|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
15-548 |
0e+00 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 600.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885 92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEHV- 253
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSKLq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 254 -CAHLGLGVQEPHPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 eSSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 333 KVFRAAAAQFQVPWLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNK-----------------------QGHEIDAFGIGTHLVTCYAQP 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 413 SLGCVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAGQelRVW---PPGAQEPCTVR 489
Cdd:PLN02885 389 ALGCVYKLVEINGQPRIKLSEDVEKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVV 466
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622962145 490 PAQVEPLLRlCLQQGQLCEP---LPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 548
Cdd:PLN02885 467 PQRVEELLK-CYWDGSSGKPreeLPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-548 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 587.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513 79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPSL 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKA-----------------------EGAPIDVYGVGTSLVTASDAPAL 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 415 GCVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAgqelrvwppgAQEPCTVRPAQVE 494
Cdd:TIGR01513 320 GGVYKLVAYEGRPVMKLSENPEKSTLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVE 389
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1622962145 495 PLLRLCLQQGQLCEPLPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 548
Cdd:TIGR01513 390 PLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-421 |
7.10e-157 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 451.26 E-value: 7.10e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570 79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:cd01570 157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570 202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPSL 414
Cdd:cd01570 271 LDEAG-------LTKVKIVASNDLDEYTIAALNA-----------------------QGAPIDAFGVGTRLVTSQSQPAL 320
|
....*..
gi 1622962145 415 GCVYKLV 421
Cdd:cd01570 321 GGVYKLV 327
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
16-555 |
2.81e-131 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 390.28 E-value: 2.81e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488 6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 96 LRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488 84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwlehvca 255
Cdd:COG1488 162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 256 hlglgvqepHPGERAAFVAYALAFPQAFQGLLDSYSVrRSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488 205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDT-LSGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 334 VFRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPS 413
Cdd:COG1488 272 LLDEAG-------LPDVRIIASDDLDEYRIAALLE-----------------------QGAPIDVFGVGTRLVTSSDRPT 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 414 LGCVYKLVAVGG----QPRMKLTEDPEKQTLPGSKAAFRlLGSDGSLLMDVLQLAEEPAPQAGqelrvwppgaqepctvr 489
Cdd:COG1488 322 LGFVYKLVAVEGdgewRPVIKLSETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP----------------- 383
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622962145 490 paqvEPLLRLCLQQGQLCEPLPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERLQALVNSL 555
Cdd:COG1488 384 ----EPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
16-143 |
8.19e-46 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 157.29 E-value: 8.19e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1622962145 96 LRSLDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767 79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
15-548 |
0e+00 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 600.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885 92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEHV- 253
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSKLq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 254 -CAHLGLGVQEPHPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 eSSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 333 KVFRAAAAQFQVPWLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNK-----------------------QGHEIDAFGIGTHLVTCYAQP 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 413 SLGCVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAGQelRVW---PPGAQEPCTVR 489
Cdd:PLN02885 389 ALGCVYKLVEINGQPRIKLSEDVEKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVV 466
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622962145 490 PAQVEPLLRlCLQQGQLCEP---LPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 548
Cdd:PLN02885 467 PQRVEELLK-CYWDGSSGKPreeLPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-548 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 587.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513 79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPSL 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKA-----------------------EGAPIDVYGVGTSLVTASDAPAL 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 415 GCVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAgqelrvwppgAQEPCTVRPAQVE 494
Cdd:TIGR01513 320 GGVYKLVAYEGRPVMKLSENPEKSTLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVE 389
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1622962145 495 PLLRLCLQQGQLCEPLPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 548
Cdd:TIGR01513 390 PLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-421 |
7.10e-157 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 451.26 E-value: 7.10e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570 79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:cd01570 157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570 202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPSL 414
Cdd:cd01570 271 LDEAG-------LTKVKIVASNDLDEYTIAALNA-----------------------QGAPIDAFGVGTRLVTSQSQPAL 320
|
....*..
