NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622953123|ref|XP_028706751|]
View 

AP-4 complex subunit epsilon-1 isoform X1 [Macaca mulatta]

Protein Classification

AP4E_app_platf domain-containing protein( domain architecture ID 13560692)

AP4E_app_platf domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Adaptin_N super family cl37648
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
52-596 1.13e-74

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


The actual alignment was detected with superfamily member pfam01602:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 257.16  E-value: 1.13e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123   52 EEKLIQQELSSLKATVSAPTTTlkmMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELL 131
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDPRK---KKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLA 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  132 LLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Cdd:pfam01602   78 ILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  212 KALCDRDVGVMAASLHIYLRMIKENSSgYKDLTGSFVTILKQVVGgklpvdfnyhsVPAPWLQIQLLRILGLLGK-DDQR 290
Cdd:pfam01602  158 ELLSDKDPGVQSAAVALLYEICKNDRL-YLKLLPLLFRRLCNLLG-----------VLNPWLQVKILRLLTRLAPlDPLL 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  291 TSELMYDVLdeslrraELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTl 370
Cdd:pfam01602  226 PKELLEDLL-------NLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPK- 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  371 ALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNVTVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Cdd:pfam01602  298 AVQHLDLIIFCLKTDDDIsIRLRALDLLYALVNESNVKEIVKELLKYVHEIADPDFKIELVRAIGRLAEKFPTDAEWYLD 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  450 TMNAVFSVGGDVMHPDIPNNFLRLLaegfddeTEDQQLRLYAVQsylTLLD-MENVIYPQrFLQVMSWVLGEYSYLL-DK 527
Cdd:pfam01602  378 VLLDLLSLAGSYVVDEIVEVIRDII-------QNVPELREYILE---HLCElLEDIESPE-ALAAALWILGEYGELIpNG 446
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622953123  528 ETPAEVIAKLYRLLMNDSVssETKTWLIAAVTKLTPQAHSSDTVERLIHEFTI-----SLDTCMRQHAFELKHL 596
Cdd:pfam01602  447 SSPPDLLRSILEVFVLESA--KVRAAALTALAKLGLTSPEETTQNLIIQLLLTlatqdSLDLEVRDRAVEYLRL 518
AP4E_app_platf pfam14807
Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of ...
1033-1133 4.59e-42

Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.


:

Pssm-ID: 464326  Cd Length: 100  Bit Score: 148.96  E-value: 4.59e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123 1033 PLKISSEDFGKLWLSFANDVKQNVKmsESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSI-PCLLHCRVYADVL 1111
Cdd:pfam14807    1 PLTISTEEFGQLWLSFSNERKQNLK--SSQVSTLSDLNLLLQKLHLHVVEVIGNEGIVACQLLNSSnPCLLHVRVNAGVL 78
                           90       100
                   ....*....|....*....|..
gi 1622953123 1112 ALWFRSSCSTLPDYLLYQCQKV 1133
Cdd:pfam14807   79 DVWVRSNDKPLADCVLYHCQRA 100
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
52-596 1.13e-74

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 257.16  E-value: 1.13e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123   52 EEKLIQQELSSLKATVSAPTTTlkmMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELL 131
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDPRK---KKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLA 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  132 LLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Cdd:pfam01602   78 ILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  212 KALCDRDVGVMAASLHIYLRMIKENSSgYKDLTGSFVTILKQVVGgklpvdfnyhsVPAPWLQIQLLRILGLLGK-DDQR 290
Cdd:pfam01602  158 ELLSDKDPGVQSAAVALLYEICKNDRL-YLKLLPLLFRRLCNLLG-----------VLNPWLQVKILRLLTRLAPlDPLL 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  291 TSELMYDVLdeslrraELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTl 370
Cdd:pfam01602  226 PKELLEDLL-------NLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPK- 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  371 ALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNVTVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Cdd:pfam01602  298 AVQHLDLIIFCLKTDDDIsIRLRALDLLYALVNESNVKEIVKELLKYVHEIADPDFKIELVRAIGRLAEKFPTDAEWYLD 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  450 TMNAVFSVGGDVMHPDIPNNFLRLLaegfddeTEDQQLRLYAVQsylTLLD-MENVIYPQrFLQVMSWVLGEYSYLL-DK 527
Cdd:pfam01602  378 VLLDLLSLAGSYVVDEIVEVIRDII-------QNVPELREYILE---HLCElLEDIESPE-ALAAALWILGEYGELIpNG 446
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622953123  528 ETPAEVIAKLYRLLMNDSVssETKTWLIAAVTKLTPQAHSSDTVERLIHEFTI-----SLDTCMRQHAFELKHL 596
Cdd:pfam01602  447 SSPPDLLRSILEVFVLESA--KVRAAALTALAKLGLTSPEETTQNLIIQLLLTlatqdSLDLEVRDRAVEYLRL 518
AP4E_app_platf pfam14807
Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of ...
1033-1133 4.59e-42

Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.


Pssm-ID: 464326  Cd Length: 100  Bit Score: 148.96  E-value: 4.59e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123 1033 PLKISSEDFGKLWLSFANDVKQNVKmsESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSI-PCLLHCRVYADVL 1111
Cdd:pfam14807    1 PLTISTEEFGQLWLSFSNERKQNLK--SSQVSTLSDLNLLLQKLHLHVVEVIGNEGIVACQLLNSSnPCLLHVRVNAGVL 78
                           90       100
                   ....*....|....*....|..
gi 1622953123 1112 ALWFRSSCSTLPDYLLYQCQKV 1133
Cdd:pfam14807   79 DVWVRSNDKPLADCVLYHCQRA 100
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
78-522 1.42e-09

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 62.44  E-value: 1.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123   78 KECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVV 157
Cdd:COG5096     37 IDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTL 116
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  158 SQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPN---QVQHIHIKfRKALCDRDVGVMAASLHIYLRMIK 234
Cdd:COG5096    117 SLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDlyhELGLIDIL-KELVADSDPIVIANALASLAEIDP 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  235 ENSSGYKdltGSFVTILKQvvggklpVDFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMydvldESLRRAELNHNVTY 314
Cdd:COG5096    196 ELAHGYS---LEVILRIPQ-------LDLLSLSVSTEWLLLIILEVLTERVPTTPDSAEDF-----EERLSPPLQHNNAE 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  315 AILfecvhtvYSIYPKSELLEKAAKC-IGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQ-------MTIIECLDHPD 386
Cdd:COG5096    261 VLL-------IAVKVILRLLVFLPSNnLFLISSPPLVTLLAKPESLIQYVLRRNIQIDLEVCsklldkvKKLFLIEYNDD 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  387 PIIKRETLELLYRITNAQNVTVIVQKMLEYLH-QSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFS---VGGD-- 460
Cdd:COG5096    334 IYIKLEKLDQLTRLADDQNLSQILLELIYYIAeNHIDAEMVSEAIKALGDLASKAESSVNDCISELLELLEgvwIRGSyi 413
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953123  461 ---------VMHPDIPNNFLRLLAegfdDETEDQQLR-LYAVQSYLTLLDMenviyPQRFLQVMS-----WVLGEYS 522
Cdd:COG5096    414 vqevrivdcISVIRISVLVLRILP----NEYPKILLRgLYALEETLELQSR-----EPRAKSVTDkylgaWLLGEFS 481
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
52-596 1.13e-74

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 257.16  E-value: 1.13e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123   52 EEKLIQQELSSLKATVSAPTTTlkmMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELL 131
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDPRK---KKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLA 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  132 LLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Cdd:pfam01602   78 ILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  212 KALCDRDVGVMAASLHIYLRMIKENSSgYKDLTGSFVTILKQVVGgklpvdfnyhsVPAPWLQIQLLRILGLLGK-DDQR 290
Cdd:pfam01602  158 ELLSDKDPGVQSAAVALLYEICKNDRL-YLKLLPLLFRRLCNLLG-----------VLNPWLQVKILRLLTRLAPlDPLL 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  291 TSELMYDVLdeslrraELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTl 370
Cdd:pfam01602  226 PKELLEDLL-------NLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPK- 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  371 ALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNVTVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Cdd:pfam01602  298 AVQHLDLIIFCLKTDDDIsIRLRALDLLYALVNESNVKEIVKELLKYVHEIADPDFKIELVRAIGRLAEKFPTDAEWYLD 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  450 TMNAVFSVGGDVMHPDIPNNFLRLLaegfddeTEDQQLRLYAVQsylTLLD-MENVIYPQrFLQVMSWVLGEYSYLL-DK 527
Cdd:pfam01602  378 VLLDLLSLAGSYVVDEIVEVIRDII-------QNVPELREYILE---HLCElLEDIESPE-ALAAALWILGEYGELIpNG 446
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622953123  528 ETPAEVIAKLYRLLMNDSVssETKTWLIAAVTKLTPQAHSSDTVERLIHEFTI-----SLDTCMRQHAFELKHL 596
Cdd:pfam01602  447 SSPPDLLRSILEVFVLESA--KVRAAALTALAKLGLTSPEETTQNLIIQLLLTlatqdSLDLEVRDRAVEYLRL 518
AP4E_app_platf pfam14807
Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of ...
1033-1133 4.59e-42

Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.


Pssm-ID: 464326  Cd Length: 100  Bit Score: 148.96  E-value: 4.59e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123 1033 PLKISSEDFGKLWLSFANDVKQNVKmsESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSI-PCLLHCRVYADVL 1111
Cdd:pfam14807    1 PLTISTEEFGQLWLSFSNERKQNLK--SSQVSTLSDLNLLLQKLHLHVVEVIGNEGIVACQLLNSSnPCLLHVRVNAGVL 78
                           90       100
                   ....*....|....*....|..
gi 1622953123 1112 ALWFRSSCSTLPDYLLYQCQKV 1133
Cdd:pfam14807   79 DVWVRSNDKPLADCVLYHCQRA 100
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
78-522 1.42e-09

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 62.44  E-value: 1.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123   78 KECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVV 157
Cdd:COG5096     37 IDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTL 116
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  158 SQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPN---QVQHIHIKfRKALCDRDVGVMAASLHIYLRMIK 234
Cdd:COG5096    117 SLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDlyhELGLIDIL-KELVADSDPIVIANALASLAEIDP 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  235 ENSSGYKdltGSFVTILKQvvggklpVDFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMydvldESLRRAELNHNVTY 314
Cdd:COG5096    196 ELAHGYS---LEVILRIPQ-------LDLLSLSVSTEWLLLIILEVLTERVPTTPDSAEDF-----EERLSPPLQHNNAE 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  315 AILfecvhtvYSIYPKSELLEKAAKC-IGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQ-------MTIIECLDHPD 386
Cdd:COG5096    261 VLL-------IAVKVILRLLVFLPSNnLFLISSPPLVTLLAKPESLIQYVLRRNIQIDLEVCsklldkvKKLFLIEYNDD 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953123  387 PIIKRETLELLYRITNAQNVTVIVQKMLEYLH-QSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFS---VGGD-- 460
Cdd:COG5096    334 IYIKLEKLDQLTRLADDQNLSQILLELIYYIAeNHIDAEMVSEAIKALGDLASKAESSVNDCISELLELLEgvwIRGSyi 413
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953123  461 ---------VMHPDIPNNFLRLLAegfdDETEDQQLR-LYAVQSYLTLLDMenviyPQRFLQVMS-----WVLGEYS 522
Cdd:COG5096    414 vqevrivdcISVIRISVLVLRILP----NEYPKILLRgLYALEETLELQSR-----EPRAKSVTDkylgaWLLGEFS 481
Coatomer_b_Cpla pfam14806
Coatomer beta subunit appendage platform; This family is found at the C-terminus of the ...
1023-1094 1.69e-04

Coatomer beta subunit appendage platform; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.


Pssm-ID: 434227  Cd Length: 128  Bit Score: 42.56  E-value: 1.69e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622953123 1023 VNLSLLDFIRPLKISSEDFGKLWLSFANDVKQNVKMSESQaaLPSALKTLQQKLRLHII----EIIGNEGLLACQL 1094
Cdd:pfam14806   10 IHIDIMDYIKPATCDDEEFREMWAEFEWENKITVNTNITD--LREYLDHLMKKTNMNCLtpeeALSGECGFLSANL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH