit Score: 494.37  E-value: 2.90e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 134 VGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLMP 213
Cdd:cd17444    63 FGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMP 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 214 GLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakklilyltqkncvspesdikgvmpelekelsrrp 293
Cdd:cd17444   143 GLAALCRDWQVLQAVIICPFLLMLSYWCIFP------------------------------------------------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 294 kkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIALASCLAMCLVVKFLGRR 373
Cdd:cd17444   174 ---------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 374 GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLG 453
Cdd:cd17444   239 GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLG 318

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720375891 454 LVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17444   319 LVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 134-485 2.90e-173

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 494.37  E-value: 2.90e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 134 VGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLMP 213
Cdd:cd17444    63 FGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMP 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 214 GLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakklilyltqkncvspesdikgvmpelekelsrrp 293
Cdd:cd17444   143 GLAALCRDWQVLQAVIICPFLLMLSYWCIFP------------------------------------------------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 294 kkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIALASCLAMCLVVKFLGRR 373
Cdd:cd17444   174 ---------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 374 GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLG 453
Cdd:cd17444   239 GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLG 318

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720375891 454 LVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17444   319 LVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 124-508 5.40e-35

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 138.23  E-value: 5.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 124 LVSSKTW---SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMV 200
Cdd:TIGR00898 141 LLGSFVFgylSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 201 ASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKNCVSPESDIKg 280
Cdd:TIGR00898 221 IQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVL- 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 281 vMPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---NSLTGYGIhhcfarsMMGHEVkvpLLENFYADYYTMASIA 356
Cdd:TIGR00898 300 -SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftTAFSYYGL-------VLDLGN---LGGNIYLDLFISGLVE 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 357 LASCLAMCLVVKFLGRR----------GGLLLFMILTALASLLQLGLLNLIGKYSqhpdsgmsdsvkdkFSIAFSIVGMF 426
Cdd:TIGR00898 369 LPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDLYFLRTALAVLGKFG--------------ITSAFQMVYLY 434

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 427 AshavgslsvffcAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRNQNL 506
Cdd:TIGR00898 435 T------------AELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPL 502


                  ..
gi 1720375891 507 PE 508
Cdd:TIGR00898 503 PE 504
Sugar_tr pfam00083
Sugar (and other) transporter;
118-485 1.50e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 57.28  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSKtWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTL---RFFEGFCLAGIILTLYALRIELCPPGKR 194
Cdd:pfam00083  58 GCFIGSLFAGK-LGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLR 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 195 -FIITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLT 267
Cdd:pfam00083 137 gALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 268 QKNCVSPEsdIKGVMPELEKelSRRPKKVCIVKVVGTRNLWKNIVVLCV----------NSLTGYGihhcfarSMMGHev 337
Cdd:pfam00083 216 GVPDVDRE--LDEIKDSLEA--GQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltgiNAIFYYS-------TTIFE-- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 338 KVPLLENFYADYYTMASIALASCLAMCLVVKFlGRRgGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGmsdsvkdkFS 417
Cdd:pfam00083 283 NLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRF-GRR-PLLLLGAAGMAICFVILGIVALLGVSKSDWAGI--------VA 352

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375891 418 IAFsIVGMFASHAVGSLSVFF--CAEITPTVIRCGGLGLVLAS---AGF--GMLTAPIIELHNQKGYFlhhIIFA 485
Cdd:pfam00083 353 IVF-IALFIAFFAMGWGPVPWviVSELFPLSVRSKAMALATAAnwlANFliGFLFPIITDAIGLGYTF---FIFA 423
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
130-248 1.07e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQ 209
Cdd:COG2814    68 LADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720375891 210 FLMPGLAALCRD---WQVLQALIICPFLLMLLY-WSIFPESLR 248
Cdd:COG2814   148 ALGPLLGGLLADlfgWRWVFLVNAVLALLALLLlLRLLPESRP 190
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
131-183 6.12e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 42.23  E-value: 6.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA 183
Cdd:PRK15402   72 SDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYA 124
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 134-485 2.90e-173

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 494.37  E-value: 2.90e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 134 VGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLMP 213
Cdd:cd17444    63 FGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMP 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 214 GLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakklilyltqkncvspesdikgvmpelekelsrrp 293
Cdd:cd17444   143 GLAALCRDWQVLQAVIICPFLLMLSYWCIFP------------------------------------------------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 294 kkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIALASCLAMCLVVKFLGRR 373
Cdd:cd17444   174 ---------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 374 GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLG 453
Cdd:cd17444   239 GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLG 318

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720375891 454 LVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17444   319 LVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 133-485 1.51e-134

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 395.35  E-value: 1.51e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLM 212
Cdd:cd17373    51 RFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLM 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 213 PGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakklilyltqkncvspesdikgvmpelekelsrr 292
Cdd:cd17373   131 PGLAALCRDWRVLQALIICPFLLMLLYWSIFP------------------------------------------------ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 293 pkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVkvpllENFYADYYTMASIALASCLAMCLVVKFLGR 372
Cdd:cd17373   163 ----------------KNILILGFNSLTGYGIRHCFARSMMGHEP-----ENFYLDYYLTAGIAAVACVFLCVTVDFLGR 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 373 RGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGL 452
Cdd:cd17373   222 RGGLLLFMILTGLASLLLLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGL 301

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1720375891 453 GLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17373   302 GLVLASGGLGMLTGPIIELHNQKGYFLQHVVFA 334
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 133-485 1.02e-57

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 196.54  E-value: 1.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLM 212
Cdd:cd17443    62 RLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 213 PGLAALCRDWQVLQALIICPFLLMLLYWSifpeslrwlmatqqFESAKKLILYLTqkncvspesdikgvmpelekelsrr 292
Cdd:cd17443   142 PGLAVLCRDWRVLQGVGTLPLLLLLLYWC--------------FPSRNGLILGFT------------------------- 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 293 pkkvcivkvvgtrnlwknivvlcvnSLTGYGIHHCFARSMMghevkvPLLENFYADYYTMASIALASCLAMCLVVKFLGR 372
Cdd:cd17443   183 -------------------------AFIGGGIRYCFARNLA------PFVPTFYLPYFLQAGLEALACIFLCLTVDRCGR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 373 RGGLLLFMILTALASLLQLgllnligkysqhpdsGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGL 452
Cdd:cd17443   232 RGVLLLGTIVTGLSSLLLL---------------ALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGL 296

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1720375891 453 GLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17443   297 GLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFA 329
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 131-485 1.09e-53

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 185.75  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQF 210
Cdd:cd17445    60 ADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHF 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 211 LMPGLAALCRDWQVLQALIICPFLLMLLYwsifpeslrwlmatqqfesakklilyltqkncvspesDIKGVmpelekels 290
Cdd:cd17445   140 LLLGLALGCGSWRVLQGTITAPLSLFLCY-------------------------------------GCPGV--------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 291 rrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFarSMMGHEVKvPLLENFYADYYTMASIALASCLAMCLVVKFL 370
Cdd:cd17445   174 ------------------KNLLILGFTTFIAHAISHCY--QSFSDDVR-GTPSTFYLSYLLSTGTAGLACLFLCATVDRF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 371 GRRGGLLLFMILTALASLLQLgllnligkysqhpdsGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCG 450
Cdd:cd17445   233 GRRGILLLAMTLTGIASLILL---------------GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGS 297

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1720375891 451 GLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17445   298 GLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLA 332
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 124-508 5.40e-35

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 138.23  E-value: 5.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 124 LVSSKTW---SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMV 200
Cdd:TIGR00898 141 LLGSFVFgylSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 201 ASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKNCVSPESDIKg 280
Cdd:TIGR00898 221 IQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVL- 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 281 vMPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---NSLTGYGIhhcfarsMMGHEVkvpLLENFYADYYTMASIA 356
Cdd:TIGR00898 300 -SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftTAFSYYGL-------VLDLGN---LGGNIYLDLFISGLVE 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 357 LASCLAMCLVVKFLGRR----------GGLLLFMILTALASLLQLGLLNLIGKYSqhpdsgmsdsvkdkFSIAFSIVGMF 426
Cdd:TIGR00898 369 LPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDLYFLRTALAVLGKFG--------------ITSAFQMVYLY 434

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 427 AshavgslsvffcAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRNQNL 506
Cdd:TIGR00898 435 T------------AELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPL 502


                  ..
gi 1720375891 507 PE 508
Cdd:TIGR00898 503 PE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 133-485 5.67e-29

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 117.30  E-value: 5.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLM 212
Cdd:cd17317    51 RFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLL 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 213 PGLAALCRDWQVLQALIICPFLLMLLYWsifpeslrWLMatqqfesakklilyltqkncvspesdikgvmpelekelsrr 292
Cdd:cd17317   131 ALLAYLIRDWRWLQLAISLPGLLFLLLL--------WWL----------------------------------------- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 293 PKKVCIVkvvgtrnlwknIVVLCVNSLTGYGIhhcfarSMMGHEvkvpLLENFYADYYTMASIALASCLAMCLVVKFLGR 372
Cdd:cd17317   162 PRRTIIV-----------GLIWFVTSLVYYGL------SLNSSN----LGGNLYLNFFLSGLVEIPAYFLALLLLDRLGR 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 373 RGGLLLFMILTAlasllqlGLLNLIGKYSQHPDSgmsdsvkdkFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGL 452
Cdd:cd17317   221 RWTLSGSLLLAG-------LACLVTALLPDDENT---------LALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGV 284

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1720375891 453 GLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17317   285 GLCSTVARVGAILAPFIVLLGKIGPLLPLIIFG 317
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 131-244 1.17e-16

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 81.31  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQF 210
Cdd:cd17446    57 SDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQL 136

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720375891 211 LMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 244
Cdd:cd17446   137 ILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFP 170
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 131-484 2.38e-16

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 80.41  E-value: 2.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQF 210
Cdd:cd17374    59 SDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQM 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 211 LMPGLAALCRDWQVLQALIICPFLLMLLYwsifpesLRWLmatqqfesakklilyltqkncvspesdikgvmpelekels 290
Cdd:cd17374   139 LLAGLAYAIRDWRLLQLVVSVPFFLFFLY-------SWWL---------------------------------------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 291 rrPKKVCIvkvvgtrnlwkNIVVLCVNSLTGYGIhhcfARSMMGHEVKVPLLENFYAdyytmASIALASCLAMcLVVKFL 370
Cdd:cd17374   172 --PKRTLI-----------LSFVWFANSFSYYGL----SLDLQHLGLNVFLLQFLFG-----AVEVPARCLAL-FLLNHM 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 371 GRRGGLLLFMILTAlaslLQLGLLNLIGKYSQHpdsgmsdsvkdkFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCG 450
Cdd:cd17374   229 GRRISQAVLLLLAG----LCILANIFVPQEMQT------------LRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQT 292

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1720375891 451 GLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIF 484
Cdd:cd17374   293 GMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIY 326
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 133-485 2.63e-13

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 71.24  E-value: 2.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLM 212
Cdd:cd17378    60 SLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 213 PGLAALC-RDWQVLQALIICPFLLMLLYWSIFpeslrwlmatqqfesakklilyltqkncvspesdikgvmpelekelsr 291
Cdd:cd17378   140 PGIAYLNgSSWRVLYFWTSIPALIYCILVYLF------------------------------------------------ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 292 rPKKVCIVKVVGtrnlwknivvlCVNSLTGYGIhhcfarSMMGHEVKVplleNFYADYYTMASIALASCLAMCLVVKFLG 371
Cdd:cd17378   172 -ARRLLAVMVIG-----------FGIGMVYYGI------PLAVGNLKF----NIYLSVALNALSELPAFVITAFLLDRFG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 372 RRGGLLLFMILTALASLLQLGllnligkysqhpdsgMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGG 451
Cdd:cd17378   230 RRPSLLGFTLLSGASCLLCFV---------------LSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAA 294

