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Conserved domains on  [gi|1701852832|ref|XP_029739416|]
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hypothetical protein EX895_004109 [Sporisorium graminicola]

Protein Classification

type I phosphoribosyltransferase( domain architecture ID 27)

type I phosphoribosyltransferase similar to phosphoribosyltransferases with specificities for hypoxanthine, guanine, and/or xanthine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRTases_typeI super family cl00309
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 1-50 1.19e-14

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


The actual alignment was detected with superfamily member pfam14681:

Pssm-ID: 444823  Cd Length: 204  Bit Score: 67.90  E-value: 1.19e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1701852832   1 MAIRVLLDHSVPEDQIVFLTLLASSQgGIHALNRAFPRVRIVVAGVDPGL 50
Cdd:pfam14681 136 AAIQVLREHGVPEENIVVLSVIAAPE-GLHRLAAAFPDVKIVTAAVDEEL 184
 
Name Accession Description Interval E-value
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 1-50 1.19e-14

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 67.90  E-value: 1.19e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1701852832   1 MAIRVLLDHSVPEDQIVFLTLLASSQgGIHALNRAFPRVRIVVAGVDPGL 50
Cdd:pfam14681 136 AAIQVLREHGVPEENIVVLSVIAAPE-GLHRLAAAFPDVKIVTAAVDEEL 184
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-50 4.88e-05

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 41.61  E-value: 4.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1701852832   1 MAIRVLLDHSVpeDQIVFLTLLASSQGgIHALNRAFPRVRIVVAGVDPGL 50
Cdd:PRK00129  142 AAIDLLKKRGA--KNIKVLCLVAAPEG-IKALEEAHPDVEIYTAAIDEKL 188
 
Name Accession Description Interval E-value
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 1-50 1.19e-14

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 67.90  E-value: 1.19e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1701852832   1 MAIRVLLDHSVPEDQIVFLTLLASSQgGIHALNRAFPRVRIVVAGVDPGL 50
Cdd:pfam14681 136 AAIQVLREHGVPEENIVVLSVIAAPE-GLHRLAAAFPDVKIVTAAVDEEL 184
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-50 4.88e-05

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 41.61  E-value: 4.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1701852832   1 MAIRVLLDHSVpeDQIVFLTLLASSQGgIHALNRAFPRVRIVVAGVDPGL 50
Cdd:PRK00129  142 AAIDLLKKRGA--KNIKVLCLVAAPEG-IKALEEAHPDVEIYTAAIDEKL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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