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Conserved domains on  [gi|1622953081|ref|XP_028706735|]
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N-acetylgalactosamine kinase isoform X5 [Macaca mulatta]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 7-411 2.07e-138

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 404.86  E-value: 2.07e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPVKTYT-LQLANTNPLYPDFSTSAN 85
Cdd:PLN02521   31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDKYTTCTFPAD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  86 NIQ-IDKTKPLWHNYFLCGLKGIQEHFG-----LTNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSK-- 157
Cdd:PLN02521  111 PDQeVDLANHKWGNYFICGYKGVFEFLKskgvdVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKke 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 158 -------------------------------AKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATS--QFNIRVMECR 204
Cdd:PLN02521  191 vaqftckcerhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAatNYNNRVVECR 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 205 LAAKLLA-KYKNLQWD---NVLRLDEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 274
Cdd:PLN02521  271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 275 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKL 348
Cdd:PLN02521  348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953081 349 GAQGSRLTGAGWGGCAVSIVPADKLPGFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVF 411
Cdd:PLN02521  428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 7-411 2.07e-138

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 404.86  E-value: 2.07e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPVKTYT-LQLANTNPLYPDFSTSAN 85
Cdd:PLN02521   31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDKYTTCTFPAD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  86 NIQ-IDKTKPLWHNYFLCGLKGIQEHFG-----LTNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSK-- 157
Cdd:PLN02521  111 PDQeVDLANHKWGNYFICGYKGVFEFLKskgvdVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKke 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 158 -------------------------------AKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATS--QFNIRVMECR 204
Cdd:PLN02521  191 vaqftckcerhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAatNYNNRVVECR 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 205 LAAKLLA-KYKNLQWD---NVLRLDEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 274
Cdd:PLN02521  271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 275 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKL 348
Cdd:PLN02521  348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953081 349 GAQGSRLTGAGWGGCAVSIVPADKLPGFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVF 411
Cdd:PLN02521  428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
7-408 1.77e-70

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 226.58  E-value: 1.77e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPVKTYTLQLANTNplYPD-FSTSAN 85
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  86 NIQIDKTKPlWHNYFLcG-LKGIQEHfGLTnLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLIEFS 164
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GYK-LGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 165 ----------------------------------PLRATDVKLP-SGAVFVIANSCVEMNkAATSQFNIRVMECRLAAKL 209
Cdd:COG0153   155 qraenefvgvpcgimdqfasalgkkghallldcrSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 210 LAKyknlqwdNVLRldEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAK 289
Cdd:COG0153   234 LGV-------KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRAR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 290 HVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKL-GAQGSRLTGAGWGGCAVSIV 368
Cdd:COG0153   265 HVVTENQRVLEAVEALRA---GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1622953081 369 PADKLPGFLANVHKAYYQRsdGSLAPEkqsLFATKPGGGA 408
Cdd:COG0153   342 PKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 9-409 2.17e-66

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 216.23  E-value: 2.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   9 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPV--KTYTLQLANTNPLYPDFSTsanN 86
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  87 IQIDKTKPL-WHNYFLCGLKGIQEHFGLTNLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------------------ 147
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLqnmghlpldskqillriq 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 148 -----------------LTVLGRNlSKAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSQFNIRVMECRLAAKL 209
Cdd:TIGR00131 158 vaenhfvgvncgimdqaASVLGKE-DHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 210 LAKYKNLQWDNVlrLDEVQAKLGISLEEMLLVTEdalhpepynpeeicrclgisleelrtqilspntqdvlifklyQRAK 289
Cdd:TIGR00131 236 LAATDKGALRDF--MNEYFARYIARLTKMLPLVE------------------------------------------ERAK 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 290 HVYSEAARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KLGAQGSRLTGAGWGGCAVSIV 368
Cdd:TIGR00131 272 HVVSENLRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLV 348

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1622953081 369 PADKLPGFLANVHKAYYQRSDgslAPEKQSLFATKPGGGAL 409
Cdd:TIGR00131 349 PNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 15-62 2.43e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 89.05  E-value: 2.43e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622953081  15 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEP 62
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 7-411 2.07e-138

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 404.86  E-value: 2.07e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPVKTYT-LQLANTNPLYPDFSTSAN 85
Cdd:PLN02521   31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDKYTTCTFPAD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  86 NIQ-IDKTKPLWHNYFLCGLKGIQEHFG-----LTNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSK-- 157
Cdd:PLN02521  111 PDQeVDLANHKWGNYFICGYKGVFEFLKskgvdVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKke 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 158 -------------------------------AKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATS--QFNIRVMECR 204
Cdd:PLN02521  191 vaqftckcerhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAatNYNNRVVECR 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 205 LAAKLLA-KYKNLQWD---NVLRLDEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 274
Cdd:PLN02521  271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 275 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKL 348
Cdd:PLN02521  348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953081 349 GAQGSRLTGAGWGGCAVSIVPADKLPGFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVF 411
Cdd:PLN02521  428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
7-408 1.77e-70

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 226.58  E-value: 1.77e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPVKTYTLQLANTNplYPD-FSTSAN 85
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  86 NIQIDKTKPlWHNYFLcG-LKGIQEHfGLTnLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLIEFS 164
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GYK-LGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 165 ----------------------------------PLRATDVKLP-SGAVFVIANSCVEMNkAATSQFNIRVMECRLAAKL 209
Cdd:COG0153   155 qraenefvgvpcgimdqfasalgkkghallldcrSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 210 LAKyknlqwdNVLRldEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAK 289
Cdd:COG0153   234 LGV-------KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRAR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 290 HVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKL-GAQGSRLTGAGWGGCAVSIV 368
Cdd:COG0153   265 HVVTENQRVLEAVEALRA---GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1622953081 369 PADKLPGFLANVHKAYYQRsdGSLAPEkqsLFATKPGGGA 408
Cdd:COG0153   342 PKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 9-409 2.17e-66

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 216.23  E-value: 2.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081   9 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPV--KTYTLQLANTNPLYPDFSTsanN 86
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  87 IQIDKTKPL-WHNYFLCGLKGIQEHFGLTNLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------------------ 147
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLqnmghlpldskqillriq 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 148 -----------------LTVLGRNlSKAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSQFNIRVMECRLAAKL 209
Cdd:TIGR00131 158 vaenhfvgvncgimdqaASVLGKE-DHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 210 LAKYKNLQWDNVlrLDEVQAKLGISLEEMLLVTEdalhpepynpeeicrclgisleelrtqilspntqdvlifklyQRAK 289
Cdd:TIGR00131 236 LAATDKGALRDF--MNEYFARYIARLTKMLPLVE------------------------------------------ERAK 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 290 HVYSEAARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KLGAQGSRLTGAGWGGCAVSIV 368
Cdd:TIGR00131 272 HVVSENLRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLV 348

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1622953081 369 PADKLPGFLANVHKAYYQRSDgslAPEKQSLFATKPGGGAL 409
Cdd:TIGR00131 349 PNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 10-384 3.23e-42

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 152.70  E-value: 3.23e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  10 KLKEMFNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEPVKTYTLQLANTNplYPD---FSTSA 84
Cdd:PRK05322    5 ELKKKFAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  85 NNIQIDKtKPLWHNYFLCGLKGIQEHfGLTNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLI--- 161
Cdd:PRK05322   81 DDLSFDK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVklg 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 162 --------------------------------------EFSPLRATDVKLpsgavfVIANScvemNKA---ATSQFNIRV 200
Cdd:PRK05322  159 qktenefigvnsgimdqfaigmgkkdhailldcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 201 MECRLAakllakyknlqwdnvlrLDEVQAKLGI-SLEEmllVTEDALhpepynpeeicrclgislEELRTQILSPNtqdv 279
Cdd:PRK05322  229 AECEKA-----------------LEELQKKLDIkSLGE---LTEEEF------------------DEYSYLIKDET---- 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 280 lifkLYQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKL-GAQGSRLTGA 358
Cdd:PRK05322  267 ----LLKRARHAVTENQRTLKAVKALKA---GDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGA 339

                         410       420
                  ....*....|....*....|....*.
gi 1622953081 359 GWGGCAVSIVPADKLPGFLANVHKAY 384
Cdd:PRK05322  340 GFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 10-388 3.28e-36

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 136.21  E-value: 3.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  10 KLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEP-----VKTYTLQLANtnpLYPDFSTSA 84
Cdd:PRK05101    6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrddriVRVIAADYDN---QQDEFSLDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  85 NnIQIDKTKpLWHNYFLCGLKGIQEHfgLTNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAK----- 159
Cdd:PRK05101   83 P-IVPHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEialng 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 160 -----------------------------LIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSQFNIRVMECRLAAKLL 210
Cdd:PRK05101  159 qeaenqfvgcncgimdqlisalgkkdhalLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 211 akyknlqwdNVLRLDEVqaklgiSLEEmLLVTEDALHPEpynpeeicrclgisleelrtqilspntqdvlifkLYQRAKH 290
Cdd:PRK05101  238 ---------GVKALRDV------TLEQ-FNAVAAELDPV----------------------------------VAKRARH 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 291 VYSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KLGAQGS-RLTGAGWGGCAVSIV 368
Cdd:PRK05101  268 VITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALV 344

                         410       420
                  ....*....|....*....|
gi 1622953081 369 PADKLPGFLANVHKAYYQRS 388
Cdd:PRK05101  345 PEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 27-387 3.83e-32

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 124.72  E-value: 3.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  27 VRAPGRVNIIGEHIDYC-GYsVLPMAIEQDVLIAVEPVKTYTLqlantnplYPDFSTSANNIQIDKTKPL--WHNYFLCG 103
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFIF--------YSENFNEEKTFELDKLEKLnsWADYIKGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 104 LKGIQEHFGltNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLI--------EF------------ 163
Cdd:PRK03817   74 IWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELAllareaenEFvgvpcgimdqfa 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 164 --------------SPLRATDVKLPSGAVFVIANSCVEmNKAATSQFNIRVMECRLAAKLLAK--YKNLQWDNVLRLDEV 227
Cdd:PRK03817  152 vafgkkdhaifldtMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKksSKEVTEEDLSKLPPL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 228 QAKlgisleemllvtedalhpepynpeeicrclgisleelrtqilspntqdvlifklyqRAKHVYSEAARVLQFKKICEE 307
Cdd:PRK03817  231 LRK--------------------------------------------------------RAGYVLRENERVLKVRDALKE 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 308 apeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKLGAQGSRLTGAGWGGCAVSIVPADKLPGFLANVHKAYYQR 387
Cdd:PRK03817  255 ---GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 15-62 2.43e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 89.05  E-value: 2.43e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622953081  15 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAIEQDVLIAVEP 62
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK00555 PRK00555
galactokinase; Provisional
 29-408 9.89e-17

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 81.06  E-value: 9.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081  29 APGRVNIIGEHIDY-CGYSvLPMAIEQDVLIAVEPVKTYTLQLANtnplypDFSTSANNIQIDkTKPlwhnyflcglkgi 107
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTP------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 108 qehfglTNLTGMNCLVDGNIppssglsssSALVCCA-----GLVTLTV---LGRNLSKAKLIEFSPLRAtdvklpsgavf 179
Cdd:PRK00555   66 ------GQVTGWAAYAAGVI---------WALRGAGhpvpgGAMSITSdveIGSGLSSSAALECAVLGA----------- 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 180 VIANSCVEMNkaatsqfniRVMECRLAAKLLAKY----KNLqwdnvlrLDEVQAKLGISLEEMLLVTED-ALHPEPYNP- 253
Cdd:PRK00555  120 VGAATGTRID---------RLEQARLAQRAENEYvgapTGL-------LDQLAALFGAPKTALLIDFRDlTVRPVAFDPd 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 254 -----------------------------EEICRCLGI-SLEELRTQILSP--NTQDVLIFKlyqRAKHVYSEAARVLQF 301
Cdd:PRK00555  184 aagvvlllmdsrarhrhaggeyaarrascERAAADLGVsSLRAVQDRGLAAlgAIADPIDAR---RARHVLTENQRVLDF 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 302 KKICEEAPenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKLGAQGSRLTGAGWGGCAVSIVPADKLPGFLANVH 381
Cdd:PRK00555  261 AAALADSD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVR 337

                         410       420
                  ....*....|....*....|....*..
gi 1622953081 382 KAYyqRSDGSLAPekqSLFATKPGGGA 408
Cdd:PRK00555  338 RAA--VTAGYPEP---AVSRTYAAPGA 359
PLN02865 PLN02865
galactokinase
 180-410 8.34e-12

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 66.36  E-value: 8.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 180 VIANSCVEMNKAATSQFNIRVMECRLAAKLLAKYKNLqwdnvlrlDEVQAKLGisleemllvtedALHPEPYnpeeicrc 259
Cdd:PLN02865  234 LLAFSGLRHALTNKPGYNLRVSECQEAARFLLEASGN--------DELEPLLC------------NVEPEVY-------- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 260 lgisleELRTQILSPNtqdvlifkLYQRAKHVYSEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELD 339
Cdd:PLN02865  286 ------EAHKCKLEAV--------LARRAEHYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLI 348

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622953081 340 QLVDICRKL-GAQGSRLTGAGWGGCAVSIVPADKLPGFLANVhKAYYQRSDGSLA---PEKQSLFATKPGGGALV 410
Cdd:PLN02865  349 QLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDCARV 422
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 283-367 3.55e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.10  E-value: 3.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 283 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKLGAQGSRLTGAGWGG 362
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1622953081 363 CAVSI 367
Cdd:PTZ00298  288 LVVAL 292
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 283-368 4.32e-10

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 60.24  E-value: 4.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 283 KLYQRAKHVYseAARVLQFKKICEEAPENMVQ----LLGELMNQSHmscRDMYE--CSCPELDQLVDICRKLGAQGSRLT 356
Cdd:COG1577   191 KLKERNPELY--EAFLEEIGDLVEEAIEALEEgdleALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLT 265

                          90
                  ....*....|..
gi 1622953081 357 GAGWGGCAVSIV 368
Cdd:COG1577   266 GAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 313-365 1.45e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 58.46  E-value: 1.45e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622953081 313 VQLLGELMNQSHmSCRDMYECSCPELDQLVDICRKLGAQGSRLTGAGWGGCAV 365
Cdd:TIGR00549 220 VESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 306-369 4.08e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 53.24  E-value: 4.08e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622953081 306 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKLGAqGSRLTGAGWGGCAVSIVP 369
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFK 67
PRK03926 PRK03926
mevalonate kinase; Provisional
 316-372 8.18e-09

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 56.60  E-value: 8.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622953081 316 LGELMNQSHmSCRDMYECSCPELDQLVDICRKLGAQGSRLTGAGWGGCAVSIVPADK 372
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
PTZ00290 PTZ00290
galactokinase; Provisional
 285-387 1.20e-08

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 56.75  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 285 YQRAKHVYSEAARVLQFKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQLVD-ICRKLGAQGSRLTGAG 359
Cdd:PTZ00290  330 FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGG 409

                          90       100
                  ....*....|....*....|....*...
gi 1622953081 360 WGGCAVSIVPADKLPGFLANVHKAYYQR 387
Cdd:PTZ00290  410 FGGCIILLLKKNAVDRVVAHVREKFKAR 437
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 286-395 8.89e-07

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 50.56  E-value: 8.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622953081 286 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKLGAQGSRLT 356
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622953081 357 GAGWGGCAVSIVPADKLPGFLANVHKAYYQRSDGSLAPE 395
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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