NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622953629|ref|XP_028706885|]
View 

multiple epidermal growth factor-like domains protein 11 isoform X2 [Macaca mulatta]

Protein Classification

calcium-binding EGF-like domain-containing protein; tyrosinase family protein( domain architecture ID 11167475)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| tyrosinase family protein such as tyrosinase, a metal-containing oxidase that catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 25-94 1.68e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 60.51  E-value: 1.68e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622953629   25 PNVCS--HWESYAVTVQESYAHPFDQIYYTRCTDIlnwFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYE 94
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 275-320 1.60e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 1.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622953629  275 CPCHHGG----QCDHVTGQCHCTAGYMGDRCqEECPFGTFGFQCSQRCDC 320
Cdd:pfam00053    1 CDCNPHGslsdTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 362-409 3.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 36.56  E-value: 3.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622953629  362 CPCD--ADNTISCHPVTGACACQPGWSGRHCNEsCPAGYYGDGCQQTCTC 409
Cdd:pfam00053    1 CDCNphGSLSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 25-94 1.68e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 60.51  E-value: 1.68e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622953629   25 PNVCS--HWESYAVTVQESYAHPFDQIYYTRCTDIlnwFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYE 94
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 275-320 1.60e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 1.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622953629  275 CPCHHGG----QCDHVTGQCHCTAGYMGDRCqEECPFGTFGFQCSQRCDC 320
Cdd:pfam00053    1 CDCNPHGslsdTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 362-409 3.69e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.56  E-value: 3.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622953629  362 CPCD--ADNTISCHPVTGACACQPGWSGRHCNEsCPAGYYGDGCQQTCTC 409
Cdd:pfam00053    1 CDCNphGSLSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 361-401 5.29e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 5.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622953629  361 PCPCD--ADNTISCHPVTGACACQPGWSGRHCNEsCPAGYYGD 401
Cdd:cd00055      1 PCDCNghGSLSGQCDPGTGQCECKPNTTGRRCDR-CAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
362-404 6.38e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 6.38e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622953629   362 CPCDADNTIS--CHPVTGACACQPGWSGRHCNEsCPAGYYGDGCQ 404
Cdd:smart00180    1 CDCDPGGSASgtCDPDTGQCECKPNVTGRRCDR-CAPGYYGDGPP 44
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 25-94 1.68e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 60.51  E-value: 1.68e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622953629   25 PNVCS--HWESYAVTVQESYAHPFDQIYYTRCTDIlnwFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYE 94
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 275-320 1.60e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 1.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622953629  275 CPCHHGG----QCDHVTGQCHCTAGYMGDRCqEECPFGTFGFQCSQRCDC 320
Cdd:pfam00053    1 CDCNPHGslsdTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 362-409 3.69e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.56  E-value: 3.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622953629  362 CPCD--ADNTISCHPVTGACACQPGWSGRHCNEsCPAGYYGDGCQQTCTC 409
Cdd:pfam00053    1 CDCNphGSLSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 361-401 5.29e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 5.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622953629  361 PCPCD--ADNTISCHPVTGACACQPGWSGRHCNEsCPAGYYGD 401
Cdd:cd00055      1 PCDCNghGSLSGQCDPGTGQCECKPNTTGRRCDR-CAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
362-404 6.38e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 6.38e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622953629   362 CPCDADNTIS--CHPVTGACACQPGWSGRHCNEsCPAGYYGDGCQ 404
Cdd:smart00180    1 CDCDPGGSASgtCDPDTGQCECKPNVTGRRCDR-CAPGYYGDGPP 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH