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Conserved domains on  [gi|1622944745|ref|XP_028705281|]
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DNA excision repair protein ERCC-8 isoform X3 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-315 3.24e-33

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 3.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  14 LSGGSDGVIVLYDLENSSRQSyytckavcsigrdHPDVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 93
Cdd:COG2319    94 ASASADGTVRLWDLATGLLLR-------------TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  94 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRR 172
Cdd:COG2319   160 gHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 173 ASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFT 252
Cdd:COG2319   236 GK-LLRTL---------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGG 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622944745 253 VSCgcsseFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:COG2319   291 VNS-----VAFSPDGKLLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-315 3.24e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 3.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  14 LSGGSDGVIVLYDLENSSRQSyytckavcsigrdHPDVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 93
Cdd:COG2319    94 ASASADGTVRLWDLATGLLLR-------------TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  94 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRR 172
Cdd:COG2319   160 gHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 173 ASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFT 252
Cdd:COG2319   236 GK-LLRTL---------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGG 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622944745 253 VSCgcsseFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:COG2319   291 VNS-----VAFSPDGKLLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-315 5.37e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 5.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  13 MLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSSFDKTLKVWDTNTLQTADVF 92
Cdd:cd00200    24 LATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  93 N-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYIlATASADSRVKLWDVR 171
Cdd:cd00200    90 TgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 172 RASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKvcNNSKKGLKF 251
Cdd:cd00200   166 TGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622944745 252 TVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:cd00200   228 SPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 129-169 4.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 4.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622944745  129 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 169
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 126-236 4.62e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 126 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 181
Cdd:PTZ00420  113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622944745 182 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 236
Cdd:PTZ00420  191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
WD40 pfam00400
WD domain, G-beta repeat;
130-169 6.41e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.41e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622944745 130 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 169
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-315 3.24e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 3.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  14 LSGGSDGVIVLYDLENSSRQSyytckavcsigrdHPDVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 93
Cdd:COG2319    94 ASASADGTVRLWDLATGLLLR-------------TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  94 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRR 172
Cdd:COG2319   160 gHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 173 ASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFT 252
Cdd:COG2319   236 GK-LLRTL---------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGG 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622944745 253 VSCgcsseFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:COG2319   291 VNS-----VAFSPDGKLLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-315 5.37e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 5.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  13 MLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSSFDKTLKVWDTNTLQTADVF 92
Cdd:cd00200    24 LATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  93 N-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYIlATASADSRVKLWDVR 171
Cdd:cd00200    90 TgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 172 RASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKvcNNSKKGLKF 251
Cdd:cd00200   166 TGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622944745 252 TVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:cd00200   228 SPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
15-315 2.07e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 2.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  15 SGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 94
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLT-------------GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  95 EE-TVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrrA 173
Cdd:COG2319   245 HSgSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDL--A 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 174 SG-CLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNssngentlvnygkvcnnskkglkft 252
Cdd:COG2319   319 TGkLLRTL---------------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD------------------------- 358

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622944745 253 vscgcssefvfvpygstiavytVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:COG2319   359 ----------------------LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
15-227 4.36e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 4.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  15 SGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRdhpdvHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN- 93
Cdd:COG2319   221 SGSADGTVRLWDLA--------TGKLLRTLTG-----HSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTg 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  94 FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRrA 173
Cdd:COG2319   287 HSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLA-T 361

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622944745 174 SGCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 227
Cdd:COG2319   362 GELLRTL---------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-232 2.76e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 2.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745   8 SWQSCMLSGGSDGVIVLYDLENSSRQSYYTCkavcsigrdhpdvHRYSVETVQWYPHDTgMFTSSSFDKTLKVWDTNTLQ 87
Cdd:cd00200    61 ADGTYLASGSSDKTIRLWDLETGECVRTLTG-------------HTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  88 TADVFNF-EETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRhDYILATASADSRVK 166
Cdd:cd00200   127 CLTTLRGhTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIK 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622944745 167 LWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 232
Cdd:cd00200   203 LWDLSTGK-CLGTL---------------RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-227 2.07e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  14 LSGGSDGVIVLYDLENssrqsyYTCKAVCsigRDHPDvhrySVETVQWyPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 93
Cdd:cd00200   109 SSSSRDKTIKVWDVET------GKCLTTL---RGHTD----WVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  94 -FEETVYSHHMSPVSTKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrHDYILATASADSRVKLWDVRR 172
Cdd:cd00200   175 gHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRT 250

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622944745 173 ASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 227
Cdd:cd00200   251 GE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
52-315 1.17e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  52 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGS 131
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 132 CSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrrASG-CLITLdqhngkksqavesanTAHNGKVNGLCFTSD 210
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDL--ATGkLLRTL---------------TGHSGAVTSVAFSPD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 211 GLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYSGE 279
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKLLAsgsadgtvrLWDLATGK 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1622944745 280 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
14-171 2.15e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 2.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  14 LSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 93
Cdd:COG2319   262 ASGSADGTVRLWDLATGELLRTLT-------------GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622944745  94 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVR 171
Cdd:COG2319   328 gHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-315 7.39e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 7.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 112 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrRASGCLITLdqhngkksqav 191
Cdd:cd00200    23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL-ETGECVRTL----------- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 192 esanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK---VCNNSKKGLKFTVSCGCSSefvfvpygS 268
Cdd:cd00200    90 ----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHtdwVNSVAFSPDGTFVASSSQD--------G 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1622944745 269 TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:cd00200   158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-315 9.71e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 9.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 132 CSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrrasgclitldqhngkKSQAVESANTAHNGKVNGLCFTSDG 211
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL----------------ETGELLRTLKGHTGPVRDVAASADG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 212 LHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS---------TIAVYTVYSGEQIT 282
Cdd:cd00200    64 TYLASGSSDKTIRLWDLETGE---------CVRTLTGHTSYVSS-----VAFSPDGRilssssrdkTIKVWDVETGKCLT 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622944745 283 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 315
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 129-169 4.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 4.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622944745  129 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 169
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 126-236 4.62e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 126 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 181
Cdd:PTZ00420  113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622944745 182 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 236
Cdd:PTZ00420  191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
WD40 pfam00400
WD domain, G-beta repeat;
130-169 6.41e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.41e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622944745 130 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 169
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 36-229 1.17e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745  36 YTCKAVCSIGRD--HPDVH---RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYSHHMSpvSTK 109
Cdd:PLN00181  510 FECESIIKDGRDihYPVVElasRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQlVTEMKEHEKRVWSIDYS--SAD 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 110 HCLVAVGTRGPKVQLCDLKSGSCSHILQGhRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGCLITLdqhngkksq 189
Cdd:PLN00181  588 PTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTM--------- 657

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622944745 190 avesanTAHNGKVNGLCFTsDGLHLLTVGTDNRMRLWNSS 229
Cdd:PLN00181  658 ------IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 127-231 1.85e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 127 LKSGSCSHI--LQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRasgclitldqhnGKKSQAVESantaHNGKVNG 204
Cdd:PTZ00421  110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER------------GKAVEVIKC----HSDQITS 173

                          90       100
                  ....*....|....*....|....*..
gi 1622944745 205 LCFTSDGLHLLTVGTDNRMRLWNSSNG 231
Cdd:PTZ00421  174 LEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-227 1.08e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.08e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622944745  196 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 227
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 146-232 3.97e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944745 146 VSWSPRHDyILATASADSRVklwDVRRASGclitldqhngkksQAVESANT-AHNGKVNGLCFTSDGlHLLTVGT-DNRM 223
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGEL---LLHRLNW-------------QRVWTLSPdKEDLEVTSLAWRPDG-KLLAVGYsDGTV 62


                  ....*....
gi 1622944745 224 RLWNSSNGE 232
Cdd:pfam12894  63 RLLDAENGK 71
WD40 pfam00400
WD domain, G-beta repeat;
196-227 7.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.62e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622944745 196 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 227
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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