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Conserved domains on  [gi|1622953217|ref|XP_028706771|]
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WD repeat-containing protein 72 isoform X2 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 402-587 5.61e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 5.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  402 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 481
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  482 CVILWDIVTEEILHKFFLEAGAVTSLLMSPEKfklrgeQIICCVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVE 561
Cdd:cd00200     74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 1622953217  562 NFLIVGCADDSVYIWEIETG----TLERHE 587
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 5.36e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 5.36e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217    3 TSLQAVALWGHKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   79 -YIVSAAENGEMCVWNVTSGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1622953217  158 wincmciVHSVRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 402-587 5.61e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 5.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  402 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 481
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  482 CVILWDIVTEEILHKFFLEAGAVTSLLMSPEKfklrgeQIICCVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVE 561
Cdd:cd00200     74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 1622953217  562 NFLIVGCADDSVYIWEIETG----TLERHE 587
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
417-594 2.57e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 2.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  417 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDIVTEEILHK 496
Cdd:COG2319    219 LASGSADGTVRL---WDLATGKLL------RTLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDLATGELLRT 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  497 FFLEAGAVTSLLMSPEkfklrGEQIICCvCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCADDSVYIW 576
Cdd:COG2319    284 LTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                          170
                   ....*....|....*...
gi 1622953217  577 EIETGTLERHETGERARI 594
Cdd:COG2319    358 DLATGELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 5.36e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 5.36e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217    3 TSLQAVALWGHKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   79 -YIVSAAENGEMCVWNVTSGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1622953217  158 wincmciVHSVRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-191 2.05e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 2.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   12 GHKappHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQP-YIVSAAENGEMC 90
Cdd:cd00200     91 GHT---SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---LRGHTDWVNSVA----FSPDGtFVASSSQDGTIK 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   91 VWNVTSGQCVekATLpYRHTAiCYYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQfpDWINCmcivhsVRI 170
Cdd:cd00200    161 LWDLRTGKCV--ATL-TGHTG-EVNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKCLGTLRGHE--NGVNS------VAF 227

                          170       180
                   ....*....|....*....|...
gi 1622953217  171 QEDSLLVVSVAGE--LKVWDLSS 191
Cdd:cd00200    228 SPDGYLLASGSEDgtIRVWDLRT 250
WD40 pfam00400
WD domain, G-beta repeat;
445-487 9.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 9.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622953217  445 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 487
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 402-587 5.61e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 5.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  402 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 481
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  482 CVILWDIVTEEILHKFFLEAGAVTSLLMSPEKfklrgeQIICCVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVE 561
Cdd:cd00200     74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 1622953217  562 NFLIVGCADDSVYIWEIETG----TLERHE 587
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
417-594 2.57e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 2.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  417 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDIVTEEILHK 496
Cdd:COG2319    219 LASGSADGTVRL---WDLATGKLL------RTLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDLATGELLRT 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  497 FFLEAGAVTSLLMSPEkfklrGEQIICCvCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCADDSVYIW 576
Cdd:COG2319    284 LTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                          170
                   ....*....|....*...
gi 1622953217  577 EIETGTLERHETGERARI 594
Cdd:COG2319    358 DLATGELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 5.36e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 5.36e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217    3 TSLQAVALWGHKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   79 -YIVSAAENGEMCVWNVTSGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1622953217  158 wincmciVHSVRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-587 6.67e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 6.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  410 YIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWDIV 489
Cdd:cd00200     59 ASADGTYLASGSSDKTIRLWD---------LETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVE 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  490 TEEILHKFFLEAGAVTSLLMSPEKfklrgeQIICCVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCA 569
Cdd:cd00200    124 TGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                          170       180
                   ....*....|....*....|..
gi 1622953217  570 DDSVYIWEIETG----TLERHE 587
Cdd:cd00200    198 DGTIKLWDLSTGkclgTLRGHE 219
WD40 COG2319
WD40 repeat [General function prediction only];
417-594 1.36e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 1.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  417 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIVTEEILH 495
Cdd:COG2319    177 LASGSDDGTVRL---WDLATGKLL------RTLTGHTGAVRSVAFsPDG-------KLLASGSADGTVRLWDLATGKLLR 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  496 KFFLEAGAVTSLLMSPEkfklrGEQIICCvCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCADDSVYI 575
Cdd:COG2319    241 TLTGHSGSVRSVAFSPD-----GRLLASG-SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                          170
                   ....*....|....*....
gi 1622953217  576 WEIETGTLERHETGERARI 594
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAV 333
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 405-589 7.92e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 7.92e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  405 VTSSEYIPSlDKLICGC-EDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCV 483
Cdd:cd00200     96 VSSVAFSPD-GRILSSSsRDKTIKVWD---------VETGKCLTTLRGHTDWVNSVAFSP------DGTFVASSSQDGTI 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  484 ILWDIVTEEILHKFFLEAGAVTSLLMSPEkfklrGEQIICCvCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENF 563
Cdd:cd00200    160 KLWDLRTGKCVATLTGHTGEVNSVAFSPD-----GEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                          170       180       190
                   ....*....|....*....|....*....|
gi 1622953217  564 LIVGCADDSVYIWEIETG----TLERHETG 589
Cdd:cd00200    234 LASGSEDGTIRVWDLRTGecvqTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
401-594 2.86e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 2.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  401 GTAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLD 480
Cdd:COG2319     77 HTAAVLSVAFSPDGRLLASASADGTVRLWD---------LATGLLLRTLTGHTGAVRSVAF----SP--DGKTLASGSAD 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  481 SCVILWDIVTEEILHKFFLEAGAVTSLLMSPEkfklrGEQIICcVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPV 560
Cdd:COG2319    142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-----GKLLAS-GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1622953217  561 ENFLIVGCADDSVYIWEIETGTLERHETGERARI 594
Cdd:COG2319    216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
417-580 1.25e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  417 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIVTEEILH 495
Cdd:COG2319    261 LASGSADGTVRL---WDLATGELL------RTLTGHSGGVNSVAFsPDG-------KLLASGSDDGTVRLWDLATGKLLR 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  496 KFFLEAGAVTSLLMSPEkfklrGEQIICCvCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCADDSVYI 575
Cdd:COG2319    325 TLTGHTGAVRSVAFSPD-----GKTLASG-SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                   ....*
gi 1622953217  576 WEIET 580
Cdd:COG2319    399 WDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
10-191 4.51e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 4.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   10 LWGHKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSKQ-PYIVSAAEN 86
Cdd:COG2319    200 LTGHTGAVRSVA---FSPDGKLLASGSADGTVRLWDLA-----TGKLLrtLTGHSGSVRSVA----FSPDgRLLASGSAD 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   87 GEMCVWNVTSGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwincmciVH 166
Cdd:COG2319    268 GTVRLWDLATGELL--RTLTGHSGGV--NSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VR 334

                          170       180
                   ....*....|....*....|....*..
gi 1622953217  167 SVRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    335 SVAFSPDGKTLASGSddGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
423-594 5.29e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 5.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  423 DGTIIITQALNAAKARLLEDSPPHKVLKGHHQSVTSLLYPhglsskLDQSWMLSGDLDSCVILWDIVTEEILHKFFLEAG 502
Cdd:COG2319     48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  503 AVTSLLMSPEkfklrGEQIICcVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 582
Cdd:COG2319    122 AVRSVAFSPD-----GKTLAS-GSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                          170
                   ....*....|..
gi 1622953217  583 LERHETGERARI 594
Cdd:COG2319    196 LLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-191 2.05e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 2.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   12 GHKappHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQP-YIVSAAENGEMC 90
Cdd:cd00200     91 GHT---SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---LRGHTDWVNSVA----FSPDGtFVASSSQDGTIK 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   91 VWNVTSGQCVekATLpYRHTAiCYYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQfpDWINCmcivhsVRI 170
Cdd:cd00200    161 LWDLRTGKCV--ATL-TGHTG-EVNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKCLGTLRGHE--NGVNS------VAF 227

                          170       180
                   ....*....|....*....|...
gi 1622953217  171 QEDSLLVVSVAGE--LKVWDLSS 191
Cdd:cd00200    228 SPDGYLLASGSEDgtIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
2-191 4.34e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217    2 RTSLQAVALWGHKAPPHSITAimiTDDQRTIVTGSQEGQLCLWNLSHELkisAKELLFGHSASVTCLARARDfskQPYIV 81
Cdd:COG2319     66 AAGALLATLLGHTAAVLSVAF---SPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPD---GKTLA 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   82 SAAENGEMCVWNVTSGQCVekATLPyRHTAICYyhcSFRMTGEG-WLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwin 160
Cdd:COG2319    137 SGSADGTVRLWDLATGKLL--RTLT-GHSGAVT---SVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---- 206

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1622953217  161 cmciVHSVRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    207 ----VRSVAFSPDGKLLASGSadGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-191 8.22e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 8.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   12 GHKAPphsITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKEllfGHSASVTCLARardFSKQPYIVSAAENGEMCV 91
Cdd:cd00200      7 GHTGG---VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAA---SADGTYLASGSSDKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   92 WNVTSGQCVEKATlpyRHTAICyYHCSFrMTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSsqFPDWINCmcivhsVRIQ 171
Cdd:cd00200     78 WDLETGECVRTLT---GHTSYV-SSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWVNS------VAFS 144

                          170       180
                   ....*....|....*....|..
gi 1622953217  172 EDSLLVVSVA--GELKVWDLSS 191
Cdd:cd00200    145 PDGTFVASSSqdGTIKLWDLRT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 402-577 3.83e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 3.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  402 TAVVTSSEYIPSLDKLICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSL-LYPhglssklDQSWMLSGDLD 480
Cdd:cd00200    135 TDWVNSVAFSPDGTFVASSSQDGTIKL---WDLRTGKCV------ATLTGHTGEVNSVaFSP-------DGEKLLSSSSD 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  481 SCVILWDIVTEEILHKFFLEAGAVTSLLMSPEKfklrgeQIICCVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPV 560
Cdd:cd00200    199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                          170
                   ....*....|....*..
gi 1622953217  561 ENFLIVGCADDSVYIWE 577
Cdd:cd00200    273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
423-594 1.44e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  423 DGTIIITQALNAAKARLLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWDIVTEEILHKFFLEAG 502
Cdd:COG2319      6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP------DGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  503 AVTSLLMSPekfklrGEQIICCVCSDHSVALLHLEGKSCLLRARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 582
Cdd:COG2319     80 AVLSVAFSP------DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                          170
                   ....*....|..
gi 1622953217  583 LERHETGERARI 594
Cdd:COG2319    154 LLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-114 5.43e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 5.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   12 GHKAPphsITAIMITDDQRTIVTGSQEGQLCLWNLShelKISAKELLFGHSASVTCLArardFSKQPYIV-SAAENGEMC 90
Cdd:cd00200    175 GHTGE---VNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENGVNSVA----FSPDGYLLaSGSEDGTIR 244

                           90       100
                   ....*....|....*....|....
gi 1622953217   91 VWNVTSGQCVekATLPyRHTAICY 114
Cdd:cd00200    245 VWDLRTGECV--QTLS-GHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 383-531 5.78e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  383 DAVSQSIIDYFSGLKDGagtavVTSSEYIPSLDKLICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYP 462
Cdd:cd00200    163 DLRTGKCVATLTGHTGE-----VNSVAFSPDGEKLLSSSSDGTIKL---WDLSTGKCL------GTLRGHENGVNSVAFS 228

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  463 HglssklDQSWMLSGDLDSCVILWDIVTEEILHKFFLEAGAVTSLLMSPEKFKLrgeqiicCVCS-DHSV 531
Cdd:cd00200    229 P------DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL-------ASGSaDGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
10-96 1.04e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   10 LWGHKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENG 87
Cdd:COG2319    323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELLrtLTGHTGAVTSVAFSPD---GRTLASGSADG 394


                   ....*....
gi 1622953217   88 EMCVWNVTS 96
Cdd:COG2319    395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-191 1.83e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   58 LFGHSASVTCLArardFS-KQPYIVSAAENGEMCVWNVTSGQCVEKATLpyrHTaICYYHCSFRMTGEgWLLCCGEYQDV 136
Cdd:cd00200      5 LKGHTGGVTCVA----FSpDGKLLATGSGDGTIKVWDLETGELLRTLKG---HT-GPVRDVAASADGT-YLASGSSDKTI 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622953217  137 LIIDAKTLAVVHSFRssQFPDWINCMCIVHSVRIqedsLLVVSVAGELKVWDLSS 191
Cdd:cd00200     76 RLWDLETGECVRTLT--GHTSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
14-100 2.14e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENGEMCV 91
Cdd:COG2319    285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLLrtLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRL 356


                   ....*....
gi 1622953217   92 WNVTSGQCV 100
Cdd:COG2319    357 WDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 548-605 2.10e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 2.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217  548 HLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI--ILNCCDDSQLV 605
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdVAASADGTYLA 67
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-93 6.54e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 6.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953217   10 LWGHKAPphsITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQ-PYIVSAAENGE 88
Cdd:cd00200    215 LRGHENG---VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGHTNSVTSLA----WSPDgKRLASGSADGT 284


                   ....*
gi 1622953217   89 MCVWN 93
Cdd:cd00200    285 IRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
445-487 9.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 9.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622953217  445 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 487
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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