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Conserved domains on  [gi|1720357816|ref|XP_030099588|]
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uridine-cytidine kinase 2 isoform X4 [Mus musculus]

Protein Classification

uridine-cytidine kinase( domain architecture ID 10113977)

uridine kinase, or uridine cytidine kinase, catalyzes the ATP-dependent phosphorylation of uridine or cytidine to yield UMP or CMP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 35-176 2.26e-65

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


:

Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 198.93  E-value: 2.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQnevdyhqKQVVILSQDSFYRVLTSEQKAKALKgqFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:cd02023    10 SGKTTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:cd02023    81 VYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRR---IER 139
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 35-176 2.26e-65

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 198.93  E-value: 2.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQnevdyhqKQVVILSQDSFYRVLTSEQKAKALKgqFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:cd02023    10 SGKTTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:cd02023    81 VYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRR---IER 139
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 35-176 1.60e-47

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 153.78  E-value: 1.60e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNevdyhqkQVVILSQDSFYR---VLTSEQKAKalkgqFNFDHPDAFDNELIFKTLKEITEGKTV 111
Cdd:PRK05480   17 SGKTTVASTIYEELGDE-------SIAVIPQDSYYKdqsHLSFEERVK-----TNYDHPDAFDHDLLIEHLKALKAGKAI 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357816 112 QIPVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:PRK05480   85 EIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRR---LKR 146
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 35-176 1.09e-43

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 144.07  E-value: 1.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:TIGR00235  17 SGKTTVARKIYEQLGKLEI-------VIISQDNYYKDQ--SHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:TIGR00235  88 VYDYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRR---IER 146
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 35-176 3.19e-43

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 142.67  E-value: 3.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:COG0572    18 SGKTTFARRLAEQLGADKV-------VVISLDDYYKDR--EHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:COG0572    89 VYDFATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRR---IVR 147
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 35-170 6.35e-34

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 118.65  E-value: 6.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEVDYHQKQ-VVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQI 113
Cdd:pfam00485  10 SGKTTVARRIVSIFGREGVPAVGIEgDSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKELKEGGSVDK 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720357816 114 PVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRR 170
Cdd:pfam00485  90 PIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARK 146
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 35-176 2.26e-65

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 198.93  E-value: 2.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQnevdyhqKQVVILSQDSFYRVLTSEQKAKALKgqFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:cd02023    10 SGKTTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:cd02023    81 VYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRR---IER 139
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 35-176 1.60e-47

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 153.78  E-value: 1.60e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNevdyhqkQVVILSQDSFYR---VLTSEQKAKalkgqFNFDHPDAFDNELIFKTLKEITEGKTV 111
Cdd:PRK05480   17 SGKTTVASTIYEELGDE-------SIAVIPQDSYYKdqsHLSFEERVK-----TNYDHPDAFDHDLLIEHLKALKAGKAI 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357816 112 QIPVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:PRK05480   85 EIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRR---LKR 146
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 35-176 1.09e-43

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 144.07  E-value: 1.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:TIGR00235  17 SGKTTVARKIYEQLGKLEI-------VIISQDNYYKDQ--SHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:TIGR00235  88 VYDYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRR---IER 146
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 35-176 3.19e-43

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 142.67  E-value: 3.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIP 114
Cdd:COG0572    18 SGKTTFARRLAEQLGADKV-------VVISLDDYYKDR--EHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720357816 115 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRdkeIRR 176
Cdd:COG0572    89 VYDFATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRR---IVR 147
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 35-170 6.35e-34

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 118.65  E-value: 6.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEVDYHQKQ-VVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQI 113
Cdd:pfam00485  10 SGKTTVARRIVSIFGREGVPAVGIEgDSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKELKEGGSVDK 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720357816 114 PVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRR 170
Cdd:pfam00485  90 PIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARK 146
PTZ00301 PTZ00301
uridine kinase; Provisional
 86-172 4.65e-20

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 83.13  E-value: 4.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  86 NFDHPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADT 165
Cdd:PTZ00301   60 NYDHPKSLEHDLLTTHLRELKSGKTVQIPQYDYVHHTRSDTAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDI 139


                  ....*..
gi 1720357816 166 RLSRRDK 172
Cdd:PTZ00301  140 CLIRRAK 146
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 23-176 4.76e-14

