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Conserved domains on  [gi|1622958853|ref|XP_028708107|]
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zinc finger protein 596 isoform X5 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-366 4.80e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 4.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 225 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 296
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622958853 297 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 366
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-213 1.33e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853  64 CGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEM 135
Cdd:COG5048   295 CNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQS 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 136 IH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKCSYLRQHERTHNGEKPYECHLCGK 206
Cdd:COG5048   375 LQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454


                  ....*....
gi 1622958853 207 --AFSHCSH 213
Cdd:COG5048   455 frRDLDLSN 463
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-366 4.80e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 4.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 225 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 296
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622958853 297 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 366
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-213 1.33e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853  64 CGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEM 135
Cdd:COG5048   295 CNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQS 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 136 IH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKCSYLRQHERTHNGEKPYECHLCGK 206
Cdd:COG5048   375 LQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454


                  ....*....
gi 1622958853 207 --AFSHCSH 213
Cdd:COG5048   455 frRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 8.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 8.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622958853 269 DLRRHERTHTGEKPYECHLCGKAFNH 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-210 7.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622958853 185 YLRQHERTHNGEKPYECHLCGKAFSH 210
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-366 4.80e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 4.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 225 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 296
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622958853 297 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 366
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-363 1.29e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 197 KPYECHLCGKAFSHCSHLRQHERS--HNGE--KPHGC--HLCGKAFTESSVLKRHERIHTGEKPYECH--VCGKAFTESS 268
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 269 DLRRHERTH-----TGEKPYEC--HLCGKAFNHSSVLRRHERTHTGEKPYECN--ICGKAFNRSYNFRLHKRVHTGEKPY 339
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|....
gi 1622958853 340 VCLLCgkafsKFFNLRQHERTHTK 363
Cdd:COG5048   448 LCSIL-----KSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-213 1.33e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853  64 CGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEM 135
Cdd:COG5048   295 CNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQS 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 136 IH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKCSYLRQHERTHNGEKPYECHLCGK 206
Cdd:COG5048   375 LQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454


                  ....*....
gi 1622958853 207 --AFSHCSH 213
Cdd:COG5048   455 frRDLDLSN 463
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 195-278 4.08e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 195 GEKPYECHL--CGKAFshcshlrqheRSHNGEKPHGCH-LCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLR 271
Cdd:COG5189   346 DGKPYKCPVegCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1622958853 272 RHeRTHT 278
Cdd:COG5189   416 YH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-364 6.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853  85 KPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEMIHTREKAQVC-HLCGKAFTHCSDLRKH 161
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 162 ERTHLGDKPYGCHLCGKAF-----------SKCSYLRQHERTHNGEK-----------PYECHLCGKAFSHCSHLRQHER 219
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllSISNLRNNPLPGNNSSSvntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 220 SHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRH------ERTHTGEKPYECHLCGKAFN 293
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622958853 294 HSSVLRRHERTHTG-EKPYECNICGKAFNRSYNFRLHKR--VHTGE--KPYVC--LLCGKAFSKFFNLRQHERTHTKK 364
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 111-193 6.28e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 6.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 111 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqvchlCGKAFTHCSDLRKHERTHLGDKPYGCHLCGKAFSKCSYLRQ 188
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1622958853 189 HeRTH 193
Cdd:COG5189   417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 207-306 7.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958853 207 AFSHCSHLRQHERSHN----GEKPHGCHL--CGKAFTESSVLKRHERihtgekpyECHvCGKAFTESSDLRRHERTHTGE 280
Cdd:COG5189   326 KLAHGGERNIDTPSRMlkvkDGKPYKCPVegCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKD 396

                          90       100
                  ....*....|....*....|....*.
gi 1622958853 281 KPYECHLCGKAFNHSSVLRRHeRTHT 306
Cdd:COG5189   397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 8.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 8.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622958853 269 DLRRHERTHTGEKPYECHLCGKAFNH 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-322 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*
gi 1622958853 298 LRRHERTHTGEKPYECNICGKAFNR 322
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-265 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....
gi 1622958853 242 LKRHERIHTGEKPYECHVCGKAFT 265
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-210 7.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622958853 185 YLRQHERTHNGEKPYECHLCGKAFSH 210
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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