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Conserved domains on  [gi|1720430946|ref|XP_030100078|]
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leucine-rich repeat-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-453 3.73e-43

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 159.33  E-value: 3.73e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 153 IPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENlltylpDSLTQLRRL 232
Cdd:COG4886    42 LLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 233 EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVISqnlle 312
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS----- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 313 tipegigklkklsilkldQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPkEIGGCCS 392
Cdd:COG4886   191 ------------------NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720430946 393 LTMFCIRDNRLTRLPAEvSQAVELHVLDVAGNRlhhlplsLTTLKLKALWLSDNQSQPLLT 453
Cdd:COG4886   252 LEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQ-------LTDLKLKELELLLGLNSLLLL 304
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
4-158 2.61e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946   4 ARRPRVGSGarrrgrwEGTLATVAKARDAARVPAASSERSGrwSPCEARASLEPATSLERAAGGEQRGgRAERAPSPGLR 83
Cdd:PRK12323  362 AFRPGQSGG-------GAGPATAAAAPVAQPAPAAAAPAAA--APAPAAPPAAPAAAPAAAAAARAVA-AAPARRSPAPE 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720430946  84 GSAGHGSGGGGGDVPLHSPVAVQPSCGGHRQAPLLAGLRPRGDLPLCPQPGGA-AAGRQPAPGAPRDIPEIPESIA 158
Cdd:PRK12323  432 ALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAApAAAPAPADDDPPPWEELPPEFA 507
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-453 3.73e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 159.33  E-value: 3.73e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 153 IPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENlltylpDSLTQLRRL 232
Cdd:COG4886    42 LLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 233 EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVISqnlle 312
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS----- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 313 tipegigklkklsilkldQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPkEIGGCCS 392
Cdd:COG4886   191 ------------------NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720430946 393 LTMFCIRDNRLTRLPAEvSQAVELHVLDVAGNRlhhlplsLTTLKLKALWLSDNQSQPLLT 453
Cdd:COG4886   252 LEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQ-------LTDLKLKELELLLGLNSLLLL 304
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
173-407 1.66e-23

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 105.16  E-value: 1.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 173 LTRLPESFPElqNLTCLSVNDISLQSLPENIGNlyNLASLELRENLLTYLPDSLTQlrRLEELDLGNNEIYNLPESIGAL 252
Cdd:PRK15370  190 LTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSA 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 253 LHLKDLWLdgNQLSELPQEIGNlkNLLCLDVSENRLERLPEEISglTSLTYLVISQNLLETIPEGIgkLKKLSILKLDQN 332
Cdd:PRK15370  264 LQSLDLFH--NKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKTLEAGEN 335

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720430946 333 RLTQLPEAIGdcENLTELVLTENRLLTLPKSIGklKKLSNLNADRNKLVSLPKEIGGccSLTMFCIRDNRLTRLP 407
Cdd:PRK15370  336 ALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 184-382 1.03e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 184 QNLTCLSVNDISLQSLpENIGNLYNLASLELRENLLTYLpDSLTQLRRLEELDLGNNEIYNLpESIGALLHLKDLWLD-- 261
Cdd:cd21340    24 KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEnq 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 262 ----GNQLSELPQEIGNLKNLLC-LDVSENRLERLpEEISGLTSLTYLVISQNLLEtipegigklkklsilkldqnRLTQ 336
Cdd:cd21340   101 rlppGEKLTFDPRSLAALSNSLRvLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS--------------------DLEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720430946 337 LPEAIGDCENLTELVLTENRLLTLPK----SIGKLKKLSNLNadrNKLVS 382
Cdd:cd21340   160 LLDLLSSWPSLRELDLTGNPVCKKPKyrdkIILASKSLEVLD---GKEIT 206
LRR_8 pfam13855
Leucine rich repeat;
254-311 6.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 254 HLKDLWLDGNQLSELPQEI-GNLKNLLCLDVSENRLERL-PEEISGLTSLTYLVISQNLL 311
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
4-158 2.61e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946   4 ARRPRVGSGarrrgrwEGTLATVAKARDAARVPAASSERSGrwSPCEARASLEPATSLERAAGGEQRGgRAERAPSPGLR 83
Cdd:PRK12323  362 AFRPGQSGG-------GAGPATAAAAPVAQPAPAAAAPAAA--APAPAAPPAAPAAAPAAAAAARAVA-AAPARRSPAPE 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720430946  84 GSAGHGSGGGGGDVPLHSPVAVQPSCGGHRQAPLLAGLRPRGDLPLCPQPGGA-AAGRQPAPGAPRDIPEIPESIA 158
Cdd:PRK12323  432 ALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAApAAAPAPADDDPPPWEELPPEFA 507
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-453 3.73e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 159.33  E-value: 3.73e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 153 IPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENlltylpDSLTQLRRL 232
Cdd:COG4886    42 LLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 233 EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVISqnlle 312
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS----- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 313 tipegigklkklsilkldQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPkEIGGCCS 392
Cdd:COG4886   191 ------------------NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720430946 393 LTMFCIRDNRLTRLPAEvSQAVELHVLDVAGNRlhhlplsLTTLKLKALWLSDNQSQPLLT 453
Cdd:COG4886   252 LEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQ-------LTDLKLKELELLLGLNSLLLL 304
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
171-447 1.62e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 1.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 171 NPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIG 250
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 251 ALLHLKDLWLDGNQlselpqEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVISQNlletipegigklkklsilkld 330
Cdd:COG4886    94 DLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN--------------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 331 qnRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEV 410
Cdd:COG4886   147 --QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL 224

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1720430946 411 SQAVELHVLDVAGNRLHHLPlSLTTL-KLKALWLSDNQ 447
Cdd:COG4886   225 ANLTNLETLDLSNNQLTDLP-ELGNLtNLEELDLSNNQ 261
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
193-447 1.92e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.51  E-value: 1.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 193 DISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 272
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 273 GNLKNLLCLDVSENrlerlpEEISGLTSLTYLVISQNlletipegigklkklsilkldqnRLTQLPEAIGDCENLTELVL 352
Cdd:COG4886    93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGN-----------------------QLTDLPEELANLTNLKELDL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 353 TENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEVSQAVELHVLDVAGNRLHHLPLS 432
Cdd:COG4886   144 SNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                         250
                  ....*....|....*.
gi 1720430946 433 LTTLK-LKALWLSDNQ 447
Cdd:COG4886   224 LANLTnLETLDLSNNQ 239
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
173-407 1.66e-23

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 105.16  E-value: 1.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 173 LTRLPESFPElqNLTCLSVNDISLQSLPENIGNlyNLASLELRENLLTYLPDSLTQlrRLEELDLGNNEIYNLPESIGAL 252
Cdd:PRK15370  190 LTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSA 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 253 LHLKDLWLdgNQLSELPQEIGNlkNLLCLDVSENRLERLPEEISglTSLTYLVISQNLLETIPEGIgkLKKLSILKLDQN 332
Cdd:PRK15370  264 LQSLDLFH--NKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKTLEAGEN 335

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720430946 333 RLTQLPEAIGdcENLTELVLTENRLLTLPKSIGklKKLSNLNADRNKLVSLPKEIGGccSLTMFCIRDNRLTRLP 407
Cdd:PRK15370  336 ALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-426 4.47e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 98.00  E-value: 4.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 152 EIPESIAFCKALQVADFSGNPLT-RLPESFPELQNLTCLSVNDISLQ-SLPENIGNLYNLASLEL-RENLLTYLPDSLTQ 228
Cdd:PLN00113  155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGG 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 229 LRRLEELDL-GNNEIYNLPESIGALLHLKDLWLDGNQLS-ELPQEIGNLKNLLCLDVSENRLE-RLPEEISGLTSLTYL- 304
Cdd:PLN00113  235 LTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILh 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 305 VISQNLLETIPEGIGKLKKLSILKLDQNRLT-QLPEAIGDCENLTELVLTENRLL-TLPKSIGKLKKLSNLNADRNKLVS 382
Cdd:PLN00113  315 LFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEG 394

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1720430946 383 -LPKEIGGCCSLTMFCIRDNRLT-RLPAEVSQAVELHVLDVAGNRL 426
Cdd:PLN00113  395 eIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
150-318 1.02e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.06  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 150 IPEIPESIAfcKALQVADFSGNPLTRLPESFPElqNLTCLSVNDISLQSLPENIGNlyNLASLELRENLLTYLPDSLTQl 229
Cdd:PRK15370  253 ITELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLPP- 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 230 rRLEELDLGNNEIYNLPESIGAllHLKDLWLDGNQLSELPQEIGnlKNLLCLDVSENRLERLPEEISGltSLTYLVISQN 309
Cdd:PRK15370  326 -GLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQASRN 398


                  ....*....
gi 1720430946 310 LLETIPEGI 318
Cdd:PRK15370  399 NLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-443 8.45e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 8.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 152 EIPESIAFCKALQVADFSGNPLT-RLPE---SFPELQNLTCLSvNDISlQSLPENIGNLYNLASLELRENLLT-YLPDSL 226
Cdd:PLN00113  299 EIPELVIQLQNLEILHLFSNNFTgKIPValtSLPRLQVLQLWS-NKFS-GEIPKNLGKHNNLTVLDLSTNNLTgEIPEGL 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 227 TQLRRLEELDLGNNEIYN-LPESIGALLHLKDLWLDGNQLS-ELPQEIGNLKNLLCLDVSENRLE--------------- 289
Cdd:PLN00113  377 CSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqm 456

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 290 ----------RLPEEiSGLTSLTYLVISQNLL-ETIPEGIGKLKKLSILKLDQNRLT-QLPEAIGDCENLTELVLTENRL 357
Cdd:PLN00113  457 lslarnkffgGLPDS-FGSKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 358 L-TLPKSIGKLKKLSNLNADRNKLV-SLPKEIGGCCSLTMFCIRDNRL-TRLP------AEVSQAVELHVLDVAGNRLHH 428
Cdd:PLN00113  536 SgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPstgaflAINASAVAGNIDLCGGDTTSG 615

                         330
                  ....*....|....*
gi 1720430946 429 LPLSLTTLKLKALWL 443
Cdd:PLN00113  616 LPPCKRVRKTPSWWF 630
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
149-360 4.38e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 4.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 149 DIPEIPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEnIGNLYNLASLELRENLLTYLPDSLtQ 228
Cdd:COG4886   193 QITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLA-N 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 229 LRRLEELDLGNNEIYNLP-ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVIS 307
Cdd:COG4886   271 LTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720430946 308 QNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTL 360
Cdd:COG4886   351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
147-387 1.09e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.51  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 147 PRDIPE--------------IPESI-AFCKALQVADfsgNPLTRLPESFPELQNLTCLSVNDISlqSLPENIGNLynLAS 211
Cdd:PRK15370  194 PACIPEqittlildnnelksLPENLqGNIKTLYANS---NQLTSIPATLPDTIQEMELSINRIT--ELPERLPSA--LQS 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 212 LELRENLLTYLPDSLTQlrRLEELDLGNNEIYNLPESIGAllHLKDLWLDGNQLSELPQEIGnlKNLLCLDVSENRLERL 291
Cdd:PRK15370  267 LDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSL 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 292 PEEISglTSLTYLVISqnlletipegigklkklsilkldQNRLTQLPEAIGdcENLTELVLTENRLLTLPKSIGklKKLS 371
Cdd:PRK15370  341 PASLP--PELQVLDVS-----------------------KNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQ 391

                         250
                  ....*....|....*.
gi 1720430946 372 NLNADRNKLVSLPKEI 387
Cdd:PRK15370  392 IMQASRNNLVRLPESL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
173-454 3.00e-14

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 75.97  E-value: 3.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 173 LTRLPESFPelQNLTCLSVNDISLQSLPeniGNLYNLASLELRENLLTYLPdslTQLRRLEELDLGNNEIYNLPESIGAL 252
Cdd:PRK15387  213 LTTLPDCLP--AHITTLVIPDNNLTSLP---ALPPELRTLEVSGNQLTSLP---VLPPGLLELSIFSNPLTHLPALPSGL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 253 LhlkDLWLDGNQLSELPQEIGNLKNllcLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLD-- 330
Cdd:PRK15387  285 C---KLWIFGNQLTSLPVLPPGLQE---LSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASlp 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 331 ------------QNRLTQLPEAIgdcENLTELVLTENRLLTLPKSIGKLKKLSnlnADRNKLVSLPKEIGGCCSLTMFci 398
Cdd:PRK15387  359 tlpselyklwayNNRLTSLPALP---SGLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLSLSVY-- 430