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 66.56  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  23 SGPprSGAarpraGSSSVCAKIVQLLGQNEVdyhqkQVVILSQDSFYRVLTSEQKAkalkgQFNFDHPDAFDNELIFKTL 102
Cdd:cd02028     5 AGP--SGS-----GKTTFAKKLSNQLRVNGI-----GPVVISLDDYYVPRKTPRDE-----DGNYDFESILDLDLLNKNL 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357816 103 KEITEGKTVQIPVYDFVSHSRK-EETVTIYPADVVLFEGILAFySQEVRDLFQMKLFVdtDADTRLSRRDKEIRR 176
Cdd:cd02028    68 HDLLNGKEVELPIYDFRTGKRRgYRKLKLPPSGVVILEGIYAL-NERLRSLLDIRVAV--SGGVHLNRLLRRVVR 139
PLN02348 PLN02348
phosphoribulokinase
 89-175 7.06e-10

phosphoribulokinase


Pssm-ID: 215198  Cd Length: 395  Bit Score: 56.78  E-value: 7.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  89 HPDAFDNELIFKTLKEITEGKTVQIPVYDFVShSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLS 168
Cdd:PLN02348  120 DPRANNFDLMYEQVKALKEGKAVEKPIYNHVT-GLLDPPELIEPPKILVIEGLHPMYDERVRDLLDFSIYLDISDDVKFA 198

                          90
                  ....*....|
gi 1720357816 169 ---RRDKEIR 175
Cdd:PLN02348  199 wkiQRDMAER 208
PLN02318 PLN02318
phosphoribulokinase/uridine kinase
 86-159 4.11e-08

phosphoribulokinase/uridine kinase


Pssm-ID: 177952 [Multi-domain]  Cd Length: 656  Bit Score: 51.78  E-value: 4.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357816  86 NFDHPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHSR-KEETVTIYPADVVLFEGILAFySQEVRDLFQMKLFV 159
Cdd:PLN02318  110 NFDDPRLTDYDTLLDNIHDLKAGKSVQVPIYDFKSSSRvGYRTLEVPSSRIVIIEGIYAL-SEKLRPLLDLRVSV 183
PRK07429 PRK07429
phosphoribulokinase; Provisional
 35-166 5.07e-08

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 51.16  E-value: 5.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEV------DYHQkqvvilsqdsfyrvLTSEQKAK----ALkgqfnfdHPDAFDNELIFKTLKE 104
Cdd:PRK07429   19 CGKTTFLRGLADLLGEELVtvictdDYHS--------------YDRKQRKElgitAL-------DPRANNLDIMYEHLKA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720357816 105 ITEGKTVQIPVYDfvsHSRK--EETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTR 166
Cdd:PRK07429   78 LKTGQPILKPIYN---HETGtfDPPEYIEPNKIVVVEGLHPLYDERVRELYDFKVYLDPPEEVK 138
PRK cd02026
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ...
 35-171 5.09e-08

Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis.


Pssm-ID: 238984 [Multi-domain]  Cd Length: 273  Bit Score: 51.18  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  35 AGSSSVCAKIVQLLGQNEV------DYHqkqvvilsqdSFYRVLTSEQKAKALkgqfnfdHPDAFDNELIFKTLKEITEG 108
Cdd:cd02026    10 CGKSTFLRRLTSLFGSDLVtvicldDYH----------SLDRKGRKETGITAL-------DPRANNFDLMYEQLKALKEG 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720357816 109 KTVQIPVYDFVSHS-RKEEtvTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLS---RRD 171
Cdd:cd02026    73 QAIEKPIYNHVTGLiDPPE--LIKPTKIVVIEGLHPLYDERVRELLDFSVYLDISDEVKFAwkiQRD 137
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 61-170 4.11e-06

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 45.01  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  61 VILSQDSFYRvlTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPV--------YDFVSHSRKEETVTIYP 132
Cdd:cd02024    27 CVIHQDDFFK--PEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGHFPKFLrshgnendPEKEFIEDAQIEETKAD 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720357816 133 AD------VVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRR 170
Cdd:cd02024   105 LLgaedlhILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRR 148
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
 90-169 8.15e-05

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 41.81  E-value: 8.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357816  90 PDAFDNELIFKTLKEITEGK-TVQIPVYDFVSH-SRKEETVTIYPADVVLFEGI--L---AFYSQEVRDLFQMKLFVDTD 162
Cdd:COG1072   146 PESYDRRGLLRFLARVKSGDpEVRAPVYSHLLYdIVPGAIVVVDQPDILIVEGNnvLqdePNPWLFVSDFFDFSIYVDAD 225


                  ....*..
gi 1720357816 163 ADTRLSR 169
Cdd:COG1072   226 EEDLREW 232
PRK07667 PRK07667
uridine kinase; Provisional
 99-176 2.93e-03

uridine kinase; Provisional


Pssm-ID: 169051  Cd Length: 193  Bit Score: 37.02  E-value: 2.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720357816  99 FKTLKEITEgktVQIPVYDFVSHSRKEETVTIYPADVVLFEGILaFYSQEVRDLFQMKLFVDTDADTRLSRRDKEIRR 176
Cdd:PRK07667   89 FRKLQNETK---LTLPFYHDETDTCEMKKVQIPIVGVIVIEGVF-LQRKEWRDFFHYMVYLDCPRETRFLRESEETQK 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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