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Conserved domains on  [gi|1720431806|ref|XP_030100265|]
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kelch-like protein 18 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 23-129 1.07e-73

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


:

Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 227.19  E-value: 1.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90       100
                  ....*....|....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRV 129
Cdd:cd18457    81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
209-450 1.68e-60

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 199.23  E-value: 1.68e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 209 WEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSK-RSAMGTVVLDGQIYVCGGYDGN 287
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 288 ----SSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRH 363
Cdd:COG3055    83 npssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 364 GAASLGS-KMFVCGGYDGSGFlsiaemyssvADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNlsSVEMYDPETD 442
Cdd:COG3055   163 AAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATN 230


                  ....*...
gi 1720431806 443 RWTFMAPM 450
Cdd:COG3055   231 TWTALGEL 238
Kelch smart00612
Kelch domain;
177-229 3.88e-11

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.95  E-value: 3.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720431806  177 LIYAVGGLNSaanfyaGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNG 229
Cdd:smart00612   1 KIYVVGGFDG------GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 3-29 9.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18234:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 47.36  E-value: 9.40e-07
                          10        20
                  ....*....|....*....|....*..
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCL 29
Cdd:cd18234    79 ACLLQLSEVVEACCGFLMKQLHPSNCL 105
 
Name Accession Description Interval E-value
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 23-129 1.07e-73

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 227.19  E-value: 1.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90       100
                  ....*....|....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRV 129
Cdd:cd18457    81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
209-450 1.68e-60

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 199.23  E-value: 1.68e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 209 WEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSK-RSAMGTVVLDGQIYVCGGYDGN 287
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 288 ----SSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRH 363
Cdd:COG3055    83 npssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 364 GAASLGS-KMFVCGGYDGSGFlsiaemyssvADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNlsSVEMYDPETD 442
Cdd:COG3055   163 AAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATN 230


                  ....*...
gi 1720431806 443 RWTFMAPM 450
Cdd:COG3055   231 TWTALGEL 238
PHA03098 PHA03098
kelch-like protein; Provisional
 3-445 4.98e-54

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 189.21  E-value: 4.98e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELN 82
Cdd:PHA03098   85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLN 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  83 VKSEEQVFEAALAWVRYDREQRGPCLPELLsnirlPLCRPQFLSdrvqqddlVRCCHKCRDLVDEAKDYHLMPERRPhLP 162
Cdd:PHA03098  165 VSSEDVVLEIIIKWLTSKKNNKYKDICLIL-----KVLRITFLS--------EEGIKKLKRWKLRIKKKKIVFNKRC-IK 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 163 AFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIaNRWEKCHPmTTARSRVGVAVVNGLLYAIGGYDGQ-L 241
Cdd:PHA03098  231 IIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPL-SEINTIID-IHYVYCFGSVVLNNVIYFIGGMNKNnL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 242 RLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVF 321
Cdd:PHA03098  309 SVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNV 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 322 EGRIYVSGG-HDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGY---DGSGFLSIAEMYSSVADQW 397
Cdd:PHA03098  389 NNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKW 468

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1720431806 398 CLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWT 445
Cdd:PHA03098  469 TELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 28-130 5.94e-47

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 157.71  E-value: 5.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  28 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPC 107
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1720431806 108 LPELLSNIRLPLCRPQFLSDRVQ 130
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 28-128 1.64e-40

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 140.55  E-value: 1.64e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806   28 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPC 107
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1720431806  108 LPELLSNIRLPLCRPQFLSDR 128
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
277-323 8.23e-17

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 73.75  E-value: 8.23e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720431806  277 QIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEG 323
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 218-263 1.94e-15

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 69.95  E-value: 1.94e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720431806 218 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMN 263
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PHA02790 PHA02790
Kelch-like protein; Provisional
 15-397 3.56e-11

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 65.06  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  15 CCTFLRERLHPKNCLgvrqfaETMMCAVLYDAAN------SFIHQHFVEVS--LSEEFLALPLEDVLElvsRDELNVKSE 86
Cdd:PHA02790  112 CINFILRDFRKEYCV------ECYMMGIEYGLSNllchtkDFIAKHFLELEddIIDNFDYLSMKLILE---SDELNVPDE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  87 EQVFEAALAWVRYDREQRGPCLpELLSNIrlplCRPQFLSDrvqqddlvRCCHKCRDLVDEAKDYHLMPE-RRPHLPAFR 165
Cdd:PHA02790  183 DYVVDFVIKWYMKRRNRLGNLL-LLIKNV----IRSNYLSP--------RGINNVKWILDCTKIFHCDKQpRKSYKYPFI 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 166 TRP----------RCCTS--IAGLIYAVGG-LNSAANFYAgDSLNVVevfdpiANRWEKCHPMTTARSRVGVAVVNGLLY 232
Cdd:PHA02790  250 EYPmnmdqiidifHMCTSthVGEVVYLIGGwMNNEIHNNA-IAVNYI------SNNWIPIPPMNSPRLYASGVPANNKLY 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 233 AIGGYDGQlrlSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSlnSVETYSPETDKWTVVTPMSSN 312
Cdd:PHA02790  323 VVGGLPNP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDT--TTEYLLPNHDQWQFGPSTYYP 397

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 313 RSAAGVTVFEGRIYVSGghdglqifSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 392
Cdd:PHA02790  398 HYKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNN 469


                  ....*
gi 1720431806 393 VADQW 397
Cdd:PHA02790  470 RTYSW 474
Kelch smart00612
Kelch domain;
177-229 3.88e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.95  E-value: 3.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720431806  177 LIYAVGGLNSaanfyaGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNG 229
Cdd:smart00612   1 KIYVVGGFDG------GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-29 9.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 47.36  E-value: 9.40e-07
                          10        20
                  ....*....|....*....|....*..
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCL 29
Cdd:cd18234    79 ACLLQLSEVVEACCGFLMKQLHPSNCL 105
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 165-216 1.55e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.91  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720431806 165 RTRPRCCTSIAGLIYAVGGLNSaanfyaGDSLNVVEVFDPIANRWEKCHPMT 216
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG------NQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 23-129 1.07e-73

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 227.19  E-value: 1.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90       100
                  ....*....|....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRV 129
Cdd:cd18457    81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
209-450 1.68e-60

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 199.23  E-value: 1.68e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 209 WEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSK-RSAMGTVVLDGQIYVCGGYDGN 287
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 288 ----SSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRH 363
Cdd:COG3055    83 npssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 364 GAASLGS-KMFVCGGYDGSGFlsiaemyssvADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNlsSVEMYDPETD 442
Cdd:COG3055   163 AAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATN 230


                  ....*...
gi 1720431806 443 RWTFMAPM 450
Cdd:COG3055   231 TWTALGEL 238
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
170-438 2.14e-58

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 193.45  E-value: 2.14e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 170 CCTSIAGLIYAVGGLNsaanfyAGDSLNVVEVFDPIANRWEKCHPM-TTARSRVGVAVVNGLLYAIGGYDGQLR----LS 244
Cdd:COG3055    17 AAALLDGKVYVAGGLS------GGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstpLN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 245 TVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNR-SAAGVTVFEG 323
Cdd:COG3055    91 DVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 324 RIYVSGGHDGlqifssvehyNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYdgSGFLSIAEMYSSVADQWCLIVPM 403
Cdd:COG3055   171 KILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWTALGEL 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720431806 404 HTRRSRVSLVASCGRLYAVGGYDGQ----SNLSSVEMYD 438
Cdd:COG3055   239 PTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 23-158 1.46e-56

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 183.75  E-value: 1.46e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERR 158
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
PHA03098 PHA03098
kelch-like protein; Provisional
 3-445 4.98e-54

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 189.21  E-value: 4.98e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELN 82
Cdd:PHA03098   85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLN 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  83 VKSEEQVFEAALAWVRYDREQRGPCLPELLsnirlPLCRPQFLSdrvqqddlVRCCHKCRDLVDEAKDYHLMPERRPhLP 162
Cdd:PHA03098  165 VSSEDVVLEIIIKWLTSKKNNKYKDICLIL-----KVLRITFLS--------EEGIKKLKRWKLRIKKKKIVFNKRC-IK 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 163 AFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIaNRWEKCHPmTTARSRVGVAVVNGLLYAIGGYDGQ-L 241
Cdd:PHA03098  231 IIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPL-SEINTIID-IHYVYCFGSVVLNNVIYFIGGMNKNnL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 242 RLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVF 321
Cdd:PHA03098  309 SVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNV 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 322 EGRIYVSGG-HDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGY---DGSGFLSIAEMYSSVADQW 397
Cdd:PHA03098  389 NNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKW 468

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1720431806 398 CLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWT 445
Cdd:PHA03098  469 TELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 23-136 3.00e-48

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 161.25  E-value: 3.00e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVR 136
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 28-130 5.94e-47

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 157.71  E-value: 5.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  28 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPC 107
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1720431806 108 LPELLSNIRLPLCRPQFLSDRVQ 130
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 22-127 2.18e-42

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 145.55  E-value: 2.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  22 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 101
Cdd:cd18444     1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                          90       100
                  ....*....|....*....|....*.
gi 1720431806 102 EQRGPCLPELLSNIRLPLCRPQFLSD 127
Cdd:cd18444    81 PERKKHLAKLLALIRLPLLTPQFLAD 106
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 23-152 7.75e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 142.51  E-value: 7.75e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYH 152
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 28-128 1.64e-40

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 140.55  E-value: 1.64e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806   28 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPC 107
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1720431806  108 LPELLSNIRLPLCRPQFLSDR 128
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 23-152 6.42e-40

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 140.17  E-value: 6.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYH 152
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 22-127 3.72e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 120.94  E-value: 3.72e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  22 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 101
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....*.
gi 1720431806 102 EQRGPCLPELLSNIRLPLCRPQFLSD 127
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 23-127 2.39e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 118.97  E-value: 2.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|....*
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSD 127
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLPPQLLAD 106
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 22-120 2.02e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 115.99  E-value: 2.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  22 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 101
Cdd:cd18459     1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                          90
                  ....*....|....*....
gi 1720431806 102 EQRGPCLPELLSNIRLPLC 120
Cdd:cd18459    81 QERRPHLPQVLQHVRLPLL 99
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 23-112 3.85e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 112.39  E-value: 3.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18458     2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81

                          90
                  ....*....|
gi 1720431806 103 QRGPCLPELL 112
Cdd:cd18458    82 NRRQYLEALL 91
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 22-127 6.31e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 112.32  E-value: 6.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  22 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 101
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|....*.
gi 1720431806 102 EQRGPCLPELLSNIRLPLCRPQFLSD 127
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLPPQLLAD 106
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 24-125 5.51e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 109.42  E-value: 5.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  24 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQ 103
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1720431806 104 RGPCLPELLSNIRLPLCRPQFL 125
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 22-118 8.44e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 108.93  E-value: 8.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  22 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 101
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 1720431806 102 EQRGPCLPELLSNIRLP 118
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 23-124 1.52e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 108.55  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90       100
                  ....*....|....*....|..
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQF 124
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 25-116 1.59e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 108.17  E-value: 1.59e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  25 PKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQR 104
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                          90
                  ....*....|..
gi 1720431806 105 GPCLPELLSNIR 116
Cdd:cd18455    82 KVHLKDLMSSCW 93
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 23-130 1.25e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 103.32  E-value: 1.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90       100
                  ....*....|....*....|....*...
gi 1720431806 103 QRGPCLPELLSNIRLPLCRPQFLSDRVQ 130
Cdd:cd18446    81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 23-119 3.26e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 101.95  E-value: 3.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPL 119
Cdd:cd18467    81 ERQKYLAQLLHCVRLPL 97
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 27-100 1.61e-24

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 96.32  E-value: 1.61e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 100
Cdd:cd18508     4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 27-119 2.55e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 96.66  E-value: 2.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 106
Cdd:cd18447     6 NCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQP 85

                          90
                  ....*....|...
gi 1720431806 107 CLPELLSNIRLPL 119
Cdd:cd18447    86 YMVDILAKVRFPL 98
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 23-100 3.95e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 95.37  E-value: 3.95e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEV-SLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 100
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 22-99 6.15e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 92.07  E-value: 6.15e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720431806  22 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRY 99
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 23-121 2.63e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 91.01  E-value: 2.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*....
gi 1720431806 103 QRGPCLPELLSNIRLPLCR 121
Cdd:cd18460    81 HRQHFWPELLQHVRLPFVR 99
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 25-125 3.10e-22

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 91.00  E-value: 3.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  25 PKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQR 104
Cdd:cd18466     3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                          90       100
                  ....*....|....*....|.
gi 1720431806 105 GPCLPELLSNIRLPLCRPQFL 125
Cdd:cd18466    83 KKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 23-119 5.33e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 90.29  E-value: 5.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPL 119
Cdd:cd18514    81 KRKDYLPELLRNVRLAL 97
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 23-122 2.20e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 88.63  E-value: 2.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18485     1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                          90       100
                  ....*....|....*....|
gi 1720431806 103 QRGPCLPELLSNIRLPLCRP 122
Cdd:cd18485    81 SRVQHLVELLKQVRLELVSP 100
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 21-119 2.59e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 88.66  E-value: 2.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  21 ERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 100
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                          90
                  ....*....|....*....
gi 1720431806 101 REQRGPCLPELLSNIRLPL 119
Cdd:cd18469    81 PQARAAHLPELLSLVHLSL 99
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 24-119 4.72e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 87.72  E-value: 4.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  24 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQ 103
Cdd:cd18515     1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                          90
                  ....*....|....*.
gi 1720431806 104 RGPCLPELLSNIRLPL 119
Cdd:cd18515    81 RHCYLSELLQTVRLAL 96
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 24-119 2.29e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 85.63  E-value: 2.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  24 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQ 103
Cdd:cd18464     1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                          90
                  ....*....|....*.
gi 1720431806 104 RGPCLPELLSNIRLPL 119
Cdd:cd18464    81 RHEVLPELLRSVRLAL 96
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 27-104 3.59e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 84.68  E-value: 3.59e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEdVLELV-SRDELNVKSEEQVFEAALAWVRYDREQR 104
Cdd:cd18480     5 NCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFE-VLEKIlEADELNVPDEEAVLKAVLRWTKHDLEAR 82
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 23-122 7.60e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 81.33  E-value: 7.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELnVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90       100
                  ....*....|....*....|
gi 1720431806 103 QRGPCLPELLSNIRLPLCRP 122
Cdd:cd18476    80 ARKGYIHDLFKKVRLQYVHP 99
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 23-119 1.28e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 80.66  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPL 119
Cdd:cd18477    81 NRQKALPTVFESIRFRL 97
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 23-119 1.09e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 78.27  E-value: 1.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....*..
gi 1720431806 103 QRGPCLPELLSNIRLPL 119
Cdd:cd18517    81 NRVKSLGEIFDCIRFRL 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
348-450 5.83e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.97  E-value: 5.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 348 ATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHT-RRSRVSLVASCGRLYAVGGYD 426
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFT 80

                          90       100
                  ....*....|....*....|....*...
gi 1720431806 427 GQSN----LSSVEMYDPETDRWTFMAPM 450
Cdd:COG3055    81 GANPsstpLNDVYVYDPATNTWTKLAPM 108
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 27-119 7.19e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 75.93  E-value: 7.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 106
Cdd:cd18462     5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                          90
                  ....*....|...
gi 1720431806 107 CLPELLSNIRLPL 119
Cdd:cd18462    85 CAYDLLSSIKLDL 97
Kelch smart00612
Kelch domain;
277-323 8.23e-17

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 73.75  E-value: 8.23e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720431806  277 QIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEG 323
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 23-97 1.62e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 73.96  E-value: 1.62e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWV 97
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 27-119 1.97e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 74.41  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 106
Cdd:cd18516     5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTK 84

                          90
                  ....*....|...
gi 1720431806 107 CLPELLSNIRLPL 119
Cdd:cd18516    85 ALPVLLESIRFRL 97
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 23-117 6.85e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 73.17  E-value: 6.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                          90
                  ....*....|....*
gi 1720431806 103 QRGPCLPELLSNIRL 117
Cdd:cd18479    81 SRSQYLSSVLSQIRI 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 218-263 1.94e-15

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 69.95  E-value: 1.94e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720431806 218 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMN 263
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 23-118 2.23e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 71.43  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*..
gi 1720431806 103 QRGPCLPELLSN-IRLP 118
Cdd:cd18483    81 KREMHLPEIFAKcIRMP 97
Kelch smart00612
Kelch domain;
230-276 2.27e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.89  E-value: 2.27e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720431806  230 LLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDG 276
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 23-114 2.68e-15

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 71.50  E-value: 2.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALP---LEDVLElvSRDELNVKSEEQVFEAALAWVRY 99
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPrlqIEVILE--SNQELESINERKLCQLVLEWVQR 78

                          90
                  ....*....|....*
gi 1720431806 100 DREQRGPCLPELLSN 114
Cdd:cd18502    79 SIEEGGLDLDDLTEK 93
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 24-78 3.79e-15

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 69.61  E-value: 3.79e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720431806  24 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSR 78
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-310 2.54e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 66.87  E-value: 2.54e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720431806 266 RSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMS 310
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 26-117 4.31e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 67.98  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  26 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDrEQRG 105
Cdd:cd18470     4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRV 82

                          90
                  ....*....|..
gi 1720431806 106 PCLPELLSNIRL 117
Cdd:cd18470    83 KYAADLLSNIRF 94
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 27-100 4.42e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 67.15  E-value: 4.42e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 100
Cdd:cd18474     5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 406-450 6.63e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 65.71  E-value: 6.63e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720431806 406 RRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPM 450
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
Kelch smart00612
Kelch domain;
418-459 1.87e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.50  E-value: 1.87e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720431806  418 RLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPMACHEGGVGV 459
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 26-119 2.69e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 65.70  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  26 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRg 105
Cdd:cd18465     4 ETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRR- 82

                          90
                  ....*....|....
gi 1720431806 106 PCLPELLSNIRLPL 119
Cdd:cd18465    83 ASASHVLCHIRFPL 96
Kelch smart00612
Kelch domain;
324-369 7.63e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.58  E-value: 7.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720431806  324 RIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHGAASLG 369
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 27-99 9.19e-12

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 60.44  E-value: 9.19e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRY 99
Cdd:cd18503     5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
PHA02790 PHA02790
Kelch-like protein; Provisional
 15-397 3.56e-11

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 65.06  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  15 CCTFLRERLHPKNCLgvrqfaETMMCAVLYDAAN------SFIHQHFVEVS--LSEEFLALPLEDVLElvsRDELNVKSE 86
Cdd:PHA02790  112 CINFILRDFRKEYCV------ECYMMGIEYGLSNllchtkDFIAKHFLELEddIIDNFDYLSMKLILE---SDELNVPDE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  87 EQVFEAALAWVRYDREQRGPCLpELLSNIrlplCRPQFLSDrvqqddlvRCCHKCRDLVDEAKDYHLMPE-RRPHLPAFR 165
Cdd:PHA02790  183 DYVVDFVIKWYMKRRNRLGNLL-LLIKNV----IRSNYLSP--------RGINNVKWILDCTKIFHCDKQpRKSYKYPFI 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 166 TRP----------RCCTS--IAGLIYAVGG-LNSAANFYAgDSLNVVevfdpiANRWEKCHPMTTARSRVGVAVVNGLLY 232
Cdd:PHA02790  250 EYPmnmdqiidifHMCTSthVGEVVYLIGGwMNNEIHNNA-IAVNYI------SNNWIPIPPMNSPRLYASGVPANNKLY 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 233 AIGGYDGQlrlSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSlnSVETYSPETDKWTVVTPMSSN 312
Cdd:PHA02790  323 VVGGLPNP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDT--TTEYLLPNHDQWQFGPSTYYP 397

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 313 RSAAGVTVFEGRIYVSGghdglqifSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 392
Cdd:PHA02790  398 HYKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNN 469


                  ....*
gi 1720431806 393 VADQW 397
Cdd:PHA02790  470 RTYSW 474
Kelch smart00612
Kelch domain;
177-229 3.88e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.95  E-value: 3.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720431806  177 LIYAVGGLNSaanfyaGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNG 229
Cdd:smart00612   1 KIYVVGGFDG------GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 313-356 2.37e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 55.70  E-value: 2.37e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720431806 313 RSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASM 356
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 27-116 2.45e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 57.13  E-value: 2.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRG 105
Cdd:cd18482     5 NCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELCeLSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKERA 84

                          90
                  ....*....|.
gi 1720431806 106 PCLPELLSNIR 116
Cdd:cd18482    85 ASAAEVLKCVR 95
PLN02193 PLN02193
nitrile-specifier protein
 159-330 2.70e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 62.28  E-value: 2.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 159 PHLPAFRTRprcCTSIAGLIYAVGGLNSAANFyagdslNVVEVFDPIANRWEKCHPMT---TARSRVGVAVVNGLLYAIG 235
Cdd:PLN02193  215 PHLSCLGVR---MVSIGSTLYVFGGRDASRQY------NGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFG 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 236 GYDGQLRLSTVEAYNPETDTW---TRVGSMNSKRSAMGTVVLDGQIYVCGGYDGnSSLNSVETYSPETDKWTVVTPMS-- 310
Cdd:PLN02193  286 GVSATARLKTLDSYNIVDKKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFGvr 364

                         170       180
                  ....*....|....*....|.
gi 1720431806 311 -SNRSAAGVTVFEGRIYVSGG 330
Cdd:PLN02193  365 pSERSVFASAAVGKHIVIFGG 385
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 27-119 2.71e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 57.46  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWvRYDREQRGP 106
Cdd:cd18461     5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83

                          90
                  ....*....|....*....
gi 1720431806 107 ---CL---PELLSNIRLPL 119
Cdd:cd18461    84 dqvSLqepPKLLEAVRFPL 102
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 27-118 8.15e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 55.51  E-value: 8.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDrEQRGP 106
Cdd:cd18449     5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                          90
                  ....*....|..
gi 1720431806 107 CLPELLSNIRLP 118
Cdd:cd18449    84 FAAKLMENIRFP 95
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 43-119 3.39e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 54.16  E-value: 3.39e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431806  43 LYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVkSEEQVFEAALAWVRYdREQRGPCLPELLSNIRLPL 119
Cdd:cd14822    21 LCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEH-NPDSKEDAKEILEAVRLPL 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 360-403 6.28e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 6.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720431806 360 RCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPM 403
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 23-104 7.88e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 52.66  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 102
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ..
gi 1720431806 103 QR 104
Cdd:cd18451    81 ER 82
PHA02713 PHA02713
hypothetical protein; Provisional
 225-344 1.26e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 57.33  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 225 AVVNGLLYAIGGYD-GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKW 303
Cdd:PHA02713  300 AIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKW 379

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1720431806 304 TVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYN 344
Cdd:PHA02713  380 KMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVHHMN 420
PHA02713 PHA02713
hypothetical protein; Provisional
 214-283 3.88e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 55.79  E-value: 3.88e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 214 PMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGG 283
Cdd:PHA02713  337 PMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
PHA02790 PHA02790
Kelch-like protein; Provisional
 278-444 1.07e-07

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 53.89  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 278 IYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGhdgLQIFSSVEHYNHHTATWHPAASML 357
Cdd:PHA02790  274 VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGG---LPNPTSVERWFHGDAAWVNMPSLL 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 358 NKRCRHGAASLGSKMFVCGGYDGSG-----------------------------------FL--SIAEMYSSVADQWCLI 400
Cdd:PHA02790  351 KPRCNPAVASINNVIYVIGGHSETDttteyllpnhdqwqfgpstyyphykscalvfgrrlFLvgRNAEFYCESSNTWTLI 430

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1720431806 401 VPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRW 444
Cdd:PHA02790  431 DDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
PRK14131 PRK14131
N-acetylneuraminate epimerase;
183-330 2.11e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 52.71  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 183 GLNSAA-NFYAGDsLNVVEvfdpiaNRWEKCHPMTT-ARSRVGVAVVNGLLYAIGGY-----DGQLRL-STVEAYNPETD 254
Cdd:PRK14131   44 GLGSAGtSWYKLD-LNAPS------KGWTKIAAFPGgPREQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 255 TWTRVGSmnskRSAMG-----TVVLDG-QIYVCGGY---------------DGNSSL-------------------NSVE 294
Cdd:PRK14131  117 SWQKLDT----RSPVGlaghvAVSLHNgKAYITGGVnknifdgyfedlaaaGKDKTPkdkindayfdkkpedyffnKEVL 192

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720431806 295 TYSPETDKWTV--VTPMSSNRSAAgVTVFEGRIYVSGG 330
Cdd:PRK14131  193 SYDPSTNQWKNagESPFLGTAGSA-VVIKGNKLWLING 229
Kelch smart00612
Kelch domain;
371-414 5.59e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 5.59e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720431806  371 KMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVA 414
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAV 44
PHA02713 PHA02713
hypothetical protein; Provisional
 249-377 6.27e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.93  E-value: 6.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 249 YNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYD-GNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYV 327
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYA 356

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720431806 328 SGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGG 377
Cdd:PHA02713  357 IGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-29 9.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 47.36  E-value: 9.40e-07
                          10        20
                  ....*....|....*....|....*..
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCL 29
Cdd:cd18234    79 ACLLQLSEVVEACCGFLMKQLHPSNCL 105
PLN02193 PLN02193
nitrile-specifier protein
 219-415 1.00e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.11  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 219 RSRVGVAVVNGLLYAIGG-------YDGQLRLstveaYNPETDTWTRVGSMNS--KRSAMGT--VVLDGQIYVCGGYDGN 287
Cdd:PLN02193  166 RCSHGIAQVGNKIYSFGGeftpnqpIDKHLYV-----FDLETRTWSISPATGDvpHLSCLGVrmVSIGSTLYVFGGRDAS 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 288 SSLNSVETYSPETDKWTVVTPMSSN---RSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAASMLNKRCRHG 364
Cdd:PLN02193  241 RQYNGFYSFDTTTNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRG 320

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720431806 365 AASL---GSKMFVCGGYDGSGFLSIaEMYSSVADQWCLIVPMHTRRSRVSLVAS 415
Cdd:PLN02193  321 GAGLevvQGKVWVVYGFNGCEVDDV-HYYDPVQDKWTQVETFGVRPSERSVFAS 373
Kelch_6 pfam13964
Kelch motif;
266-309 1.05e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.40  E-value: 1.05e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720431806 266 RSAMGTVVLDGQIYVCGGY-DGNSSLNSVETYSPETDKWTVVTPM 309
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 165-216 1.55e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.91  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720431806 165 RTRPRCCTSIAGLIYAVGGLNSaanfyaGDSLNVVEVFDPIANRWEKCHPMT 216
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG------NQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
218-266 2.24e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 44.63  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720431806 218 ARSRVGVAVVNGLLYAIGGYDGQL-RLSTVEAYNPETDTWTRVGSMNSKR 266
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 219-445 3.42e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.83  E-value: 3.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 219 RSRVGVAVVNGLLYAIGG-------YDGQLRLstveaYNPETDTWT---------RVGSMNSKRSAMGTvvldgQIYVCG 282
Cdd:PLN02153   23 RCSHGIAVVGDKLYSFGGelkpnehIDKDLYV-----FDFNTHTWSiapangdvpRISCLGVRMVAVGT-----KLYIFG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 283 GYDGNSSLNSVETYSPETDKWTVVTPMSSN-----RSAAGVTVFEGRIYVSGG--HDGLQI----FSSVEHYNHHTATW- 350
Cdd:PLN02153   93 GRDEKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvsKGGLMKtperFRTIEAYNIADGKWv 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 351 ---HPAASmLNKRCRHGAASLGSKMFVCGGYDGSgflsiaemyssvadqwclIVPMhtrrsrvslvascgrlyavGGYDG 427
Cdd:PLN02153  173 qlpDPGEN-FEKRGGAGFAVVQGKIWVVYGFATS------------------ILPG-------------------GKSDY 214

                         250
                  ....*....|....*...
gi 1720431806 428 QSNlsSVEMYDPETDRWT 445
Cdd:PLN02153  215 ESN--AVQFFDPASGKWT 230
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-32 3.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 46.19  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLGVR 32
Cdd:cd18336    97 ACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-22 4.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 45.73  E-value: 4.00e-06
                          10        20
                  ....*....|....*....|..
gi 1720431806   1 MGASFLQLQSIKDACCTFLRER 22
Cdd:cd18247    95 VGASFLQLQSVKDACCEFLKER 116
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 406-450 4.12e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 43.48  E-value: 4.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720431806 406 RRSRVSLVASCGRLYAVGGYDGQSNLSSVEM--YDPETDRWTFMAPM 450
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVlvYDPETNVWTEVPRL 47
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-309 7.27e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 43.09  E-value: 7.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720431806 266 RSAMGTVVLDGQIYVCGGYD--GNSSLNSVETYSPETDKWTVVTPM 309
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWTEVPRL 47
PLN02153 PLN02153
epithiospecifier protein
 178-318 1.07e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 47.29  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 178 IYAVGGLNSAANFyagdslNVVEVFDPIANRW-------EKCHPmtTARSRVGVAVVNGLLYAIGGYD-GQL-----RLS 244
Cdd:PLN02153   88 LYIFGGRDEKREF------SDFYSYDTVKNEWtfltkldEEGGP--EARTFHSMASDENHVYVFGGVSkGGLmktpeRFR 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 245 TVEAYNPETDTWTRV---GSMNSKRSAMGTVVLDGQIYVCGGYdGNSSL---------NSVETYSPETDKWTVVTPMSSN 312
Cdd:PLN02153  160 TIEAYNIADGKWVQLpdpGENFEKRGGAGFAVVQGKIWVVYGF-ATSILpggksdyesNAVQFFDPASGKWTEVETTGAK 238


                  ....*.
gi 1720431806 313 RSAAGV 318
Cdd:PLN02153  239 PSARSV 244
Kelch_3 pfam13415
Galactose oxidase, central domain;
228-267 1.43e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 1.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1720431806 228 NGLLYAIGGYD--GQLRLSTVEAYNPETDTWTRVGSMNSKRS 267
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRS 42
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-30 1.44e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 44.32  E-value: 1.44e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18256    98 ADMLQLTEVVEICCEFLKGQLHPSNCIG 125
Kelch_6 pfam13964
Kelch motif;
407-450 1.97e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.94  E-value: 1.97e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720431806 407 RSRVSLVASCGRLYAVGGYDGQSNLSS-VEMYDPETDRWTFMAPM 450
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPL 46
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-30 2.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 43.43  E-value: 2.40e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18238    93 ASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 60-133 2.56e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 43.08  E-value: 2.56e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720431806  60 LSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPCLPELLSNIRLPLCRPQFLSDRVQQDD 133
Cdd:cd18453    29 LVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVD 102
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 27-119 2.85e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 42.97  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  27 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEV--SLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD-REQ 103
Cdd:cd18471     5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELlkSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHNcRYQ 84

                          90
                  ....*....|....*.
gi 1720431806 104 RgpcLPELLSNIRLPL 119
Cdd:cd18471    85 Y---MDELLQYVRFGL 97
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-30 3.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 43.59  E-value: 3.01e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18249   101 ACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 26-105 3.41e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 42.18  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  26 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRdelNVKSEEQVFEAALAWVRYDREQRG 105
Cdd:cd18481     4 RNCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEERE 80
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-30 3.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 43.25  E-value: 3.89e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18237    99 ANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-32 5.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 43.13  E-value: 5.03e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLGVR 32
Cdd:cd18337   101 ACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 48-119 6.09e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 41.75  E-value: 6.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720431806  48 NSFIHQHFVEVSLSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPCLpELLSNIRLPL 119
Cdd:cd18475    26 DSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPERENEAY-QVLSNIHFPL 97
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-31 7.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 43.05  E-value: 7.17e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720431806   6 LQLQSIKDACCTFLRERLHPKNCLGV 31
Cdd:cd18267   122 LEFQDIRDACAEFLEKNLHPTNCLGM 147
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 219-262 8.65e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 40.01  E-value: 8.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720431806 219 RSRVGVAVVNGLLYAIGGYDGQLRLS--TVEAYNPETDTWTRVGSM 262
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSssDVLVYDPETNVWTEVPRL 47
Kelch_6 pfam13964
Kelch motif;
171-219 9.57e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 9.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431806 171 CTSIAGLIYAVGGLNsaanfYAGDSLNVVEVFDPIANRWEKCHPMTTAR 219
Cdd:pfam13964   7 VVSVGGYIYVFGGYT-----NASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 33-97 1.35e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 40.25  E-value: 1.35e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431806  33 QFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWV 97
Cdd:cd18493    10 QYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
Kelch_3 pfam13415
Galactose oxidase, central domain;
275-321 1.52e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 1.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431806 275 DGQIYVCGGYD--GNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVF 321
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
256-337 1.70e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.85  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 256 WTRVGSM-NSKRSAMGTVVLDGQIYVCGGYDGNSS------LNSVETYSPETDKWTVV---TPMSSNrSAAGVTVFEGRI 325
Cdd:PRK14131   64 WTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVYKYDPKTNSWQKLdtrSPVGLA-GHVAVSLHNGKA 142

                          90
                  ....*....|..
gi 1720431806 326 YVSGGHDgLQIF 337
Cdd:PRK14131  143 YITGGVN-KNIF 153
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 48-122 1.86e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 40.65  E-value: 1.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720431806  48 NSFIHQHFVEVSLSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDReQRGPCLPELLSNIRLPLCRP 122
Cdd:cd18454    28 DSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDR-RRWRHTDTIIQNIRFCLMTP 102
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-32 2.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 41.18  E-value: 2.16e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720431806   2 GASFLQLQSIKDACCTFLRERLHPKNCLGVR 32
Cdd:cd18335    96 AACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-25 2.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 40.87  E-value: 2.49e-04
                          10        20
                  ....*....|....*....|...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHP 25
Cdd:cd18235    99 ANLLQLTDVRDACCDFLQSQLHP 121
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 35-98 2.90e-04

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 39.42  E-value: 2.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431806  35 AETMMCAVLydaanSFIHQHFVEVSLSEEFLALPlEDVLELV-SRDELNVKsEEQVFEAALAWVR 98
Cdd:cd18507    21 TKTLVQKVL-----EFVDKHGTDVLNLPEFLLLP-EHVVRLIlSRDSLGAD-EMTKFQAALAWSR 78
Kelch_4 pfam13418
Galactose oxidase, central domain;
221-264 6.47e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 6.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431806 221 RVGVAVV---NGLLYAIGGY--DGQLrLSTVEAYNPETDTWTRVGSMNS 264
Cdd:pfam13418   2 RAYHTSTsipDDTIYLFGGEgeDGTL-LSDLWVFDLSTNEWTRLGSLPS 49
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-31 7.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 39.17  E-value: 7.91e-04
                          10        20
                  ....*....|....*....|....*....
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLGV 31
Cdd:cd18306    96 AKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-28 1.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 38.96  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNC 28
Cdd:cd18242    99 ACLLQLKGVKQACCEFLESQLDPSNC 124
PHA02713 PHA02713
hypothetical protein; Provisional
 343-450 1.23e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.15  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806 343 YNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGfLSIAEMYS-SVADQWCL-IVPMHTRRSRVSLVASCGRLY 420
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNN-PSLNKVYKiNIENKIHVeLPPMIKNRCRFSLAVIDDTIY 355

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720431806 421 AVGGYDGQSNLSSVEMYDPETDRWTFMAPM 450
Cdd:PHA02713  356 AIGGQNGTNVERTIECYTMGDDKWKMLPDM 385
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-30 1.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 38.45  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 1720431806   6 LQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18254   104 LQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-31 2.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 38.43  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|....*....
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLGV 31
Cdd:cd18274   101 ASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-25 3.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 37.74  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|....
gi 1720431806   2 GASFLQLQSIKDACCTFLRERLHP 25
Cdd:cd18338    98 AAGLLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-30 3.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 37.91  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|....*...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18236   102 ASLFQFLRMVDACASFLTEALHPENCVG 129
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 23-125 3.30e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 37.02  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431806  23 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSE----EFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVR 98
Cdd:cd18473     1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                          90       100
                  ....*....|....*....|....*..
gi 1720431806  99 YDrEQRGPCLPELLSNIRLPLCRPQFL 125
Cdd:cd18473    81 QD-ESRLAYANALLSRIRYGLVPVEEL 106
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 57-105 3.90e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 36.58  E-value: 3.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720431806  57 EVSL-SEEFLALPLEDVLELVSRDELNVKsEEQVFEAALAWVRYDREQRG 105
Cdd:cd18488    34 ELALkSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAECQRRG 82
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-30 5.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 37.06  E-value: 5.64e-03
                          10        20
                  ....*....|....*....|....*...
gi 1720431806   3 ASFLQLQSIKDACCTFLRERLHPKNCLG 30
Cdd:cd18265   101 SDLLQVSKLREACVRFLEGQLHPCNCLG 128
Kelch_4 pfam13418
Galactose oxidase, central domain;
267-309 9.64e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 9.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720431806 267 SAMGTVVLDGQIYVCGGYDGNSS-LNSVETYSPETDKWTVVTPM 309
Cdd:pfam13418   4 YHTSTSIPDDTIYLFGGEGEDGTlLSDLWVFDLSTNEWTRLGSL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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