|
Name |
Accession |
Description |
Interval |
E-value |
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1065-1276 |
6.79e-116 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
:
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 360.40 E-value: 6.79e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1065 PHPSDCSQVQQNSNAASGLYTIYLHGdSSRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTKEFWLGL 1144
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPG-SNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1145 DKLHNLTTGTPtrYEVRVDLQT-ANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDALSYHNGWKFTTFDRDNDIALSN 1223
Cdd:cd00087 80 EKIHLLTSQGP--YELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 1224 CALTHHGGWWYKNCHLANPNGRYGETKH----SEGVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:cd00087 158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
709-791 |
1.93e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 1.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNLVTDWVTENMATVSWDPVQAT---IDRYVVRYTSAKDGETREVPVGK-EQNSTVLTGLRPGVEYTVHVWAQKGAQ 784
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 785 ESKKADT 791
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
688-1068 |
3.25e-12 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.80 E-value: 3.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 688 VWAQKGDQESKKTDTKAQTDIDSPQNLVTDWVTENMATVSWDPVQATIDRYVVRYTSAKDGETREVPVGKEQNSTVLTGL 767
Cdd:COG3401 30 GGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 768 RPGVEYTVHVWAQKGAQESKKADTKAQTDIDSPKNLVTDRVTENTATVSWDLVQATIDRYVVRYTSANGETREVPVGKEQ 847
Cdd:COG3401 110 GLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 848 SSTVLTGLR--PGVEYTVHVWAQKGNQESKKAD----TKAQTEIDSPKNLVTDRVTENMATVSWDPVQAT-IDKYVV-RY 919
Cdd:COG3401 190 TTLVDGGGDiePGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVyRS 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 920 TSADGETREVPVGKEhSSTVLTGLRPGMEYMVHVWAQKGD-QESKKADT-KAQTEI---DPPRNLRPSAVTQSGGVLTWT 994
Cdd:COG3401 270 NSGDGPFTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSSITLSWT 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 995 PPS-AQIHGYILTY-QFPDGTVKEIQLGREDQRFELQGLEQGATYPVSLVAF-KGGLRSRNVSTTLSTVGARFPHPS 1068
Cdd:COG3401 349 ASSdADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGES 425
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
532-614 |
3.43e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.67 E-value: 3.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWDPVQAT---IDKYVVHYTSADNQETREVPVGK-EQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 608 ESKKANT 614
Cdd:cd00063 82 ESPPSES 88
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
264-342 |
6.16e-12 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 6.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEP----SSQVDHYFLNYYPLGKELSGKQIRVPKEQHSYEILGLLPGTKYIVTLRNVKKDIF 339
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
|
...
gi 1622827697 340 SSP 342
Cdd:pfam00041 82 GPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
444-517 |
7.06e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 7.06e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKP---VQAVIDKYVVRYTSADG--DTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGN 517
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
621-697 |
3.44e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
:
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDPVQAT-----IDKYMVRYTSADGETREVPVGKEHSSTILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 696 ES 697
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
359-434 |
3.55e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 3.55e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 359 VTEETEHSLDVEWENPS---TEVDYYKLRYGPMTGQEVTEVTVPKSSDPksRYDITGLHPGTEYKITVVPMRGTLEGKP 434
Cdd:cd00063 9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
171-197 |
3.19e-05 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 41.90 E-value: 3.19e-05
10 20
....*....|....*....|....*..
