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Conserved domains on  [gi|1622955814|ref|XP_028707410|]
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trans-3-hydroxy-L-proline dehydratase isoform X2 [Macaca mulatta]

Protein Classification

4-hydroxyproline epimerase; proline racemase family protein( domain architecture ID 1905033)

4-hydroxyproline epimerase catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)| proline racemase family protein similar to trans-3-hydroxy-L-proline (t3LHyp) dehydratase (aka 4-hydroxyproline 2-epimerase) that catalyzes the dehydration of t3LHyp to delta(1)-pyrroline-2-carboxylate (Pyr2C), and the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_racemase super family cl42407
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 1-181 9.29e-82

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


The actual alignment was detected with superfamily member pfam05544:

Pssm-ID: 478179  Cd Length: 325  Bit Score: 244.90  E-value: 9.29e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   1 MVDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDA 80
Cdd:pfam05544 147 EVEVPGLGRVRVDIAYGGNFYAIVDAEQLGFDIEPAEARELVAAGEKIRDALNEQLKVVHPENPDIRGVSHVQLTGPPTR 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  81 YTKePTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFKsSTTGSVFTGKAVREAKCGDFKAVIVEVSGQA 160
Cdd:pfam05544 227 AEA-HARNAVIIGPGAIDRSPCGTGTSARMAQLHAKGKLKVGETFVHE-SIIGSEFEGRVEGETEVGGRPAIVPSISGRA 304

                         170       180
                  ....*....|....*....|.
gi 1622955814 161 HYTGTASFIVEDDDPLRDGFL 181
Cdd:pfam05544 305 WITGTNQLLLDPSDPFAHGFR 325
 
Name Accession Description Interval E-value
Pro_racemase pfam05544
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 1-181 9.29e-82

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


Pssm-ID: 398923  Cd Length: 325  Bit Score: 244.90  E-value: 9.29e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   1 MVDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDA 80
Cdd:pfam05544 147 EVEVPGLGRVRVDIAYGGNFYAIVDAEQLGFDIEPAEARELVAAGEKIRDALNEQLKVVHPENPDIRGVSHVQLTGPPTR 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  81 YTKePTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFKsSTTGSVFTGKAVREAKCGDFKAVIVEVSGQA 160
Cdd:pfam05544 227 AEA-HARNAVIIGPGAIDRSPCGTGTSARMAQLHAKGKLKVGETFVHE-SIIGSEFEGRVEGETEVGGRPAIVPSISGRA 304

                         170       180
                  ....*....|....*....|.
gi 1622955814 161 HYTGTASFIVEDDDPLRDGFL 181
Cdd:pfam05544 305 WITGTNQLLLDPSDPFAHGFR 325
PrdF COG3938
Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];
2-183 6.79e-67

Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];


Pssm-ID: 443139  Cd Length: 335  Bit Score: 207.26  E-value: 6.79e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   2 VDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSEDLAFLYGTILTdGKDAY 81
Cdd:COG3938   156 VEVPGLGTVTVDIAYGGNFYAIVDAQQLGLDLEPENARELIRLGLEIRDAANEQLEVVHPENPDINGVSHVEFT-GPPTD 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  82 TKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFkSSTTGSVFTGKAVREAKCGDFKAVIVEVSGQAH 161
Cdd:COG3938   235 PDADARNAVVFGPGAIDRSPCGTGTSARMALLHARGELKVGETFVH-ESIIGSRFTGRILEETTVGGYPAIIPEITGRAW 313

                         170       180
                  ....*....|....*....|..
gi 1622955814 162 YTGTASFIVEDDDPLRDGFLLK 183
Cdd:COG3938   314 ITGFNQFVLDPDDPLPEGFLLR 335
PRK13969 PRK13969
proline racemase; Provisional
 2-182 1.45e-47

proline racemase; Provisional


Pssm-ID: 184427 [Multi-domain]  Cd Length: 334  Bit Score: 157.71  E-value: 1.45e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   2 VDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSE-----DLAFLYGTilTD 76
Cdd:PRK13969  156 IDVPDYGKVTLDISFGGSFFAIVDAEQLGIKISPANSQKLNDLGMKIRHAVNEQIEIKHPVLEhiktvDLVEIYDE--AK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  77 GKDAYTKepttNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQtRAFKSSTTGSVFTGKAVREAKCGDFKAVIVEV 156
Cdd:PRK13969  234 HPDADYK----NVVIFGQGQVDRSPCGTGTSAKMATLYAKGKLKVGE-EFVYESIIGTKFKGKILEETKVGEYDAIIPEI 308

                         170       180
                  ....*....|....*....|....*.
gi 1622955814 157 SGQAHYTGTASFIVEDDDPLRDGFLL 182
Cdd:PRK13969  309 TGSAYITGFNQFVIDEEDPVKYGFVL 334
 
Name Accession Description Interval E-value
Pro_racemase pfam05544
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 1-181 9.29e-82

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


Pssm-ID: 398923  Cd Length: 325  Bit Score: 244.90  E-value: 9.29e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   1 MVDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDA 80
Cdd:pfam05544 147 EVEVPGLGRVRVDIAYGGNFYAIVDAEQLGFDIEPAEARELVAAGEKIRDALNEQLKVVHPENPDIRGVSHVQLTGPPTR 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  81 YTKePTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFKsSTTGSVFTGKAVREAKCGDFKAVIVEVSGQA 160
Cdd:pfam05544 227 AEA-HARNAVIIGPGAIDRSPCGTGTSARMAQLHAKGKLKVGETFVHE-SIIGSEFEGRVEGETEVGGRPAIVPSISGRA 304

                         170       180
                  ....*....|....*....|.
gi 1622955814 161 HYTGTASFIVEDDDPLRDGFL 181
Cdd:pfam05544 305 WITGTNQLLLDPSDPFAHGFR 325
PrdF COG3938
Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];
2-183 6.79e-67

Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];


Pssm-ID: 443139  Cd Length: 335  Bit Score: 207.26  E-value: 6.79e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   2 VDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSEDLAFLYGTILTdGKDAY 81
Cdd:COG3938   156 VEVPGLGTVTVDIAYGGNFYAIVDAQQLGLDLEPENARELIRLGLEIRDAANEQLEVVHPENPDINGVSHVEFT-GPPTD 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  82 TKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFkSSTTGSVFTGKAVREAKCGDFKAVIVEVSGQAH 161
Cdd:COG3938   235 PDADARNAVVFGPGAIDRSPCGTGTSARMALLHARGELKVGETFVH-ESIIGSRFTGRILEETTVGGYPAIIPEITGRAW 313

                         170       180
                  ....*....|....*....|..
gi 1622955814 162 YTGTASFIVEDDDPLRDGFLLK 183
Cdd:COG3938   314 ITGFNQFVLDPDDPLPEGFLLR 335
PRK13969 PRK13969
proline racemase; Provisional
 2-182 1.45e-47

proline racemase; Provisional


Pssm-ID: 184427 [Multi-domain]  Cd Length: 334  Bit Score: 157.71  E-value: 1.45e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   2 VDVPGHGKVVVDIAYGGAFYAFVSAEKLGLDICSAKTRDLVDAASTVTEAVKAQFKINHPDSE-----DLAFLYGTilTD 76
Cdd:PRK13969  156 IDVPDYGKVTLDISFGGSFFAIVDAEQLGIKISPANSQKLNDLGMKIRHAVNEQIEIKHPVLEhiktvDLVEIYDE--AK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  77 GKDAYTKepttNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQtRAFKSSTTGSVFTGKAVREAKCGDFKAVIVEV 156
Cdd:PRK13969  234 HPDADYK----NVVIFGQGQVDRSPCGTGTSAKMATLYAKGKLKVGE-EFVYESIIGTKFKGKILEETKVGEYDAIIPEI 308

                         170       180
                  ....*....|....*....|....*.
gi 1622955814 157 SGQAHYTGTASFIVEDDDPLRDGFLL 182
Cdd:PRK13969  309 TGSAYITGFNQFVIDEEDPVKYGFVL 334
PRK13971 PRK13971
4-hydroxyproline epimerase;
2-183 1.63e-29

4-hydroxyproline epimerase;


Pssm-ID: 184428  Cd Length: 333  Bit Score: 110.81  E-value: 1.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   2 VDVPGHGKVVVDIAYGGAFYAFVSAEK--LGLDICSAKtrDLVDAASTVTEAVKAQFKINHPDSEDLAFLYGTILTDgkD 79
Cdd:PRK13971  154 VEIPGLGPLKVDVAYGGNFYAIVEPQEnfPGLDHYSAS--DILRWSPVLRQALNEKYEFVHPEDPRIRGVSHVLWTG--K 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  80 AYTKEPTTNICVFA-DEQVDRSPTGSGVTARIALQYHKGLLELNQtrAF-KSSTTGSVFTGKAVREAKCGDFKAVIVEVS 157
Cdd:PRK13971  230 PISPGADARNAVFYgDKAIDRSPCGTGTSARMAQLAAKGKLKVGD--EFvHESIIGSLFEGRVEAAATVGGRPAILPSIE 307

                         170       180
                  ....*....|....*....|....*.
gi 1622955814 158 GQAHYTGTASFIVEDDDPLRDGFLLK 183
Cdd:PRK13971  308 GWARVTGHNTIFVDDRDPYAHGFQVK 333
PRK13970 PRK13970
4-hydroxyproline epimerase;
2-176 9.31e-13

4-hydroxyproline epimerase;


Pssm-ID: 172473  Cd Length: 311  Bit Score: 65.04  E-value: 9.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814   2 VDVPGHGKVVVDIAYGGAFYAFVSAEklGLDICSAKTRDLVDAASTVTEAVKAQfkinhpdsedlaflyGTILTDGKday 81
Cdd:PRK13970  146 VDVPGYGPVKGDIAWGGNWFFLISDH--GQRVAGDNVAALTAYASAVRAGLERA---------------GITGANGG--- 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622955814  82 tkePTTNICVFADE--------------QVDRSPTGSGVTARIALQYHKGLLELNQTRAfKSSTTGSVFTGKAVReAKCG 147
Cdd:PRK13970  206 ---EIDHIELFADDpehdsrsfvlcpghAYDRSPCGTGTSAKLACLAADGKLAPGVVWR-QASVIGSVFSASYAA-AEGG 280

                         170       180
                  ....*....|....*....|....*....
gi 1622955814 148 dfkaVIVEVSGQAHYTGTASFIVEDDDPL 176
Cdd:PRK13970  281 ----IVPTIRGSAHLSAEATLLIEDDDPF 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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