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Conserved domains on  [gi|1720396590|ref|XP_030102218|]
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eF-hand calcium-binding domain-containing protein 8 isoform X9 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 381-673 2.44e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 109.73  E-value: 2.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 381 HPNWCQQVKYIPQLNVVASCSAVEKsslvlIILPGKEPEKPRLSSLNLRKGILCFDYCPDRNFLATGGYDPHIRLWNpLV 460
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD-LE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 461 SKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFCGKlfplgNCPITSTYFYRSSTLICSTYN 540
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-----TDWVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 541 IGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKKRMEIPVSgiqESELTAMALDQS 619
Cdd:cd00200   156 DGTIKLWdLRTGKCVAT--LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH---ENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720396590 620 ERCLLTGLRDGTMQMWNYNTGECLMTFPNPDRvEISGIVHMN--KVFYTTGWSKRI 673
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-SVTSLAWSPdgKRLASGSADGTI 285
EF-hand_8 pfam13833
EF-hand domain pair;
126-178 9.34e-04

EF-hand domain pair;


:

Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 37.68  E-value: 9.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720396590 126 ENGALKKEGFIRIMK-GVLSSMSEEMLELLFLKVDSDCNGFVTWQKYVDYMMRE 178
Cdd:pfam13833   1 EKGVITREELKRALAlLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 381-673 2.44e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.73  E-value: 2.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 381 HPNWCQQVKYIPQLNVVASCSAVEKsslvlIILPGKEPEKPRLSSLNLRKGILCFDYCPDRNFLATGGYDPHIRLWNpLV 460
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD-LE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 461 SKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFCGKlfplgNCPITSTYFYRSSTLICSTYN 540
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-----TDWVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 541 IGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKKRMEIPVSgiqESELTAMALDQS 619
Cdd:cd00200   156 DGTIKLWdLRTGKCVAT--LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH---ENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720396590 620 ERCLLTGLRDGTMQMWNYNTGECLMTFPNPDRvEISGIVHMN--KVFYTTGWSKRI 673
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-SVTSLAWSPdgKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
439-650 2.85e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 2.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 439 PDRNFLATGGYDPHIRLWNpLVSKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFCGklfpl 518
Cdd:COG2319   130 PDGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 519 GNCPITSTYFYRSSTLICSTYNIGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKk 597
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWdLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE- 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720396590 598 rmEIPVSGIQESELTAMALDQSERCLLTGLRDGTMQMWNYNTGECLMTFPNPD 650
Cdd:COG2319   280 --LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 461-501 3.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.56e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720396590  461 SKKPVWLMKGHQTSVTHLLVNSrNASILISISRDKNIRVWD 501
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
EF-hand_8 pfam13833
EF-hand domain pair;
126-178 9.34e-04

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 37.68  E-value: 9.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720396590 126 ENGALKKEGFIRIMK-GVLSSMSEEMLELLFLKVDSDCNGFVTWQKYVDYMMRE 178
Cdd:pfam13833   1 EKGVITREELKRALAlLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
WD40 pfam00400
WD domain, G-beta repeat;
429-457 2.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.44e-03
                          10        20
                  ....*....|....*....|....*....
gi 1720396590 429 RKGILCFDYCPDRNFLATGGYDPHIRLWN 457
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 447-502 3.54e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 3.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720396590 447 GGYDPHIRLWNPlVSKKPVWLMKGHQTSVTHLLVNSRNASILISISRDKNIRVWDL 502
Cdd:PTZ00420   50 GGLIGAIRLENQ-MRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEI 104
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 381-673 2.44e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.73  E-value: 2.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 381 HPNWCQQVKYIPQLNVVASCSAVEKsslvlIILPGKEPEKPRLSSLNLRKGILCFDYCPDRNFLATGGYDPHIRLWNpLV 460
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD-LE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 461 SKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFCGKlfplgNCPITSTYFYRSSTLICSTYN 540
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-----TDWVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 541 IGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKKRMEIPVSgiqESELTAMALDQS 619
Cdd:cd00200   156 DGTIKLWdLRTGKCVAT--LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH---ENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720396590 620 ERCLLTGLRDGTMQMWNYNTGECLMTFPNPDRvEISGIVHMN--KVFYTTGWSKRI 673
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-SVTSLAWSPdgKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
439-650 2.85e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 2.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 439 PDRNFLATGGYDPHIRLWNpLVSKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFCGklfpl 518
Cdd:COG2319   130 PDGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 519 GNCPITSTYFYRSSTLICSTYNIGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKk 597
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWdLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE- 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720396590 598 rmEIPVSGIQESELTAMALDQSERCLLTGLRDGTMQMWNYNTGECLMTFPNPD 650
Cdd:COG2319   280 --LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330
WD40 COG2319
WD40 repeat [General function prediction only];
431-636 1.90e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 431 GILCFDYCPDRNFLATGGYDPHIRLWNpLVSKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQS 510
Cdd:COG2319   206 AVRSVAFSPDGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRT 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 511 FCGklfplGNCPITSTYFYRSSTLICSTYNIGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSV 589
Cdd:COG2319   284 LTG-----HSGGVNSVAFSPDGKLLASGSDDGTVRLWdLATGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1720396590 590 WDISTGKkrmEIPVSGIQESELTAMALDQSERCLLTGLRDGTMQMWN 636
Cdd:COG2319   357 WDLATGE---LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
439-646 2.83e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 2.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 439 PDRNFLATGGYDPHIRLWNpLVSKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFcgklfPL 518
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAF-SPDGKLLASGSADGTVRLWDLATGKLLRTL-----TG 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 519 GNCPITSTYFYRSSTLICSTYNIGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKk 597
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLWdLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK- 321