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1720375891 452 LGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 485
Cdd:cd17378   295 LGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFG 328
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 131-244 5.36e-13

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 70.53  E-value: 5.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQF 210
Cdd:cd17447    59 SDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNM 138

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720375891 211 LMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 244
Cdd:cd17447   139 LLALVAYLIRDWRWLILAVTLPCAPGIITWWWVP 172
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 133-251 1.23e-10

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 63.14  E-value: 1.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLM 212
Cdd:cd17379    59 RFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLIL 138

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720375891 213 PGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLM 251
Cdd:cd17379   139 PGIAYFIPHWRWLQLAVTLPNFLFLLYYWFIPKHTFILM 177
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 118-250 1.87e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.76  E-value: 1.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSkTWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-FI 196
Cdd:TIGR00895  64 GMAFGALFFG-PLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgTA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720375891 197 ITMVAS--FVAMAGQFLMPGLAALCRDWQVLQAL-IICPFLLMLLYWSIFPESLRWL 250
Cdd:TIGR00895 143 VGLMFCgyPIGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLLLLMRFLPESIDFL 199
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 118-485 4.35e-10

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 61.82  E-value: 4.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSKTwSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFII 197
Cdd:cd17358    53 GALIGALLSGKL-ADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 198 TMVASfVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKNC--VSPE 275
Cdd:cd17358   132 GSLNQ-LLVNIGILLGYVLGSFLPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDAdiSKEA 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 276 SDIKGVMPELEKELSRRPKKVCIVKVVGtRNLWKNIVVLCVNSLTG-YGIhhCFARSMMGHEVKVPLLENfyadyytMAS 354
Cdd:cd17358   211 AEIQEELAELEKEAKESSFSDLFQRKYL-KPLVIGLGLMLFQQLSGiNAV--IFYASSIFDEAGSGLDPN-------TAT 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 355 IALA-----SCLAMCLVVKFLGRRgglLLFMILTAlaslLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAfSIVGMFASH 429
Cdd:cd17358   281 IIIGvvqvvGTLVATLLVDRLGRR---PLLLVSAI----GMGIGLLALGLYFYLQEHGALLSSVSWLPLV-GLVIYIISF 352

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720375891 430 AVGSLSVFFC--AEITPTVIR---CGGLGLVLASAGFGML-TAPIIELH-NQKGYFLhhiIFA 485
Cdd:cd17358   353 SIGLGPLPWVimSEIFPAKIKglaGSLVTLVNWLFAFIVTkTFPFLTLAwGASGTFW---IFA 412
Sugar_tr pfam00083
Sugar (and other) transporter;
118-485 1.50e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 57.28  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSKtWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTL---RFFEGFCLAGIILTLYALRIELCPPGKR 194
Cdd:pfam00083  58 GCFIGSLFAGK-LGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLR 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 195 -FIITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLT 267
Cdd:pfam00083 137 gALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 268 QKNCVSPEsdIKGVMPELEKelSRRPKKVCIVKVVGTRNLWKNIVVLCV----------NSLTGYGihhcfarSMMGHev 337
Cdd:pfam00083 216 GVPDVDRE--LDEIKDSLEA--GQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltgiNAIFYYS-------TTIFE-- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 338 KVPLLENFYADYYTMASIALASCLAMCLVVKFlGRRgGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGmsdsvkdkFS 417
Cdd:pfam00083 283 NLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRF-GRR-PLLLLGAAGMAICFVILGIVALLGVSKSDWAGI--------VA 352

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375891 418 IAFsIVGMFASHAVGSLSVFF--CAEITPTVIRCGGLGLVLAS---AGF--GMLTAPIIELHNQKGYFlhhIIFA 485
Cdd:pfam00083 353 IVF-IALFIAFFAMGWGPVPWviVSELFPLSVRSKAMALATAAnwlANFliGFLFPIITDAIGLGYTF---FIFA 423
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 125-444 2.27e-08

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 56.50  E-value: 2.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 125 VSSKTWSARVGRRPVLLFSTIFILIFGLTVALS---VNVTMFSTLRFFEGFClAGIILTLYALRI-ELCPPGKR----FI 196
Cdd:cd17357    67 FISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIA-CGLSTGFVPMYLqEISPSELRgalgSL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 197 ITMVASFVAMAGQFL-MPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFES-AKKLILYLTQKncvsp 274
Cdd:cd17357   146 TQIGVTLGILLGQVFgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEeAEKSLKFLRGI----- 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 275 ESDIKGVMPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGY--GIHHCFARSM-----MGHEVKVPLLENF 345
Cdd:cd17357   221 EDDVDQELEEIKKESEQmgDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQfsGINAIFFYSTfifenAGFSPQLAEWANL 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 346 YAdyyTMASIaLASCLAMCLVVKFlGRRGGLLLFMILTAlasllQLGLLNLIGKYSQHPDSGMSdsvkdKFSIAFSIV-G 424
Cdd:cd17357   301 GI---GIVNV-LSTIVGPFLIEKV-GRRPLLLISLSVCA-----VALLLMSVFLFLSEQNSWMS-----YGCIVAIFLfI 365

                         330       340
                  ....*....|....*....|
gi 1720375891 425 MFASHAVGSLSVFFCAEITP 444
Cdd:cd17357   366 FFFAIGLGPIPWFIGAELFP 385
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
130-248 1.07e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQ 209
Cdd:COG2814    68 LADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720375891 210 FLMPGLAALCRD---WQVLQALIICPFLLMLLY-WSIFPESLR 248
Cdd:COG2814   148 ALGPLLGGLLADlfgWRWVFLVNAVLALLALLLlLRLLPESRP 190
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 133-252 2.50e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.51  E-value: 2.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLM 212
Cdd:COG0477    75 RYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALG 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720375891 213 PGLAALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMA 252
Cdd:COG0477   155 PLLGGLLVAalgWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 133-373 4.04e-07

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 52.62  E-value: 4.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTL---RFFEGFClAGIILTLYALRI-ELCPPGKRFIITMV-ASFVAMA 207
Cdd:cd17432    76 RLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIivgRFLVGIN-AGISLNVVPMYLgESAPKNLRGAVGLVpAIFITLG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 208 ---GQFLmpGLAALC---RDWQVLQALIICPFLLMLLYWSIFPESLRW-LMATQQFESAKKLILYLTQKNCVSPEsdIKG 280
Cdd:cd17432   155 illGQVL--GLRELLgneEGWPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRGKEDVDDE--MEE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 281 VMPELEKELSRRPKKVCivKVVGTRNL-WKNIVVLCVNSltgyGIHHCFARSMmghevkvplleNFYADY-YTMASIALA 358
Cdd:cd17432   231 MLEEQRAEKGVGTVSVL--ELFRDRSVrWQLISIIVLMA----GQQLCGINAI-----------YFYADSiFLEAGIPED 293

                         250       260       270
                  ....*....|....*....|....*....|
gi 1720375891 359 ---------------SCLAMCLVVKFLGRR 373
Cdd:cd17432   294 kiqyvtvgtgacevlATITCVLVIERLGRR 323
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 133-211 4.88e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.83  E-value: 4.88e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720375891 133 RVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFL 211
Cdd:cd17316    62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALL 140
MFS_1 pfam07690
Major Facilitator Superfamily;
130-245 6.12e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 6.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQ 209
Cdd:pfam07690  55 LSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGA 134

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720375891 210 FLMPGLAALC---RDWQVLQALIICPFLLMLLYWSIFPE 245
Cdd:pfam07690 135 ALGPLLGGLLaslFGWRAAFLILAILSLLAAVLLLLPRP 173
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 118-243 7.18e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.43  E-value: 7.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSkTWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-FI 196
Cdd:cd17365    46 GMAIGALLAG-PLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRsLA 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720375891 197 ITMVASFV---AMAGQFLMPGLAALCrDWQVL------QALIICPFLL-MLLYWSIF 243
Cdd:cd17365   125 VTLMFCGYplgAALGGFLAAALIPAF-GWRSVfllggvPPLILLPLLRgTLLLWVTF 180
2_A_01_02 TIGR00880
Multidrug resistance protein;
127-246 1.79e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 47.64  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 127 SKTWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAM 206
Cdd:TIGR00880  18 SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIA 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720375891 207 AGQFLMPGLAALCRD---WQVLQALIICPFLL-MLLYWSIFPES 246
Cdd:TIGR00880  98 LGPLLGPPLGGVLAQflgWRAPFLFLAILALAaFILLAFLLPET 141
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 131-244 3.11e-06

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 49.39  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMA-GQ 209
Cdd:cd17376    59 SDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIFYAiGY 138

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720375891 210 FLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 244
Cdd:cd17376   139 MLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP 173
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 118-460 9.97e-06

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 48.10  E-value: 9.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSKTwSARVGRRPVLLFSTIFIL---IFGLTVALSVNVTMFSTLRFFEGFCLaGIILTLYALRI-ELCPPGK 193
Cdd:TIGR00879  83 GGFIGALFAGWL-SDRFGRKKSLLIIALLFVigaILMGLAAFALSVEMLIVGRVLLGIGV-GIASALVPMYLsEIAPKAL 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 194 RFIITMVASFVAMAGQFL------MPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKK-LILYL 266
Cdd:TIGR00879 161 RGALTSLYQLAITFGILVaygfgsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKsLARLR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 267 TQKNCVSPESDIK-GVMPELEKELSRRPKKVCIVKVVGTRNLWK--NIVVLCV-------NSLTGYGihhcfarSMMGHE 336
Cdd:TIGR00879 241 GTSGEDKELLDELeLIDIKRSIEKRSVQPSWGSLFSSTRRIRRRlfLGVVLQWfqqftgiNAIMYYS-------PTIFEN 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 337 VKVPLLENFYADYYTMASIALASCLAMCLVVKFlGRRGGLLL-FMILTAlasllqLGLLNLIGKYSQHPDSGMSDSVKDK 415
Cdd:TIGR00879 314 AGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRF-GRRPLLLIgAAGMAI------CLFVLGILGASFVTGSSKSSGNVAI 386

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1720375891 416 FSIAFSIvgmfASHAVGSLSVFFC--AEITPTVIRcgGLGLVLASAG 460
Cdd:TIGR00879 387 VFILLFI----AFFAMGWGPVPWVivSEIFPLSLR--PKGISIAVAA 427
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 130-469 2.65e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.65  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPP---GKRF-IITMVASFVA 205
Cdd:cd06174    54 LADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPErerGRALgLLQAFGSVGG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 206 MAGQFLMPGLA-ALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMAtqqfesakklilyltqkncvspesdikgvmpE 284
Cdd:cd06174   134 ILGPLLGGILAsSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-------------------------------A 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 285 LEKELSRRPKKVCIVKVVGTRNLWKnIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIALASCLAMC 364
Cdd:cd06174   183 KNEEASSKSVLKLLKRVLKNPGLWL-LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 365 LVVKFLGRRGGLLLFMILTALASLLQLGLlnligkysqhpdsgmsdSVKDKFSIAFSIVGMFAShAVGSLSVFFCAEITP 444
Cdd:cd06174   262 LSDRLIGRKPLLLIGLLLMALGLALLLLA-----------------PSLLLLLLLLLLLGFGLG-GLLPLSFALIAELFP 323

                         330       340
                  ....*....|....*....|....*
gi 1720375891 445 TVIRCGGLGLVLASAGFGMLTAPII 469
Cdd:cd06174   324 PEIRGTAFGLLNTFGFLGGAIGPLL 348
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 107-208 4.55e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 107 GTTTQIATATRGTTASALVSSKTWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRI 186
Cdd:cd17324    34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113

