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Conserved domains on  [gi|1622953130|ref|XP_028706753|]
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AP-4 complex subunit epsilon-1 isoform X3 [Macaca mulatta]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 1001770)

HEAT repeat domain-containing protein similar to the N-terminal region of various adaptins

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Adaptin_N super family cl37648
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
52-596 7.71e-78

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


The actual alignment was detected with superfamily member pfam01602:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 259.86  E-value: 7.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130  52 EEKLIQQELSSLKATVSAPTTTlkmMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELL 131
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDPRK---KKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 132 LLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Cdd:pfam01602  78 ILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 212 KALCDRDVGVMAASLHIYLRMIKENSSgYKDLTGSFVTILKQVVGgklpvdfnyhsVPAPWLQIQLLRILGLLGK-DDQR 290
Cdd:pfam01602 158 ELLSDKDPGVQSAAVALLYEICKNDRL-YLKLLPLLFRRLCNLLG-----------VLNPWLQVKILRLLTRLAPlDPLL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 291 TSELMYDVLdeslrraELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTl 370
Cdd:pfam01602 226 PKELLEDLL-------NLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPK- 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 371 ALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNVTVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Cdd:pfam01602 298 AVQHLDLIIFCLKTDDDIsIRLRALDLLYALVNESNVKEIVKELLKYVHEIADPDFKIELVRAIGRLAEKFPTDAEWYLD 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 450 TMNAVFSVGGDVMHPDIPNNFLRLLaegfddeTEDQQLRLYAVQsylTLLD-MENVIYPQrFLQVMSWVLGEYSYLL-DK 527
Cdd:pfam01602 378 VLLDLLSLAGSYVVDEIVEVIRDII-------QNVPELREYILE---HLCElLEDIESPE-ALAAALWILGEYGELIpNG 446
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622953130 528 ETPAEVIAKLYRLLMNDSVssETKTWLIAAVTKLTPQAHSSDTVERLIHEFTI-----SLDTCMRQHAFELKHL 596
Cdd:pfam01602 447 SSPPDLLRSILEVFVLESA--KVRAAALTALAKLGLTSPEETTQNLIIQLLLTlatqdSLDLEVRDRAVEYLRL 518
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
52-596 7.71e-78

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 259.86  E-value: 7.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130  52 EEKLIQQELSSLKATVSAPTTTlkmMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELL 131
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDPRK---KKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 132 LLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Cdd:pfam01602  78 ILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 212 KALCDRDVGVMAASLHIYLRMIKENSSgYKDLTGSFVTILKQVVGgklpvdfnyhsVPAPWLQIQLLRILGLLGK-DDQR 290
Cdd:pfam01602 158 ELLSDKDPGVQSAAVALLYEICKNDRL-YLKLLPLLFRRLCNLLG-----------VLNPWLQVKILRLLTRLAPlDPLL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 291 TSELMYDVLdeslrraELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTl 370
Cdd:pfam01602 226 PKELLEDLL-------NLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPK- 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 371 ALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNVTVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Cdd:pfam01602 298 AVQHLDLIIFCLKTDDDIsIRLRALDLLYALVNESNVKEIVKELLKYVHEIADPDFKIELVRAIGRLAEKFPTDAEWYLD 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 450 TMNAVFSVGGDVMHPDIPNNFLRLLaegfddeTEDQQLRLYAVQsylTLLD-MENVIYPQrFLQVMSWVLGEYSYLL-DK 527
Cdd:pfam01602 378 VLLDLLSLAGSYVVDEIVEVIRDII-------QNVPELREYILE---HLCElLEDIESPE-ALAAALWILGEYGELIpNG 446
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622953130 528 ETPAEVIAKLYRLLMNDSVssETKTWLIAAVTKLTPQAHSSDTVERLIHEFTI-----SLDTCMRQHAFELKHL 596
Cdd:pfam01602 447 SSPPDLLRSILEVFVLESA--KVRAAALTALAKLGLTSPEETTQNLIIQLLLTlatqdSLDLEVRDRAVEYLRL 518
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
78-522 4.78e-11

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 66.29  E-value: 4.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130  78 KECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVV 157
Cdd:COG5096    37 IDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 158 SQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPN---QVQHIHIKfRKALCDRDVGVMAASLHIYLRMIK 234
Cdd:COG5096   117 SLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDlyhELGLIDIL-KELVADSDPIVIANALASLAEIDP 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 235 ENSSGYKdltGSFVTILKQvvggklpVDFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMydvldESLRRAELNHNVTY 314
Cdd:COG5096   196 ELAHGYS---LEVILRIPQ-------LDLLSLSVSTEWLLLIILEVLTERVPTTPDSAEDF-----EERLSPPLQHNNAE 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 315 AILfecvhtvYSIYPKSELLEKAAKC-IGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQ-------MTIIECLDHPD 386
Cdd:COG5096   261 VLL-------IAVKVILRLLVFLPSNnLFLISSPPLVTLLAKPESLIQYVLRRNIQIDLEVCsklldkvKKLFLIEYNDD 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 387 PIIKRETLELLYRITNAQNVTVIVQKMLEYLH-QSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFS---VGGD-- 460
Cdd:COG5096   334 IYIKLEKLDQLTRLADDQNLSQILLELIYYIAeNHIDAEMVSEAIKALGDLASKAESSVNDCISELLELLEgvwIRGSyi 413
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953130 461 ---------VMHPDIPNNFLRLLAegfdDETEDQQLR-LYAVQSYLTLLDMenviyPQRFLQVMS-----WVLGEYS 522
Cdd:COG5096   414 vqevrivdcISVIRISVLVLRILP----NEYPKILLRgLYALEETLELQSR-----EPRAKSVTDkylgaWLLGEFS 481
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
52-596 7.71e-78

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 259.86  E-value: 7.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130  52 EEKLIQQELSSLKATVSAPTTTlkmMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELL 131
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDPRK---KKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 132 LLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Cdd:pfam01602  78 ILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 212 KALCDRDVGVMAASLHIYLRMIKENSSgYKDLTGSFVTILKQVVGgklpvdfnyhsVPAPWLQIQLLRILGLLGK-DDQR 290
Cdd:pfam01602 158 ELLSDKDPGVQSAAVALLYEICKNDRL-YLKLLPLLFRRLCNLLG-----------VLNPWLQVKILRLLTRLAPlDPLL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 291 TSELMYDVLdeslrraELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTl 370
Cdd:pfam01602 226 PKELLEDLL-------NLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPK- 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 371 ALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNVTVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Cdd:pfam01602 298 AVQHLDLIIFCLKTDDDIsIRLRALDLLYALVNESNVKEIVKELLKYVHEIADPDFKIELVRAIGRLAEKFPTDAEWYLD 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 450 TMNAVFSVGGDVMHPDIPNNFLRLLaegfddeTEDQQLRLYAVQsylTLLD-MENVIYPQrFLQVMSWVLGEYSYLL-DK 527
Cdd:pfam01602 378 VLLDLLSLAGSYVVDEIVEVIRDII-------QNVPELREYILE---HLCElLEDIESPE-ALAAALWILGEYGELIpNG 446
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622953130 528 ETPAEVIAKLYRLLMNDSVssETKTWLIAAVTKLTPQAHSSDTVERLIHEFTI-----SLDTCMRQHAFELKHL 596
Cdd:pfam01602 447 SSPPDLLRSILEVFVLESA--KVRAAALTALAKLGLTSPEETTQNLIIQLLLTlatqdSLDLEVRDRAVEYLRL 518
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
78-522 4.78e-11

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 66.29  E-value: 4.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130  78 KECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVV 157
Cdd:COG5096    37 IDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 158 SQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPN---QVQHIHIKfRKALCDRDVGVMAASLHIYLRMIK 234
Cdd:COG5096   117 SLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDlyhELGLIDIL-KELVADSDPIVIANALASLAEIDP 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 235 ENSSGYKdltGSFVTILKQvvggklpVDFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMydvldESLRRAELNHNVTY 314
Cdd:COG5096   196 ELAHGYS---LEVILRIPQ-------LDLLSLSVSTEWLLLIILEVLTERVPTTPDSAEDF-----EERLSPPLQHNNAE 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 315 AILfecvhtvYSIYPKSELLEKAAKC-IGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQ-------MTIIECLDHPD 386
Cdd:COG5096   261 VLL-------IAVKVILRLLVFLPSNnLFLISSPPLVTLLAKPESLIQYVLRRNIQIDLEVCsklldkvKKLFLIEYNDD 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953130 387 PIIKRETLELLYRITNAQNVTVIVQKMLEYLH-QSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFS---VGGD-- 460
Cdd:COG5096   334 IYIKLEKLDQLTRLADDQNLSQILLELIYYIAeNHIDAEMVSEAIKALGDLASKAESSVNDCISELLELLEgvwIRGSyi 413
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953130 461 ---------VMHPDIPNNFLRLLAegfdDETEDQQLR-LYAVQSYLTLLDMenviyPQRFLQVMS-----WVLGEYS 522
Cdd:COG5096   414 vqevrivdcISVIRISVLVLRILP----NEYPKILLRgLYALEETLELQSR-----EPRAKSVTDkylgaWLLGEFS 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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