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Conserved domains on  [gi|1622961041|ref|XP_028708610|]
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cadherin-17 isoform X2 [Macaca mulatta]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182789)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-663 2.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 570 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961041 646 SLSSVSQFHLILTDVNDN 663
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-122 9.62e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  33 PMTFSIYEGQEPSQIIFQFKANPP------AVTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGA 104
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgengEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961041 105 IVEGPVPITIEVKDVNDN 122
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 271-338 3.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 3.29e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961041  271 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDNPP 338
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 131-235 4.88e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 4.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTRegsqELNPAKNPSYNLV 210
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 1622961041 211 ISVKDMGGqseNSFSDTTSVDIIVT 235
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 346-444 1.10e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 346 VFEVQENERLGNSIGALTAHDSDEENtaNSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 425
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 1622961041 426 DKD---FKTLCFVQINVIDIND 444
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-562 8.62e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 8.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 456 NLTLAEDTNVGSTILTIQATDADEPFTGssKILYHVIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAISNIVFKAEN 535
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622961041 536 PEPLVFgvtynaSSFAKFTLFVTDVNE 562
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-763 2.40e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 681 SAPGSLI--FEATDDDQHlfRGPHFTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPLES 756
Cdd:cd11304    10 APPGTVVltVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGE---ITTAKPlDREEQsSYTLTVTATDGGGPPLSS 84


                  ....*..
gi 1622961041 757 TVSLTVT 763
Cdd:cd11304    85 TATVTIT 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-663 2.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 570 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961041 646 SLSSVSQFHLILTDVNDN 663
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-122 9.62e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  33 PMTFSIYEGQEPSQIIFQFKANPP------AVTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGA 104
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgengEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961041 105 IVEGPVPITIEVKDVNDN 122
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 271-338 3.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 3.29e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961041  271 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDNPP 338
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 131-235 4.88e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 4.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTRegsqELNPAKNPSYNLV 210
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 1622961041 211 ISVKDMGGqseNSFSDTTSVDIIVT 235
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 346-444 1.10e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 346 VFEVQENERLGNSIGALTAHDSDEENtaNSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 425
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 1622961041 426 DKD---FKTLCFVQINVIDIND 444
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-336 2.27e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 245 VEMVENSTDPHPIkiTQVRWNDPGA------QYSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG 317
Cdd:cd11304     4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622961041 318 KPLSYPLEIHVKVQDINDN 336
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-562 8.62e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 8.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 456 NLTLAEDTNVGSTILTIQATDADEPFTGssKILYHVIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAISNIVFKAEN 535
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622961041 536 PEPLVFgvtynaSSFAKFTLFVTDVNE 562
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 58-124 3.80e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 3.80e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961041   58 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDNRP 124
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-665 2.67e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 2.67e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961041  592 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSQFHLILTDVNDNPP 665
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
571-640 3.45e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.45e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622961041 571 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 640
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
131-235 4.70e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIvIQLPMINNvmyFQINNKTGGISLTRegsqELNPAKNPSYNLV 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI-LGGGPGGN---FRIDPDTGDISTTK----PLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....*
gi 1622961041 211 ISVKDMGGQSEnsfSDTTSVDIIVT 235
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
35-116 2.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  35 TFSIYEGQEPSQIIFQFKANPP-------AVTFELTGETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIV 106
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPdlgpngrIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 1622961041 107 EGPVPITIEV 116
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
346-428 3.14e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 346 VFEVQENERLGNSIGALTAHDSDEenTANSLLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 425
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 1622961041 426 DKD 428
Cdd:pfam00028  75 DSG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 363-447 9.33e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 9.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  363 TAHDSDEEntANSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 439
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 1622961041  440 IDINDQIP 447
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
284-331 1.21e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.21e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622961041 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQ 331
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 149-235 2.04e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  149 NATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTREgsqeLNPAKNPSYNLVISVKDMGGQsenSFSDTT 228
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTTKP----LDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*..
gi 1622961041  229 SVDIIVT 235
Cdd:smart00112  68 TVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-564 1.02e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  473 QATDADEPFtgSSKILYHVIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAISNIVFKAENpeplvfGVTYNASSFAK 552
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 1622961041  553 FTLFVTDVNEAP 564
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
458-535 1.82e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.82e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622961041 458 TLAEDTNVGSTILTIQATDADEPftGSSKILYHVIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAISNIVFKAEN 535
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-763 2.40e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 681 SAPGSLI--FEATDDDQHlfRGPHFTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPLES 756
Cdd:cd11304    10 APPGTVVltVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGE---ITTAKPlDREEQsSYTLTVTATDGGGPPLSS 84


                  ....*..
gi 1622961041 757 TVSLTVT 763
Cdd:cd11304    85 TATVTIT 91
Cadherin pfam00028
Cadherin domain;
681-765 6.66e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 6.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 681 SAPGSLI--FEATDDDqhlfRGPH--FTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPL 754
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 1622961041 755 ESTVSLTVTFC 765
Cdd:pfam00028  82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 690-763 2.66e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.41  E-value: 2.66e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961041  690 ATDDDQHLFRgpHFTFSIASESLQNDWQVSKINGThaRLSTRHTDFEEK-EYVVSIRINDGGRPPLESTVSLTVT 763
Cdd:smart00112   2 ATDADSGENG--KVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTIT 72
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-663 2.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 570 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961041 646 SLSSVSQFHLILTDVNDN 663
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-122 9.62e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  33 PMTFSIYEGQEPSQIIFQFKANPP------AVTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGA 104
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgengEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961041 105 IVEGPVPITIEVKDVNDN 122
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 271-338 3.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 3.29e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961041  271 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDNPP 338
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 131-235 4.88e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 4.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTRegsqELNPAKNPSYNLV 210
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 1622961041 211 ISVKDMGGqseNSFSDTTSVDIIVT 235
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 346-444 1.10e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 346 VFEVQENERLGNSIGALTAHDSDEENtaNSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 425
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 1622961041 426 DKD---FKTLCFVQINVIDIND 444
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-336 2.27e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 245 VEMVENSTDPHPIkiTQVRWNDPGA------QYSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG 317
Cdd:cd11304     4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622961041 318 KPLSYPLEIHVKVQDINDN 336
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-562 8.62e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 8.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 456 NLTLAEDTNVGSTILTIQATDADEPFTGssKILYHVIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAISNIVFKAEN 535
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622961041 536 PEPLVFgvtynaSSFAKFTLFVTDVNE 562
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 58-124 3.80e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 3.80e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961041   58 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDNRP 124
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-665 2.67e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 2.67e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961041  592 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSQFHLILTDVNDNPP 665
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
571-640 3.45e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.45e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622961041 571 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 640
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
131-235 4.70e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIvIQLPMINNvmyFQINNKTGGISLTRegsqELNPAKNPSYNLV 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI-LGGGPGGN---FRIDPDTGDISTTK----PLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....*
gi 1622961041 211 ISVKDMGGQSEnsfSDTTSVDIIVT 235
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
35-116 2.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  35 TFSIYEGQEPSQIIFQFKANPP-------AVTFELTGETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIV 106
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPdlgpngrIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 1622961041 107 EGPVPITIEV 116
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
346-428 3.14e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 346 VFEVQENERLGNSIGALTAHDSDEenTANSLLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 425
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 1622961041 426 DKD 428
Cdd:pfam00028  75 DSG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 363-447 9.33e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 9.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  363 TAHDSDEEntANSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 439
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 1622961041  440 IDINDQIP 447
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
284-331 1.21e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.21e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622961041 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQ 331
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 149-235 2.04e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  149 NATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTREgsqeLNPAKNPSYNLVISVKDMGGQsenSFSDTT 228
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTTKP----LDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*..
gi 1622961041  229 SVDIIVT 235
Cdd:smart00112  68 TVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-564 1.02e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041  473 QATDADEPFtgSSKILYHVIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAISNIVFKAENpeplvfGVTYNASSFAK 552
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 1622961041  553 FTLFVTDVNEAP 564
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
458-535 1.82e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.82e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622961041 458 TLAEDTNVGSTILTIQATDADEPftGSSKILYHVIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAISNIVFKAEN 535
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-763 2.40e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 681 SAPGSLI--FEATDDDQHlfRGPHFTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPLES 756
Cdd:cd11304    10 APPGTVVltVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGE---ITTAKPlDREEQsSYTLTVTATDGGGPPLSS 84


                  ....*..
gi 1622961041 757 TVSLTVT 763
Cdd:cd11304    85 TATVTIT 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-336 2.90e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.57  E-value: 2.90e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 268 GAQYSLVDKEKLPRFpFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDN 336
Cdd:cd00031    30 IIKISAAGKEALPSW-LHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
681-765 6.66e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 6.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961041 681 SAPGSLI--FEATDDDqhlfRGPH--FTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPL 754
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 1622961041 755 ESTVSLTVTFC 765
Cdd:pfam00028  82 SSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 69-122 2.31e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622961041  69 IFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDN 122
Cdd:cd00031    44 WLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 690-763 2.66e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.41  E-value: 2.66e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961041  690 ATDDDQHLFRgpHFTFSIASESLQNDWQVSKINGThaRLSTRHTDFEEK-EYVVSIRINDGGRPPLESTVSLTVT 763
Cdd:smart00112   2 ATDADSGENG--KVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin_3 pfam16184
Cadherin-like;
435-506 5.22e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 37.58  E-value: 5.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961041 435 VQINVIDINDQIPIFEKSdyGNLTLAEDtnvGSTILT---IQATDADEPftgSSKILYHVIKGDSEGRLGVDTDP 506
Cdd:pfam16184   7 FNITIIPVNDEAPVLTTN--TGLRLWEG---SSRPITpdlLQAEDPDTP---PEDLTYTVVQGPSHGHLALKGAP 73
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 608-663 7.76e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 36.55  E-value: 7.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622961041 608 GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSQFHLILTDVNDN 663
Cdd:cd00031    43 SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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