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Conserved domains on  [gi|1622943987|ref|XP_028705189|]
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cadherin-18 isoform X3 [Macaca mulatta]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 387-484 8.48e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 8.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 387 SYVMEVYENAKIGTVVGTVLAQDPDS-ANSLVRYFInYNAEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDN 465
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622943987 466 PDLLSHVTVGIRVLDVNDN 484
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-264 6.41e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 6.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 163 PYIVTVPEMSDMGTSVLQVTATDADDptyGNSARVVYSILQGQP--YFSVDPKTGVIRTAlHNMDREAREHYSVVIQAKD 240
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1622943987 241 MAGQvgGLSGSTTVNITLTDVNDN 264
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-379 1.73e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 272 HYQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDketrEGILSLKKPLNYEKKKSYTLNIEGAN 351
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*...
gi 1622943987 352 THLDFRFSHlgpfkdaTMLKIIVGDVDE 379
Cdd:cd11304    77 GGGPPLSST-------ATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-157 1.65e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987   79 SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDrRTNKPLEPESEFIIKVQDINDNAP 157
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-539 1.14e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622943987 491 EYDIVVCENSKPGQVIHTISATDKDDFANGpRFNFFLDEHlPVNPNFTL 539
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSG-NEDGLFSI 47
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 387-484 8.48e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 8.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 387 SYVMEVYENAKIGTVVGTVLAQDPDS-ANSLVRYFInYNAEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDN 465
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622943987 466 PDLLSHVTVGIRVLDVNDN 484
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-264 6.41e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 6.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 163 PYIVTVPEMSDMGTSVLQVTATDADDptyGNSARVVYSILQGQP--YFSVDPKTGVIRTAlHNMDREAREHYSVVIQAKD 240
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1622943987 241 MAGQvgGLSGSTTVNITLTDVNDN 264
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 407-486 1.03e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.81  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  407 AQDPDS-ANSLVRYFINYNaEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDNPDLLSHVTVGIRVLDVNDNP 485
Cdd:smart00112   2 ATDADSgENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1622943987  486 P 486
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
388-479 7.06e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.13  E-value: 7.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 388 YVMEVYENAKIGTVVGTVLAQDPDSA-NSLVRYFINYNaEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDNP 466
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1622943987 467 DLLSHVTVGIRVL 479
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-379 1.73e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 272 HYQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDketrEGILSLKKPLNYEKKKSYTLNIEGAN 351
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*...
gi 1622943987 352 THLDFRFSHlgpfkdaTMLKIIVGDVDE 379
Cdd:cd11304    77 GGGPPLSST-------ATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 182-266 6.60e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 6.60e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  182 TATDADDptyGNSARVVYSILQG--QPYFSVDPKTGVIRTAlHNMDREAREHYSVVIQAKDMAGQvgGLSGSTTVNITLT 259
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1622943987  260 DVNDNPP 266
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
164-259 3.12e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 3.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 164 YIVTVPEMSDMGTSVLQVTATDADDPTygnSARVVYSILQGQPY--FSVDPKTGVIRTAlHNMDREAREHYSVVIQAKDM 241
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 1622943987 242 AGQvgGLSGSTTVNITLT 259
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-157 1.65e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987   79 SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDrRTNKPLEPESEFIIKVQDINDNAP 157
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 59-155 7.01e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 7.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  59 QFFVLEEHmgPDPQYVGKLH-SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTN 136
Cdd:cd11304     3 EVSVPENA--PPGTVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 1622943987 137 kPLEPESEFIIKVQDINDN 155
Cdd:cd11304    81 -PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
273-348 1.57e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.57e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622943987 273 YQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKetreGILSLKKPLNYEKKKSYTLNIE 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVE 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-381 1.71e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 1.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  291 KANDADTGSNADMTYSIINGDGMGIFSIstDKETreGILSLKKPLNYEKKKSYTLNIEGANthldfrfSHLGPFKDATML 370
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|..
gi 1622943987  371 KIIVGDV-DEPP 381
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
69-150 4.23e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 4.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  69 PDPQYVGKLH-SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTnKPLEPESEFI 146
Cdd:pfam00028  10 PVGTEVLTVTaTDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PPLSSTATVT 88


                  ....
gi 1622943987 147 IKVQ 150
Cdd:pfam00028  89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-539 1.14e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622943987 491 EYDIVVCENSKPGQVIHTISATDKDDFANGpRFNFFLDEHlPVNPNFTL 539
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSG-NEDGLFSI 47
Cadherin pfam00028
Cadherin domain;
492-539 5.54e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 5.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622943987 492 YDIVVCENSKPGQVIHTISATDKDDFANGpRFNFFLDEHlPVNPNFTL 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGG-GPGGNFRI 46
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 387-484 8.48e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 8.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 387 SYVMEVYENAKIGTVVGTVLAQDPDS-ANSLVRYFInYNAEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDN 465
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1622943987 466 PDLLSHVTVGIRVLDVNDN 484
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-264 6.41e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 6.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 163 PYIVTVPEMSDMGTSVLQVTATDADDptyGNSARVVYSILQGQP--YFSVDPKTGVIRTAlHNMDREAREHYSVVIQAKD 240
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1622943987 241 MAGQvgGLSGSTTVNITLTDVNDN 264
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 407-486 1.03e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.81  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  407 AQDPDS-ANSLVRYFINYNaEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDNPDLLSHVTVGIRVLDVNDNP 485
Cdd:smart00112   2 ATDADSgENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1622943987  486 P 486
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
388-479 7.06e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.13  E-value: 7.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 388 YVMEVYENAKIGTVVGTVLAQDPDSA-NSLVRYFINYNaEDDRFFNIDANTGTIKTTKVLDREETPWYNITVTASENDNP 466
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1622943987 467 DLLSHVTVGIRVL 479
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-379 1.73e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 272 HYQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDketrEGILSLKKPLNYEKKKSYTLNIEGAN 351
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*...
gi 1622943987 352 THLDFRFSHlgpfkdaTMLKIIVGDVDE 379
Cdd:cd11304    77 GGGPPLSST-------ATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 182-266 6.60e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 6.60e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  182 TATDADDptyGNSARVVYSILQG--QPYFSVDPKTGVIRTAlHNMDREAREHYSVVIQAKDMAGQvgGLSGSTTVNITLT 259
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1622943987  260 DVNDNPP 266
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
164-259 3.12e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 3.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987 164 YIVTVPEMSDMGTSVLQVTATDADDPTygnSARVVYSILQGQPY--FSVDPKTGVIRTAlHNMDREAREHYSVVIQAKDM 241
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 1622943987 242 AGQvgGLSGSTTVNITLT 259
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-157 1.65e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987   79 SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDrRTNKPLEPESEFIIKVQDINDNAP 157
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 59-155 7.01e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 7.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  59 QFFVLEEHmgPDPQYVGKLH-SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTN 136
Cdd:cd11304     3 EVSVPENA--PPGTVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 1622943987 137 kPLEPESEFIIKVQDINDN 155
Cdd:cd11304    81 -PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
273-348 1.57e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.57e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622943987 273 YQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKetreGILSLKKPLNYEKKKSYTLNIE 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVE 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-381 1.71e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 1.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  291 KANDADTGSNADMTYSIINGDGMGIFSIstDKETreGILSLKKPLNYEKKKSYTLNIEGANthldfrfSHLGPFKDATML 370
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|..
gi 1622943987  371 KIIVGDV-DEPP 381
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
69-150 4.23e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 4.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  69 PDPQYVGKLH-SNSDKGD-GSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTnKPLEPESEFI 146
Cdd:pfam00028  10 PVGTEVLTVTaTDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PPLSSTATVT 88


                  ....
gi 1622943987 147 IKVQ 150
Cdd:pfam00028  89 ITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-155 6.27e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.03  E-value: 6.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943987  62 VLEEHMGPdpQYVGKLHSNSDKGDGsVKYILTGEGA---GTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKP 138
Cdd:cd00031     6 AVEGRSRG--SFRVSIPTDLIASSG-EIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                          90
                  ....*....|....*..
gi 1622943987 139 LEPeSEFIIKVQDINDN 155
Cdd:cd00031    83 QTS-SVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-539 1.14e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622943987 491 EYDIVVCENSKPGQVIHTISATDKDDFANGpRFNFFLDEHlPVNPNFTL 539
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSG-NEDGLFSI 47
Cadherin pfam00028
Cadherin domain;
492-539 5.54e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 5.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622943987 492 YDIVVCENSKPGQVIHTISATDKDDFANGpRFNFFLDEHlPVNPNFTL 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGG-GPGGNFRI 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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