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Conserved domains on  [gi|1720431611|ref|XP_030100222|]
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zinc finger protein 846 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-448 1.67e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611  80 KTYPCKICGKAFGRSSNLNRHLRSHTGEKPYEC--KECGKAFTTYSRLVEHFRTHTGEKPYKC-KDCGKAFAKRSGLITH 156
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 157 ISTHASEKPFACKECGKAFASSPRLSQHIRIHSGERPYICKECGRAFLTSSylrNHVGRTHSGERPYICGEcgkAFHSYS 236
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLHPPLPANSLSKD---PSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 237 NLRRHVRTHSGERPYICKECGKAFLNSSYLHNHIRKTHSGEMPhiCGECGKVFHASSYLRRHLRTHSGERPCICKECGKA 316
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP--LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 317 FL------NSSYLRKHLTIHTG-DKPYECKECGKAYRRYNLLHDHLKTHAVE----KPFECDV--CGKSFQYFSYLNKHI 383
Cdd:COG5048   264 SLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 384 RIHTGTKPYKCKY-------------------------------------CGKDFTTSSSRTEHIRTHTGERPYEC--SE 424
Cdd:COG5048   344 LLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                         410       420
                  ....*....|....*....|....
gi 1720431611 425 CEKTFTSSSNLIHHVKIHAREKPF 448
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPL 447
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-448 1.67e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611  80 KTYPCKICGKAFGRSSNLNRHLRSHTGEKPYEC--KECGKAFTTYSRLVEHFRTHTGEKPYKC-KDCGKAFAKRSGLITH 156
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 157 ISTHASEKPFACKECGKAFASSPRLSQHIRIHSGERPYICKECGRAFLTSSylrNHVGRTHSGERPYICGEcgkAFHSYS 236
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLHPPLPANSLSKD---PSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 237 NLRRHVRTHSGERPYICKECGKAFLNSSYLHNHIRKTHSGEMPhiCGECGKVFHASSYLRRHLRTHSGERPCICKECGKA 316
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP--LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 317 FL------NSSYLRKHLTIHTG-DKPYECKECGKAYRRYNLLHDHLKTHAVE----KPFECDV--CGKSFQYFSYLNKHI 383
Cdd:COG5048   264 SLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 384 RIHTGTKPYKCKY-------------------------------------CGKDFTTSSSRTEHIRTHTGERPYEC--SE 424
Cdd:COG5048   344 LLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                         410       420
                  ....*....|....*....|....
gi 1720431611 425 CEKTFTSSSNLIHHVKIHAREKPF 448
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-121 7.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720431611  96 NLNRHLRSHTGEKPYECKECGKAFTT 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 222-275 6.95e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 6.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720431611 222 PYICGECGKAFHSYSNLRRHVRThsGERPYICKECGKAFLNSSYLHNHIRKTHS 275
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKHN 124
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-448 1.67e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611  80 KTYPCKICGKAFGRSSNLNRHLRSHTGEKPYEC--KECGKAFTTYSRLVEHFRTHTGEKPYKC-KDCGKAFAKRSGLITH 156
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 157 ISTHASEKPFACKECGKAFASSPRLSQHIRIHSGERPYICKECGRAFLTSSylrNHVGRTHSGERPYICGEcgkAFHSYS 236
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLHPPLPANSLSKD---PSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 237 NLRRHVRTHSGERPYICKECGKAFLNSSYLHNHIRKTHSGEMPhiCGECGKVFHASSYLRRHLRTHSGERPCICKECGKA 316
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP--LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 317 FL------NSSYLRKHLTIHTG-DKPYECKECGKAYRRYNLLHDHLKTHAVE----KPFECDV--CGKSFQYFSYLNKHI 383
Cdd:COG5048   264 SLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 384 RIHTGTKPYKCKY-------------------------------------CGKDFTTSSSRTEHIRTHTGERPYEC--SE 424
Cdd:COG5048   344 LLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                         410       420
                  ....*....|....*....|....
gi 1720431611 425 CEKTFTSSSNLIHHVKIHAREKPF 448
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-121 7.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720431611  96 NLNRHLRSHTGEKPYECKECGKAFTT 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-196 1.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611  65 LTHSDHDVSAQVHTIKTYPCKICGKAFGRSSNLNRHLRS--HTGE--KPYECKE--CGKAFTTYSRLVEHFRTHTGEKPY 138
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 139 KCK-------------------------------------DCGKAFAKRSGLITHISTHASEKP--FACKECGKAFASSP 179
Cdd:COG5048   353 KEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432

                         170
                  ....*....|....*..
gi 1720431611 180 RLSQHIRIHSGERPYIC 196
Cdd:COG5048   433 NLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 6.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.93e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720431611 378 YLNKHIRIHTGTKPYKCKYCGKDFTT 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 222-275 6.95e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 6.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720431611 222 PYICGECGKAFHSYSNLRRHVRThsGERPYICKECGKAFLNSSYLHNHIRKTHS 275
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKHN 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-383 8.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 8.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611  95 SNLNRHLRSHTGEKPYECKECGKAFTTYSRLVEHFRTHTGEKPYKCKDCGKAFAKRSGLITHISTHASEKPFACKECGKA 174
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 175 FASSPRLSQHIRIHSGER-------PYICKECGRAFLTSSYLRNHV-GRTHSGE--RPYICGE--CGKAFHSYSNLRRHV 242
Cdd:COG5048   264 SLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 243 RTHSGERPYICKECgkaflnssylhnhirkTHSGEMPHICGECGKVFHASSYLRRHLRTHSGERPCICKecgkAFLNSSY 322
Cdd:COG5048   344 LLHTSISPAKEKLL----------------NSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIR----NFKRDSN 403

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720431611 323 LRKHLTIHTGDKPYECK--ECGKAYRRYNLLHDHLKTHAVEKPFECDVCGKSFQYFSYLNKHI 383
Cdd:COG5048   404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
124-149 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720431611 124 RLVEHFRTHTGEKPYKCKDCGKAFAK 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-260 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....
gi 1720431611 237 NLRRHVRTHSGERPYICKECGKAF 260
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-459 4.27e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720431611 389 TKPYKCKYCGKDFTTSSSRTEHIRTHTGERPYECS--ECEKTFTSSSNLIHHVKIHAREKPFVENIGKPTVDF 459
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS 103
PHA00733 PHA00733
hypothetical protein
 363-411 5.32e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431611 363 PFECDVCGKSFQYFSYLNKHIRIHTGTKpyKCKYCGKDFTTSSSRTEHI 411
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 6.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720431611 322 YLRKHLTIHTGDKPYECKECGKAYRR 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 332-415 7.54e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 7.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431611 332 GDKPYECK--ECGKAYR-----RYNLLHDHLKTHAVEKPFEcdvcgKSFQYFSYLNKhirihtgtkPYKCKYCGKDFTTS 404
Cdd:COG5189   346 DGKPYKCPveGCNKKYKnqnglKYHMLHGHQNQKLHENPSP-----EKMNIFSAKDK---------PYRCEVCDKRYKNL 411

                          90
                  ....*....|.
gi 1720431611 405 SSRTEHiRTHT 415
Cdd:COG5189   412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-431 8.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.48e-03
                          10        20
                  ....*....|....*....|...
gi 1720431611 409 EHIRTHTGERPYECSECEKTFTS 431
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 82-104 8.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.69e-03
                          10        20
                  ....*....|....*....|...
gi 1720431611  82 YPCKICGKAFGRSSNLNRHLRSH 104
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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