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Conserved domains on  [gi|1720375456|ref|XP_030103187|]
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galectin-8 isoform X3 [Mus musculus]

Protein Classification

galectin family protein( domain architecture ID 10658251)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-148 1.30e-47

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 155.83  E-value: 1.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456   24 EQLKPGSLIVIRGHVPKDSERFQVDFQLGnslkPRADVAFHFNPRFKRSsCIVCNTLTQEKWGWEEITYDMPFRKEKSFE 103
Cdd:smart00908   2 GGLSPGSSITIRGIVLPDAKRFSINLQCG----PNADIALHFNPRFDEG-TIVRNSKQNGKWGKEERSGGFPFQPGQPFE 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1720375456  104 IVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:smart00908  77 LEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 194-313 3.20e-44

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 147.35  E-value: 3.20e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  194 MGPGRTVVIKGEVNTNARSFNVDLVAGKTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNiTCFPFSSGMYFEMIIYCD 273
Cdd:smart00908   4 LSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFELEILVE 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720375456  274 VREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRLLDV 313
Cdd:smart00908  83 EDEFKVAVNGQHFLEFPHRLP-LESIDTLEISGDVQLTSV 121
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-148 1.30e-47

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 155.83  E-value: 1.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456   24 EQLKPGSLIVIRGHVPKDSERFQVDFQLGnslkPRADVAFHFNPRFKRSsCIVCNTLTQEKWGWEEITYDMPFRKEKSFE 103
Cdd:smart00908   2 GGLSPGSSITIRGIVLPDAKRFSINLQCG----PNADIALHFNPRFDEG-TIVRNSKQNGKWGKEERSGGFPFQPGQPFE 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1720375456  104 IVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:smart00908  77 LEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 17-148 4.07e-46

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 152.40  E-value: 4.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  17 PYVGTITEQLKPGSLIVIRGHVPKDSERFQVDFQLGNSlkpraDVAFHFNPRFKRSsCIVCNTLTQEKWGWEEITYDMPF 96
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-----DIALHFNPRFDEN-VIVRNSFLNGNWGPEERSGGFPF 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720375456  97 RKEKSFEIVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:cd00070    75 QPGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 194-313 3.20e-44

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 147.35  E-value: 3.20e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  194 MGPGRTVVIKGEVNTNARSFNVDLVAGKTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNiTCFPFSSGMYFEMIIYCD 273
Cdd:smart00908   4 LSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFELEILVE 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720375456  274 VREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRLLDV 313
Cdd:smart00908  83 EDEFKVAVNGQHFLEFPHRLP-LESIDTLEISGDVQLTSV 121
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-148 3.22e-44

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 147.40  E-value: 3.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  24 EQLKPGSLIVIRGHVPKDSERFQVDFQlgNSLKPRADVAFHFNPRFKRSScIVCNTLTQEKWGWEEITYDMPFRKEKSFE 103
Cdd:pfam00337   2 GGLQPGSSLTIKGIVLPDAQRFSINLQ--TGVGPSDDIALHFNPRFDENV-IVRNSRQNGQWGQEEREGGFPFQPGQPFE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720375456 104 IVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:pfam00337  79 LTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 185-310 1.87e-41

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 140.08  E-value: 1.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456 185 PFEARLNASMGPGRTVVIKGEVNTNARSFNVDLVAGKTrDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITcFPFSSGM 264
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-DIALHFNPRFDENVIVRNSFLNGNWGPEERSGG-FPFQPGQ 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720375456 265 YFEMIIYCDVREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRL 310
Cdd:cd00070    79 PFELTILVEEDKFQIFVNGQHFFSFPHRLP-LESIDYLSINGDVSL 123
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 194-313 3.01e-40

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 137.00  E-value: 3.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456 194 MGPGRTVVIKGEVNTNARSFNVDLVAG--KTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITcFPFSSGMYFEMIIY 271
Cdd:pfam00337   4 LQPGSSLTIKGIVLPDAQRFSINLQTGvgPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEREGG-FPFQPGQPFELTIL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720375456 272 CDVREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRLLDV 313
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLP-PEDIDALQVRGDVKLTSV 123
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-148 1.30e-47

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 155.83  E-value: 1.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456   24 EQLKPGSLIVIRGHVPKDSERFQVDFQLGnslkPRADVAFHFNPRFKRSsCIVCNTLTQEKWGWEEITYDMPFRKEKSFE 103
Cdd:smart00908   2 GGLSPGSSITIRGIVLPDAKRFSINLQCG----PNADIALHFNPRFDEG-TIVRNSKQNGKWGKEERSGGFPFQPGQPFE 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1720375456  104 IVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:smart00908  77 LEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 17-148 4.07e-46

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 152.40  E-value: 4.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  17 PYVGTITEQLKPGSLIVIRGHVPKDSERFQVDFQLGNSlkpraDVAFHFNPRFKRSsCIVCNTLTQEKWGWEEITYDMPF 96
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-----DIALHFNPRFDEN-VIVRNSFLNGNWGPEERSGGFPF 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720375456  97 RKEKSFEIVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:cd00070    75 QPGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 194-313 3.20e-44

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 147.35  E-value: 3.20e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  194 MGPGRTVVIKGEVNTNARSFNVDLVAGKTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNiTCFPFSSGMYFEMIIYCD 273
Cdd:smart00908   4 LSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFELEILVE 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720375456  274 VREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRLLDV 313
Cdd:smart00908  83 EDEFKVAVNGQHFLEFPHRLP-LESIDTLEISGDVQLTSV 121
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-148 3.22e-44

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 147.40  E-value: 3.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  24 EQLKPGSLIVIRGHVPKDSERFQVDFQlgNSLKPRADVAFHFNPRFKRSScIVCNTLTQEKWGWEEITYDMPFRKEKSFE 103
Cdd:pfam00337   2 GGLQPGSSLTIKGIVLPDAQRFSINLQ--TGVGPSDDIALHFNPRFDENV-IVRNSRQNGQWGQEEREGGFPFQPGQPFE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720375456 104 IVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSI 148
Cdd:pfam00337  79 LTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 185-310 1.87e-41

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 140.08  E-value: 1.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456 185 PFEARLNASMGPGRTVVIKGEVNTNARSFNVDLVAGKTrDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITcFPFSSGM 264
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-DIALHFNPRFDENVIVRNSFLNGNWGPEERSGG-FPFQPGQ 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720375456 265 YFEMIIYCDVREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRL 310
Cdd:cd00070    79 PFELTILVEEDKFQIFVNGQHFFSFPHRLP-LESIDYLSINGDVSL 123
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 194-313 3.01e-40

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 137.00  E-value: 3.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456 194 MGPGRTVVIKGEVNTNARSFNVDLVAG--KTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITcFPFSSGMYFEMIIY 271
Cdd:pfam00337   4 LQPGSSLTIKGIVLPDAQRFSINLQTGvgPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEREGG-FPFQPGQPFELTIL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720375456 272 CDVREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRLLDV 313
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLP-PEDIDALQVRGDVKLTSV 123
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 186-314 3.05e-40

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 136.97  E-value: 3.05e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456  186 FEARLNASMGPGRTVVIKGEVNTNARSFNVDLVAGKtRDIALHLNPRLNVKAFVRNSFLQDAWGEEERnITCFPFSSGMY 265
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGG-DDIALHFNPRFNENKIVCNSKLNGSWGSEER-EGGFPFQPGQP 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1720375456  266 FEMIIYCDVREFKVAINGVHSLEYKHRFKdLSSIDTLSVDGDIRLLDVR 314
Cdd:smart00276  79 FDLTIIVQPDHFQIFVNGVHITTFPHRLP-LESIDYLSINGDVQLTSVS 126
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 18-150 2.60e-39

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 134.66  E-value: 2.60e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375456   18 YVGTITEQLKPGSLIVIRGHVPKDSERFQVDFQLGNSlkpraDVAFHFNPRFKrSSCIVCNTLTQEKWGWEEITYDMPFR 97
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGD-----DIALHFNPRFN-ENKIVCNSKLNGSWGSEEREGGFPFQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720375456   98 KEKSFEIVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSIGF 150
Cdd:smart00276  75 PGQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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