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720430946 399 rDNRLTRLPAEVSQAVELHVLDVAGNrlhhlPLSLTTLK-LKALWLSDNQSQPLLTF 454
Cdd:PRK15387  431 -RNQLTRLPESLIHLSSETTVNLEGN-----PLSERTLQaLREITSAPGYSGPIIRF 481
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 184-382 1.03e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 184 QNLTCLSVNDISLQSLpENIGNLYNLASLELRENLLTYLpDSLTQLRRLEELDLGNNEIYNLpESIGALLHLKDLWLD-- 261
Cdd:cd21340    24 KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEnq 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 262 ----GNQLSELPQEIGNLKNLLC-LDVSENRLERLpEEISGLTSLTYLVISQNLLEtipegigklkklsilkldqnRLTQ 336
Cdd:cd21340   101 rlppGEKLTFDPRSLAALSNSLRvLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS--------------------DLEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720430946 337 LPEAIGDCENLTELVLTENRLLTLPK----SIGKLKKLSNLNadrNKLVS 382
Cdd:cd21340   160 LLDLLSSWPSLRELDLTGNPVCKKPKyrdkIILASKSLEVLD---GKEIT 206
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 224-407 2.43e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 224 DSLTQLRRLEELDLGNNEIYNLpESIGALLHLKDLWLDGNQLSELpQEIGNLKNLLCLDVSENRLERLpEEISGLTSLTY 303
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 304 LVIS-QNLletiPEGigklkklsilkldqNRLTQLPE---AIGDCenLTELVLTENRLLTLpKSIGKLKKLSNLNADRNK 379
Cdd:cd21340    95 LHIEnQRL----PPG--------------EKLTFDPRslaALSNS--LRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQ 153

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720430946 380 LVSLpKEI----GGCCSLTMFCIRDNRLTRLP 407
Cdd:cd21340   154 ISDL-EELldllSSWPSLRELDLTGNPVCKKP 184
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
170-357 3.21e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.71  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 170 GNPLTRLPESFPELQNltcLSVNDISLQSLPENIGNLYNLASLelrENLLTYLPdslTQLRRLEELDLGNNEIYNLPESI 249
Cdd:PRK15387  291 GNQLTSLPVLPPGLQE---LSVSDNQLASLPALPSELCKLWAY---NNQLTSLP---TLPSGLQELSVSDNQLASLPTLP 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 250 GALLhlkDLWLDGNQLSELPQEIGNLKNLLcldVSENRLERLPEEISgltSLTYLVISQNLLETIPEgigKLKKLSILKL 329
Cdd:PRK15387  362 SELY---KLWAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLPS---ELKELMVSGNRLTSLPM---LPSGLLSLSV 429

                         170       180
                  ....*....|....*....|....*...
gi 1720430946 330 DQNRLTQLPEAIGDCENLTELVLTENRL 357
Cdd:PRK15387  430 YRNQLTRLPESLIHLSSETTVNLEGNPL 457
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
343-438 1.23e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 343 DC--ENLTELVLTENRLLTLPKSIGKlkKLSNLNADRNKLVSLPKEIGGccSLTMFCIRDNRLTRLPAEVSQAVElhVLD 420
Cdd:PRK15370  174 DClkNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPDTIQ--EME 247

                          90       100
                  ....*....|....*....|..
gi 1720430946 421 VAGNRL----HHLPLSLTTLKL 438
Cdd:PRK15370  248 LSINRItelpERLPSALQSLDL 269
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 176-396 6.08e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 52.57  E-value: 6.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946  176 LPESFPEL-QNLTCLSVNDISLQSLPENIgNLYNLASLELRENLLTYLPD---SLTQLR--------------------R 231
Cdd:PLN03210   580 LPEGFDYLpPKLRLLRWDKYPLRCMPSNF-RPENLVKLQMQGSKLEKLWDgvhSLTGLRnidlrgsknlkeipdlsmatN 658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946  232 LEELDLGN-NEIYNLPESIGALLHLKDLWLDG-NQLSELPQEIgNLKNLLCLDVSE-NRLERLPeEISglTSLTYLVISQ 308
Cdd:PLN03210   659 LETLKLSDcSSLVELPSSIQYLNKLEDLDMSRcENLEILPTGI-NLKSLYRLNLSGcSRLKSFP-DIS--TNISWLDLDE 734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946  309 NLLETIPE----------GIGKLKKLSILKLDQNR---LTQLPEAigdcenLTELVLTEN-RLLTLPKSIGKLKKLSNLN 374
Cdd:PLN03210   735 TAIEEFPSnlrlenldelILCEMKSEKLWERVQPLtplMTMLSPS------LTRLFLSDIpSLVELPSSIQNLHKLEHLE 808

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1720430946  375 ADRNK-LVSLPKEIG----------GCCSLTMF 396
Cdd:PLN03210   809 IENCInLETLPTGINleslesldlsGCSRLRTF 841
LRR_8 pfam13855
Leucine rich repeat;
254-311 6.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 254 HLKDLWLDGNQLSELPQEI-GNLKNLLCLDVSENRLERL-PEEISGLTSLTYLVISQNLL 311
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 199-273 7.94e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.66  E-value: 7.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720430946 199 LPENIGNLYNLASLELRENLLT-YLPDSLTQLRRLEELDLGNNEIYNL-PESIGALLHLKDLWLDGNQLS-ELPQEIG 273
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSiPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 216-298 2.39e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 216 ENLLTYLPDSLTQLRRLEELDLGNNEIY-NLPESIGALLHLKDLWLDGNQLS-ELPQEIGNLKNLLCLDVSENRLE-RLP 292
Cdd:PLN03150  428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVP 507


                  ....*.
gi 1720430946 293 EEISGL 298
Cdd:PLN03150  508 AALGGR 513
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
4-158 2.61e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946   4 ARRPRVGSGarrrgrwEGTLATVAKARDAARVPAASSERSGrwSPCEARASLEPATSLERAAGGEQRGgRAERAPSPGLR 83
Cdd:PRK12323  362 AFRPGQSGG-------GAGPATAAAAPVAQPAPAAAAPAAA--APAPAAPPAAPAAAPAAAAAARAVA-AAPARRSPAPE 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720430946  84 GSAGHGSGGGGGDVPLHSPVAVQPSCGGHRQAPLLAGLRPRGDLPLCPQPGGA-AAGRQPAPGAPRDIPEIPESIA 158
Cdd:PRK12323  432 ALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAApAAAPAPADDDPPPWEELPPEFA 507
LRR_8 pfam13855
Leucine rich repeat;
184-242 2.80e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.80e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720430946 184 QNLTCLSVNDISLQSL-PENIGNLYNLASLELRENLLTYL-PDSLTQLRRLEELDLGNNEI 242
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 172-371 4.22e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 43.32  E-value: 4.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946  172 PLTRLPESFPelQNLTCLSVNDI-SLQSLPENIGNLYNLASLELRE--NLLTyLPDSLtQLRRLEELDL-GNNEIYNLPE 247
Cdd:PLN03210   768 PLTPLMTMLS--PSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENciNLET-LPTGI-NLESLESLDLsGCSRLRTFPD 843

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946  248 sIGAllHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSE-NRLERLPEEISGLTSLTYLVISQnlLETIPEGIGKLKKLSI 326
Cdd:PLN03210   844 -IST--NISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLETVDFSD--CGALTEASWNGSPSEV 918

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1720430946  327 LKLDQNRLTQLPEAIgdCENLTELVLTENRLLTLPKSIGKLKKLS 371
Cdd:PLN03210   919 AMATDNIHSKLPSTV--CINFINCFNLDQEALLQQQSIFKQLILS 961
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 148-286 1.52e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 148 RDIPEIPEsIAFCKALQVADFSGNPLTRLpESFPELQNLTCLSV--NDIS----LQSLP---------------ENIGNL 206
Cdd:cd21340    12 KNITKIDN-LSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLqnNQIEkienLENLVnlkklylggnrisvvEGLENL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946 207 YNLA-------------SLELRENLLTYLPDSLT----------------QLRRLEELDLGNNEIYNLPE---SIGALLH 254
Cdd:cd21340    90 TNLEelhienqrlppgeKLTFDPRSLAALSNSLRvlnisgnnidsleplaPLRNLEQLDASNNQISDLEElldLLSSWPS 169

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1720430946 255 LKDLWLDGNQLSELPQE----IGNLKNLLCLD---VSEN 286
Cdd:cd21340   170 LRELDLTGNPVCKKPKYrdkiILASKSLEVLDgkeITDT 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-158 1.75e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720430946    2 PSARRPRVGSGARRRGRWEgtlatvaKARDAARVPAASSERSgRWSPCEARASLEPATSLERAAGGEQRGGRAERAPSPG 81
Cdd:PHA03247  2647 PPPERPRDDPAPGRVSRPR-------RARRLGRAAQASSPPQ-RPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSA 2718

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720430946   82 LRGSAGHGSGGGGGDVPLHSPVAVQPSCGghrqAPLLAGLRPRGDLPLCPQPGGAAAGRQPAPGAPRDIPEIPESIA 158
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAAPAPPAVPAG----PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASL 2791
LRR_8 pfam13855
Leucine rich repeat;
332-380 2.06e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720430946 332 NRLTQL-PEAIGDCENLTELVLTENRLLTL-PKSIGKLKKLSNLNADRNKL 380
Cdd:pfam13855  11 NRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 268-342 5.32e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 5.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720430946 268 LPQEIGNLKNLLCLDVSENRLE-RLPEEISGLTSLTYLVISQNLLE-TIPEGIGKLKKLSILKLDQNRLT-QLPEAIG 342
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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