gi 1622827697 171 CPGACSGHGRCVDGRCLCHEPYVGADC 197
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
236-259 |
6.81e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.79 E-value: 6.81e-05
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
131-253 |
1.15e-04 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.59 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 131 CCQGATDLSRRCSDhgtfsLETCSCHCEegregpaceqlACPGACSGHGRCVDGRCLCHEPYVG------------ADCG 198
Cdd:NF041328 21 CPEGLSVCGGACVD-----LRSDPSNCG-----------ACGVACGAGQTCVAGACGCGPGTVAcggacvdtasdpAHCG 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622827697 199 ypACPENCSGHGECVRGVCQ--CHEDFTseDCSeRRC------PGDCSGHG-FCDTGEcYCEEG 253
Cdd:NF041328 85 --ACGAACAPGQVCEGGACReaCSEGLT--RCG-GACvdlatdPLHCGACGvACDPGE-SCRGG 142
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1065-1276 |
6.79e-116 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 360.40 E-value: 6.79e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1065 PHPSDCSQVQQNSNAASGLYTIYLHGdSSRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTKEFWLGL 1144
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPG-SNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1145 DKLHNLTTGTPtrYEVRVDLQT-ANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDALSYHNGWKFTTFDRDNDIALSN 1223
Cdd:cd00087 80 EKIHLLTSQGP--YELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 1224 CALTHHGGWWYKNCHLANPNGRYGETKH----SEGVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:cd00087 158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1066-1276 |
5.53e-103 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 325.39 E-value: 5.53e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1066 HPSDCSQVQQNSNAASGLYTIYLHGdSSRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTKEFWLGLD 1145
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1146 KLHNLTTGTPtrYEVRVDLQ-TANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDA-LSYHNGWKFTTFDRDNDIALSN 1223
Cdd:smart00186 80 NIHLLTSQGK--YELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDAsLTYHNGMQFSTYDRDNDKYSGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1622827697 1224 CALTHHGGWWYKNCHLANPNGRYG-ETKHSEGVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:smart00186 158 CAEEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1067-1276 |
1.28e-85 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 277.87 E-value: 1.28e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1067 PSDCSQVQQNSNAASGLYTIYLHGDSsRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTK-EFWLGLD 1145
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPgEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1146 KLHNLTTGTPtrYEVRVDLQTAN-ESAYAIYDFFQVASSKERYKLTVGKYRGTAGDAL-------SYHNGWKFTTFDRDN 1217
Cdd:pfam00147 81 KIHLLTKQGP--YVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtagrsmTYHNGMQFSTWDRDN 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622827697 1218 DIALSNCALTHHGGWWYKNCHLANPNGRY--GETKHSE-GVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:pfam00147 159 DSPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRP 220
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
709-791 |
1.93e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 1.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNLVTDWVTENMATVSWDPVQAT---IDRYVVRYTSAKDGETREVPVGK-EQNSTVLTGLRPGVEYTVHVWAQKGAQ 784
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 785 ESKKADT 791
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
688-1068 |
3.25e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.80 E-value: 3.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 688 VWAQKGDQESKKTDTKAQTDIDSPQNLVTDWVTENMATVSWDPVQATIDRYVVRYTSAKDGETREVPVGKEQNSTVLTGL 767
Cdd:COG3401 30 GGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 768 RPGVEYTVHVWAQKGAQESKKADTKAQTDIDSPKNLVTDRVTENTATVSWDLVQATIDRYVVRYTSANGETREVPVGKEQ 847
Cdd:COG3401 110 GLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 848 SSTVLTGLR--PGVEYTVHVWAQKGNQESKKAD----TKAQTEIDSPKNLVTDRVTENMATVSWDPVQAT-IDKYVV-RY 919
Cdd:COG3401 190 TTLVDGGGDiePGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVyRS 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 920 TSADGETREVPVGKEhSSTVLTGLRPGMEYMVHVWAQKGD-QESKKADT-KAQTEI---DPPRNLRPSAVTQSGGVLTWT 994
Cdd:COG3401 270 NSGDGPFTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSSITLSWT 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 995 PPS-AQIHGYILTY-QFPDGTVKEIQLGREDQRFELQGLEQGATYPVSLVAF-KGGLRSRNVSTTLSTVGARFPHPS 1068
Cdd:COG3401 349 ASSdADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGES 425
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
532-614 |
3.43e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.67 E-value: 3.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWDPVQAT---IDKYVVHYTSADNQETREVPVGK-EQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 608 ESKKANT 614
Cdd:cd00063 82 ESPPSES 88
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
532-610 |
3.64e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.20 E-value: 3.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWDP---VQATIDKYVVHYTSADNQE-TREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 1622827697 608 ESK 610
Cdd:pfam00041 81 EGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
264-342 |
6.16e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 6.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEP----SSQVDHYFLNYYPLGKELSGKQIRVPKEQHSYEILGLLPGTKYIVTLRNVKKDIF 339
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
|
...
gi 1622827697 340 SSP 342
Cdd:pfam00041 82 GPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
798-875 |
2.00e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.28 E-value: 2.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 798 DSPKNLVTDRVTENTATVSW---DLVQATIDRYVVRYTSANGET--REVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGNQ 872
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 1622827697 873 ESK 875
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
798-874 |
2.26e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.09 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 798 DSPKNLVTDRVTENTATVSWDLVQAT-----IDRYVVRYTSANGETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGNQ 872
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 873 ES 874
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
532-609 |
2.64e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.71 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWD-PVQATIDKYVVHYT---SADNQETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRveyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 608 ES 609
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
709-786 |
4.34e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.32 E-value: 4.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNLVTDWVTENMATVSWD-PVQATIDRYVVRYT---SAKDGETREVPVGKEQNSTVLTGLRPGVEYTVHVWAQKGAQ 784
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRveyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 785 ES 786
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
709-787 |
6.79e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 6.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNL-VTDwVTENMATVSWDP---VQATIDRYVVRYTSAKDGE-TREVPVGKEQNSTVLTGLRPGVEYTVHVWAQKGA 783
Cdd:pfam00041 1 SAPSNLtVTD-VTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....
gi 1622827697 784 QESK 787
Cdd:pfam00041 80 GEGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
444-517 |
7.06e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 7.06e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKP---VQAVIDKYVVRYTSADG--DTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGN 517
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1070-1109 |
2.17e-10 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 56.80 E-value: 2.17e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1622827697 1070 CSQV-QQNSNAASGLYTIYLHGDSSR-PLQVYCDMDTDGGGW 1109
Cdd:NF040941 2 CWEIlQAGPSAPSGVYWIDPDGMGGLaPFQVYCDMTTDGGGW 43
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
327-832 |
2.97e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.64 E-value: 2.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 327 YIVTLRNVKKDIFSSPQHLLATTDLAALGTAWVTEETEHSLDVEWENPSTEVDYYKLRYGPMTGQEVTEVTVPKSSDPKS 406
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 407 RYDI-TGLHPGTEYKITVVPMRGTLEGKPILLNGRTEIDSPTNVVTDRVTEDTATVSWKPVQAVIDKYVVRYTSADGDTK 485
Cdd:COG3401 104 GGATnTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 486 EMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQGSKKAD----TNALTEIDSPANLVTDRVTENTATISWDPVQAT-IDK 560
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 561 YVVHYTSADNQETREVPVGKEQSSTVlTGLRPGVEYTVHVWAQKGD-RESKKANT-NAPTDI---DSPKNLVTDRVTENM 635
Cdd:COG3401 264 YRVYRSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSS 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 636 ATVSWDPV-QATIDKYMVrYTSADGETREVPVGKEHSST--ILTGLRPGMEYMVHVWAQ-KGDQESKKTDTKAQTDIDSP 711
Cdd:COG3401 343 ITLSWTASsDADVTGYNV-YRSTSGGGTYTKIAETVTTTsyTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAA 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 712 QNLVTD---WVTENMATVSWDPVQATIDRYVVRYTSAKDGETREVPVGKEQNSTVLTGLRPGVEYTVHV--WAQKGAQES 786
Cdd:COG3401 422 SGESLTasvDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSvtTGSLVGGSG 501
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1622827697 787 KKADTKAQTDID-SPKNLVTDRVTENTATVSWDLVQATIDRYVVRYT 832
Cdd:COG3401 502 ASSVTNSVSVIGaSAAAAVGGAPDGTPNVTGASPVTVGASTGDVLIT 548
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
621-697 |
3.44e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDPVQAT-----IDKYMVRYTSADGETREVPVGKEHSSTILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 696 ES 697
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
444-525 |
3.55e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 3.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKPVQ---AVIDKYVVRYTSADGDTKEMAVHKDESST--VLTGLKPGEAYKVYVWAERGNQ 518
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 519 GSKKADT 525
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
359-434 |
3.55e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 3.55e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 359 VTEETEHSLDVEWENPS---TEVDYYKLRYGPMTGQEVTEVTVPKSSDPksRYDITGLHPGTEYKITVVPMRGTLEGKP 434
Cdd:cd00063 9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
444-520 |
3.57e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 3.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKPVQ-----AVIDKYVVRYTSADGDTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQ 518
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 519 GS 520
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
359-434 |
4.29e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.42 E-value: 4.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 359 VTEETEHSLDVEWENPST---EVDYYKLRYGPMTGQEV-TEVTVPKSsdpKSRYDITGLHPGTEYKITVVPMRGTLEGKP 434
Cdd:pfam00041 8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
798-879 |
4.84e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 4.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 798 DSPKNLVTDRVTENTATVSWDLVQAT---IDRYVVRYTSANGET-REVPVGK-EQSSTVLTGLRPGVEYTVHVWAQKGNQ 872
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 873 ESKKADT 879
Cdd:cd00063 82 ESPPSES 88
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
621-700 |
6.04e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.04 E-value: 6.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDP---VQATIDKYMVRYTSADGET--REVPVGKEHSSTILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1622827697 696 ESKKT 700
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
621-702 |
5.23e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.81 E-value: 5.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDPVQAT---IDKYMVRYTSADGETREVPVGKEHSST--ILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 696 ESKKTDT 702
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
264-332 |
1.25e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.39 E-value: 1.25e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622827697 264 APQGLQLLKSTEESLLVSWEP--SSQVDHYFLNYYPLGKELSGKQIRVPK--EQHSYEILGLLPGTKYIVTLR 332
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPppDDGITGYIVGYRVEYREEGSEWKEVNVtpSSTSYTLTGLKPGTEYEFRVR 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
264-342 |
1.75e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEPS----SQVDHYFLNYYPLGKELSGKQIRVPKEQHSYEILGLLPGTKYIVTLRNVKKDIF 339
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
...
gi 1622827697 340 SSP 342
Cdd:cd00063 83 SPP 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
359-424 |
1.67e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.92 E-value: 1.67e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 359 VTEETEHSLDVEWENPSTE-VDYYKLRYGPMTGQEVTEVTVPKSSDPKSRYDITGLHPGTEYKITVV 424
Cdd:smart00060 9 VTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
171-197 |
3.19e-05 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 41.90 E-value: 3.19e-05
10 20
....*....|....*....|....*..
gi 1622827697 171 CPGACSGHGRCVDGRCLCHEPYVGADC 197
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
236-259 |
6.81e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.79 E-value: 6.81e-05
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
131-253 |
1.15e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.59 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 131 CCQGATDLSRRCSDhgtfsLETCSCHCEegregpaceqlACPGACSGHGRCVDGRCLCHEPYVG------------ADCG 198
Cdd:NF041328 21 CPEGLSVCGGACVD-----LRSDPSNCG-----------ACGVACGAGQTCVAGACGCGPGTVAcggacvdtasdpAHCG 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622827697 199 ypACPENCSGHGECVRGVCQ--CHEDFTseDCSeRRC------PGDCSGHG-FCDTGEcYCEEG 253
Cdd:NF041328 85 --ACGAACAPGQVCEGGACReaCSEGLT--RCG-GACvdlatdPLHCGACGvACDPGE-SCRGG 142
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
202-229 |
1.42e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 1.42e-03
10 20
....*....|....*....|....*...
gi 1622827697 202 CPENCSGHGECVRGVCQCHEDFTSEDCS 229
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1065-1276 |
6.79e-116 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 360.40 E-value: 6.79e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1065 PHPSDCSQVQQNSNAASGLYTIYLHGdSSRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTKEFWLGL 1144
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPG-SNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1145 DKLHNLTTGTPtrYEVRVDLQT-ANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDALSYHNGWKFTTFDRDNDIALSN 1223
Cdd:cd00087 80 EKIHLLTSQGP--YELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 1224 CALTHHGGWWYKNCHLANPNGRYGETKH----SEGVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:cd00087 158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1066-1276 |
5.53e-103 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 325.39 E-value: 5.53e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1066 HPSDCSQVQQNSNAASGLYTIYLHGdSSRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTKEFWLGLD 1145
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1146 KLHNLTTGTPtrYEVRVDLQ-TANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDA-LSYHNGWKFTTFDRDNDIALSN 1223
Cdd:smart00186 80 NIHLLTSQGK--YELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDAsLTYHNGMQFSTYDRDNDKYSGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1622827697 1224 CALTHHGGWWYKNCHLANPNGRYG-ETKHSEGVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:smart00186 158 CAEEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1067-1276 |
1.28e-85 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 277.87 E-value: 1.28e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1067 PSDCSQVQQNSNAASGLYTIYLHGDSsRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPTK-EFWLGLD 1145
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPgEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 1146 KLHNLTTGTPtrYEVRVDLQTAN-ESAYAIYDFFQVASSKERYKLTVGKYRGTAGDAL-------SYHNGWKFTTFDRDN 1217
Cdd:pfam00147 81 KIHLLTKQGP--YVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtagrsmTYHNGMQFSTWDRDN 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622827697 1218 DIALSNCALTHHGGWWYKNCHLANPNGRY--GETKHSE-GVNWEPWKGHEFSIPYVELKIRP 1276
Cdd:pfam00147 159 DSPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRP 220
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
709-791 |
1.93e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 1.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNLVTDWVTENMATVSWDPVQAT---IDRYVVRYTSAKDGETREVPVGK-EQNSTVLTGLRPGVEYTVHVWAQKGAQ 784
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 785 ESKKADT 791
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
688-1068 |
3.25e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.80 E-value: 3.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 688 VWAQKGDQESKKTDTKAQTDIDSPQNLVTDWVTENMATVSWDPVQATIDRYVVRYTSAKDGETREVPVGKEQNSTVLTGL 767
Cdd:COG3401 30 GGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 768 RPGVEYTVHVWAQKGAQESKKADTKAQTDIDSPKNLVTDRVTENTATVSWDLVQATIDRYVVRYTSANGETREVPVGKEQ 847
Cdd:COG3401 110 GLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 848 SSTVLTGLR--PGVEYTVHVWAQKGNQESKKAD----TKAQTEIDSPKNLVTDRVTENMATVSWDPVQAT-IDKYVV-RY 919
Cdd:COG3401 190 TTLVDGGGDiePGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVyRS 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 920 TSADGETREVPVGKEhSSTVLTGLRPGMEYMVHVWAQKGD-QESKKADT-KAQTEI---DPPRNLRPSAVTQSGGVLTWT 994
Cdd:COG3401 270 NSGDGPFTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSSITLSWT 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 995 PPS-AQIHGYILTY-QFPDGTVKEIQLGREDQRFELQGLEQGATYPVSLVAF-KGGLRSRNVSTTLSTVGARFPHPS 1068
Cdd:COG3401 349 ASSdADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGES 425
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
532-614 |
3.43e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.67 E-value: 3.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWDPVQAT---IDKYVVHYTSADNQETREVPVGK-EQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 608 ESKKANT 614
Cdd:cd00063 82 ESPPSES 88
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
532-610 |
3.64e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.20 E-value: 3.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWDP---VQATIDKYVVHYTSADNQE-TREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 1622827697 608 ESK 610
Cdd:pfam00041 81 EGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
264-342 |
6.16e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 6.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEP----SSQVDHYFLNYYPLGKELSGKQIRVPKEQHSYEILGLLPGTKYIVTLRNVKKDIF 339
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
|
...
gi 1622827697 340 SSP 342
Cdd:pfam00041 82 GPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
798-875 |
2.00e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.28 E-value: 2.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 798 DSPKNLVTDRVTENTATVSW---DLVQATIDRYVVRYTSANGET--REVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGNQ 872
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 1622827697 873 ESK 875
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
798-874 |
2.26e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.09 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 798 DSPKNLVTDRVTENTATVSWDLVQAT-----IDRYVVRYTSANGETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGNQ 872
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 873 ES 874
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
532-609 |
2.64e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.71 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 532 DSPANLVTDRVTENTATISWD-PVQATIDKYVVHYT---SADNQETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDR 607
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRveyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 608 ES 609
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
709-786 |
4.34e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.32 E-value: 4.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNLVTDWVTENMATVSWD-PVQATIDRYVVRYT---SAKDGETREVPVGKEQNSTVLTGLRPGVEYTVHVWAQKGAQ 784
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRveyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 785 ES 786
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
709-787 |
6.79e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 6.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 709 DSPQNL-VTDwVTENMATVSWDP---VQATIDRYVVRYTSAKDGE-TREVPVGKEQNSTVLTGLRPGVEYTVHVWAQKGA 783
Cdd:pfam00041 1 SAPSNLtVTD-VTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....
gi 1622827697 784 QESK 787
Cdd:pfam00041 80 GEGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
444-517 |
7.06e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 7.06e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKP---VQAVIDKYVVRYTSADG--DTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGN 517
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
886-962 |
8.51e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 59.55 E-value: 8.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 886 DSPKNLVTDRVTENMATVSWDPVQAT-----IDKYVVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGDQ 960
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 961 ES 962
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
886-963 |
1.63e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.58 E-value: 1.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 886 DSPKNLVTDRVTENMATVSWDP---VQATIDKYVVRYTSADGET--REVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGDQ 960
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 1622827697 961 ESK 963
Cdd:pfam00041 81 EGP 83
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1070-1109 |
2.17e-10 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 56.80 E-value: 2.17e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1622827697 1070 CSQV-QQNSNAASGLYTIYLHGDSSR-PLQVYCDMDTDGGGW 1109
Cdd:NF040941 2 CWEIlQAGPSAPSGVYWIDPDGMGGLaPFQVYCDMTTDGGGW 43
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
327-832 |
2.97e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.64 E-value: 2.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 327 YIVTLRNVKKDIFSSPQHLLATTDLAALGTAWVTEETEHSLDVEWENPSTEVDYYKLRYGPMTGQEVTEVTVPKSSDPKS 406
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 407 RYDI-TGLHPGTEYKITVVPMRGTLEGKPILLNGRTEIDSPTNVVTDRVTEDTATVSWKPVQAVIDKYVVRYTSADGDTK 485
Cdd:COG3401 104 GGATnTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 486 EMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQGSKKAD----TNALTEIDSPANLVTDRVTENTATISWDPVQAT-IDK 560
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 561 YVVHYTSADNQETREVPVGKEQSSTVlTGLRPGVEYTVHVWAQKGD-RESKKANT-NAPTDI---DSPKNLVTDRVTENM 635
Cdd:COG3401 264 YRVYRSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSS 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 636 ATVSWDPV-QATIDKYMVrYTSADGETREVPVGKEHSST--ILTGLRPGMEYMVHVWAQ-KGDQESKKTDTKAQTDIDSP 711
Cdd:COG3401 343 ITLSWTASsDADVTGYNV-YRSTSGGGTYTKIAETVTTTsyTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAA 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 712 QNLVTD---WVTENMATVSWDPVQATIDRYVVRYTSAKDGETREVPVGKEQNSTVLTGLRPGVEYTVHV--WAQKGAQES 786
Cdd:COG3401 422 SGESLTasvDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSvtTGSLVGGSG 501
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1622827697 787 KKADTKAQTDID-SPKNLVTDRVTENTATVSWDLVQATIDRYVVRYT 832
Cdd:COG3401 502 ASSVTNSVSVIGaSAAAAVGGAPDGTPNVTGASPVTVGASTGDVLIT 548
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
621-697 |
3.44e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDPVQAT-----IDKYMVRYTSADGETREVPVGKEHSSTILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 696 ES 697
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
444-525 |
3.55e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 3.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKPVQ---AVIDKYVVRYTSADGDTKEMAVHKDESST--VLTGLKPGEAYKVYVWAERGNQ 518
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 519 GSKKADT 525
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
359-434 |
3.55e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 3.55e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 359 VTEETEHSLDVEWENPS---TEVDYYKLRYGPMTGQEVTEVTVPKSSDPksRYDITGLHPGTEYKITVVPMRGTLEGKP 434
Cdd:cd00063 9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
444-520 |
3.57e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 3.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 444 DSPTNVVTDRVTEDTATVSWKPVQ-----AVIDKYVVRYTSADGDTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQ 518
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1622827697 519 GS 520
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
359-434 |
4.29e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.42 E-value: 4.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 359 VTEETEHSLDVEWENPST---EVDYYKLRYGPMTGQEV-TEVTVPKSsdpKSRYDITGLHPGTEYKITVVPMRGTLEGKP 434
Cdd:pfam00041 8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
798-879 |
4.84e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 4.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 798 DSPKNLVTDRVTENTATVSWDLVQAT---IDRYVVRYTSANGET-REVPVGK-EQSSTVLTGLRPGVEYTVHVWAQKGNQ 872
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 873 ESKKADT 879
Cdd:cd00063 82 ESPPSES 88
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
621-700 |
6.04e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.04 E-value: 6.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDP---VQATIDKYMVRYTSADGET--REVPVGKEHSSTILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1622827697 696 ESKKT 700
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
886-967 |
1.02e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 886 DSPKNLVTDRVTENMATVSWDPVQAT---IDKYVVRYTSADGETREVPVGKEHSST--VLTGLRPGMEYMVHVWAQKGDQ 960
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 961 ESKKADT 967
Cdd:cd00063 82 ESPPSES 88
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
612-924 |
1.51e-09 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 62.66 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 612 ANTNAPTDIDSPKNL--VTDRVTENMATVSWDPVQATIDkYMVRYTSADGETREVPVGKEhSSTILTGLRPGmEYMVHVW 689
Cdd:COG4733 528 PPQWPPVNVTTSESLsvVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNWVSVPRTSG-TSFEVPGIYAG-DYEVRVR 604
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 690 A-QKGDQESKKTDTKAQT---DIDSPQNLVTDWVTEN--MATVSWD-PVQATIDRYVVRYTSAKDGETREVPVGK-EQNS 761
Cdd:COG4733 605 AiNALGVSSAWAASSETTvtgKTAPPPAPTGLTATGGlgGITLSWSfPVDADTLRTEIRYSTTGDWASATVAQALyPGNT 684
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 762 TVLTGLRPGVEYTVHVWA--QKGAQESKKADTKAQTDIDSPKNLVTDRVTENTATVSWDLVQATIDryVVRYTSANGETR 839
Cdd:COG4733 685 YTLAGLKAGQTYYYRARAvdRSGNVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT--VAEVVAATVTDV 762
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 840 EVPVGKEQS-STVLTGLRPGVEYTVhVWAQKGNQESKKADTKAQTEIDSPKNLVTDrvTENMATVSWDPVQATIDKYVVR 918
Cdd:COG4733 763 TAQIDTAVLfAGVATAAAIGAEARV-AATVAESATAAAATGTAADAAGDASGGVTA--GTSGTTGAGDTAASTTRVAAAV 839
|
....*.
gi 1622827697 919 YTSADG 924
Cdd:COG4733 840 VLAGVV 845
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
621-702 |
5.23e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.81 E-value: 5.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 621 DSPKNLVTDRVTENMATVSWDPVQAT---IDKYMVRYTSADGETREVPVGKEHSST--ILTGLRPGMEYMVHVWAQKGDQ 695
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
....*..
gi 1622827697 696 ESKKTDT 702
Cdd:cd00063 82 ESPPSES 88
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
264-332 |
1.25e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.39 E-value: 1.25e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622827697 264 APQGLQLLKSTEESLLVSWEP--SSQVDHYFLNYYPLGKELSGKQIRVPK--EQHSYEILGLLPGTKYIVTLR 332
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPppDDGITGYIVGYRVEYREEGSEWKEVNVtpSSTSYTLTGLKPGTEYEFRVR 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
264-342 |
1.75e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEPS----SQVDHYFLNYYPLGKELSGKQIRVPKEQHSYEILGLLPGTKYIVTLRNVKKDIF 339
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
...
gi 1622827697 340 SSP 342
Cdd:cd00063 83 SPP 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
974-1047 |
2.67e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 52.42 E-value: 2.67e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 974 DPPRNLRPSAVTQSGGVLTWTPP---SAQIHGYILTYQFPDGT--VKEIQLGREDQRFELQGLEQGATYPVSLVAFKGG 1047
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
443-648 |
1.34e-07 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 56.11 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 443 IDSPTNVVTDRVTEDTATVSWKPVQAVIDkYVVRYTSADGDTKEMAVhKDESSTVLTGLKPGEaYKVYVWAeRGNQGSKK 522
Cdd:COG4733 538 TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNWVSVPR-TSGTSFEVPGIYAGD-YEVRVRA-INALGVSS 613
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 523 ADTNALT-----EIDSPANLVTDRVTENT--ATISWD-PVQATIDKYVVHYTSADNQETREVPVGKEQSST-VLTGLRPG 593
Cdd:COG4733 614 AWAASSEttvtgKTAPPPAPTGLTATGGLggITLSWSfPVDADTLRTEIRYSTTGDWASATVAQALYPGNTyTLAGLKAG 693
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 594 VEYtvHVWAQKGDRESKK----ANTNAPTDIDSPKNLVTDRVTENMATVSWDPVQATID 648
Cdd:COG4733 694 QTY--YYRARAVDRSGNVsawwVSGQASADAAGILDAITGQILETELGQELDAIIQNAT 750
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
359-424 |
1.67e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.92 E-value: 1.67e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622827697 359 VTEETEHSLDVEWENPSTE-VDYYKLRYGPMTGQEVTEVTVPKSSDPKSRYDITGLHPGTEYKITVV 424
Cdd:smart00060 9 VTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
974-1050 |
3.09e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.42 E-value: 3.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 974 DPPRNLRPSAVTQSGGVLTWTPPS---AQIHGYILTYQ-FPDGTVKEIQLGREDQ-RFELQGLEQGATYPVSLVAFKGGL 1048
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 1622827697 1049 RS 1050
Cdd:cd00063 82 ES 83
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
524-844 |
3.35e-06 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 51.87 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 524 DTNALTEI---DSPANLVTDRVT--------ENTATISWDPVQATIDKYVVHYtsADNQETREVPVGKEQSSTVlTGLRP 592
Cdd:COG4733 520 DAGAFDDVppqWPPVNVTTSESLsvvaqgtaVTTLTVSWDAPAGAVAYEVEWR--RDDGNWVSVPRTSGTSFEV-PGIYA 596
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 593 GvEYTVHVWA-QKGDRESKKANT---------NAPTDidsPKNLVTDRVTEnMATVSWD-PVQATIDKYMVRY-TSADGE 660
Cdd:COG4733 597 G-DYEVRVRAiNALGVSSAWAASsettvtgktAPPPA---PTGLTATGGLG-GITLSWSfPVDADTLRTEIRYsTTGDWA 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 661 TREVPVGKEHSST-ILTGLRPGMEYmvHVWAQKGDQESKKTD----TKAQTDIDSPQNLVTDWVTEnmaTVSWDPVQATI 735
Cdd:COG4733 672 SATVAQALYPGNTyTLAGLKAGQTY--YYRARAVDRSGNVSAwwvsGQASADAAGILDAITGQILE---TELGQELDAII 746
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 736 DRYVVRYTSAKDGETREVPVGKEQN-STVLTGLRPGVEYTVhVWAQKGAQESKKADTKAQTDIDSPKNLVTDR---VTEN 811
Cdd:COG4733 747 QNATVAEVVAATVTDVTAQIDTAVLfAGVATAAAIGAEARV-AATVAESATAAAATGTAADAAGDASGGVTAGtsgTTGA 825
|
330 340 350
....*....|....*....|....*....|...
gi 1622827697 812 TATVSWDLVQATIDRYVVRYTSANGETREVPVG 844
Cdd:COG4733 826 GDTAASTTRVAAAVVLAGVVVYGDAIIESGNTG 858
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
974-1047 |
5.21e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 45.68 E-value: 5.21e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622827697 974 DPPRNLRPSAVTQSGGVLTWTPPSAQ-----IHGYILTYQFPDGTVKEIQLGREDQRFELQGLEQGATYPVSLVAFKGG 1047
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
171-197 |
3.19e-05 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 41.90 E-value: 3.19e-05
10 20
....*....|....*....|....*..
gi 1622827697 171 CPGACSGHGRCVDGRCLCHEPYVGADC 197
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
236-259 |
6.81e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.79 E-value: 6.81e-05
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
131-253 |
1.15e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.59 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 131 CCQGATDLSRRCSDhgtfsLETCSCHCEegregpaceqlACPGACSGHGRCVDGRCLCHEPYVG------------ADCG 198
Cdd:NF041328 21 CPEGLSVCGGACVD-----LRSDPSNCG-----------ACGVACGAGQTCVAGACGCGPGTVAcggacvdtasdpAHCG 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622827697 199 ypACPENCSGHGECVRGVCQ--CHEDFTseDCSeRRC------PGDCSGHG-FCDTGEcYCEEG 253
Cdd:NF041328 85 --ACGAACAPGQVCEGGACReaCSEGLT--RCG-GACvdlatdPLHCGACGvACDPGE-SCRGG 142
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
264-560 |
9.79e-04 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 43.45 E-value: 9.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEPSSQVDhyfLNYYPL--GKELSGKQIRVPKEQH-SYEILGLLPGTKYIVTLRNVKKDIFS 340
Cdd:COG3401 235 APTGLTATADTPGSVTLSWDPVTESD---ATGYRVyrSNSGDGPFTKVATVTTtSYTDTGLTNGTTYYYRVTAVDAAGNE 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 341 SP--QHLLATTDLAALGTAW---VTEETEHSLDVEWENPSTE-VDYYKLRYGPMTGQEVTEVTvpkSSDPKSRYDITGLH 414
Cdd:COG3401 312 SApsNVVSVTTDLTPPAAPSgltATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGGTYTKIA---ETVTTTSYTDTGLT 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 415 PGTEYKITVVPMRGT-LEGKP-----ILLNGRTEIDSPTNVVTDRVTEDTATVSWKPVQAVIDKYVVRYTSADGDTKEMA 488
Cdd:COG3401 389 PGTTYYYKVTAVDAAgNESAPseevsATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAV 468
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622827697 489 VHKDESSTVLTGLKPGEAYKVYV-WAERGNQGSKKADTNALTEID-SPANLVTDRVTENTATISWDPVQATIDK 560
Cdd:COG3401 469 PFTTTSSTVTATTTDTTTANLSVtTGSLVGGSGASSVTNSVSVIGaSAAAAVGGAPDGTPNVTGASPVTVGAST 542
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
202-229 |
1.42e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 1.42e-03
10 20
....*....|....*....|....*...
gi 1622827697 202 CPENCSGHGECVRGVCQCHEDFTSEDCS 229
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
174-197 |
1.99e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 1.99e-03
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
264-486 |
5.21e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 41.14 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 264 APQGLQLLKSTEESLLVSWEPSSQVD--HYFLnYYPLGKELSGKQIRVPKEQHSYEILGLLPGTKYIVTLRNVKKDIFSS 341
Cdd:COG3401 329 APSGLTATAVGSSSITLSWTASSDADvtGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNES 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827697 342 PQHLLATtdlaalGTAWVTEETEHSLDVEWENPSTEVDYYKLRYGPMTGQEVTEVTVPKSSDPKSrYDITGLHPGTEYKI 421
Cdd:COG3401 408 APSEEVS------ATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGN-AVPFTTTSSTVTAT 480
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622827697 422 TVVPMRGTLEGKPILLNGRTEIDSPTNVVTDRVTEDTATVSWKPVQAVIDKYVVRYTSADGDTKE 486
Cdd:COG3401 481 TTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDV 545
|
|
| DUF4998 |
pfam16389 |
Domain of unknown function; This family around 200 residues locates in the N-terminal of some ... |
455-509 |
5.34e-03 |
|
Domain of unknown function; This family around 200 residues locates in the N-terminal of some uncharacterized proteins in various Bacteroides and Parabacteroides species. The function of this family remains unknown.
Pssm-ID: 435316 [Multi-domain] Cd Length: 199 Bit Score: 39.60 E-value: 5.34e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1622827697 455 TEDTATVSWKPVQAVIDKYV-VRYTSADGDTKEMAVHKDESSTVLTGLKPGEAYKV 509
Cdd:pfam16389 130 AGSNLTINWSPVLASALVGTeVTYTNNDGKVKTVRIKNGETQTVLPDFKPGTSFKY 185
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
233-260 |
5.42e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 35.74 E-value: 5.42e-03
10 20
....*....|....*....|....*...
gi 1622827697 233 CPGDCSGHGFCDTGECYCEEGFTGLDCA 260
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EB |
pfam01683 |
EB module; This domain has no known function. It is found in several C. elegans proteins. The ... |
181-224 |
9.30e-03 |
|
EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.
Pssm-ID: 460294 Cd Length: 52 Bit Score: 35.48 E-value: 9.30e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1622827697 181 CVDGRCLchePYV--GADCGYPacpENCSGHGECVRGVCQCHEDFT 224
Cdd:pfam01683 7 LVNGQCV---PKVapGESCEAD---EQCPGGSVCVNGVCQCPPGFT 46
|
|
| |
