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Conserved domains on  [gi|1720423546|ref|XP_030098675|]
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zinc finger protein 111 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
39-88 6.42e-20

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.42e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720423546   39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
377-672 2.75e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 377 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 453
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 454 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 511
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 512 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 591
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 592 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 658
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330
                  ....*....|....*.
gi 1720423546 659 YKC--DRCGKAFSQKS 672
Cdd:COG5048   352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-425 2.34e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 148 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 227
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 228 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 307
Cdd:COG5048   278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 308 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 377
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720423546 378 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 425
Cdd:COG5048   416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
674-696 4.68e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|...
gi 1720423546 674 LQVHKRIHTGEKPFKCEECGKEF 696
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
39-88 6.42e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.42e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720423546   39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-79 2.67e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.67e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720423546  39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 79
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 39-75 7.53e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 7.53e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720423546  39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 75
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
377-672 2.75e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 377 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 453
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 454 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 511
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 512 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 591
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 592 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 658
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330
                  ....*....|....*.
gi 1720423546 659 YKC--DRCGKAFSQKS 672
Cdd:COG5048   352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-425 2.34e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 148 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 227
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 228 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 307
Cdd:COG5048   278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 308 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 377
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720423546 378 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 425
Cdd:COG5048   416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
645-670 2.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423546 645 HLQSHQRVHTGEKPYKCDRCGKAFSQ 670
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
674-696 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|...
gi 1720423546 674 LQVHKRIHTGEKPFKCEECGKEF 696
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 629-677 4.99e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720423546 629 KPFqCNECQKRFSQVSHLQSHQRvhtgEKPYKCDRCGKAFSQKSGLQVH 677
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-335 6.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.47e-04
                          10        20
                  ....*....|....*....|....*
gi 1720423546 311 LQAHKRIHTGEKPYKCGDCGKRFSC 335
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 655-707 8.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720423546 655 GEKPYKCD--RCGKAFSQKSGLQVHKR-------------------IHTGEKPFKCEECGKEFIWSSGLSAHRK 707
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
39-88 6.42e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.42e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720423546   39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-79 2.67e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.67e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720423546  39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 79
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 39-75 7.53e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 7.53e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720423546  39 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 75
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
377-672 2.75e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 377 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 453
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 454 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 511
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 512 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 591
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 592 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 658
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330
                  ....*....|....*.
gi 1720423546 659 YKC--DRCGKAFSQKS 672
Cdd:COG5048   352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
240-649 6.15e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 6.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 240 YRCQECGKAFRQSSALQTHQRVHTGEKPY--RGNSRGKNFSRSSDLNIHRQVHTREKPYTCKvckkrfmQCSLLQAHKRI 317
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 318 HTGEKPYKCGDCGKRFSCISNFHIHQRVHTKSKP-SKCDYGKPFNLRCN------------------------------F 366
Cdd:COG5048   107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLlSISNLRNNPLPGNNsssvntpqsnslhpplpanslskdpssnlsL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 367 HSHQRVHTGEKPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQ 446
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 447 LSHLQAHERIHTD-------QKPYKCGDCGKRFSCSSNLHTHQR--VHTGE--KPYKCEE--CGKGFSLVSGLQAHQRVE 513
Cdd:COG5048   267 TASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 514 TGKKPFKCNACQkrfsqawnlhaHQRVHTGEKPYKcdtcgkafgqRSGLQIHQRIHTGEKPFKCE--ECGKEFSLNSGLI 591
Cdd:COG5048   347 TSISPAKEKLLN-----------SSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 592 AHRRVHTGEKPYECKD--CGKGFSLASSLRTHQRVHTGEKPFQCNeCQKRFSQVSHLQSH 649
Cdd:COG5048   406 LHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
432-715 3.56e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 432 DKPYQCDSCGKGFTQLSHLQAHERIHTDQKPYKCGD--CGKRFSCSSNLHTHQRVHTGEKPYKCE--------------- 494
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 495 -ECGKGFSLVSGLQAHQRVETGKKPFKCNACQKRFSQ-----------------AWNLHAHQRVHTGEKPYKCDTCG--- 553
Cdd:COG5048   111 sSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRnnplpgnnsssvntpqsNSLHPPLPANSLSKDPSSNLSLLiss 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 554 -KAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSlNSGLIAHRRVHTGEKPYECkdcgkgfSLASSLRTHQRVHTGEKPFQ 632
Cdd:COG5048   191 nVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLS-------QSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 633 CNECQKRFSQVSHLQSHQRVHTG-EKPYKCDRCGKAFSQKSGLQVHKR--IHTGE--KPFKCEE--CGKEFIWSSGLSAH 705
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330
                  ....*....|
gi 1720423546 706 RKVHTGEKPY 715
Cdd:COG5048   343 ILLHTSISPA 352
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-425 2.34e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 148 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 227
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 228 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 307
Cdd:COG5048   278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 308 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 377
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720423546 378 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 425
Cdd:COG5048   416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
645-670 2.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423546 645 HLQSHQRVHTGEKPYKCDRCGKAFSQ 670
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
674-696 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|...
