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Conserved domains on  [gi|1720372711|ref|XP_030102698|]
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leucine-rich repeat-containing protein 74A isoform X3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 28-253 1.60e-39

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 146.09  E-value: 1.60e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  28 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLC 107
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLDLSNNQIGDEGVIALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 108 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 187
Cdd:COG5238   258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720372711 188 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 253
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 28-253 1.60e-39

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 146.09  E-value: 1.60e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  28 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLC 107
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLDLSNNQIGDEGVIALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 108 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 187
Cdd:COG5238   258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720372711 188 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 253
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-244 3.23e-33

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 126.32  E-value: 3.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   2 EESCVNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGiMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFL 81
Cdd:cd00116    54 KELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG-CGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  82 QENNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVA 161
Cdd:cd00116   133 KDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 162 LCNGLRSNVTLKKLDVSMNGFGNEGALALGDALR-LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSL 240
Cdd:cd00116   213 LAETLASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292


                  ....
gi 1720372711 241 EGAY 244
Cdd:cd00116   293 EGAQ 296
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 28-253 1.60e-39

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 146.09  E-value: 1.60e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  28 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLC 107
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLDLSNNQIGDEGVIALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 108 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 187
Cdd:COG5238   258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720372711 188 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 253
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 6-252 1.85e-38

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 143.39  E-value: 1.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   6 VNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQeNN 85
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK-NN 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  86 SSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNG 165
Cdd:COG5238   264 TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKA 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 166 LRSNVTLKKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNEcLQVLKLFLNPLSLEGAYS 245
Cdd:COG5238   344 LQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQR 422


                  ....*..
gi 1720372711 246 LIMAIKR 252
Cdd:COG5238   423 LEQLLER 429
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 16-254 1.58e-36

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 138.00  E-value: 1.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  16 MGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHE--NYYLQELNVSDNNLGLEGARIISNFLQENNSsLWKLKL 93
Cdd:COG5238   137 LPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKAlqNNSVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  94 SGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLK 173
Cdd:COG5238   216 KRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 174 KLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 253
Cdd:COG5238   296 SLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGN 375


                  .
gi 1720372711 254 P 254
Cdd:COG5238   376 T 376
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-244 3.23e-33

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 126.32  E-value: 3.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   2 EESCVNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGiMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFL 81
Cdd:cd00116    54 KELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG-CGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  82 QENNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVA 161
Cdd:cd00116   133 KDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 162 LCNGLRSNVTLKKLDVSMNGFGNEGALALGDALR-LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSL 240
Cdd:cd00116   213 LAETLASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292


                  ....
gi 1720372711 241 EGAY 244
Cdd:cd00116   293 EGAQ 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-255 1.15e-28

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 116.04  E-value: 1.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  67 NNLGLEGARIISNFLQenNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQS 146
Cdd:COG5238   163 ARLGLLAAISMAKALQ--NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 147 LNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNE 226
Cdd:COG5238   241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320

                         170       180
                  ....*....|....*....|....*....
gi 1720372711 227 CLQVLKLFLNPLSLEGAYSLIMAIKRNPK 255
Cdd:COG5238   321 TLHTLNLAYNGIGAQGAIALAKALQENTT 349
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 25-286 6.77e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 109.37  E-value: 6.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  25 LVSNTTVLKLElgDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLG--LEGARIISNFLQeNNSSLWKLKLSGNSFKEEC 102
Cdd:cd00116    21 KLLCLQVLRLE--GNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLT-KGCGLQELDLSDNALGPDG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 103 AALLcQALSSNYRIRSLNLSHNEFSDIGGEHLG---QMLALNvgLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSM 179
Cdd:cd00116    98 CGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAkglKDLPPA--LEKLVLGRNRLEGASCEALAKALRANRDLKELNLAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 180 NGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIkRNPKSRME 259
Cdd:cd00116   175 NGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL-LSPNISLL 253

                         250       260
                  ....*....|....*....|....*..
gi 1720372711 260 DIDISNVLVSEQFVKVLDGVCAIHPQL 286
Cdd:cd00116   254 TLSLSCNDITDDGAKDLAEVLAEKESL 280
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 8-199 2.30e-25

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 104.74  E-value: 2.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   8 LNHHGLGPMGTKAIAITLVSNTTVL-KLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnS 86
Cdd:cd00116   115 LNNNGLGDRGLRLLAKGLKDLPPALeKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKAN-C 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  87 SLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHL-GQMLALNVGLQSLNLSWNHFNIRGAVALCNG 165
Cdd:cd00116   194 NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTLSLSCNDITDDGAKDLAEV 273

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1720372711 166 LRSNVTLKKLDVSMNGFGNEGALALGDALRLNSC 199
Cdd:cd00116   274 LAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-150 1.70e-14

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 73.54  E-value: 1.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   6 VNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENN 85
Cdd:cd00116   170 LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPN 249

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720372711  86 SSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALN-VGLQSLNLS 150
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPgNELESLWVK 315
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 6-119 6.58e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 6.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   6 VNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENN 85
Cdd:COG5238   325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR 404

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720372711  86 ssLWKLKLSGNSFKEECAALLCQALSsnyRIRSL 119
Cdd:COG5238   405 --LHTLILDGNLIGAEAQQRLEQLLE---RIKSV 433
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-98 2.03e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711   6 VNLNHHGLGPMGTKAIAITLVS-NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQEN 84
Cdd:cd00116   226 LNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEP 305

                          90
                  ....*....|....
gi 1720372711  85 NSSLWKLKLSGNSF 98
Cdd:cd00116   306 GNELESLWVKDDSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 196-310 2.82e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 196 LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNPKSRMedIDISNVLVSEQFVKV 275
Cdd:COG5238   178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT--LDLSNNQIGDEGVIA 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720372711 276 LDGVCAIHPQLDVVY---------------KGLQGLSTKKSISLGTNPMR 310
Cdd:COG5238   256 LAEALKNNTTVETLYlsgnqigaegaialaKALQGNTTLTSLDLSVNRIG 305
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-239 3.46e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711  70 GLEGARIISNFLQENNSSLWKLKLSGNSFKEecaalLCQALSSNYRIRSLNLSHNEFSDIGGEhlgqmLALNVGLQSLNL 149
Cdd:COG4886    97 NLTELDLSGNEELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP-----LGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372711 150 SWNhfNIRGavaLCNGLRSNVTLKKLDVSMNGFGNegalaLGDALRLNSCLVYVDVSRNGITNegaskISKGLENNECLQ 229
Cdd:COG4886   167 SNN--QLTD---LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLE 231

                         170
                  ....*....|
gi 1720372711 230 VLKLFLNPLS 239
Cdd:COG4886   232 TLDLSNNQLT 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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