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Conserved domains on  [gi|1622950687|ref|XP_028706203|]
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leucine-rich repeat-containing protein 28 isoform X3 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-152 3.72e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687   5 LCKTISVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAI 84
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPEEL 178

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622950687  85 GSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPDLGRSRELQYVYVDNNiHLKGLPS 152
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDLPE 245
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-152 3.72e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687   5 LCKTISVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAI 84
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPEEL 178

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622950687  85 GSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPDLGRSRELQYVYVDNNiHLKGLPS 152
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDLPE 245
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-237 4.73e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 4.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687   3 SELC------KTISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-YLERLYMKRNSLTTLPENlaqkLPNLVE-LYLHS 74
Cdd:PRK15370  181 TELRlkilglTTIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  75 NNIVVVPEAIGSlvKLQCLDLSDNALEIVcPEiGRLRALRHLRLANNQLQFLPPDLGRSreLQYVYVDNNiHLKGLPSYL 154
Cdd:PRK15370  251 NRITELPERLPS--ALQSLDLFHNKISCL-PE-NLPEELRYLSVYDNSIRTLPAHLPSG--ITHLNVQSN-SLTALPETL 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687 155 Y---------NKVIGCSGCGAPiqvSEVKLLSFSSGQRTVF---LPAEVKAIGTEHDHVLPLQE---LAMRSLYHTYHSL 219
Cdd:PRK15370  324 PpglktleagENALTSLPASLP---PELQVLDVSKNQITVLpetLPPTITTLDVSRNALTNLPEnlpAALQIMQASRNNL 400

                         250
                  ....*....|....*...
gi 1622950687 220 LKdlnflSPISLPRSLLE 237
Cdd:PRK15370  401 VR-----LPESLPHFRGE 413
LRR_8 pfam13855
Leucine rich repeat;
43-100 9.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622950687  43 LERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-100 1.35e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622950687  38 EGLQYLERLYMKRNSLTTLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNAL 100
Cdd:cd21340    43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRL 102
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-152 3.72e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687   5 LCKTISVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAI 84
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPEEL 178

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622950687  85 GSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPDLGRSRELQYVYVDNNiHLKGLPS 152
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDLPE 245
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-144 7.24e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 7.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTTLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPEEL---GNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLTN 229

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622950687  90 LQCLDLSDNALEIVcPEIGRLRALRHLRLANNQLQFLPPdLGRSRELQYVYVDNN 144
Cdd:COG4886   230 LETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNN 282
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-237 4.73e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 4.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687   3 SELC------KTISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-YLERLYMKRNSLTTLPENlaqkLPNLVE-LYLHS 74
Cdd:PRK15370  181 TELRlkilglTTIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  75 NNIVVVPEAIGSlvKLQCLDLSDNALEIVcPEiGRLRALRHLRLANNQLQFLPPDLGRSreLQYVYVDNNiHLKGLPSYL 154
Cdd:PRK15370  251 NRITELPERLPS--ALQSLDLFHNKISCL-PE-NLPEELRYLSVYDNSIRTLPAHLPSG--ITHLNVQSN-SLTALPETL 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687 155 Y---------NKVIGCSGCGAPiqvSEVKLLSFSSGQRTVF---LPAEVKAIGTEHDHVLPLQE---LAMRSLYHTYHSL 219
Cdd:PRK15370  324 PpglktleagENALTSLPASLP---PELQVLDVSKNQITVLpetLPPTITTLDVSRNALTNLPEnlpAALQIMQASRNNL 400

                         250
                  ....*....|....*...
gi 1622950687 220 LKdlnflSPISLPRSLLE 237
Cdd:PRK15370  401 VR-----LPESLPHFRGE 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-238 4.12e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  46 LYMKRNSLTTLPENLAQklpNLVELYLHSNNIVVVPEAIGSLVklQCLDLSDNALeIVCPEiGRLRALRHLRLANNQLQF 125
Cdd:PRK15370  204 LILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTI--QEMELSINRI-TELPE-RLPSALQSLDLFHNKISC 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687 126 LPPDLgrSRELQYVYV-DNNIhlKGLPSYLynkvigcsgcgaPIQVSEVKLLSFSsgqrTVFLPAEVkAIGTEhdhVLPL 204
Cdd:PRK15370  277 LPENL--PEELRYLSVyDNSI--RTLPAHL------------PSGITHLNVQSNS----LTALPETL-PPGLK---TLEA 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622950687 205 QELAMRSLYHTYHSLLKDLNF------LSPISLPRSLLEL 238
Cdd:PRK15370  333 GENALTSLPASLPPELQVLDVsknqitVLPETLPPTITTL 372
LRR_8 pfam13855
Leucine rich repeat;
43-100 9.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622950687  43 LERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
18-77 4.17e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 4.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  18 KNLFLNYRNLHHFPLELLKdeGLQYLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-107 7.72e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  12 ARLEKHKNL---FLNYRNLH-HFPLELLKDEGLQYLERLYmkrNSLT-TLPENLAQkLPNLVELYLHSNNIV-VVPEAIG 85
Cdd:PLN00113  206 RELGQMKSLkwiYLGYNNLSgEIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIF 281

                          90       100
                  ....*....|....*....|..
gi 1622950687  86 SLVKLQCLDLSDNALEIVCPEI 107
Cdd:PLN00113  282 SLQKLISLDLSDNSLSGEIPEL 303
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-100 1.35e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622950687  38 EGLQYLERLYMKRNSLTTLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNAL 100
Cdd:cd21340    43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRL 102
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-152 2.30e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  39 GLQYLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCPE-IGRLRALRHL 116
Cdd:PLN00113  473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPAsFSEMPVLSQL 552

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1622950687 117 RLANNQLQF-LPPDLGRSRELQYVYVDNNiHLKG-LPS 152
Cdd:PLN00113  553 DLSQNQLSGeIPKNLGNVESLVQVNISHN-HLHGsLPS 589
LRR_9 pfam14580
Leucine-rich repeat;
25-98 3.78e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.44  E-value: 3.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622950687  25 RNLHHFPLellkdegLQYLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNI--VVVPEAIGSLVKLQCLDLSDN 98
Cdd:pfam14580  55 RKLDGFPL-------LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLqeLGDLDPLASLKKLTFLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
65-106 4.01e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 4.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622950687  65 PNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNALEIVCPE 106
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPG 43
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-152 9.12e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.52  E-value: 9.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622950687  40 LQYLERLYMKRNSLT-TLPENLAQkLPNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCPE-IGRLRALRHL 116
Cdd:PLN00113  307 LQNLEILHLFSNNFTgKIPVALTS-LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSSGNLFKL 385

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1622950687 117 RLANNQLQF-LPPDLGRSRELQYVYVDNNiHLKG-LPS 152
Cdd:PLN00113  386 ILFSNSLEGeIPKSLGACRSLRRVRLQDN-SFSGeLPS 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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