NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622961039|ref|XP_028708609|]
View 

cadherin-17 isoform X1 [Macaca mulatta]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 11254458)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-671 2.60e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 578 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 653
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961039 654 SLSSVSQFHLILTDVNDN 671
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-346 3.70e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 3.70e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961039  279 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDNPP 346
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-243 5.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 139 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTRegsqELNPAKNPSYNLV 218
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 1622961039 219 ISVKDMGGqseNSFSDTTSVDIIVT 243
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-452 1.32e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 354 VFEVQENERLGNSIGALTAHDSDEENtaNSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 433
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 1622961039 434 DKD---FKTLCFVQINVIDIND 452
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-570 9.98e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 9.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 464 NLTLAEDTNVGSTILTIQATDADEPFTGssKILYHVIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAISNIVFKAEN 543
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622961039 544 PEPLVFgvtynaSSFAKFTLFVTDVNE 570
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-132 4.44e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.44e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961039   66 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDNRP 132
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 689-771 2.78e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 689 SAPGSLI--FEATDDDQHlfRGPHFTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPLES 764
Cdd:cd11304    10 APPGTVVltVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGE---ITTAKPlDREEQsSYTLTVTATDGGGPPLSS 84


                  ....*..
gi 1622961039 765 TVSLTVT 771
Cdd:cd11304    85 TATVTIT 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-671 2.60e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 578 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 653
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961039 654 SLSSVSQFHLILTDVNDN 671
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-346 3.70e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 3.70e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961039  279 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDNPP 346
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-243 5.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 139 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTRegsqELNPAKNPSYNLV 218
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 1622961039 219 ISVKDMGGqseNSFSDTTSVDIIVT 243
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-452 1.32e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 354 VFEVQENERLGNSIGALTAHDSDEENtaNSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 433
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 1622961039 434 DKD---FKTLCFVQINVIDIND 452
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-344 2.66e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 253 VEMVENSTDPHPIkiTQVRWNDPGA------QYSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG 325
Cdd:cd11304     4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622961039 326 KPLSYPLEIHVKVQDINDN 344
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-570 9.98e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 9.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 464 NLTLAEDTNVGSTILTIQATDADEPFTGssKILYHVIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAISNIVFKAEN 543
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622961039 544 PEPLVFgvtynaSSFAKFTLFVTDVNE 570
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-132 4.44e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.44e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961039   66 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDNRP 132
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 600-673 3.21e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.21e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961039  600 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSQFHLILTDVNDNPP 673
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
579-648 3.70e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.70e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622961039 579 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 648
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 66-130 1.50e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622961039  66 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDN 130
Cdd:cd11304    32 VTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
139-243 5.14e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 5.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 139 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIvIQLPMINNvmyFQINNKTGGISLTRegsqELNPAKNPSYNLV 218
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI-LGGGPGGN---FRIDPDTGDISTTK----PLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....*
gi 1622961039 219 ISVKDMGGQSEnsfSDTTSVDIIVT 243
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
354-436 3.24e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 354 VFEVQENERLGNSIGALTAHDSDEenTANSLLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 433
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 1622961039 434 DKD 436
Cdd:pfam00028  75 DSG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 371-455 1.11e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039  371 TAHDSDEEntANSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 447
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 1622961039  448 IDINDQIP 455
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
292-339 1.29e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.29e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622961039 292 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQ 339
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-243 2.45e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039  157 NATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTREgsqeLNPAKNPSYNLVISVKDMGGQsenSFSDTT 236
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTTKP----LDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*..
gi 1622961039  237 SVDIIVT 243
Cdd:smart00112  68 TVTITVL 74
Cadherin pfam00028
Cadherin domain;
65-124 1.85e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 1.85e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622961039  65 AVTFELTGETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEV 124
Cdd:pfam00028  31 IFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 481-572 1.24e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039  481 QATDADEPFtgSSKILYHVIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAISNIVFKAENpeplvfGVTYNASSFAK 560
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 1622961039  561 FTLFVTDVNEAP 572
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
466-543 1.89e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.89e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622961039 466 TLAEDTNVGSTILTIQATDADEPftGSSKILYHVIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAISNIVFKAEN 543
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 689-771 2.78e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 689 SAPGSLI--FEATDDDQHlfRGPHFTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPLES 764
Cdd:cd11304    10 APPGTVVltVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGE---ITTAKPlDREEQsSYTLTVTATDGGGPPLSS 84


                  ....*..
gi 1622961039 765 TVSLTVT 771
Cdd:cd11304    85 TATVTIT 91
Cadherin pfam00028
Cadherin domain;
689-773 7.00e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 7.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 689 SAPGSLI--FEATDDDqhlfRGPH--FTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPL 762
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 1622961039 763 ESTVSLTVTFC 773
Cdd:pfam00028  82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 698-771 2.93e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.03  E-value: 2.93e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961039  698 ATDDDQHLFRgpHFTFSIASESLQNDWQVSKINGThaRLSTRHTDFEEK-EYVVSIRINDGGRPPLESTVSLTVT 771
Cdd:smart00112   2 ATDADSGENG--KVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTIT 72
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-671 2.60e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 578 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 653
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1622961039 654 SLSSVSQFHLILTDVNDN 671
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-346 3.70e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 3.70e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961039  279 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDNPP 346
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-243 5.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 139 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTRegsqELNPAKNPSYNLV 218
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 1622961039 219 ISVKDMGGqseNSFSDTTSVDIIVT 243
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-452 1.32e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 354 VFEVQENERLGNSIGALTAHDSDEENtaNSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 433
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 1622961039 434 DKD---FKTLCFVQINVIDIND 452
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-344 2.66e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 253 VEMVENSTDPHPIkiTQVRWNDPGA------QYSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG 325
Cdd:cd11304     4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622961039 326 KPLSYPLEIHVKVQDINDN 344
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-570 9.98e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 9.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 464 NLTLAEDTNVGSTILTIQATDADEPFTGssKILYHVIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAISNIVFKAEN 543
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622961039 544 PEPLVFgvtynaSSFAKFTLFVTDVNE 570
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-132 4.44e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.44e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622961039   66 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDNRP 132
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 600-673 3.21e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.21e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961039  600 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSQFHLILTDVNDNPP 673
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
579-648 3.70e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.70e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622961039 579 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 648
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 66-130 1.50e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622961039  66 VTFELT-GETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDN 130
Cdd:cd11304    32 VTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
139-243 5.14e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 5.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 139 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLSYQIvIQLPMINNvmyFQINNKTGGISLTRegsqELNPAKNPSYNLV 218
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI-LGGGPGGN---FRIDPDTGDISTTK----PLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....*
gi 1622961039 219 ISVKDMGGQSEnsfSDTTSVDIIVT 243
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
354-436 3.24e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 354 VFEVQENERLGNSIGALTAHDSDEenTANSLLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 433
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 1622961039 434 DKD 436
Cdd:pfam00028  75 DSG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 371-455 1.11e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039  371 TAHDSDEEntANSLLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 447
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 1622961039  448 IDINDQIP 455
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
292-339 1.29e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.29e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622961039 292 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQ 339
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-243 2.45e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039  157 NATDLDDPatPNGQLSYQIVIQlpmiNNVMYFQINNKTGGISLTREgsqeLNPAKNPSYNLVISVKDMGGQsenSFSDTT 236
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTTKP----LDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*..
gi 1622961039  237 SVDIIVT 243
Cdd:smart00112  68 TVTITVL 74
Cadherin pfam00028
Cadherin domain;
65-124 1.85e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 1.85e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622961039  65 AVTFELTGETDNIFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEV 124
Cdd:pfam00028  31 IFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 481-572 1.24e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039  481 QATDADEPFtgSSKILYHVIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAISNIVFKAENpeplvfGVTYNASSFAK 560
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 1622961039  561 FTLFVTDVNEAP 572
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
466-543 1.89e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.89e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622961039 466 TLAEDTNVGSTILTIQATDADEPftGSSKILYHVIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAISNIVFKAEN 543
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 689-771 2.78e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 689 SAPGSLI--FEATDDDQHlfRGPHFTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPLES 764
Cdd:cd11304    10 APPGTVVltVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGE---ITTAKPlDREEQsSYTLTVTATDGGGPPLSS 84


                  ....*..
gi 1622961039 765 TVSLTVT 771
Cdd:cd11304    85 TATVTIT 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-344 2.60e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.57  E-value: 2.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 276 GAQYSLVDKEKLPRFpFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVQDINDN 344
Cdd:cd00031    30 IIKISAAGKEALPSW-LHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
689-773 7.00e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 7.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622961039 689 SAPGSLI--FEATDDDqhlfRGPH--FTFSIASESLQNDWQVSKINGTharLSTRHT-DFEEK-EYVVSIRINDGGRPPL 762
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 1622961039 763 ESTVSLTVTFC 773
Cdd:pfam00028  82 SSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 77-130 2.07e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.07e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622961039  77 IFKIERE-GLLYYTKALDRETRSTHNLQVAALDANGAIVEGPVPITIEVKDVNDN 130
Cdd:cd00031    44 WLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 698-771 2.93e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.03  E-value: 2.93e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961039  698 ATDDDQHLFRgpHFTFSIASESLQNDWQVSKINGThaRLSTRHTDFEEK-EYVVSIRINDGGRPPLESTVSLTVT 771
Cdd:smart00112   2 ATDADSGENG--KVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin_3 pfam16184
Cadherin-like;
443-514 5.13e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 37.58  E-value: 5.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622961039 443 VQINVIDINDQIPIFEKSdyGNLTLAEDtnvGSTILT---IQATDADEPftgSSKILYHVIKGDSEGRLGVDTDP 514
Cdd:pfam16184   7 FNITIIPVNDEAPVLTTN--TGLRLWEG---SSRPITpdlLQAEDPDTP---PEDLTYTVVQGPSHGHLALKGAP 73
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-671 7.11e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 36.94  E-value: 7.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622961039 616 GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSQFHLILTDVNDN 671
Cdd:cd00031    43 SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH