NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622957874|ref|XP_028707906|]
View 

neurexin 3 isoform X21 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
282-413 2.34e-34

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 128.61  E-value: 2.34e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   282 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 359
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957874   360 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 413
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
899-1027 5.18e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.15  E-value: 5.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  899 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 978
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957874  979 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1027
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
470-619 2.34e-30

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.34e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   470 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 549
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957874   550 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 619
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.19e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 3.19e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957874  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1091-1240 6.88e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.11  E-value: 6.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1091 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1170
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1171 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLtIFNTQAQIAIGGKDKGRLFQGQLSGLYYDG 1240
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDLKSPGLPVSPGFVG 143
LamG smart00282
Laminin G domain;
708-842 1.37e-21

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.37e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   708 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 786
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   787 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 842
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
647-680 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957874  647 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 680
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957874  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
4.1m super family cl02555
putative band 4.1 homologues' binding motif;
1487-1505 2.94e-03

putative band 4.1 homologues' binding motif;


The actual alignment was detected with superfamily member smart00294:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 2.94e-03
                            10
                    ....*....|....*....
gi 1622957874  1487 MYKYRNRDEGSYQVDETRN 1505
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1467-1523 4.96e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 4.96e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957874 1467 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1523
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
282-413 2.34e-34

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 128.61  E-value: 2.34e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   282 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 359
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957874   360 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 413
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
899-1027 5.18e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.15  E-value: 5.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  899 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 978
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957874  979 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1027
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
258-410 6.39e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.92  E-value: 6.39e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  258 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 335
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622957874  336 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 410
Cdd:cd00110     76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
287-410 1.97e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 122.91  E-value: 1.97e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  287 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRQVTISVDGILTTT 365
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622957874  366 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 410
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
872-1025 5.66e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 5.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  872 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 949
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957874  950 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1025
Cdd:cd00110     78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
470-619 2.34e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.34e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   470 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 549
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957874   550 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 619
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
894-1027 2.49e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.36  E-value: 2.49e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   894 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 972
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957874   973 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1027
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.19e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 3.19e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957874  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
448-617 5.42e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.42e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  448 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 526
Cdd:cd00110      1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  527 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 605
Cdd:cd00110     68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                          170
                   ....*....|..
gi 1622957874  606 GYVGCIRDLFID 617
Cdd:cd00110    140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 7.07e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.12  E-value: 7.07e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874    50 DLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957874   129 G-QSGELQPQRPYMDVVSDLFLGGVPADIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
475-619 1.10e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  475 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 554
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957874  555 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 619
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1091-1240 6.88e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.11  E-value: 6.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1091 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1170
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1171 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLtIFNTQAQIAIGGKDKGRLFQGQLSGLYYDG 1240
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.14e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.57  E-value: 1.14e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   55 FKTNVSTGLLLYLDDGGiCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957874  134 LQPQRPY-MDVVSDLFLGGVPADirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1122-1240 8.60e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 8.60e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1122 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1201
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1622957874 1202 HYPTGRQLtIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1240
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
1117-1240 2.59e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 97.02  E-value: 2.59e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  1117 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1196
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957874  1197 -WPVNEHYPTGrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1240
Cdd:smart00282   80 gNRVSGESPGG--LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
708-842 1.37e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.37e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   708 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 786
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   787 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 842
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
713-842 5.33e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 5.33e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  713 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 792
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957874  793 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 842
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
686-841 6.00e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.69  E-value: 6.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  686 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 765
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  766 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 838
Cdd:cd00110     72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                   ...
gi 1622957874  839 MFN 841
Cdd:cd00110    149 KVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
647-680 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957874  647 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 680
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957874  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
647-678 6.98e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 6.98e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622957874  647 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 678
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
647-680 1.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.44e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1622957874   647 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 680
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1487-1505 2.94e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 2.94e-03
                            10
                    ....*....|....*....
gi 1622957874  1487 MYKYRNRDEGSYQVDETRN 1505
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1467-1523 4.96e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 4.96e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957874 1467 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1523
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 7.01e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.01e-03
                           10        20
                   ....*....|....*....|....*....
gi 1622957874  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
282-413 2.34e-34

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 128.61  E-value: 2.34e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   282 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 359
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957874   360 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 413
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
899-1027 5.18e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.15  E-value: 5.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  899 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 978
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957874  979 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1027
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
258-410 6.39e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.92  E-value: 6.39e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  258 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 335
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622957874  336 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 410
Cdd:cd00110     76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
287-410 1.97e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 122.91  E-value: 1.97e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  287 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRQVTISVDGILTTT 365
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622957874  366 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 410
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
872-1025 5.66e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 5.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  872 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 949
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957874  950 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1025
Cdd:cd00110     78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
470-619 2.34e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.34e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   470 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 549
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957874   550 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 619
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
894-1027 2.49e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.36  E-value: 2.49e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   894 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 972
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957874   973 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1027
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.19e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 3.19e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957874  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
448-617 5.42e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.42e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  448 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 526
Cdd:cd00110      1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  527 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 605
Cdd:cd00110     68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                          170
                   ....*....|..
gi 1622957874  606 GYVGCIRDLFID 617
Cdd:cd00110    140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 7.07e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.12  E-value: 7.07e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874    50 DLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957874   129 G-QSGELQPQRPYMDVVSDLFLGGVPADIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
475-619 1.10e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  475 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 554
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957874  555 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 619
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1091-1240 6.88e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.11  E-value: 6.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1091 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1170
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1171 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLtIFNTQAQIAIGGKDKGRLFQGQLSGLYYDG 1240
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.14e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.57  E-value: 1.14e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   55 FKTNVSTGLLLYLDDGGiCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957874  134 LQPQRPY-MDVVSDLFLGGVPADirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1122-1240 8.60e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 8.60e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1122 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1201
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1622957874 1202 HYPTGRQLtIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1240
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
1117-1240 2.59e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 97.02  E-value: 2.59e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  1117 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1196
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957874  1197 -WPVNEHYPTGrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1240
Cdd:smart00282   80 gNRVSGESPGG--LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
899-1027 3.28e-22

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 93.92  E-value: 3.28e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  899 FKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSdrPLNDNQWHNVVITRDNSNThSLKVD---TK 974
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD--KLNDGKWHSVELERNGRSG-TLSVDgeaRP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622957874  975 VVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKlvASRDGFQGCLASVDLNGR 1027
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSLGVKKRRL--AISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
708-842 1.37e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.37e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   708 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 786
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   787 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 842
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
287-412 3.94e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 87.76  E-value: 3.94e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  287 FKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAfeaIVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTT 364
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRLEVSYDLGSGA---AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622957874  365 TGYTQEDYTMLGS-DDFFYVGGSPSTADLP-GSPVSNNFMGCLKEVVYKN 412
Cdd:pfam00054   78 TGESPLGATTDLDvDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
475-619 2.51e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.45  E-value: 2.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  475 FRTTEPNGLILFThgkpqerkdarsQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQkKANDGEWYHVDIQRDGRSG 554
Cdd:pfam00054    1 FRTTEPSGLLLYN------------GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSG 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957874  555 TISVNSRRTPFTAS--GESEILDLEGDMYLGGLPEnragliLPTELWTAMLNYGYVGCIRDLFIDGR 619
Cdd:pfam00054   68 TLSVDGEARPTGESplGATTDLDVDGPLYVGGLPS------LGVKKRRLAISPSFDGCIRDVIVNGK 128
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
713-842 5.33e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 5.33e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  713 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 792
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957874  793 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 842
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
686-841 6.00e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.69  E-value: 6.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  686 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 765
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  766 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 838
Cdd:cd00110     72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                   ...
gi 1622957874  839 MFN 841
Cdd:cd00110    149 KVN 151
Laminin_G_1 pfam00054
Laminin G domain;
720-842 3.41e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  720 GLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-DVAE 798
Cdd:pfam00054    8 GLLLYNGTQTERDFLALELRDGRLEVSYDL---------GSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPT 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957874  799 GTMVgdHTRLEFHNIETGIM-------TEKRYISVVPSSFIGHLQSLMFNG 842
Cdd:pfam00054   79 GESP--LGATTDLDVDGPLYvgglpslGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
55-183 3.65e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874   55 FKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGEL 134
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622957874  135 QPQRPYM--DVVSDLFLGGVPADI---RPSALTldgvqamPGFKGLILDLKYGN 183
Cdd:pfam00054   81 SPLGATTdlDVDGPLYVGGLPSLGvkkRRLAIS-------PSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
1122-1222 1.83e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 51.55  E-value: 1.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874 1122 FSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEErTPVNDGKYHVVRFTRNGGNATLQVDnwpvNE 1201
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGAAVVRSG-DKLNDGKWHSVELERNGRSGTLSVD----GE 74
                           90       100
                   ....*....|....*....|....*
gi 1622957874 1202 HYPTGRQ----LTIFNTQAQIAIGG 1222
Cdd:pfam00054   75 ARPTGESplgaTTDLDVDGPLYVGG 99
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
647-680 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957874  647 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 680
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957874  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
647-678 6.98e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 6.98e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622957874  647 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 678
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
279-391 4.34e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 42.37  E-value: 4.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957874  279 SSDEITLSFktW------QRNGLILHTGKSADYVNLAL-KDGAVSLVINLGSGAFEAIVepVNGKFNDNAWHDVKVTRNL 351
Cdd:pfam13385   15 PTSDFTVSA--WvkpdslPGWARAIISSSGGGGYSLGLdGDGRLRFAVNGGNGGWDTVT--SGASVPLGQWTHVAVTYDG 90
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1622957874  352 RQVTISVDGILTTTGyTQEDYTMLGSDDFFYVGGSPSTAD 391
Cdd:pfam13385   91 GTLRLYVNGVLVGSS-TLTGGPPPGTGGPLYIGRSPGGDD 129
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
648-680 8.42e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 8.42e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622957874  648 DSYPCKNNAVCKDGWNRFICDCTgTGYWG-RTCE 680
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCP-PGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
647-680 1.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.44e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1622957874   647 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 680
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1487-1505 2.94e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 2.94e-03
                            10
                    ....*....|....*....
gi 1622957874  1487 MYKYRNRDEGSYQVDETRN 1505
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1467-1523 4.96e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 4.96e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957874 1467 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1523
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 7.01e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.01e-03
                           10        20
                   ....*....|....*....|....*....
gi 1622957874  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH