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Conserved domains on  [gi|1673177480|ref|XP_029232973|]
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putative 2Fe-2S iron-sulfur cluster binding domain containing protein [Trypanosoma rangeli]

Protein Classification

FAD-linked sulfhydryl oxidase( domain architecture ID 10521466)

FAD-linked sulfhydryl oxidase catalyzes disulfide bond formation, similar to mammalian FAD-linked sulfhydryl oxidase ALR and Arabidopsis thaliana FAD-linked sulfhydryl oxidase ERV1

CATH:  1.20.120.310
EC:  1.8.3.2
Gene Ontology:  GO:0016972|GO:0050660|GO:0016971
PubMed:  16893552
SCOP:  4002787

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 23-115 2.08e-30

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


:

Pssm-ID: 461423  Cd Length: 93  Bit Score: 110.02  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673177480  23 AGWDVLHTAAAVYPYRPSPLQQEAFAAFLHSWSHVYACSHCGYHMRRYLKRNPPVVTDKLALNRYLCEFHNTVNKSVKKP 102
Cdd:pfam04777   2 STWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGKP 81

                          90
                  ....*....|...
gi 1673177480 103 MYDCDpmTVLRRW 115
Cdd:pfam04777  82 EFDCS--KVKERW 92
 
Name Accession Description Interval E-value
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 23-115 2.08e-30

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 110.02  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673177480  23 AGWDVLHTAAAVYPYRPSPLQQEAFAAFLHSWSHVYACSHCGYHMRRYLKRNPPVVTDKLALNRYLCEFHNTVNKSVKKP 102
Cdd:pfam04777   2 STWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGKP 81

                          90
                  ....*....|...
gi 1673177480 103 MYDCDpmTVLRRW 115
Cdd:pfam04777  82 EFDCS--KVKERW 92
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 15-115 8.19e-27

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 103.41  E-value: 8.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673177480  15 PTPGNLGHAGWDVLHTAAAVYPYRPSPLQQEAFAAFLHSWSHVYACSHCGYHMRRYLKRNPPVVTDKLALNRYLCEFHNT 94
Cdd:COG5054    77 PDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREAATTWACEVHNK 156

                          90       100
                  ....*....|....*....|.
gi 1673177480  95 VNKSVKKPMYDCDpmTVLRRW 115
Cdd:COG5054   157 VNEKLGKPKFDCD--TWNERY 175
 
Name Accession Description Interval E-value
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 23-115 2.08e-30

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 110.02  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673177480  23 AGWDVLHTAAAVYPYRPSPLQQEAFAAFLHSWSHVYACSHCGYHMRRYLKRNPPVVTDKLALNRYLCEFHNTVNKSVKKP 102
Cdd:pfam04777   2 STWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGKP 81

                          90
                  ....*....|...
gi 1673177480 103 MYDCDpmTVLRRW 115
Cdd:pfam04777  82 EFDCS--KVKERW 92
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 15-115 8.19e-27

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 103.41  E-value: 8.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673177480  15 PTPGNLGHAGWDVLHTAAAVYPYRPSPLQQEAFAAFLHSWSHVYACSHCGYHMRRYLKRNPPVVTDKLALNRYLCEFHNT 94
Cdd:COG5054    77 PDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREAATTWACEVHNK 156

                          90       100
                  ....*....|....*....|.
gi 1673177480  95 VNKSVKKPMYDCDpmTVLRRW 115
Cdd:COG5054   157 VNEKLGKPKFDCD--TWNERY 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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