gi 1720423546 674 LQVHKRIHTGEKPFKCEECGKEF 696
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 629-677 4.99e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720423546 629 KPFqCNECQKRFSQVSHLQSHQRvhtgEKPYKCDRCGKAFSQKSGLQVH 677
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 601-653 5.95e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720423546 601 KPYeCKDCGKGFSLASSLRTHQRvhtgEKPFQCNECQKRFSQVSHLQSH-QRVH 653
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-335 6.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.47e-04
                          10        20
                  ....*....|....*....|....*
gi 1720423546 311 LQAHKRIHTGEKPYKCGDCGKRFSC 335
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
617-642 6.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720423546 617 SLRTHQRVHTGEKPFQCNECQKRFSQ 642
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-585 7.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.72e-04
                          10        20
                  ....*....|....*....|....
gi 1720423546 562 LQIHQRIHTGEKPFKCEECGKEFS 585
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 655-707 8.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720423546 655 GEKPYKCD--RCGKAFSQKSGLQVHKR-------------------IHTGEKPFKCEECGKEFIWSSGLSAHRK 707
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 543-594 9.23e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720423546 543 GEKPYKCDT--CGKAFGQRSGLQIH-------------------QRIHTGEKPFKCEECGKEFSLNSGLIAHR 594
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmlhghqnqklhenpspekmNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 487-565 1.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 487 GEKPYKCE--ECGKGFSLVSGLQAHQrvetgkkpfKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQI 564
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720423546 565 H 565
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 375-459 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 375 GEKPYKCE--ECGKGFTSASSFQRHqRVHtgekpfvcSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQLSHLQA 452
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 1720423546 453 HERIHTD 459
Cdd:COG5189   417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-418 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720423546 393 SFQRHQRVHTGEKPFVCSVCGKGFSR 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 545-597 1.97e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720423546 545 KPYkCDTCGKAFGQRSGLQIHQRIHTgekpFKCEECGKEFSLNSGLIAH-RRVH 597
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-446 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720423546 421 YLQTHQRVHSGDKPYQCDSCGKGFTQ 446
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 592-678 2.82e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 592 AHRRVHTGEKPYECK--DCGKGFSLASSLRTHqRVHtgekpfqcNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFS 669
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                  ....*....
gi 1720423546 670 QKSGLQVHK 678
Cdd:COG5189   410 NLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 431-509 3.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 431 GDKPYQCD--SCGKGFTQLSHLQAHeRIHtdqkpykcGDCGKRFSCSSNLHTHQRVHTGEKPYKCEECGKGFSLVSGLQA 508
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720423546 509 H 509
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-390 3.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|...
gi 1720423546 368 SHQRVHTGEKPYKCEECGKGFTS 390
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-474 3.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720423546 449 HLQAHERIHTDQKPYKCGDCGKRFSC 474
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 379-401 5.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.86e-03
                          10        20
                  ....*....|....*....|...
gi 1720423546 379 YKCEECGKGFTSASSFQRHQRVH 401
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-556 5.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.89e-03
                          10        20
                  ....*....|....*....|
gi 1720423546 537 HQRVHTGEKPYKCDTCGKAF 556
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 240-262 6.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|...
gi 1720423546 240 YRCQECGKAFRQSSALQTHQRVH 262
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
459-710 6.37e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 459 DQKPYKCGDCGKRFSCSSNLHTHQRVHTGEKPYKC--EECGKGFSLVSGLQAHQRVETGKKPFKCNAC-----QKRFSQA 531
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplsnSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 532 WNLHAHQRVhtgeKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEF-----SLNSGLIAHRRVHTGEKPYEck 606
Cdd:COG5048   110 LSSSSSNSN----DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqSNSLHPPLPANSLSKDPSSN-- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423546 607 dcgkgfslaSSLRTHQRVHTGEKPFQCNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFSQKSGLQVHKRIHTGEKP 686
Cdd:COG5048   184 ---------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         250       260
                  ....*....|....*....|....
gi 1720423546 687 FKCEECGKEFIWSSGLSAHRKVHT 710
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNES 278
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-501 6.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.90e-03
                          10        20
                  ....*....|....*....|....*
gi 1720423546 477 NLHTHQRVHTGEKPYKCEECGKGFS 501
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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