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Conserved domains on  [gi|1622961951|ref|XP_028708841|]
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DENN domain-containing protein 3 isoform X3 [Macaca mulatta]

Protein Classification

DENN and dDENN domain-containing protein( domain architecture ID 13089868)

protein containing domains DENN, dDENN, and WD40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN super family cl11519
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 182-276 1.22e-38

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


The actual alignment was detected with superfamily member pfam02141:

Pssm-ID: 472208  Cd Length: 186  Bit Score: 142.33  E-value: 1.22e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  182 CFRPEKVLQVLTCFLTEQRIVFFSSDWALLTLVAECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 261
Cdd:pfam02141   92 CLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLL 171

                           90
                   ....*....|....*
gi 1622961951  262 SKEADGLVLVNIDHG 276
Cdd:pfam02141  172 EDPLDDVVLVDLDTG 186
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 887-1183 1.20e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  887 GHLDP--AEKVEDAHPKLWCALSDGKVTVFDASSwTIHQHSFKVGTAKVN-CMVMADQNQVWVGSEDSVIYIINVHSMSC 963
Cdd:cd00200      7 GHTGGvtCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRdVAASADGTYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  964 NKQLTDHCSSVTDLIVQDGQRVprcseVYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIRLHGGRLW---CCTGNSIM 1040
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRI-----LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFvasSSQDGTIK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1041 VMTTNGFLCQELkIEEHFKDISTsfLAFqlLPEQEQLwAACAGRSEVYIWSLKDLAQLpqrVPLKDCSEIICmirvkkQV 1120
Cdd:cd00200    161 LWDLRTGKCVAT-LTGHTGEVNS--VAF--SPDGEKL-LSSSSDGTIKLWDLSTGKCL---GTLRGHENGVN------SV 225

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622961951 1121 WVGSRGLW--QGTPRGKIYVIDAERKTVEKELVAHTDTVRTLCSAED-RYVLSGSgrEEGKIAIWK 1183
Cdd:cd00200    226 AFSPDGYLlaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGS--ADGTIRIWD 289
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 340-402 4.68e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.00  E-value: 4.68e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961951   340 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAAGDHQFYKQVLDTYMFHSFLKAR 402
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 182-276 1.22e-38

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 142.33  E-value: 1.22e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  182 CFRPEKVLQVLTCFLTEQRIVFFSSDWALLTLVAECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 261
Cdd:pfam02141   92 CLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLL 171

                           90
                   ....*....|....*
gi 1622961951  262 SKEADGLVLVNIDHG 276
Cdd:pfam02141  172 EDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 182-276 1.37e-36

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 136.56  E-value: 1.37e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951   182 CFRPEKVLQVLTCFLTEQRIVFFSSDWALLTLVAECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 261
Cdd:smart00799   88 CLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEV 167

                            90
                    ....*....|....*.
gi 1622961951   262 SKEADG-LVLVNIDHG 276
Cdd:smart00799  168 KELPDEdVVVVDLDTG 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 887-1183 1.20e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  887 GHLDP--AEKVEDAHPKLWCALSDGKVTVFDASSwTIHQHSFKVGTAKVN-CMVMADQNQVWVGSEDSVIYIINVHSMSC 963
Cdd:cd00200      7 GHTGGvtCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRdVAASADGTYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  964 NKQLTDHCSSVTDLIVQDGQRVprcseVYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIRLHGGRLW---CCTGNSIM 1040
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRI-----LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFvasSSQDGTIK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1041 VMTTNGFLCQELkIEEHFKDISTsfLAFqlLPEQEQLwAACAGRSEVYIWSLKDLAQLpqrVPLKDCSEIICmirvkkQV 1120
Cdd:cd00200    161 LWDLRTGKCVAT-LTGHTGEVNS--VAF--SPDGEKL-LSSSSDGTIKLWDLSTGKCL---GTLRGHENGVN------SV 225

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622961951 1121 WVGSRGLW--QGTPRGKIYVIDAERKTVEKELVAHTDTVRTLCSAED-RYVLSGSgrEEGKIAIWK 1183
Cdd:cd00200    226 AFSPDGYLlaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGS--ADGTIRIWD 289
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 340-402 4.68e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.00  E-value: 4.68e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961951   340 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAAGDHQFYKQVLDTYMFHSFLKAR 402
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 COG2319
WD40 repeat [General function prediction only];
907-1182 5.11e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 5.11e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  907 SDGKVTVFDASSWTIhQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTDHCSSVTDLIV-QDGQR 984
Cdd:COG2319    140 ADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  985 VprcsevYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIRLH--GGRLWCCTG-NSIMVMTTNGFlcQELKIEEHFKDI 1061
Cdd:COG2319    219 L------ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSAdGTVRLWDLATG--ELLRTLTGHSGG 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1062 STSfLAFqlLPEQEQLWAACAGRSeVYIWSLKDLAQLPQRVPLKDCSEIICMIRVKKQVWVGSRGlwqgtprGKIYVIDA 1141
Cdd:COG2319    291 VNS-VAF--SPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD-------GTVRLWDL 359

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1622961951 1142 ERKTVEKELVAHTDTVRTLC-SAEDRYVLSGSgrEEGKIAIW 1182
Cdd:COG2319    360 ATGELLRTLTGHTGAVTSVAfSPDGRTLASGS--ADGTVRLW 399
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 369-406 9.07e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 38.33  E-value: 9.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622961951  369 FNSEEFLKTRAAGDHQFYKQVLDTYMFHSFLKARLNRR 406
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS 38
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 182-276 1.22e-38

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 142.33  E-value: 1.22e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  182 CFRPEKVLQVLTCFLTEQRIVFFSSDWALLTLVAECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 261
Cdd:pfam02141   92 CLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLL 171

                           90
                   ....*....|....*
gi 1622961951  262 SKEADGLVLVNIDHG 276
Cdd:pfam02141  172 EDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 182-276 1.37e-36

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 136.56  E-value: 1.37e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951   182 CFRPEKVLQVLTCFLTEQRIVFFSSDWALLTLVAECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 261
Cdd:smart00799   88 CLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEV 167

                            90
                    ....*....|....*.
gi 1622961951   262 SKEADG-LVLVNIDHG 276
Cdd:smart00799  168 KELPDEdVVVVDLDTG 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 887-1183 1.20e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  887 GHLDP--AEKVEDAHPKLWCALSDGKVTVFDASSwTIHQHSFKVGTAKVN-CMVMADQNQVWVGSEDSVIYIINVHSMSC 963
Cdd:cd00200      7 GHTGGvtCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRdVAASADGTYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  964 NKQLTDHCSSVTDLIVQDGQRVprcseVYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIRLHGGRLW---CCTGNSIM 1040
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRI-----LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFvasSSQDGTIK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1041 VMTTNGFLCQELkIEEHFKDISTsfLAFqlLPEQEQLwAACAGRSEVYIWSLKDLAQLpqrVPLKDCSEIICmirvkkQV 1120
Cdd:cd00200    161 LWDLRTGKCVAT-LTGHTGEVNS--VAF--SPDGEKL-LSSSSDGTIKLWDLSTGKCL---GTLRGHENGVN------SV 225

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622961951 1121 WVGSRGLW--QGTPRGKIYVIDAERKTVEKELVAHTDTVRTLCSAED-RYVLSGSgrEEGKIAIWK 1183
Cdd:cd00200    226 AFSPDGYLlaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGS--ADGTIRIWD 289
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 340-402 4.68e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.00  E-value: 4.68e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961951   340 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAAGDHQFYKQVLDTYMFHSFLKAR 402
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 COG2319
WD40 repeat [General function prediction only];
907-1182 5.11e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 5.11e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  907 SDGKVTVFDASSWTIhQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTDHCSSVTDLIV-QDGQR 984
Cdd:COG2319    140 ADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  985 VprcsevYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIRLH--GGRLWCCTG-NSIMVMTTNGFlcQELKIEEHFKDI 1061
Cdd:COG2319    219 L------ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSAdGTVRLWDLATG--ELLRTLTGHSGG 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1062 STSfLAFqlLPEQEQLWAACAGRSeVYIWSLKDLAQLPQRVPLKDCSEIICMIRVKKQVWVGSRGlwqgtprGKIYVIDA 1141
Cdd:COG2319    291 VNS-VAF--SPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD-------GTVRLWDL 359

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1622961951 1142 ERKTVEKELVAHTDTVRTLC-SAEDRYVLSGSgrEEGKIAIW 1182
Cdd:COG2319    360 ATGELLRTLTGHTGAVTSVAfSPDGRTLASGS--ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
905-1182 7.36e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 7.36e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  905 ALSDGKVTVFDASSwTIHQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTDHCSSVTDLIV-QDG 982
Cdd:COG2319     96 ASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDG 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  983 QRvprcseVYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIRLH--GGRLWCCTG-NSIMV--MTTNgflcQELKIEEH 1057
Cdd:COG2319    175 KL------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSAdGTVRLwdLATG----KLLRTLTG 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1058 FKDISTSfLAFqlLPEQEQLWAACAGRSeVYIWslkDLAQLPQRVPLKDCSEIICmiRVK-----KQVWVGSRGlwqgtp 1132
Cdd:COG2319    245 HSGSVRS-VAF--SPDGRLLASGSADGT-VRLW---DLATGELLRTLTGHSGGVN--SVAfspdgKLLASGSDD------ 309

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622961951 1133 rGKIYVIDAERKTVEKELVAHTDTVRTLC-SAEDRYVLSGSgrEEGKIAIW 1182
Cdd:COG2319    310 -GTVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGS--DDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
907-1007 1.26e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  907 SDGKVTVFDASSWTIhQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTDHCSSVTDL-IVQDGQR 984
Cdd:COG2319    308 DDGTVRLWDLATGKL-LRTLTGHTGAVRSVAFsPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFSPDGRT 386

                           90       100
                   ....*....|....*....|...
gi 1622961951  985 VprcsevYSCSMDGTVLAWNVST 1007
Cdd:COG2319    387 L------ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 963-1182 1.08e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951  963 CNKQLTDHCSSVTDLIVQDGQRVprcseVYSCSMDGTVLAWNVSTLQVTGRFQLSSGGLTSIrlhggrLWCCTGNSIMVM 1042
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKL-----LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV------AASADGTYLASG 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1043 TTNGFL-CQELK-------IEEHFKDISTsfLAFQllpeQEQLWAACAGR-SEVYIWslkDLAQLPQRVPLKDCSEIICM 1113
Cdd:cd00200     70 SSDKTIrLWDLEtgecvrtLTGHTSYVSS--VAFS----PDGRILSSSSRdKTIKVW---DVETGKCLTTLRGHTDWVNS 140

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961951 1114 IRVKKQVWVGSRGLWQGTprgkIYVIDAERKTVEKELVAHTDTVRTLCSAEDRY-VLSGSGreEGKIAIW 1182
Cdd:cd00200    141 VAFSPDGTFVASSSQDGT----IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEkLLSSSS--DGTIKLW 204
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 369-406 9.07e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 38.33  E-value: 9.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622961951  369 FNSEEFLKTRAAGDHQFYKQVLDTYMFHSFLKARLNRR 406
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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