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Conserved domains on  [gi|1720423572|ref|XP_030098685|]
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zinc finger protein 109 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-54 1.95e-20

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.95  E-value: 1.95e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720423572    8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQVPNK 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKP 47
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-579 2.89e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 323 WSVLHAHQRIHTGEKPYKCGDCGRRFRFSSNLHIHQRVHTGEKPYKCHVCGKCFRFRFYSHQRVHTGEKPYK--CDECG- 399
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSssASESPr 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 400 -----KGFTSASNVKVHQRVHTG-VKPFCCNVCGKCFSRSFHLHTHQR--VHTGEKL--YKCDA--CGKAFSQRSSLQVH 467
Cdd:COG5048   263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRH 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 468 RLIHTGEKPYKC--EECGKGFTSASSFQGHQRVH-----TGEKPFHCDV--CGKDFSRSSYLQIHQRMHTGEKPYKCDS- 537
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720423572 538 -CGKAFSQRAHLQVHQRTHTGEKPFKCEECGKeFRQRSGLSSH 579
Cdd:COG5048   423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-439 4.25e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 194 NNTLHKGDKGQSNSDFDKLTFPVSPVTPHHVYTERKSYKCSKAQEAFIDRPTLELHQQ------DLVGKKSPVRSTYEVS 267
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSlsssdsSSSASESPRSSLPTAS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 268 RHSSIQKSVHAGTKRYW-----CHECGKAFSQSSALQTHRR--VHTGE--KPYRCDS--CGKAFTQWSVLHAHQRIHTGE 336
Cdd:COG5048   270 SQSSSPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 337 KPYKCGDCGRRFRFSSNLHI--HQRV--HTGEKPYKCHVC--GKCF-----RFRFYSHQRVHTGEKPY--KCDECGKGFT 403
Cdd:COG5048   350 SPAKEKLLNSSSKFSPLLNNepPQSLqqYKDLKNDKKSETlsNSCIrnfkrDSNLSLHIITHLSFRPYncKNPPCSKSFN 429

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720423572 404 SASNVKVHQRVHTGVKPFCCNVCGKcFSRSFHLHTH 439
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-54 1.95e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.95  E-value: 1.95e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720423572    8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQVPNK 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKP 47
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 2.36e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.36e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720423572   8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 6.65e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 6.65e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720423572   8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-579 2.89e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 323 WSVLHAHQRIHTGEKPYKCGDCGRRFRFSSNLHIHQRVHTGEKPYKCHVCGKCFRFRFYSHQRVHTGEKPYK--CDECG- 399
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSssASESPr 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 400 -----KGFTSASNVKVHQRVHTG-VKPFCCNVCGKCFSRSFHLHTHQR--VHTGEKL--YKCDA--CGKAFSQRSSLQVH 467
Cdd:COG5048   263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRH 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 468 RLIHTGEKPYKC--EECGKGFTSASSFQGHQRVH-----TGEKPFHCDV--CGKDFSRSSYLQIHQRMHTGEKPYKCDS- 537
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720423572 538 -CGKAFSQRAHLQVHQRTHTGEKPFKCEECGKeFRQRSGLSSH 579
Cdd:COG5048   423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 531-585 8.94e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 8.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720423572 531 KPYkCDSCGKAFSQRAHLQVHQRTHTgekpFKCEECGKEFRQRSGLSSH-QIVHKE 585
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKE 51
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-544 2.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 519 YLQIHQRMHTGEKPYKCDSCGKAFSQ 544
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-439 4.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 194 NNTLHKGDKGQSNSDFDKLTFPVSPVTPHHVYTERKSYKCSKAQEAFIDRPTLELHQQ------DLVGKKSPVRSTYEVS 267
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSlsssdsSSSASESPRSSLPTAS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 268 RHSSIQKSVHAGTKRYW-----CHECGKAFSQSSALQTHRR--VHTGE--KPYRCDS--CGKAFTQWSVLHAHQRIHTGE 336
Cdd:COG5048   270 SQSSSPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 337 KPYKCGDCGRRFRFSSNLHI--HQRV--HTGEKPYKCHVC--GKCF-----RFRFYSHQRVHTGEKPY--KCDECGKGFT 403
Cdd:COG5048   350 SPAKEKLLNSSSKFSPLLNNepPQSLqqYKDLKNDKKSETlsNSCIrnfkrDSNLSLHIITHLSFRPYncKNPPCSKSFN 429

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720423572 404 SASNVKVHQRVHTGVKPFCCNVCGKcFSRSFHLHTH 439
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 4.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 297 ALQTHRRVHTGEKPYRCDSCGKAFTQ 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-54 1.95e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.95  E-value: 1.95e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720423572    8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQVPNK 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKP 47
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 2.36e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.36e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720423572   8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 6.65e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 6.65e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720423572   8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-579 2.89e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 323 WSVLHAHQRIHTGEKPYKCGDCGRRFRFSSNLHIHQRVHTGEKPYKCHVCGKCFRFRFYSHQRVHTGEKPYK--CDECG- 399
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSssASESPr 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 400 -----KGFTSASNVKVHQRVHTG-VKPFCCNVCGKCFSRSFHLHTHQR--VHTGEKL--YKCDA--CGKAFSQRSSLQVH 467
Cdd:COG5048   263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRH 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 468 RLIHTGEKPYKC--EECGKGFTSASSFQGHQRVH-----TGEKPFHCDV--CGKDFSRSSYLQIHQRMHTGEKPYKCDS- 537
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720423572 538 -CGKAFSQRAHLQVHQRTHTGEKPFKCEECGKeFRQRSGLSSH 579
Cdd:COG5048   423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
285-640 1.52e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 285 CHECGKAFSQSSALQTHRRVHTGEKPYRC--DSCGKAFTQWSVLHAHQRIHTGEKPYKCGDCGRRFRF--SSNLHIHQRV 360
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 361 HTgEKPYKCHVCGKCFRFRFYSHQRVHTGEKPYKC------------------------DECGKGFTSASNVKVHQRVHT 416
Cdd:COG5048   116 NS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSNVST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 417 GVKPFCCNVCGKCFSRSFHLHTHQRVHTGEKLYKCDACGKAFSQRSSLQVHRLIHTGEKPYKCEECGKGFTSASSFQGHQ 496
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSS 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 497 RVHTGE-------KPFHCDVCGKDFSRSSYLQIHQRM--HTGE--KPYKCDS--CGKAFSQRAHLQVHQRTHTGEKPFKC 563
Cdd:COG5048   275 PNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 564 --EECGKEFRQ----RSGLSSHQIVHKEEKPYTCW---ECGKGFSQPSLFERHRRVHTGERP--YICGTCCKGFSQRSHL 632
Cdd:COG5048   355 klLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434


                  ....*...
gi 1720423572 633 VKHQRVHS 640
Cdd:COG5048   435 IPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
309-640 6.11e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 309 KPYRCDSCGKAFTQWSVLHAHQRIHTGEKPYKCGDCGRRFRFS--SNLHIHQRVHTGEKPYKChvcgkcfrfrfySHQRV 386
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLN------------SKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 387 HTGEKPYKC--DECGKGFTSASNVKVHQRVHTGVKPFCCNVCGKCFSRSFHLHTHQRVHTGEKlykcdacgKAFSQRSSL 464
Cdd:COG5048   100 LSNSKASSSslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP--------QSNSLHPPL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 465 QVHRLIHTGEKPYKCEECGKGFTSASSFQ-GHQRVHTGEKPFHCDVCGKDFSRSSYLQIHQrmhtgekpykcdSCGKAFS 543
Cdd:COG5048   172 PANSLSKDPSSNLSLLISSNVSTSIPSSSeNSPLSSSYSIPSSSSDQNLENSSSSLPLTTN------------SQLSPKS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 544 QRAHLQVHQRTHTgeKPFKCEECGKEFRQRSGLSSHQIVHKEE-------KPYTCWECGKGFSQPSLFERHRR--VHTGE 614
Cdd:COG5048   240 LLSQSPSSLSSSD--SSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350
                  ....*....|....*....|....*....|
gi 1720423572 615 --RPYICG--TCCKGFSQRSHLVKHQRVHS 640
Cdd:COG5048   318 slKPFSCPysLCGKLFSRNDALKRHILLHT 347
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 531-585 8.94e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 8.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720423572 531 KPYkCDSCGKAFSQRAHLQVHQRTHTgekpFKCEECGKEFRQRSGLSSH-QIVHKE 585
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKE 51
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-544 2.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 519 YLQIHQRMHTGEKPYKCDSCGKAFSQ 544
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 2.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 547 HLQVHQRTHTGEKPFKCEECGKEFRQ 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-439 4.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 194 NNTLHKGDKGQSNSDFDKLTFPVSPVTPHHVYTERKSYKCSKAQEAFIDRPTLELHQQ------DLVGKKSPVRSTYEVS 267
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSlsssdsSSSASESPRSSLPTAS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 268 RHSSIQKSVHAGTKRYW-----CHECGKAFSQSSALQTHRR--VHTGE--KPYRCDS--CGKAFTQWSVLHAHQRIHTGE 336
Cdd:COG5048   270 SQSSSPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 337 KPYKCGDCGRRFRFSSNLHI--HQRV--HTGEKPYKCHVC--GKCF-----RFRFYSHQRVHTGEKPY--KCDECGKGFT 403
Cdd:COG5048   350 SPAKEKLLNSSSKFSPLLNNepPQSLqqYKDLKNDKKSETlsNSCIrnfkrDSNLSLHIITHLSFRPYncKNPPCSKSFN 429

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720423572 404 SASNVKVHQRVHTGVKPFCCNVCGKcFSRSFHLHTH 439
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 4.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 297 ALQTHRRVHTGEKPYRCDSCGKAFTQ 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-488 2.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 463 SLQVHRLIHTGEKPYKCEECGKGFTS 488
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 468-556 2.69e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423572 468 RLIHTGEKPYKCE--ECGKGFTSASSFQ-----GHQRVHTGEKPfhcdvcgkdfSRSSylqiHQRMHTGEKPYKCDSCGK 540
Cdd:COG5189   341 MLKVKDGKPYKCPveGCNKKYKNQNGLKyhmlhGHQNQKLHENP----------SPEK----MNIFSAKDKPYRCEVCDK 406

                          90
                  ....*....|....*.
gi 1720423572 541 AFSQRAHLQVHqRTHT 556
Cdd:COG5189   407 RYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720423572 379 RFYSHQRVHTGEKPYKCDECGKGFTS 404
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 309-361 4.54e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 4.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720423572 309 KPYrCDSCGKAFTQWSVLHAHQRIHTgekpYKCGDCGRRFRFSSNLHIH-QRVH 361
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-516 5.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.63e-03
                          10        20
                  ....*....|....*....|..
gi 1720423572 495 HQRVHTGEKPFHCDVCGKDFSR 516
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 503-551 7.20e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720423572 503 KPFhCDVCGKDFSRSSYLQIHQRMHTgekpYKCDSCGKAFSQRAHLQVH 551
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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