gi 1622962145 415 GCVYKLV 421
Cdd:cd01570 321 GGVYKLV 327
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
15-548 |
5.31e-144 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 423.41 E-value: 5.31e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243 10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDCSEvTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243 88 YLRNFRFTG-DVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:PRK09243 166 GPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA------------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 255 ahlglgvqepHPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK09243 210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVRKM 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPSL 414
Cdd:PRK09243 279 LDEAG-------FTDTKIVASNDLDEYTIASLKL-----------------------QGAPIDGFGVGTKLVTGSDAPAL 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 415 GCVYKLVAVGG----QPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPaPQAGQELrVWPPGAQEPCTVRP 490
Cdd:PRK09243 329 GGVYKLVAIEGeggmIPKIKLSNSPEKVTTPGRKQVYRIYDKGGKAEADVITLADEE-EEEPLKM-FHPVHTYKSKTVKN 406
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1622962145 491 AQVEPLLRLCLQQGQLCEPLPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 548
Cdd:PRK09243 407 FDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
16-555 |
2.81e-131 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 390.28 E-value: 2.81e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488 6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 96 LRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488 84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwlehvca 255
Cdd:COG1488 162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 256 hlglgvqepHPGERAAFVAYALAFPQAFQGLLDSYSVrRSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488 205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDT-LSGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 334 VFRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPS 413
Cdd:COG1488 272 LLDEAG-------LPDVRIIASDDLDEYRIAALLE-----------------------QGAPIDVFGVGTRLVTSSDRPT 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 414 LGCVYKLVAVGG----QPRMKLTEDPEKQTLPGSKAAFRlLGSDGSLLMDVLQLAEEPAPQAGqelrvwppgaqepctvr 489
Cdd:COG1488 322 LGFVYKLVAVEGdgewRPVIKLSETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP----------------- 383
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622962145 490 paqvEPLLRLCLQQGQLCEPLPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERLQALVNSL 555
Cdd:COG1488 384 ----EPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
16-560 |
1.45e-99 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 308.98 E-value: 1.45e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 16 LLTDLYQATMALGYWRAGrARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484 6 LLTDLYEVTMANAYLREG-MSAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRsLDCSevtVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484 85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK12484 205 -----------PDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsevnvigigtgwahchllsptQGSEVNVIGIGTSVVTCPQQPSL 414
Cdd:PRK12484 272 LDAAG-------LEQVKIVASGGLDEYRIAALLA-----------------------AGAPIDGFGVGTRLGVAADAPVL 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 415 GCVYKLVAVGGQPRMKLTedPEKQTLPGSKAAFRLLGSdGSLLMDVLQLAEEPApqagqelrvwPPGAqepctvrpaqvE 494
Cdd:PRK12484 322 DSAYKLVAYEGRGVTKLS--SGKVTYPGRKQVFRLYEH-GTACGDVIGLHTENI----------PDGR-----------E 377
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622962145 495 PLLRLCLQQGQLCEPLPSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERLQALVNSLHARAS 560
Cdd:PRK12484 378 PLLVPVMTNGRRIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTAEAH 443
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
15-419 |
1.65e-93 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 289.55 E-value: 1.65e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 15 PLLTDLYQATMALGYWrAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567 1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 95 HLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAG-----------PEK 163
Cdd:cd01567 77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 164 RLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdla 243
Cdd:cd01567 157 KLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 244 akaqvwlehvcahlglgvqephpgerAAFVAYALAFPQAFQGLL----DSYSVRRsGLPNFLAVALALGElGYRAVGVRL 319
Cdd:cd01567 218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 320 DSGDLLQQAQEIRKVFRAAAAqfqvpWLESVPIAVSNNID-EEALARLAQEGsevnvigigtgwahchllsptqGSEVNV 398
Cdd:cd01567 270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLLEQG----------------------ASPNDA 322
|
410 420
....*....|....*....|.
gi 1622962145 399 IGIGTSVVTCPQQPSLGCVYK 419
Cdd:cd01567 323 FGVGTSLTNDLGRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
19-419 |
3.35e-51 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 177.05 E-value: 3.35e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 19 DLYQATMALGYwraGRARDAAEFELFFRRCPFGgafaLAAGLRDCVRFLRAFRLRDAdvqflasvlppdtdpaffehlrs 98
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPGP----------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 99 ldcseVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516 51 -----LVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 178 GGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvcahl 257
Cdd:cd00516 125 LRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 258 glgvqephpGERAAFVAYALAFPQAFQGLLDSYSvrrSGLPNFLAVALALgelgyRAVGVRLDSGDL--LQQAQEIRKVF 335
Cdd:cd00516 167 ---------GELAAVKALRRWLPELFIALIDVEV---DTLEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 336 RAaaaqFQVPWLESVPIAVSNNIDEEALARLAQEGsevnvigigtgwahchllsptqgseVNVIGIGTSVVTCpqqPSLG 415
Cdd:cd00516 230 AH----LDGKGLPRVKIEASGGLDEENIRAYAETG-------------------------VDVFGVGTLLHSA---PPLD 277
|
....
gi 1622962145 416 CVYK 419
Cdd:cd00516 278 IVLK 281
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
16-143 |
8.19e-46 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 157.29 E-value: 8.19e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1622962145 96 LRSLDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767 79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
444-551 |
1.93e-30 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 114.97 E-value: 1.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 444 KAAFRLLGSDGSLLMDVLQLAEEPAPQAGQELRVWPPGA-QEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALVQL 522
Cdd:pfam17956 2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDeWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
90 100
....*....|....*....|....*....
gi 1622962145 523 SLSQLSPEHRRLQSPAQYQVVLSERLQAL 551
Cdd:pfam17956 82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
94-380 |
2.85e-24 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 103.12 E-value: 2.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 94 EHLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571 43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 173 --AQGPDGGLTAstysYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdlaakaqvwl 250
Cdd:cd01571 122 hpAIQPMDGRAA----YIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQV-------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 251 ehvcahlglgvqephpgerAAFVAYALAFPQAFQ--GLLDSYSVRRsglpnfLAVALALGELGYRAVGVRLDS-----GD 323
Cdd:cd01571 172 -------------------EAWKAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDTpssrrGV 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1622962145 324 LLQQAQEIRKVFRAAAAQfqvpwleSVPIAVSNNIDEEALARLAQEGseVNVIGIGT 380
Cdd:cd01571 227 FRYLIREVRWALDIRGYK-------HVKIFVSGGLDEEDIKELEDVG--VDAFGVGT 274
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
103-380 |
3.29e-18 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 86.08 E-value: 3.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 103 EVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR---AQGPdgg 179
Cdd:PRK08662 69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARHvhpAIAP--- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 180 lTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsGSEVppdpmlapaagegpgvdLAAKAqvWLEHVcahlgl 259
Cdd:PRK08662 145 -MMDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIF-GDQV-----------------EAWKA--FDEVV------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 260 gvqephPGE--RAAfvayalafpqafqgLLDSYSVRRSglpNFLAVALALGElgyRAVGVRLDS-----GDLLQQAQEIR 332
Cdd:PRK08662 198 ------PPDvpRIA--------------LVDTFKDERE---EALRAAEALGD---RLDGVRLDTpssrrGNFRKIVREVR 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1622962145 333 KVFRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsEVNVIGIGT 380
Cdd:PRK08662 252 WTLDIRG-------YEHVKIFVSGGLDPERIRELRD---VVDGFGVGT 289
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
14-213 |
5.33e-08 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 55.15 E-value: 5.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 14 RPLL-TDLYQATMALGYWRagRARDA-AEFELffrRCPFGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPD 87
Cdd:PRK05321 10 RSLLdTDFYKLTMQQAVLH--HYPDAqVEYEF---ICRNDEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 88 tdpaFFEHLRS--LDCSEVTVRAlPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS-----YASLVATNA---ARL-- 155
Cdd:PRK05321 85 ----FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwe 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622962145 156 ---RLIAGPEK---RLLEMGLRRaqgpdggltasTYSYL--------------GGFDSSSNVLAGQLRGVPVAGTLAH 213
Cdd:PRK05321 154 kieLLKALPDLsgfKIADFGTRR-----------RFSFEwqeevvealkeglpGAFVGTSNVHLAMKLGLTPIGTMAH 220
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
14-439 |
1.32e-07 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 53.79 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 14 RPLL-TDLYQATMALGYWRA-GRARDAAEF-----ELFFRRcpfggafaLAAGLRDCVRFLRAFRLRDADVQFLASVLPP 86
Cdd:cd01401 1 RSLLdTDLYKLTMQQAVLHHyPDVQVTYEFtnrspEDFLEE--------AAEALREQIDHLANLRFSEEELAYLRRSLPF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 87 DTdPAFFEHLRS--LDCSEVTVRA-LPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS--YASLVATNA--------- 152
Cdd:cd01401 73 LK-PDYLDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekl 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 153 --------ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGGfdsSSNVLAGQLRGVPVAGTLAHsfvts 218
Cdd:cd01401 146 eeklerllEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLTG---TSNVHFAMKYGLTPIGTVAH----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 219 fsgsevppdpmlapaagegpgvdlaakaqvwlEHVCAHLGLGVQEPHpGERAAFVAYAlafpQAFQGLL-----DSYsvr 293
Cdd:cd01401 218 --------------------------------EWFMAHQALTGDLKD-SQKAALERWV----REYGGDLgialtDTF--- 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962145 294 rsGLPNFLAVALAlgELGYRAVGVRLDSGDLLQQAQEIRKvfraaaaqfqvpWLESVPIA-------VSNNIDEEALARL 366
Cdd:cd01401 258 --GTDAFLRDFDL--YFAKLFDGVRHDSGDPFEWGEKAIA------------HYEKLGIDpktktlvFSDGLDVEKALEL 321
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622962145 367 AQegsevnvigigtgwaHCHllsptqgSEVNVI-GIGTS----VVTCPQQPSLGCVYKLVAVGGQPRMKLTEDPEKQT 439
Cdd:cd01401 322 YE---------------YFK-------GRIKVSfGIGTNltndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
104-158 |
3.72e-04 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 43.34 E-value: 3.72e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1622962145 104 VTVRALPEGSLAFPGVPLLQVSG--PLL--VVQLLETPLLCLVSYASLVATNAARLRLI 158
Cdd:PRK09198 98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQL 156
|
|
| |