                          90       100
                  ....*....|....*....|...
gi 1720375891 187 ELCPPGKR-FIITMVASFVAMAG 208
Cdd:cd17324   114 DLVPPEKRgRAIGLVFSGLTLGL 136
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 131-245 6.26e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.25  E-value: 6.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR---FIITMVASFVAMA 207
Cdd:cd17474    58 ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERakaMGLYEAALGLGIA 137

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1720375891 208 GQFLMPGLAALCrDWQVLQALIICPFLLMLLYWSIFPE 245
Cdd:cd17474   138 VGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLP 174
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 108-256 7.74e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 44.95  E-value: 7.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 108 TTTQIATATRGTTASALVSS---KTWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFC--LAGIILTLY 182
Cdd:cd17360    33 STGWQELIVSSTVAGAAVGAaigGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgIASMTVPLY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 183 AlrIELCPPGKRFIITMVASFVAMAGQFLMPGLAA----LCRDWQVLQALIICPFLLMLLYWSIFPESLRW--------- 249
Cdd:cd17360   113 I--AEAAPPRIRGRLVTINVLFITGGQFVAYVINGafsyLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWpstrraliv 190

                         170
                  ....*....|
gi 1720375891 250 ---LMATQQF 256
Cdd:cd17360   191 gcgLQAFQQF 200
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 118-256 2.42e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 43.72  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSKTwSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLaGIILTLYALRI-ELCPPGKRFI 196
Cdd:cd17315    46 GAAIGSLFGGPL-ADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGV-GLASVLVPLYIsEIAPAKIRGA 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 197 ITMVASFVAMAGQFL--MPGLAALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMA-----TQQF 256
Cdd:cd17315   124 LGTLNQLMITFGILLayLLGLALSLSPpgwWRLMFALAAVPALLQLLLMFFLPESRALLVGvglqlLQQL 193
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 130-246 2.97e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.33  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQ 209
Cdd:cd17325    54 LSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGF 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1720375891 210 FLMPGLAALCRDWQVLQA----LIICPFLLMLLYWSIFPES 246
Cdd:cd17325   134 LIGPLLGGLLADALGYRApflvCAALALLALVLALLLLPEP 174
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 131-255 3.81e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.94  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFC--LAGIILTLYAlrIELCPPGKR---------FIIT- 198
Cdd:cd17359    60 ADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvgGASALVPMYI--AEVAPAEIRgrlvslnqlMIVFg 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 199 MVASFV---AMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYwsIFPESLRWLMATQQ 255
Cdd:cd17359   138 QLLAYIvnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGML--FIPESPRWLVSKGK 195
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 131-235 5.09e-04

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 42.43  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITM-VASFVAmAGQ 209
Cdd:cd17375    59 ADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMhVHAFFA-VGI 137

                          90       100
                  ....*....|....*....|....*....
gi 1720375891 210 FLMPGLAALCRDW---QVLQALIICPFLL 235
Cdd:cd17375   138 MVVALVGYLVRTWwiyQIILSLVTIPFIL 166
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 131-247 5.15e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.56  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-------FIITMVASF 203
Cdd:cd17320    58 SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELakifsllMMILAIAPA 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720375891 204 VA-MAGQFLMPGLaalcrDWQ---VLQALIIcpFLLMLLYWSIFPESL 247
Cdd:cd17320   138 LApLLGGLLLLFF-----GWRaifVFLALLG--LLLLLLVLLFLPETL 178
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 118-268 5.47e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 42.62  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 118 GTTASALVSSKTwSARVGRRPVLLFST-IFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-- 194
Cdd:cd17356    57 GSFFGALISSFL-SDRIGRKKSIQIGCvIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRgt 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 195 ------FIIT---MVASFVAMAGQFLMPGLAalcrdWQVLQALIICPFLLMLLYWSIFPESLRWL---------MATQQF 256
Cdd:cd17356   136 lvslyqLAITigiLVAYCINYGTHKLDGSAQ-----WRIPLGLQIVWGLLLLIGMFFLPESPRWLyrtilgimlQLFQQL 210

