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Conserved domains on  [gi|1622948108|ref|XP_028705722|]
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complement C1q tumor necrosis factor-related protein 2 isoform X5 [Macaca mulatta]

Protein Classification

complement C1q domain-containing protein( domain architecture ID 10448922)

complement C1q domain-containing protein may be involved in the regulation of the inflammatory network

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 130-252 1.40e-53

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


:

Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 169.39  E-value: 1.40e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622948108 130 GRTVTKSYPRERlPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLAN-KHLAIGLVHNGQYRIRTFDANT-GNH 207
Cdd:pfam00386   5 GRTTGLTAPNEQ-PVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVDgKSLYVSLVKNGQEVVSFYDQPQkGSL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622948108 208 DVASGSTILALKQGDEVWLQIFYseQNGLFYDPYWTDSLFTGFLI 252
Cdd:pfam00386  84 DVASGSVVLELQRGDEVWLQLTG--YNGLYYDGSDTDSTFSGFLL 126
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 103-131 2.89e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 41.81  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622948108 103 GRMGFP---GKDGQDGQDGDRGDSGEEGPPGR 131
Cdd:NF038329  293 GKDGLPgkdGKDGQNGKDGLPGKDGKDGQPGK 324
 
Name Accession Description Interval E-value
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 130-252 1.40e-53

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 169.39  E-value: 1.40e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622948108 130 GRTVTKSYPRERlPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLAN-KHLAIGLVHNGQYRIRTFDANT-GNH 207
Cdd:pfam00386   5 GRTTGLTAPNEQ-PVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVDgKSLYVSLVKNGQEVVSFYDQPQkGSL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622948108 208 DVASGSTILALKQGDEVWLQIFYseQNGLFYDPYWTDSLFTGFLI 252
Cdd:pfam00386  84 DVASGSVVLELQRGDEVWLQLTG--YNGLYYDGSDTDSTFSGFLL 126
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 134-255 2.15e-42

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 141.29  E-value: 2.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622948108  134 TKSYPRERLPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLANKHLAIGLVHNGQYRIRTFDANT-GNHDVASG 212
Cdd:smart00110  15 SNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVMSTYDEYQkGLYDVASG 94

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1622948108  213 STILALKQGDEVWLQIfYSEQNGLfYDPYWTDSLFTGFLIYAD 255
Cdd:smart00110  95 GALLQLRQGDQVWLEL-PDEKNGL-YAGEYVDSTFSGFLLFPD 135
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 103-131 2.89e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 41.81  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622948108 103 GRMGFP---GKDGQDGQDGDRGDSGEEGPPGR 131
Cdd:NF038329  293 GKDGLPgkdGKDGQNGKDGLPGKDGKDGQPGK 324
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 103-136 2.98e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 38.73  E-value: 2.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622948108 103 GRMGFPGKDGQDGQDGDRG---DSGEEGPPGRTVTKS 136
Cdd:NF038329  308 GKDGLPGKDGKDGQPGKDGlpgKDGKDGQPGKPAPKT 344
 
Name Accession Description Interval E-value
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 130-252 1.40e-53

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 169.39  E-value: 1.40e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622948108 130 GRTVTKSYPRERlPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLAN-KHLAIGLVHNGQYRIRTFDANT-GNH 207
Cdd:pfam00386   5 GRTTGLTAPNEQ-PVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVDgKSLYVSLVKNGQEVVSFYDQPQkGSL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622948108 208 DVASGSTILALKQGDEVWLQIFYseQNGLFYDPYWTDSLFTGFLI 252
Cdd:pfam00386  84 DVASGSVVLELQRGDEVWLQLTG--YNGLYYDGSDTDSTFSGFLL 126
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 134-255 2.15e-42

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 141.29  E-value: 2.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622948108  134 TKSYPRERLPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLANKHLAIGLVHNGQYRIRTFDANT-GNHDVASG 212
Cdd:smart00110  15 SNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVMSTYDEYQkGLYDVASG 94

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1622948108  213 STILALKQGDEVWLQIfYSEQNGLfYDPYWTDSLFTGFLIYAD 255
Cdd:smart00110  95 GALLQLRQGDQVWLEL-PDEKNGL-YAGEYVDSTFSGFLLFPD 135
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 103-131 2.89e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 41.81  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622948108 103 GRMGFP---GKDGQDGQDGDRGDSGEEGPPGR 131
Cdd:NF038329  293 GKDGLPgkdGKDGQNGKDGLPGKDGKDGQPGK 324
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 103-136 2.98e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 38.73  E-value: 2.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622948108 103 GRMGFPGKDGQDGQDGDRG---DSGEEGPPGRTVTKS 136
Cdd:NF038329  308 GKDGLPGKDGKDGQPGKDGlpgKDGKDGQPGKPAPKT 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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