F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624094995 173 IGSCHGLLCFAIKAeSVLLWNPSIRVSKKSPPLGNNWRPGCYTAFGLGYDHVADDYKVVAvFCDPNVYFSETKVKIFSMA 252
Cdd:TIGR01640   1 VVPCDGLICFSYGK-RLVVWNPSTGQSRWLPTPKSRRSNKESDTYFLGYDPIEKQYKVLC-FSDRSGNRNQSEHQVYTLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624094995 253 SNSWRRIQDFPfGVTPYQNPGKFVSGSLNWAAnYSSGPASLWVIVSLDLHNETYREVHPPEYEKE-ECSTPTLGVLRGCL 331
Cdd:TIGR01640  79 SNSWRTIECSP-PHHPLKSRGVCINGVLYYLA-YTLKTNPDYFIVSFDVSSERFKEFIPLPCGNSdSVDYLSLINYKGKL 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1624094995 332 CM-NYDYKKTHFVVWLMKDYGVREsWVKLVSIPYLPNPEDFSYSLPYCISKNGQVLLMFEFD----LVLYDPKDQ 401
Cdd:TIGR01640 157 AVlKQKKDTNNFDLWVLNDAGKQE-WSKLFTVPIPPLPDLVDDNFLSGFTDKGEIVLCCEDEnpfyIFYYNVGEN 230

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624094995 173 IGSCHGLLCFAIKAeSVLLWNPSIRVSKKSPPLGNNWRPGCYTAFGLGYDHVADDYKVVAvFCDPNVYFSETKVKIFSMA 252
Cdd:TIGR01640   1 VVPCDGLICFSYGK-RLVVWNPSTGQSRWLPTPKSRRSNKESDTYFLGYDPIEKQYKVLC-FSDRSGNRNQSEHQVYTLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624094995 253 SNSWRRIQDFPfGVTPYQNPGKFVSGSLNWAAnYSSGPASLWVIVSLDLHNETYREVHPPEYEKE-ECSTPTLGVLRGCL 331
Cdd:TIGR01640  79 SNSWRTIECSP-PHHPLKSRGVCINGVLYYLA-YTLKTNPDYFIVSFDVSSERFKEFIPLPCGNSdSVDYLSLINYKGKL 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1624094995 332 CM-NYDYKKTHFVVWLMKDYGVREsWVKLVSIPYLPNPEDFSYSLPYCISKNGQVLLMFEFD----LVLYDPKDQ 401
Cdd:TIGR01640 157 AVlKQKKDTNNFDLWVLNDAGKQE-WSKLFTVPIPPLPDLVDDNFLSGFTDKGEIVLCCEDEnpfyIFYYNVGEN 230

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1624094995   74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISDSYFVRKH 114
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624094995 173 IGSCHGLLCFAIKAeSVLLWNPSIRVSKKSPPLGNNWRPGCYTAFGLGYDHVADDYKVVAvFCDPNVYFSETKVKIFSMA 252
Cdd:TIGR01640   1 VVPCDGLICFSYGK-RLVVWNPSTGQSRWLPTPKSRRSNKESDTYFLGYDPIEKQYKVLC-FSDRSGNRNQSEHQVYTLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624094995 253 SNSWRRIQDFPfGVTPYQNPGKFVSGSLNWAAnYSSGPASLWVIVSLDLHNETYREVHPPEYEKE-ECSTPTLGVLRGCL 331
Cdd:TIGR01640  79 SNSWRTIECSP-PHHPLKSRGVCINGVLYYLA-YTLKTNPDYFIVSFDVSSERFKEFIPLPCGNSdSVDYLSLINYKGKL 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1624094995 332 CM-NYDYKKTHFVVWLMKDYGVREsWVKLVSIPYLPNPEDFSYSLPYCISKNGQVLLMFEFD----LVLYDPKDQ 401
Cdd:TIGR01640 157 AVlKQKKDTNNFDLWVLNDAGKQE-WSKLFTVPIPPLPDLVDDNFLSGFTDKGEIVLCCEDEnpfyIFYYNVGEN 230

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1624094995   74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISDSYFVRKH 114
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLIS 106
Cdd:cd09917     3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20
                  ....*....|....*....|....*...
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRW 101
Cdd:cd22151     3 LPDDLLQEIFKRLDPKSLARAACVCRRW 30

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1624094995  73 FLPDELIEEILSRLPVKSLL-RFRCVCKRWNSLIS 106
Cdd:cd22083     3 EIPEELLLEILTHVPATSLItNCRLVCTLWRDIID 37

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISDS 108
Cdd:cd22114     4 LPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDE 38

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISDS-YFVRKHL 115
Cdd:cd22113     4 LPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENSdYLWRPHC 46

F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also called F-box only protein 37 (FBXO37), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Smad ubiquitination regulatory factor 1 (SMURF1), thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance. It also mediates ubiquitination of SMURF2 and WWP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1624094995  71 LPFlPDELIEEILSRLPVKSLLRFRCVCKRWNSLIsDSYFVR 112
Cdd:cd22126     4 LPW-EDVLFPHILPHLSLKDLFNLRRVSKAFKSLV-DEYFSK 43

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISD 107
Cdd:cd22149     4 LSDEIILSIFKWLPKKTLARCARVCRRWKRLCFD 37

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISD 107
Cdd:cd22091     4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLAND 37

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1624094995  71 LPFLPDELIEEILSRLPVKSLLRFRCVCKRWNSLISD 107
Cdd:cd22087     1 LLALPPEIKLRILSLLDVRSLLSLSQVCRDLNSATND 37

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1624094995  70 FLPFLPDELIEEILSRLPVKSLLRFRCVCKRWNSLIS 106
Cdd:cd22131     2 FLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVIS 38

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1624094995  74 LPDELIEEILSRLPVKSLLR-FRCVCKRWNSLIsDSYFVRKH 114
Cdd:cd22168     7 LPEDVLLEILSLVPARDLILsCRLVCSRWRDLV-DLPTLWKR 47

F-box domain found in Arabidopsis thaliana F-box protein FBW2 (AtFBW2) and similar proteins; AtFBW2, also called SKP1-interacting partner 18 (SKIP18), is an F-box protein that contains four tandem WD-40 repeats. It is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1, CUL2 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLIS 106
Cdd:cd22158     4 LPPDLLELIFSHLPLHDILICRSVCKFWNRLTT 36

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISD 107
Cdd:cd22120     4 LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWD 37

F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called FBX22, or F-box protein FBX22p44, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. FBXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1624094995  71 LPFLPdELIEEILSRLPVKSLLRFRCVCKRWN 102
Cdd:cd22097     1 LTSIA-EIVERILSFLPAKALLRCARVCRLWR 31

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1624094995  70 FLPFLP----DELIEEILSRLPVKSLLRFRCVCKRWNSLISDSYFVRK 113
Cdd:cd22183     4 FITALPakglDHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLIS 106
Cdd:cd22090     5 LPLELWRLILAYLPVRDLCRCCQVCRAWYELIL 37

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1624094995  70 FLPFLP----DELIEEILSRLPVKSLLRFRCVCKRWNSLISDSYFVRK 113
Cdd:cd22130     4 FISALPakglDHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1624094995  71 LPFLPDELIEEILSR--LPVKSLLRFRCVCKRWNSL 104
Cdd:cd22096     1 LLELPDELLEYILCSdnLDHHDIIRLSCTCRRLREV 36

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1624094995  74 LPDELIEEILSRLPVKSLLRFRCVCKRWNSLISD 107
Cdd:cd22115     7 LPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALD 40