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1720396590 598 rmEIPVSGIQESELTAMALDQSERCLLTGLRDGTMQMWNYNTGECLMTF 646
Cdd:COG2319   322 --LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 303-591 5.17e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 5.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 303 DSCVMVMDYWTDCHKAVFCygdtkgNATIFISDnVAGGLFNPQILprASKWDHwfTVSLKKLlnEKAPLYRSFRMkglHP 382
Cdd:cd00200    30 DGTIKVWDLETGELLRTLK------GHTGPVRD-VAASADGTYLA--SGSSDK--TIRLWDL--ETGECVRTLTG---HT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 383 NWCQQVKYIPQLNVVASCSA--------VEKSSLVlIILPGKEpekprlsslnlrKGILCFDYCPDRNFLATGGYDPHIR 454
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRdktikvwdVETGKCL-TTLRGHT------------DWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 455 LWNpLVSKKPVWLMKGHQTSVTHLLVNSRNASILISiSRDKNIRVWDLQDYVCLQSFCGKlfplgNCPITSTYFYRSSTL 534
Cdd:cd00200   161 LWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGH-----ENGVNSVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720396590 535 ICSTYNIGILRGY-LESQGPLKTGRMttHNTPLCAVLYSKIFKQVVSGCLQGLVSVWD 591
Cdd:cd00200   234 LASGSEDGTIRVWdLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
439-650 1.14e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 439 PDRNFLATGGYDPHIRLWNpLVSKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQSFCGklfpl 518
Cdd:COG2319    88 PDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAF-SPDGKTLASGSADGTVRLWDLATGKLLRTLTG----- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 519 GNCPITSTYFyrS---STLICSTYNIGILRGYLESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTG 595
Cdd:COG2319   161 HSGAVTSVAF--SpdgKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720396590 596 KkrmEIPVSGIQESELTAMALDQSERCLLTGLRDGTMQMWNYNTGECLMTFPNPD 650
Cdd:COG2319   237 K---LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS 288
WD40 COG2319
WD40 repeat [General function prediction only];
431-594 2.84e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 2.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 431 GILCFDYCPDRNFLATGGYDPHIRLWNpLVSKKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWDLQDYVCLQS 510
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 511 FCGKlfplgNCPITSTYFYRSSTLICSTYNIGILRGY-LESQGPLKTgrMTTHNTPLCAVLYSKIFKQVVSGCLQGLVSV 589
Cdd:COG2319   326 LTGH-----TGAVRSVAFSPDGKTLASGSDDGTVRLWdLATGELLRT--LTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                  ....*
gi 1720396590 590 WDIST 594
Cdd:COG2319   399 WDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-647 2.09e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 2.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 469 KGHQTSVTHLLVNSRNaSILISISRDKNIRVWDLQDYVCLQSFCGklfplgncpitstyfyrsstlicstynigilrgyl 548
Cdd:cd00200     6 KGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKG----------------------------------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 549 esqgplktgrmttHNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKKRMEIpvSGiQESELTAMALDQSERCLLTGLR 628
Cdd:cd00200    50 -------------HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL--TG-HTSYVSSVAFSPDGRILSSSSR 113

                         170
                  ....*....|....*....
gi 1720396590 629 DGTMQMWNYNTGECLMTFP 647
Cdd:cd00200   114 DKTIKVWDVETGKCLTTLR 132
WD40 COG2319
WD40 repeat [General function prediction only];
482-647 1.38e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 482 SRNASILISISRDKNIRVWDLQDYVCLQSFCGKLFPLgncpITSTYFYRSSTLICSTYNIGILRGYLESQGPLKTGrmTT 561
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAV----ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL--LG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720396590 562 HNTPLCAVLYSKIFKQVVSGCLQGLVSVWDISTGKkrmEIPVSGIQESELTAMALDQSERCLLTGLRDGTMQMWNYNTGE 641
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153


                  ....*.
gi 1720396590 642 CLMTFP 647
Cdd:COG2319   154 LLRTLT 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 461-501 3.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.56e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720396590  461 SKKPVWLMKGHQTSVTHLLVNSrNASILISISRDKNIRVWD 501
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
EF-hand_8 pfam13833
EF-hand domain pair;
126-178 9.34e-04

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 37.68  E-value: 9.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720396590 126 ENGALKKEGFIRIMK-GVLSSMSEEMLELLFLKVDSDCNGFVTWQKYVDYMMRE 178
Cdd:pfam13833   1 EKGVITREELKRALAlLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 429-457 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.41e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720396590  429 RKGILCFDYCPDRNFLATGGYDPHIRLWN 457
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
429-457 2.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.44e-03
                          10        20
                  ....*....|....*....|....*....
gi 1720396590 429 RKGILCFDYCPDRNFLATGGYDPHIRLWN 457
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 447-502 3.54e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 3.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720396590 447 GGYDPHIRLWNPlVSKKPVWLMKGHQTSVTHLLVNSRNASILISISRDKNIRVWDL 502
Cdd:PTZ00420   50 GGLIGAIRLENQ-MRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEI 104
WD40 pfam00400
WD domain, G-beta repeat;
462-501 5.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720396590 462 KKPVWLMKGHQTSVTHLLVnSRNASILISISRDKNIRVWD 501
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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