                         170
                  ....*....|..
gi 1720375891 257 ESAKKLILYLTQ 268
Cdd:cd17356   211 TGINYFFYYGTT 222
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
131-183 6.12e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 42.23  E-value: 6.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA 183
Cdd:PRK15402   72 SDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYA 124
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 107-254 9.75e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.52  E-value: 9.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 107 GTTTQIATATRGTTASALvssktwSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRI 186
Cdd:cd17371    40 GTVTLAGGAIGGILGGIL------ADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMA 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375891 187 ELCPPGKR-FIITMVASF------VAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQ 254
Cdd:cd17371   114 EYVPARHRgKALGYVQSGwavgwlLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARA 188
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 107-238 1.01e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 107 GTTTQIATATRGTTASALVS---SKTWSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA 183
Cdd:cd17489    28 GSEAVAGLVVGLFTLAALLArpfAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAAT 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375891 184 LRIELCPPGKRF-IITM--VASFVAMAgqfLMPGLAALCRDWQVLQALIICPFLLMLL 238
Cdd:cd17489   108 LVADIIPPSRRGeGIGYygLATTLAMA---LGPALGLFLYQHLGFAVLFIVAAVLALL 162
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
130-239 3.05e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.24  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQ 209
Cdd:COG2271    68 LADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720375891 210 FLMPGLAALC---RDWQVLQALIICPFLLMLLY 239
Cdd:COG2271   148 ALAPPLLGWLlaaFGWRAAFLILGLPGLLLALL 180
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 135-173 4.46e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.48  E-value: 4.46e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720375891 135 GRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFC 173
Cdd:cd17323    62 GRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 131-270 4.71e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 39.67  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 131 SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPP---GKRFIITMVASFVAMA 207
Cdd:TIGR00710  64 SDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGeelSRIYSILMPVLALAPA 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720375891 208 GQFLMPGLAALCRDWQ-VLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKN 270
Cdd:TIGR00710 144 VAPLLGGYILVWLSWHaIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKM 207
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
130-240 5.00e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-F---IITMVASFVA 205
Cdd:COG2223    63 LVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRgLalgLAAGGGNLGA 142

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720375891 206 MAGQFLMPGLAALcRDWQ-VLQALIICPFLLMLLYW 240
Cdd:COG2223   143 AVAAFLAPLLIAA-FGWRnAFLILGILLLVVAVLAW 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 130-238 5.59e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQ 209
Cdd:cd17325   258 LSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGM 337

                          90       100
                  ....*....|....*....|....*....
gi 1720375891 210 FLMPGLAALCRDWQVLQALIICPFLLMLL 238
Cdd:cd17325   338 VLGPLLGGFLYDAFGFATPFLAAAALLLL 366
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
130-248 6.53e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 6.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 130 WSARVGRR--PVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMA 207
Cdd:COG2271   239 LSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720375891 208 GQFLMPGLAALCRDWQ----VLQALIICPFLLMLLYWSIFPESLR 248
Cdd:COG2271   319 GGALGPLLVGYLLDATgyqaAFLLLAALALLAALLALLLLRETRK 363
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 108-250 6.68e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 39.03  E-value: 6.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375891 108 TTTQIATATRGTTASALVSSKTW---SARVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGI--ILTLY 182
Cdd:cd17441    32 PSWQVALLTSVVFIGMMLSSSLWgniSDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVpqSVTLY 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375891 183 ALRIELCPPGKRFIITMV-----ASFVAMAGQFLMPGLAalcrdWQVLQALIICPFLL--MLLYWsiFPESLRWL 250
Cdd:cd17441   112 AEFLPMKSRAKCILLIEVfwalgTVFEVLLAVFVMPTLG-----WRWLLILSALPLLIfaVLCFW--LPESARYW 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH