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Conserved domains on  [gi|1622946049|ref|XP_028705444|]
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peptidyl-glycine alpha-amidating monooxygenase isoform X8 [Macaca mulatta]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
501-808 2.24e-149

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 442.09  E-value: 2.24e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 501 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 580
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 581 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 660
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 661 SPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 739
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946049 740 GLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
197-343 3.29e-62

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 207.10  E-value: 3.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 197 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 265
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 266 LP--QAFYPVEHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDTFRTIP 343
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
60-169 1.58e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.41  E-value: 1.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049  60 LDIRMPGV-IPKQSDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 132
Cdd:pfam01082   1 FDLLNPNVtVPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622946049 133 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 169
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
501-808 2.24e-149

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 442.09  E-value: 2.24e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 501 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 580
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 581 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 660
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 661 SPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 739
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946049 740 GLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
197-343 3.29e-62

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 207.10  E-value: 3.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 197 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 265
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 266 LP--QAFYPVEHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDTFRTIP 343
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
60-169 1.58e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.41  E-value: 1.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049  60 LDIRMPGV-IPKQSDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 132
Cdd:pfam01082   1 FDLLNPNVtVPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622946049 133 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 169
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
558-814 1.48e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 77.75  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 558 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPI-LILGrsmqPGSDQNhfcqPTD 636
Cdd:COG4257    38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 637 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGEFitqwgeeSSGSSPLPGQFtvPHSLALVPhLGQLCVADRENARIQCFKTD 715
Cdd:COG4257   107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 716 TKEFVREIKHSSFGRNVfaisyipGLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVRKHFdmPHDIVASEDGTVY 795
Cdd:COG4257   175 TGTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVW 245
                         250
                  ....*....|....*....
gi 1622946049 796 IGDAHTNTVWKFTLTEKVE 814
Cdd:COG4257   246 FAESGANRIVRFDPDTELT 264
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
684-712 1.11e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.00  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*....
gi 1622946049 684 FTVPHSLALVPhLGQLCVADRENARIQCF 712
Cdd:pfam01436   1 FNRPHGVAVDS-NGDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
501-808 2.24e-149

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 442.09  E-value: 2.24e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 501 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 580
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 581 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 660
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 661 SPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 739
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946049 740 GLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
197-343 3.29e-62

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 207.10  E-value: 3.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 197 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 265
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 266 LP--QAFYPVEHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDTFRTIP 343
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
516-807 5.41e-45

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 163.26  E-value: 5.41e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 516 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPNNAAVLQ--SSGKNL--FYLPHGLSIDKDG 591
Cdd:cd05819    11 QGIAVDSSGNIYVADTGNN------------------------RIQVFDPDGNFITSfgSFGSGDgqFNEPAGVAVDSDG 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 592 NYWVTDVALHQVFKLDPNNKEgpILILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGEFITQWG 671
Cdd:cd05819    67 NLYVADTGNHRIQKFDPDGNF--LASFGGS---GDGDGEFNGPRGIAVDS-SGNIYVAD-TGNHRIQKFDPDGEFLTTFG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 672 EESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTkEFVREIKHSSFGRNVFaiSYIPGLLFAVNGKPHF 751
Cdd:cd05819   140 SGGSG----PGQFNGPTGVAVDSD-GNIYVADTGNHRIQVFDPDG-NFLTTFGSTGTGPGQF--NYPTGIAVDSDGNIYV 211
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622946049 752 GDQEPVQGFVMNFSSGEIIDI--FKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKF 807
Cdd:cd05819   212 ADSGNNRVQVFDPDGAGFGGNgnFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
574-808 7.61e-30

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 119.99  E-value: 7.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 574 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPILILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 653
Cdd:cd14955   104 SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSG--TFITKWGSF---GSGDGQFNSPTGIAVD-SAGNVYVADTG- 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 654 NSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCFKTDTkEFVreikhSSFGrnvf 733
Cdd:cd14955   177 NNRIQKFTSTGTFLTKWGSEGSG----DGQFNAPYGIA-VDSAGNVYVADTGNNRIQKFDSSG-TFI-----TKWG---- 241
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622946049 734 aiSYIPGllfavngkphfgdqepvqgfvmnfsSGEiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14955   242 --SEGSG-------------------------DGQ-----------FNSPSGIAVDSAGNVYVADSGNNRIQKFA 278
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
579-715 1.50e-26

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 110.06  E-value: 1.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 579 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpilILGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIV 658
Cdd:cd14956   106 FNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNYPRGVAVDPD-GTLYVADTY-NDRIQ 178
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946049 659 QFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPhLGQLCVADRENARIQCFKTD 715
Cdd:cd14956   179 VFDNDGAFLRKWGGRGTG----PGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFTAD 230
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
60-169 1.58e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.41  E-value: 1.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049  60 LDIRMPGV-IPKQSDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 132
Cdd:pfam01082   1 FDLLNPNVtVPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622946049 133 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 169
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
558-807 2.23e-25

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 106.60  E-value: 2.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 558 DTILVIDPNNAAVL--------------QSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILILGRsmq 623
Cdd:cd14956    24 DNVYVADARNGRIQvfdkdgtflrrfgtTGDGPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGE--LQTIGGS--- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 624 PGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVAD 703
Cdd:cd14956    99 SGSGPGQFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSFLRQWGGTGIE----PGSFNYPRGVAVDPD-GTLYVAD 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 704 RENARIQCFKTDTKeFVREI-KHSSFG---RNVFAISYIP-GLLFAVNgkphFGDQEpVQGFVMNfssGEIIDIF--KPV 776
Cdd:cd14956   172 TYNDRIQVFDNDGA-FLRKWgGRGTGPgqfNYPYGIAIDPdGNVFVAD----FGNNR-IQKFTAD---GTFLTSWgsPGT 242
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622946049 777 RKH-FDMPHDIVASEDGTVYIGDAHTNTVWKF 807
Cdd:cd14956   243 GPGqFKNPWGVVVDADGTVYVADSNNNRVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
514-712 1.19e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 101.88  E-value: 1.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 514 QVSGVALDPKNNLvifhrgdHVWD-GNS----FDSKFVY------------QQIGLGPIEEDT---ILVIDPNNAAV--L 571
Cdd:cd14955    64 SPTGIAVDSDGNV-------YVADtGNHriqkFDSTGTFltkwgssgsgdgQFNSPSGIAVDSagnVYVTDSGNNRIqkF 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 572 QSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPILILGRsmqPGSDQNHFCQPTDVAV 639
Cdd:cd14955   137 DSSGTFItkwgsfgsgdgqFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAV 211
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946049 640 DpGTGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCF 712
Cdd:cd14955   212 D-SAGNVYVADTG-NNRIQKFDSSGTFITKWGSEGSG----DGQFNSPSGIA-VDSAGNVYVADSGNNRIQKF 277
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
574-810 4.02e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 100.34  E-value: 4.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 574 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPILILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 653
Cdd:cd14955    10 SGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDST---GTFLTKWGS--SGSGDGQFYSPTGIAVD-SDGNVYVADTG- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 654 NSRIVQFSPSGEFITQWGEESSGSsplpGQFTVPHSLAlVPHLGQLCVADRENARIQcfktdtkefvreiKHSSFGrnvf 733
Cdd:cd14955    83 NHRIQKFDSTGTFLTKWGSSGSGD----GQFNSPSGIA-VDSAGNVYVTDSGNNRIQ-------------KFDSSG---- 140
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946049 734 aisyipgllfavngkphfgdqepvqGFVMNFSSGEIIDifkpvrKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 810
Cdd:cd14955   141 -------------------------TFITKWGSFGSGD------GQFNSPTGIAVDSAGNVYVADTGNNRIQKFTST 186
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
575-730 2.33e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 88.80  E-value: 2.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 575 GKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILILGRSMQpgsdqnhFCQPTDVAVDPGTGAIYVSDGYcN 654
Cdd:cd14962    52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGK--FLRAIGAGAL-------FKRPTGIAVDPAGKRLYVVDTL-A 121
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946049 655 SRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVReikhsSFGR 730
Cdd:cd14962   122 HKVKVFDLDGRLLFDIGKRGSG----PGEFNLPTDLAVDRD-GNLYVTDTMNFRVQIFDADGK-FLR-----SFGE 186
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
517-712 3.55e-19

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 88.76  E-value: 3.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 517 GVALDPKNNLVIFHRGDH---VWDGN-SFDSKFVYQQIGLGPIEEdtilvidpnnaavlqssgknlfylPHGLSIDKDGN 592
Cdd:cd14954   122 GVAVDSEGRIYVSDTRNHrvqVFDSDgQFIRKFGFEGAGPGQLDS------------------------PRGVAVNPDGN 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 593 YWVTDVALHQVFKLDPNNKegPILILGrsmQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGE 672
Cdd:cd14954   178 IVVSDFNNHRLQVFDPDGQ--FLRFFG---SEGSGNGQFKRPRGVAVDDE-GNIIVADSG-NHRVQVFSPDGEFLCSFGT 250
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622946049 673 ESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCF 712
Cdd:cd14954   251 EGNG----EGQFDRPSGVAVTPD-GRIVVVDRGNHRIQVF 285
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
512-712 4.02e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 88.49  E-value: 4.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 512 PGQ---VSGVALDPKNNLVIfhrgdhvwdgnsfdSKFVYQQIglgpieedtiLVIDPNNAAVLQ----SSGKNLFYLPHG 584
Cdd:cd14956   103 PGQfnaPRGVAVDADGNLYV--------------ADFGNQRI----------QKFDPDGSFLRQwggtGIEPGSFNYPRG 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 585 LSIDKDGNYWVTDVALH--QVFkldpNNKEGPILILGrsmQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSP 662
Cdd:cd14956   159 VAVDPDGTLYVADTYNDriQVF----DNDGAFLRKWG---GRGTGPGQFNYPYGIAIDP-DGNVFVADFG-NNRIQKFTA 229
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622946049 663 SGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCF 712
Cdd:cd14956   230 DGTFLTSWGSPGTG----PGQFKNPWGVV-VDADGTVYVADSNNNRVQRF 274
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
573-808 6.42e-19

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 88.09  E-value: 6.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 573 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGP-ILILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVS 649
Cdd:cd14957    11 GSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVF-----TSSGVySYSIGSG---GTGSGQFNSPYGIAVD-SNGNIYVA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 650 DgYCNSRIVQFSPSGEFITQWGeeSSGSSplPGQFTVPHSLALVPHlGQLCVADRENARIQCFkTDTKEFVREIKHSSFG 729
Cdd:cd14957    82 D-TDNNRIQVFNSSGVYQYSIG--TGGSG--DGQFNGPYGIAVDSN-GNIYVADTGNHRIQVF-TSSGTFSYSIGSGGTG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 730 RNVFaiSYIPGLLFAVNGKPHFGDQ--EPVQGFVmnfSSGEIIDIF---KPVRKHFDMPHDIVASEDGTVYIGDAHTNTV 804
Cdd:cd14957   155 PGQF--NGPQGIAVDSDGNIYVADTgnHRIQVFT---SSGTFQYTFgssGSGPGQFSDPYGIAVDSDGNIYVADTGNHRI 229

                  ....
gi 1622946049 805 WKFT 808
Cdd:cd14957   230 QVFT 233
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
579-810 1.78e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 86.57  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 579 FYLPHGLSIDKDGNYWVTDVALH--QVFKLDPNNKegpililGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDgYCNSR 656
Cdd:cd14956    12 FKDPRGIAVDADDNVYVADARNGriQVFDKDGTFL-------RRFGTTGDGPGQFGRPRGLAVDKD-GWLYVAD-YWGDR 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 657 IVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIkhssfgrnvfais 736
Cdd:cd14956    83 IQVFTLTGELQTIGGSSGSG----PGQFNAPRGVAVDAD-GNLYVADFGNQRIQKFDPDGS-FLRQW------------- 143
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622946049 737 yipgllfavnGKPhfgDQEPVQgfvmnfssgeiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 810
Cdd:cd14956   144 ----------GGT---GIEPGS---------------------FNYPRGVAVDPDGTLYVADTYNDRIQVFDND 183
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
555-798 2.93e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 85.81  E-value: 2.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 555 IEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVA--LHQVFkldpnNKEGPILil 618
Cdd:cd14963    17 VSDGRIYVADTNNhrVQVFDYEGKFKksfggpgtgpgeFKYPYGIAVDSDGNIYVADLYngRIQVF-----DPDGKFL-- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 619 gRSMQPGSDQNHFCQPTDVAVDPGTgaIYVSD-GYcnSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlG 697
Cdd:cd14963    90 -KYFPEKKDRVKLISPAGLAIDDGK--LYVSDvKK--HKVIVFDLEGKLLLEFGKPGSE----PGELSYPNGIAVDED-G 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 698 QLCVADRENARIQCFKTDTKeFVREIKHSSFGRNVFA----ISYIP-GLLFAVNGKPHFgdqepVQGFVMNFSSGEIIDI 772
Cdd:cd14963   160 NIYVADSGNGRIQVFDKNGK-FIKELNGSPDGKSGFVnprgIAVDPdGNLYVVDNLSHR-----VYVFDEQGKELFTFGG 233
                         250       260
                  ....*....|....*....|....*.
gi 1622946049 773 FKPVRKHFDMPHDIVASEDGTVYIGD 798
Cdd:cd14963   234 RGKDDGQFNLPNGLFIDDDGRLYVTD 259
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
573-712 7.33e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 81.93  E-value: 7.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 573 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPILILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSD 650
Cdd:cd14957   152 GTGPGQFNGPQGIAVDSDGNIYVADTGNHriQVF----TSSGTFQYTFG---SSGSGPGQFSDPYGIAVD-SDGNIYVAD 223
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946049 651 gYCNSRIVQFSPSGEFITQWGeeSSGSSplPGQFTVPHSLAlVPHLGQLCVADRENARIQCF 712
Cdd:cd14957   224 -TGNHRIQVFTSSGAYQYSIG--TSGSG--NGQFNYPYGIA-VDNDGKIYVADSNNNRIQVF 279
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
573-804 7.52e-16

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 78.85  E-value: 7.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 573 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPILILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSD 650
Cdd:cd14957    58 GTGSGQFNSPYGIAVDSNGNIYVADTDNNriQVF----NSSGVYQYSIGTG---GSGDGQFNGPYGIAVDS-NGNIYVAD 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 651 GYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFkTDTKEFVREIKHSSFGr 730
Cdd:cd14957   130 TG-NHRIQVFTSSGTFSYSIGSGGTG----PGQFNGPQGIAVDSD-GNIYVADTGNHRIQVF-TSSGTFQYTFGSSGSG- 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 731 nvfaisyiPGLLF-----AV--NGKPHFGDQ--EPVQGFVmnfSSGEI---IDIFKPVRKHFDMPHDIVASEDGTVYIGD 798
Cdd:cd14957   202 --------PGQFSdpygiAVdsDGNIYVADTgnHRIQVFT---SSGAYqysIGTSGSGNGQFNYPYGIAVDNDGKIYVAD 270

                  ....*.
gi 1622946049 799 AHTNTV 804
Cdd:cd14957   271 SNNNRI 276
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
558-814 1.48e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 77.75  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 558 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPI-LILGrsmqPGSDQNhfcqPTD 636
Cdd:COG4257    38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 637 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGEFitqwgeeSSGSSPLPGQFtvPHSLALVPhLGQLCVADRENARIQCFKTD 715
Cdd:COG4257   107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 716 TKEFVREIKHSSFGRNVfaisyipGLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVRKHFdmPHDIVASEDGTVY 795
Cdd:COG4257   175 TGTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVW 245
                         250
                  ....*....|....*....
gi 1622946049 796 IGDAHTNTVWKFTLTEKVE 814
Cdd:COG4257   246 FAESGANRIVRFDPDTELT 264
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
625-812 1.88e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 77.33  E-value: 1.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 625 GSDQNHFCQPTDVAVDPGTgaIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADR 704
Cdd:cd14963     3 GPFGDPLNKPMGVAVSDGR--IYVADTN-NHRVQVFDYEGKFKKSFGGPGTG----PGEFKYPYGIAVDSD-GNIYVADL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 705 ENARIQCFKTDTKeFVReikhsSFGRNVFAISYI-PGLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVRK--HFD 781
Cdd:cd14963    75 YNGRIQVFDPDGK-FLK-----YFPEKKDRVKLIsPAGLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEpgELS 148
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1622946049 782 MPHDIVASEDGTVYIGDAHTNTVWKFTLTEK 812
Cdd:cd14963   149 YPNGIAVDEDGNIYVADSGNGRIQVFDKNGK 179
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
579-721 2.70e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 74.12  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 579 FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILI-LGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYcNS 655
Cdd:cd14954    23 LCRPWGVAVDKDGRIIVADRSNNrvQVF-----DPDGKFLRkFGSY---GSRDGQFDRPAGVAVN-SRGRIIVADKD-NH 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946049 656 RIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCFKTDTKeFVR 721
Cdd:cd14954    93 RIQVFDLNGRFLLKFGERGTK----NGQFNYPWGVA-VDSEGRIYVSDTRNHRVQVFDSDGQ-FIR 152
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
551-804 5.83e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 73.35  E-value: 5.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 551 GLGPIEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkegpil 616
Cdd:cd14954    28 GVAVDKDGRIIVADRSNnrVQVFDPDGKFLrkfgsygsrdgqFDRPAGVAVNSRGRIIVADKDNHRIQVFDLN------- 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 617 ilGRSM----QPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGEESsgssPLPGQFTVPHSLAl 692
Cdd:cd14954   101 --GRFLlkfgERGTKNGQFNYPWGVAVDSE-GRIYVSDTR-NHRVQVFDSDGQFIRKFGFEG----AGPGQLDSPRGVA- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 693 VPHLGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRNVFAISYipGLlfAVngkphfgDQEpvqGFVMNFSSGEI-ID 771
Cdd:cd14954   172 VNPDGNIVVSDFNNHRLQVFDPDGQ-FLRFFGSEGSGNGQFKRPR--GV--AV-------DDE---GNIIVADSGNHrVQ 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622946049 772 IFKP----VRK---------HFDMPHDIVASEDGTVYIGDAHTNTV 804
Cdd:cd14954   237 VFSPdgefLCSfgtegngegQFDRPSGVAVTPDGRIVVVDRGNHRI 282
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
516-709 9.63e-14

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 73.33  E-value: 9.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 516 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPN-------------------NAAvlqssgk 576
Cdd:cd14953    26 SGVAVDAAGNLYVADRGNH------------------------RIRKITPDgvvttvagtgtagfadgggAAA------- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 577 nLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPIL------ILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSD 650
Cdd:cd14953    75 -QFNTPSGVAVDAAGNLYVADTGNHRIRKITPD---GVVStlagtgTAGFSDDGGATAAQFNYPTGVAVDA-AGNLYVAD 149
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946049 651 GYcNSRIVQFSPSGEFITQWGEESSGSSPL-PG---QFTVPHSLALVPHlGQLCVADRENARI 709
Cdd:cd14953   150 TG-NHRIRKITPDGVVTTVAGTGGAGYAGDgPAtaaQFNNPTGVAVDAA-GNLYVADRGNHRI 210
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
582-815 9.73e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 72.36  E-value: 9.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 582 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEgpililGRSMQPGSdqnhFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFS 661
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGE------FTEYPLGG----GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 662 PSGEFITQWgeessgssPLPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKEfVREIKHSSFGRNVFAISYIPG- 740
Cdd:COG4257    87 PKTGEITTF--------ALPGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPYGIAVDPDg 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946049 741 -LLFAVNGKPHFGdqepvqgfVMNFSSGEiIDIFKPVRKhFDMPHDIVASEDGTVYIGDAHTNTVWKF-TLTEKVEH 815
Cdd:COG4257   157 nLWVTDFGANAIG--------RIDPDTGT-LTEYALPTP-GAGPRGLAVDPDGNLWVADTGSGRIGRFdPKTGTVTE 223
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
624-808 1.52e-13

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 71.91  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 624 PGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGeeSSGSSplPGQFTVPHSLAlVPHLGQLCVAD 703
Cdd:cd14957    10 NGSGNGQFNTPRGIAVDSA-GNIYVADTG-NNRIQVFTSSGVYSYSIG--SGGTG--SGQFNSPYGIA-VDSNGNIYVAD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 704 RENARIQCFkTDTKEFVREIKHSSFGRNVFaiSYIPGLLFAVNGKPHFGDQ--EPVQGFVmnfSSGEI---IDIFKPVRK 778
Cdd:cd14957    83 TDNNRIQVF-NSSGVYQYSIGTGGSGDGQF--NGPYGIAVDSNGNIYVADTgnHRIQVFT---SSGTFsysIGSGGTGPG 156
                         170       180       190
                  ....*....|....*....|....*....|
gi 1622946049 779 HFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14957   157 QFNGPQGIAVDSDGNIYVADTGNHRIQVFT 186
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
560-713 3.44e-13

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 70.84  E-value: 3.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 560 ILVIDPNNAAVL--QSSGKNLFYL-------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpilILGRSMQPGSDQNH 630
Cdd:cd14960    77 IIIADYDNKWVSifSPDGKFKSKIgagklmgPKGVAVDRNGHIIVVDNKACCVFIFQPNGK-----LVTRFGSRGNGDRQ 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 631 FCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQ 710
Cdd:cd14960   152 FAGPHFAAVNN-NNEIIVTD-FHNHSVKVFNAEGEFLFKFGSNGEG----NGQFNAPTGVAVDSN-GNIIVADWGNSRIQ 224

                  ...
gi 1622946049 711 CFK 713
Cdd:cd14960   225 VFD 227
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
502-716 5.58e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 69.34  E-value: 5.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 502 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 579
Cdd:COG3391    38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 580 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpiliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 656
Cdd:COG3391   112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622946049 657 IVQ-FSP-SGEFITQWgeessgssPLPGQftvPHSLALVPHLGQLCVADREN-------ARIQCFKTDT 716
Cdd:COG3391   179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSntsnggsNTVSVIDLAT 236
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
506-712 9.30e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 69.24  E-value: 9.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 506 PGVYLLPgqvSGVALDPKNNLVI---FHRGDHVWD--GNsFDSKFVYQQIGLGP-------IEEDTILVID--PNNAAVL 571
Cdd:cd14963    52 PGEFKYP---YGIAVDSDGNIYVadlYNGRIQVFDpdGK-FLKYFPEKKDRVKLispaglaIDDGKLYVSDvkKHKVIVF 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 572 QSSGKNLFYL------------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILIL-GRSMQPGSdqnhFCQPTDVA 638
Cdd:cd14963   128 DLEGKLLLEFgkpgsepgelsyPNGIAVDEDGNIYVADSGNGRIQVFDKNGK--FIKELnGSPDGKSG----FVNPRGIA 201
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622946049 639 VDPgTGAIYVSDGYCNsRIVQFSPSGEFITQWGeeSSGSSPlpGQFTVPHSLALVPHlGQLCVADRENARIQCF 712
Cdd:cd14963   202 VDP-DGNLYVVDNLSH-RVYVFDEQGKELFTFG--GRGKDD--GQFNLPNGLFIDDD-GRLYVTDRENNRVAVY 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
504-716 2.36e-12

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 68.46  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 504 DWPGVYLLPgqvSGVALDPKNNLVIFHrgdhvwDGNS----FDSK-FVYQQIGlgPIEEDTILVIDPNNAAV-------- 570
Cdd:cd14961     5 GWPGTLNNP---TGVAVTPTGRVVVAD------DGNKriqvFDSDgNCLQQFG--PKGDAGQDIRYPLDVAVtpdghivv 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 571 ----------------LQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSmqpgsdQNHFCQP 634
Cdd:cd14961    74 tdagdrsvkvfsfdgrLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGILKKGQKL------CSQLCRP 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 635 TDVAVDPgTGAIYVSD-------GYCNSRIVQFSPSGEFITQWGeeSSGSSPLPGQFTVPHSLAlVPHLGQLCVADRENA 707
Cdd:cd14961   148 RFVAVSR-LGAVAVTEhlfangtRSSSTRVKVFSSGGQLLGQID--SFGLNLVFPSLICASGVA-FDSEGNVIVADTGSG 223

                  ....*....
gi 1622946049 708 RIQCFKTDT 716
Cdd:cd14961   224 AILCLGKPE 232
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
516-709 1.60e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 66.40  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 516 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPN--------NAAVLQSSGKN----LFYLPH 583
Cdd:cd14953   135 TGVAVDAAGNLYVADTGNHR------------------------IRKITPDgvvttvagTGGAGYAGDGPataaQFNNPT 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 584 GLSIDKDGNYWVTDVALHQVFKLDPNnkeGPIL-ILGRSMQPGSDQNH-----FCQPTDVAVDpGTGAIYVSDgYCNSRI 657
Cdd:cd14953   191 GVAVDAAGNLYVADRGNHRIRKITPD---GVVTtVAGTGTAGFSGDGGataaqLNNPTGVAVD-AAGNLYVAD-SGNHRI 265
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946049 658 VQFSPSGEFIT----QWGEESSGSSPLPGQFTVPHSLALVPHlGQLCVADRENARI 709
Cdd:cd14953   266 RKITPAGVVTTvaggGAGFSGDGGPATSAQFNNPTGVAVDAA-GNLYVADTGNNRI 320
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
609-712 4.01e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 61.79  E-value: 4.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 609 NNKEGPILILGRSmqpGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPH 688
Cdd:cd14954     4 RAKGRPLLSFGKE---GSKDGELCRPWGVAVDKD-GRIIVADRS-NNRVQVFDPDGKFLRKFGSYGSR----DGQFDRPA 74
                          90       100
                  ....*....|....*....|....
gi 1622946049 689 SLAlVPHLGQLCVADRENARIQCF 712
Cdd:cd14954    75 GVA-VNSRGRIIVADKDNHRIQVF 97
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
579-808 1.45e-09

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 60.62  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 579 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPILILGRSMQPGSD-----QNHFCQPTDVAVDPGtGAIYVSDGYc 653
Cdd:cd14953    22 FNSPSGVAVDAAGNLYVADRGNHRIRKITPD---GVVTTVAGTGTAGFAdgggaAAQFNTPSGVAVDAA-GNLYVADTG- 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 654 NSRIVQFSPSGEFITQWGEESSGSSPLPG----QFTVPHSLALVPHlGQLCVADRENARIQcfKTDTKEFVReikhssfg 729
Cdd:cd14953    97 NHRIRKITPDGVVSTLAGTGTAGFSDDGGataaQFNYPTGVAVDAA-GNLYVADTGNHRIR--KITPDGVVT-------- 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622946049 730 rnVFAISYIPGllFAVNGkphfgdqepvqgfvmnfssgeiidifKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14953   166 --TVAGTGGAG--YAGDG--------------------------PATAAQFNNPTGVAVDAAGNLYVADRGNHRIRKIT 214
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
582-841 4.04e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 58.37  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 582 PHGLSIDKDGNYWVTDVALHQVFKLD-PNNKEGPIlilgrsmQPGSDqNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQF 660
Cdd:cd14962    14 PYGVAADGRGRIYVADTGRGAVFVFDlPNGKVFVI-------GNAGP-NRFVSPIGVAIDAN-GNLYVSDAE-LGKVFVF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 661 SPSGEFITQWGEessgssplPGQFTVPHSLALVPHLGQLCVADRENARIQCFKTDTKEfvreikhssfgrnVFAIsyipg 740
Cdd:cd14962    84 DRDGKFLRAIGA--------GALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL-------------LFDI----- 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 741 llfavnGKPHFGDQEpvqgfvmnfssgeiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTltekvehrsvkK 820
Cdd:cd14962   138 ------GKRGSGPGE------------------------FNLPTDLAVDRDGNLYVTDTMNFRVQIFD-----------A 176
                         250       260
                  ....*....|....*....|.
gi 1622946049 821 AGIEVQEIkgkGSGGLNLGNF 841
Cdd:cd14962   177 DGKFLRSF---GERGDGPGSF 194
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
625-798 7.20e-09

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 57.67  E-value: 7.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 625 GSDQNHFCQPTDVAVDpGTGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGSsplpGQFTVPHSLALVPHLGQLCVADR 704
Cdd:cd14959    15 GSGEGQFNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPGKRD----GQLWYPNKVAVCRVTGRYVVTDR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 705 --ENARIQCFkTDTKEFVREikhssfgrnvFAISYI--PGLLfAVNGKPHFGDQEPVQGFVMNFS-SGEIIDIFKpVRKH 779
Cdd:cd14959    89 gnPRHRMQIF-TKRGQFVRK----------FGARYLqhVRGL-TVDAAGHIIVVESKVMRVFIFDeSGNVLKWFD-CSKY 155
                         170
                  ....*....|....*....
gi 1622946049 780 FDMPHDIVASeDGTVYIGD 798
Cdd:cd14959   156 LEEPSDVAVN-DNEIYICD 173
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
582-709 8.12e-09

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 57.22  E-value: 8.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 582 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILilgrsmqPGSDQNhfcQPTDVAVDpGTGAIYVSDGYcNSRIVQFS 661
Cdd:cd14952    12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVL-------PFTGLY---QPQGVAVD-AAGTVYVTDFG-NNRVLKLA 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622946049 662 PSgefitqwgeeSSGSSPLPgqFT---VPHSLAlVPHLGQLCVADRENARI 709
Cdd:cd14952    80 AG----------STTQTVLP--FTglnDPTGVA-VDAAGNVYVADTGNNRV 117
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
516-662 2.52e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 56.06  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 516 SGVALDPKNNLV-IFHRGDH---VWDGnsfDSKFVYQ--QIGLGPIE-----------EDTILVIDPNNA--AVLQSSGK 576
Cdd:cd14962   103 TGIAVDPAGKRLyVVDTLAHkvkVFDL---DGRLLFDigKRGSGPGEfnlptdlavdrDGNLYVTDTMNFrvQIFDADGK 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 577 NL------------FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILI-LGrsmQPGSDQNHFCQPTDVAVDp 641
Cdd:cd14962   180 FLrsfgergdgpgsFARPKGIAVDSEGNIYVVDAAFDnvQIF-----NPEGELLLtVG---GPGSGPGEFYLPSGIAID- 250
                         170       180
                  ....*....|....*....|.
gi 1622946049 642 GTGAIYVSDGYcNSRIVQFSP 662
Cdd:cd14962   251 KDDRIYVVDQF-NRRIQVFQY 270
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
574-667 2.95e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 53.04  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 574 SGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILilgrsMQ---PGSDQNHFCQPTDVAVDPGTGAIYV 648
Cdd:cd14959    16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVF-----DKEGEFK-----FQfgiPGKRDGQLWYPNKVAVCRVTGRYVV 85
                          90       100
                  ....*....|....*....|
gi 1622946049 649 SD-GYCNSRIVQFSPSGEFI 667
Cdd:cd14959    86 TDrGNPRHRMQIFTKRGQFV 105
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
582-709 4.88e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.82  E-value: 4.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 582 PHGLSIDKDGNYWVTDVALHQVFKLDPnnkegpililGRSMQ---PGSDQNHfcqPTDVAVDPGtGAIYVSDGYcNSRIV 658
Cdd:cd14952    96 PTGVAVDAAGNVYVADTGNNRVLKLAA----------GSNTQtvlPFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVL 160
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622946049 659 QFsPSGefitqwgeeSSGSSPLPgqFT---VPHSLAlVPHLGQLCVADRENARI 709
Cdd:cd14952   161 KL-AAG---------STTQTVLP--FTglnSPSGVA-VDTAGNVYVTDHGNNRV 201
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
646-804 5.46e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 5.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 646 IYVSDGYcNSRIVQFSP-SGEFITQWgeeSSGSSPlpgqftvpHSLALVPHLGQLCVADRENARIQCFKTDTKEFVREIK 724
Cdd:COG3391    82 LYVANSG-SGRVSVIDLaTGKVVATI---PVGGGP--------RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIP 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 725 hssFGRNVFAISYIP--GLLFAVNgkphFGDQEpVQGFV--MNFSSGEIIDIFKPvrkhFDMPHDIVASEDG-TVYIGDA 799
Cdd:COG3391   150 ---VGAGPHGIAVDPdgKRLYVAN----SGSNT-VSVIVsvIDTATGKVVATIPV----GGGPVGVAVSPDGrRLYVANR 217

                  ....*
gi 1622946049 800 HTNTV 804
Cdd:COG3391   218 GSNTS 222
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
582-659 6.54e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.44  E-value: 6.54e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622946049 582 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILilgrsmqPGSDQNHfcqPTDVAVDPgTGAIYVSDgYCNSRIVQ 659
Cdd:cd14952   180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTVL-------PFTGLNG---PLGVAVDA-AGNVYVAD-RGNDRVVK 245
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
560-713 1.34e-06

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 50.81  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 560 ILVIDPNNAAVL--QSSGK------------NLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILILGRSMQ 623
Cdd:cd14960   119 IIVVDNKACCVFifQPNGKlvtrfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHsvKVF-----NAEGEFLFKFGSNG 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 624 PGSDQnhFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGEFITQWGeesSGSSPLPGqftvPHSLALVPHlGQLCVAD 703
Cdd:cd14960   194 EGNGQ--FNAPTGVAVDS-NGNIIVAD-WGNSRIQVFDSSGSFLSYIN---TSADPLYG----PQGLALTSD-GHVVVAD 261
                         170
                  ....*....|
gi 1622946049 704 RENAriqCFK 713
Cdd:cd14960   262 SGNH---CFK 268
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
572-661 3.04e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 49.96  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 572 QSSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILilgRSM-QPGSDQNHFCQPTDVAVDpGTGAIYV 648
Cdd:cd14957   198 SGSGPGQFSDPYGIAVDSDGNIYVADTGNHriQVF-----TSSGAYQ---YSIgTSGSGNGQFNYPYGIAVD-NDGKIYV 268
                          90
                  ....*....|...
gi 1622946049 649 SDGYcNSRIVQFS 661
Cdd:cd14957   269 ADSN-NNRIQVFN 280
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
636-807 3.93e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 636 DVAVDPGTGAIYVSDGYCNSRIVQFSPSGEFITQWGEESSGSSPLPGQFTVPHSLALVPHLGQ-LCVADRENARIQCFKT 714
Cdd:COG3391    18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 715 DTKEFVREIKHSSFGRNVfAISYIPGLLFAVNGKPHFgdqepVQgfVMNFSSGEIIDIFKPvrkhFDMPHDIVASEDG-T 793
Cdd:COG3391    98 ATGKVVATIPVGGGPRGL-AVDPDGGRLYVADSGNGR-----VS--VIDTATGKVVATIPV----GAGPHGIAVDPDGkR 165
                         170
                  ....*....|....
gi 1622946049 794 VYIGDAHTNTVWKF 807
Cdd:COG3391   166 LYVANSGSNTVSVI 179
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
625-840 5.76e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 48.81  E-value: 5.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 625 GSDQNHFCQPTDVAVDPgTGAIYVSD-GycNSRIVQFSPSGEFITQWGEESSGSsplpGQFTVPHSLALVPHlGQLCVAD 703
Cdd:cd14961     4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGPKGDAG----QDIRYPLDVAVTPD-GHIVVTD 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 704 RENARIqcfktdtKEFVREIKHSSFGRNVFAISYipGLlfAVNGKPHF--GDQEpvQG----FVMNFSSGEIIDIFKpVR 777
Cdd:cd14961    76 AGDRSV-------KVFSFDGRLKLFVRKSFSLPW--GV--AVNPSGEIlvTDSE--AGklfvLTVDFKLGILKKGQK-LC 141
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946049 778 KHFDMPHDIVASEDGTVYIgdahtntvwkftltekVEHRSVKKAGIEVQEIKGKGSGGLNLGN 840
Cdd:cd14961   142 SQLCRPRFVAVSRLGAVAV----------------TEHLFANGTRSSSTRVKVFSSGGQLLGQ 188
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
666-808 1.97e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 47.19  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 666 FITQWGEESSGSsplpGQFTVPHSLAlVPHLGQLCVADRENARIQCFKTDtkefvreikhssfgrnvfaisyipGLLFAV 745
Cdd:cd14955     1 FVTQWGSYGSGD----GQFNSPSGIA-VDSAGNVYVADTGNNRIQKFDST------------------------GTFLTK 51
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946049 746 NGKPHFGDqepvqgfvmnfssGEiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 808
Cdd:cd14955    52 WGSSGSGD-------------GQ-----------FYSPTGIAVDSDGNVYVADTGNHRIQKFD 90
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
555-715 3.70e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.42  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 555 IEEDTILVIDPNNAAV---LQSSGknlfyLPHGLSIDKDGNYWVTDvALHQVFKLDPNNKEgPILILGRSMQPGSdqnhf 631
Cdd:COG3386    26 IPGGRIHRYDPDGGAVevfAEPSG-----RPNGLAFDPDGRLLVAD-HGRGLVRFDPADGE-VTVLADEYGKPLN----- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 632 cQPTDVAVDPGtGAIYVSD---GYCNSRIVQFSPSGEFitqwgeessgsSPLPGQFTVPHSLALVPHLGQLCVADRENAR 708
Cdd:COG3386    94 -RPNDGVVDPD-GRLYFTDmgeYLPTGALYRVDPDGSL-----------RVLADGLTFPNGIAFSPDGRTLYVADTGAGR 160

                  ....*..
gi 1622946049 709 IQCFKTD 715
Cdd:COG3386   161 IYRFDLD 167
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
684-712 1.11e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.00  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*....
gi 1622946049 684 FTVPHSLALVPhLGQLCVADRENARIQCF 712
Cdd:pfam01436   1 FNRPHGVAVDS-NGDIYVADSENHRVQVF 28
MALA cd12811
Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia ...
634-739 2.51e-03

Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.


Pssm-ID: 411995 [Multi-domain]  Cd Length: 304  Bit Score: 41.08  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946049 634 PTDVAVDPgTGAIYVSDGYCNSrIVQFSPSGEFITQWGEESSGSSPLPGqFTvphSLALVPHLGQLCVADRENARIQCFK 713
Cdd:cd12811   123 FQDSAQDS-DGNSYVVGALPPA-IAKVSPDGKTVTPWFLEAPNGSTRPG-YT---GIAYIPEDNVLLASGGEPGQLTRFD 196
                          90       100       110
                  ....*....|....*....|....*....|
gi 1622946049 714 TD----TKEFVReIKHSSFGRNVFAIsYIP 739
Cdd:cd12811   197 LSsatpTPIPVK-ISGENFGGLDDGE-KLP 224
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
631-660 3.42e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.84  E-value: 3.42e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1622946049 631 FCQPTDVAVDPGtGAIYVSDgYCNSRIVQF 660
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVAD-SENHRVQVF 28
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
780-807 4.73e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 4.73e-03
                          10        20
                  ....*....|....*....|....*...
gi 1622946049 780 FDMPHDIVASEDGTVYIGDAHTNTVWKF 807
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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